柳紅

1991.9.1-1993.8.31，山東新華製藥廠四車間，助理工程師。

1999.8.1-2001.8.31，中國科學院上海藥物研究所，博士。

2002.2.1-2002.10.30，美國University of Texas Medical Branch 大學，訪問科學家（Visiting Scientist）。

2005.1.1-2005.10.30，美國University of Texas Medical Branch 大學，訪問科學家（Visiting Scientist）。

2001.9.1-2006.6.30，中國科學院上海藥物研究所，副研究員、碩士生導師。

2006.1.7-至今，中國科學院上海藥物研究所，研究員、博士生導師。

1.發展高效的合成方法學構建類藥性(手性)雜環化合物庫

2.針對重大疾病的創新藥物研究

（1）抗糖尿病藥物DPPIV抑製劑的發現研究

（2）抗老年痴獃藥物的發現研究

（3）靶向α1A-AR的新型抗前列腺增生藥物的發現研究

（4）抗腫瘤藥物c-Met抑製劑的發現研究

（5）抗HIV藥物CCR5抑製劑的發現研究

承擔科研項目情況

1.國家自然科學基金重大研究計劃重點支持項目，S1P在腫瘤細胞糖脂代謝異常及非可控性炎症向腫瘤癌轉化中的分子調控，項目負責人，2013.01-2016.12

2.國家科技十二五重大專項，抗糖尿病類LJN系列新葯候選物的臨床前研究，項目負責人，2012.01-2015.12

3.上海市優秀學術帶頭人計劃，手性藥物優勢骨架化合物庫的構建與新葯設計與發現研究，項目負責人，2012.07-2014.06

4.國家傑出青年基金，藥物化學，項目負責人，2011.01-2014.12

5.歐盟F7框架計劃SILVER項目，Small-molecule inhibitor leads versus emerging and neglected RNA viruses，中方負責人，2010.10-2014.09

6.科技部對歐盟合作項目，抗腸道病毒（EV68、EV71）小分子抑製劑研究，項目負責人，2011.12-2013.12

7.國家高技術研究發展計劃（863）基金JG3，DC06及DC032的研究與開發，項目負責人，2006.11-2010.12

8.國家自然科學基金項目，新型鉀離子通道阻滯劑的發現及其亞型的選擇性和功能研究，項目負責人，2008.1-2011.12

研究領域

主要從事藥物化學基礎和應用基礎的研究工作，研究領域涉及藥物化學、有機合成和計算機輔助藥物設計等學科。作為課題負責人先後承擔了國家高技術“863”計劃、國家自然科學基金、上海市科委等基金項目。近年來，圍繞新結構類型先導化合物的合成，開展新的有機合成方法學研究，在Chemistry & Biology、Journal of Biological Chemistry、Journal of Medicinal Chemistry、Organic Letters、 Journal of Organic Chemistry、Journal of Combinatorial Chemistry、Biophysical Journal、Journal of Pharmacology Experimental Therapeutics、Current Medicinal Chemistry、Bioorganic & Medicinal Chemistry、Tetrahedron Letters和Drug Metabolism and Disposition等雜誌上發表國內外論文百餘篇。參加5本專著的編寫，申請專利30項，獲得專利證書5項。

代表論著

1. Shengbin Zhou, Jiang Wang, Xia Chen, José Luis Aceña Vadim A. Soloshonok,* and Hong Liu*. Chemical Kinetic Resolution of Unprotected b-Substituted-b-Amino Acids Using Recyclable Chiral Ligands. Angewandte Chemie. 2014, 53, 7883-7886. (IF=13.734).

2. Jiang Wang, José Luis Aceña, Santos Fustero, Carlos del Pozo, María Sánchez-Roselló, Vadim A. Soloshonok,* Alexander E. Sorochinsky, , Hong Liu*. Fluorine in Pharmaceutical Industry; Fluorinated Drugs Introduced to the Market in the Last Decade. Chemical Reviews. 2014,114, 2432−2506. (IF=41.298)

3. Wei Yang, Liliang Huang, Hong Liu, Wei Wang* and Hao Li*. Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines. Chem Comm 2013, 49, 4667-4669. (IF=6.378)

4. Enguang Feng, Woo-Jin Shin, Xuelian Zhu, Jian Li, Deju Ye, Jiang Wang, Jian-Ping Zuo, Kyoung Tai No, Mingyue Zheng, Weiliang Zhu, * Wei Tang, * Baik-Lin Seong,* Hualiang Jiang, and Hong Liu* Structure-Based Design, Synthesis of C-1 and C-4 modified analogs of zanamivir as neuraminidase inhibitors. Journal of Medicinal Chemistry 2013, 56, 671-684. (IF=5.614)

5. Jiahui Wu, Dengyou Zhang, Lei Chen, Jianneng Li, Jianling Wang, Chengqing Ning,Niefang Yu, Fei Zhao,Dongying Chen,Xiaoyan Chen,Kaixian Chen, Hualiang Jiang, Hong Liu*,and Dongxiang Liu*, Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate Journal of Medicinal Chemistry 2013, 56,761-780. (IF=5.614)

