謝東

畢業於江西大學(現南昌大學)生物學系，在中科院遺傳研究所獲得碩士學位，在美國南卡羅來納大學生物系獲得博士學位。之後在美國加州大學洛杉磯分校(UCLA)醫學院先後為博士后和擔任助理教授。2003年起任中國科學院上海生命科學研究院營養科學研究所研究員，研究組長。2003年入選中國科學院“百人計劃”，2007年獲得“國家傑出青年基金”。目前承擔國家自然科學基金項目，國家重點基礎研究發展計劃(973計劃)，國家高技術研究發展計劃(863計劃)，中國科學院知識創新工程重點項目以及上海市重大基礎研究項目。擔任《Journal of Cell Communication and Signaling》和《Molecular Nutrition Food Research》編委。

腫瘤發生和轉移過程中的分子機制。利用分子生物學，細胞生物學以及動物模型研究癌基因和抑癌基因在腫瘤中的作用機理和信號轉導。目前工作主要集中研究CCN家族和Eph家族基因在腫瘤發生髮展中的作用。

Yu-Xiong Feng, Tao Wang, Pengyuan Yang, Jing-Jing Li, Yue-Zhen Deng, Fan Yao, Hui Wang, Nan Li, Meng-Chao Wu, Hong-Yang Wang, Xiao-Fan Wang, Shu-Qun Cheng and Dong Xie*. Sorafenib Suppresses Postsurgical Recurrence and Metastasis of HCC through Negative Regulation of Cell Growth Signaling Related to Liver Regeneration. Hepatology. 53(2):483-92, 2011.

Xiao-Dan Ji,, Guo Li, Yu-Xiong Feng, Jiang-Sha Zhao, Jingjing Li, Shuo Shi, Yue-Zheng Deng, Jun-Feng Xu, H. Phillip Koeffler, Xiang-Jun Tong, Dong Xie*. EphB3 Is Overexpressed in Non-Small Cell Lung Cancer and Promotes Tumor Metastasis by Enhancing Cell Survival and Migration. Cancer Research. 71(3):1156-66, 2011.

Yu-Xiong Feng, Jiang-Sha Zhao, Jing-Jing Li, Tao Wang, Shu-Qun Cheng Yunfei Yuan, Xiao-Fan Wang and Dong Xie*. Liver Cancer: EphrinA2 Promotes Tumorigenicity through Rac1/Akt/NF-kappaB Signaling Pathway. Hepatology, 51(2): 535-544, 2010.

Haiyan Ying, Lifen Yang, Guilin Qiao, Zhenping Li, Li Zhang, Fei Yin, Dong Xie*, and Jian Zhang*. Cutting edge: CTLA-4-B7 interaction suppresses Th17 cell differentiation. Journal of Immunology, 185(3):1375-8. 2010.

Zhen Cai, Jiang-Sa Zhao, Xiao-Yan Wang, Jing-Jing Li, Li-Yan Xu, Li-Yan Xu, En-Ming Li, Wei Jia and Dong Xie*. A Combined Proteomic and Metabolomic Profiling of Gastric Cardia Cancer Reveals Characteristic Dysregulations in Glucose Metabolism. Molecular and Celularl Proteomics, 9(12):2617-28. 2010.

Wang LD, Zhou FY, Li XM, Sun LD, Song X, Jin Y, Li JM, Kong GQ, Qi H, Cui J, Zhang LQ, Yang JZ, Dong Xie, Chen SQ, Yang WC, Hong JY, Wang L, Qiu SL, Cai ZM, Zhang XJ. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nature Genetics, Sep; 42(9):759-63, 2010.

Jian-Jun Xie, Li-Yan Xu, Jian-Yi Wu, Zhong-Ying Shen, Qing Zhao, Ze-Peng Du, Zhuo Lv, Wei Gu, Feng Pan, Xiu-E Xu , Dong Xie*and En-Min Li. Involvement of CYR61 and CTGF in the Fascin-Mediated Proliferation and Invasiveness of Esophageal Squamous Cell Carcinomas Cells. The American Journal of Pathology, 176(2):939-51, 2010.

Yifu Qiu, Ting Mao, Yongliang Zhang, Mengle Shao, Jia You, Qiurong Ding, Yan Chen, Dongmei Wu, Dong Xie, Xu Lin, Xiang Gao, Randal J. Kaufman, Wenjun Li, and Yong Liu. A crucial role for RACK1 in the regulation of glucose stimulated IRE1alpha activation in pancreatic beta cells. Science Signaling, 3, 106, 2010.

Xiao-Feng Lu, En-Min Li, Ze-Peng Du, Jian-Jun Xie, Zhang-Yan Guo, Shu-Ying Gao, Lian-Di Liao, Zhong-Ying Shen, Dong Xie*and Li-Yan Xu. Specificity protein 1 regulates fascin expression in esophageal squamous cell carcinoma as the result of the epidermal growth factor/extracellular signal-regulated kinase signaling pathway activation. Cellular and Molecular Life Sciences, 67(19):3313-29, 2010.

Peizhan Chen, Pingting Hu, Dong Xie, Ying Qin, Fudi Wang and Hui Wang Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Research Treatment, (2):469-77, 2010.

Tao Wang, Hua-Sheng Hu, Yu-Xiong Feng, J Shi, N Li, W X Guo, Jing Xue, Dong Xie, S R Liu, M C Wu and S Q Cheng. Characterisation of a novel cell line (CSQT-2) with high metastatic activity derived from portal vein tumour thrombus of hepatocellular carcinoma. British Journal of Cancer, 25;102(11):1618-26, 2010.

Dong Yin, Weikai Chen, James O'Kelly, Daning Lu, Michelle Ham, Ngan B. Doan, Dong Xie, Charles Wang, Jay Vadgama, Jonathan W. Said, Keith L. Black, H. Phillip Koeffler Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. International Journal of Cancer, 15; 127(10):2257-67. 2010.

Nan Li, Weixing Guo, Jie Shi, Jie Xue, Huasheng Hu , Dong Xie, Mengchao Wu and Shuqun Cheng, Expression of the chemokine receptor CXCR4 in human hepatocellular carcinoma and its role in portal vein tumor thrombus. J Exp Clin Cancer Res. Nov 27; 29(1):156. 2010.

Jing-jing Li, Dong-Ping Liu, Gentao Liu and Dong Xie*, EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor. Oncogene, 16 :1759-68 2009.

Jing-jing Li, Robert Z.Qi, Gary Kar Ho Ng and Dong Xie*. Proteomics in gastric cancer research: benefits and challenges. Proteomics Clinical Application, 3. 185-196. 2009.

Wu Zhou , Xiao-Lei Ye, Zhi-Jian Sun, Xiao-Dan Ji, Hai-Xiang Chen, Dong Xie*. Overexpression of degenerative spermatocyte homolog 1 up-regulates the expression of cyclin D1 and enhances metastatic efficiency in esophageal carcinoma Eca109 cells. Mol Carcinog, 48(10):886-94, 2009.

Yan Wang, Dong-Ping Liu, Ping-Ping Chen, Xiang-Jun Tong, Dong Xie*. Negative Feedback Regulation of IFN-gamma Pathway by IFN Regulatory Factor 2 in Esophageal Cancers. Cancer Research, 68: 1136-1143, 2008.

Zhi-Jian Sun, Yan Wang, Zhen Cai, Ping-Ping Chen, Xiang-Jun Tong and Dong Xie*, Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cells. British Journal of Cancer, 18, 99(10):1656-67, 2008.

Jing-Jing Li , Changjiang Huang and Dong Xie*. Anti-obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid. Mol Nutr Food Res. Jun;52(6):631-45, 2008.

Fengmin Lu, Hairu Chen, Chun Zhou, Shuang Liu, Mingzhou Guo, Pingping Chen, Hui Zhuang, Dong Xieand Songwei Wu. T-type Ca2+ channel expression in human esophageal carcinomas: a functional role in proliferation. Cell Calcium, 43(1):49-58, 2008.

Peizhan Chen, Jie Liang, Zhanwei Wang, Xiaoyi Zhou, Lu Chen, Mian Li, Dong Xie, Zhibin Hu, Hongbing Shen and Hui Wang Association of common PALB2 polymorphisms with breast cancer risk: a case-control study. Clin Cancer Res. Sep 15;14(18):5931-7, 2008.

Yue-Zhen Deng, Ping-Ping Chen, Yan Wang, Dong Yin, H. Phillip Koeffler, Baojie Li, Xiang-Jun Tong, and Dong Xie*. Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-TCF/lef signaling. J Biol Chem. 282. 36571-36581, 2007.

Yan Wang, Dong-Ping Liu, Ping-Ping Chen, H. Phillip Koeffler, Xiang-Jun Tong, Dong Xie*. Involvements of Interferon Regulatory Factor-1 and -2 in the Formation and Progression of Human Esophageal Cancers. Cancer Research, 67: 2535-2543, 2007.

Dong-Ping Liu, Robert Z. Qi, Yan Wang, Ping-Ping Chen, H. Phillip Koeffler, Dong Xie*Discovery of Stage-related Proteins in Esophageal Squamous Cell Carcinoma using Proteomic Analysis. PROTEOMICS-clinical applications, 1,312-320, 2007.

Ping-Ping Chen, Wei-Jie Li, Yan Wang, Song Zhao, De-Yun Li, Li-Yun Feng, and Dong Xie*. Expression of Cyr61, CTGF, and WISP-1 Correlates with Clinical Features of Lung Cancer. PLoS ONE, 6:534, 2007.

Dong-Ping Liu, Yan Wang, H. Phillip Koeffler, Dong Xie*. Ephrin-A1 Is a Negative Regulator in Glioma through Downreguation of EphA2 and FAK. International Journal of Oncology, 30(4); 865-874, 2007.

Jing-Jing Li and Dong Xie*. Cleavage of focal adhesion kinase (FAK) is essential in adipocyte differentiation. Biochem Biophys Res Commun, 357(3):648-54, 2007.