6. Shengtao Xu, Yu Zhou, Jinyi Xu*, Hualiang Jiang, and Hong Liu* Gold-catalyzed Michael Addition/Intramolecular Annulation Cascade: an Effective Pathway for the Chemoselective- and Regioselective Synthesis of Tetracyclic Indole Derivatives in Water Green Chemistry. 2013,15,718-726. (IF=6.828)

7. Lei Zhang, Fei Zhao, Mingyue Zheng, Yun Zhai and Hong Liu* Rapid and selective access to three distinct sets of indole-based heterocycles from a single set of Ugi-adducts under microwave heating Chem Comm 2013,49,2894-2896. (IF=6.378)

8. Daizong Lin, Jiang Wang, Xu Zhang, Shengbin Zhou, Jie Lian, Hualiang Jiang and Hong Liu* Highly diastereoselective synthesis of 3-indolylglycines Chem Comm 2013,49,2575-2577. (IF=6.378)

9. Jinfang Wang, Yu Zhou,* Lei Zhang, Zeng Li, Xianjie Chen and Hong Liu*. Asymmetric Michael Addition of N-tert-Butanesulfinyl Imidates: an Efficient Strategy for the Synthesis of (R)-3-Substituted Indanone Derivertives. Organic Letters. 2013,15,1508-1511. (IF=6.142)

10. Xianjie Chen , Hui Chen, Xun Ji, Hualiang Jiang, Zhu-Jun Yao, and Hong Liu*. Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro [pyrrolidin-3, 2′-oxindole] Derivatives Organic Letters. 2013,15,1846-1849. (IF=6.142)

11. Enguang Feng, Yu Zhou, Fei Zhao, Xianjie Chen, Lei Zhang, Hualiang Jiang, Hong Liu* Gold-catalyzed tandem reaction in water: An efficient and convenient synthesis of fused polycyclic indoles. Green Chemistry. 2012, 14, 1888-1895. (IF=6.828)

12. Xianjie Chen, Wei Zhu, Wangke Qian, Enguang Feng, Yu Zhou, Jinfang Wang, Hualiang Jiang, Zhu-Jun Yao,* and Hong Liu.* Highly Enantioselective of 2-Oxindoles-3-carboxylate Ester to Nitroolefins Promoted by Cinchona Alkaloid Thiourea-Brønsted Acid Co-catalysts. Advanced Synthesis & Catalysis 2012, 354, 2151-2156. (IF=5.353)

13. Wangke Qian, Lei Zhang, Haifeng Sun, Hualiang Jiang, and Hong Liu* Microwave-assisted One-step Synthesis of Acetophenones via Palladium-catalyzed Regioselective Arylation of Vinyloxy-trimethylsilane Advanced Synthesis & Catalysis 2012, 354, 3231-3236. (IF=5.535)

14. Qian Ba, Miao Hao, He Huang, Junmei Hou, Shichao Ge, Zhuzhen Zhang, Jun Yin, Ruiai Chu, Liang Hua Jiang, Fudi Wang, Kaixian Chen, Hong Liu*, and Hui Wang* . Iron deprivation suppresses hepatocellular carcinoma growth in experimental studies. Clin. Cancer Res. 2011, 17, 7625-7633. (IF=7.837)

15. Jiang Wang, Shengbin Zhou, Daizong Lin, Xiao Ding, Hualiang Jiang and Hong Liu*. Highly diastereo- and enantioselective synthesis of syn-β-substituted tryptophans via asymmetric Michael addition of a chiral equivalent of nucleophilic glycine and sulfonylindoles. Chem. Commun. 2011, 47, 8355-8357. (IF=6.378)

16. Haifeng Sun, He Huang, Dengyou Zhang, Enguang Feng, Wangke Qian, Lei Zhang, Kaixian Chen and Hong Liu*. Synthesis of 4-Aryl-2(5H)-furanones by Gold(I)-Catalyzed Intramolecular Annulation. Adv. Synth. Catal. 2011, 353, 1413-1419. (IF=5.535)

17. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang and Hong Liu*. An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization. Adv. Synth. Catal. 2011, 353, 1429-1437. (IF=5.535)

18. Diliang Guo, Tao Chen, Deju Ye, Jinyi Xu, Hualiang Jiang, Kaixian Chen, Hui Wang*, and Hong Liu*. Cell-Permeable Iminocoumarine-Based Fluorescent Dyes for Mitochondria. Org. Lett. 2011, 13, 2884-2887. (IF=6.142)

19. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang and Hong Liu*. Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles. Green Chem. 2011, 3, 397-405. (IF=6.828)

20. Jin-gui Ma, He Huang, Ling-hua Meng, Si-meng Chen, Yi Chen, Xian-liang Xin, Li-ping Lin , Hong Liu*, Jian Ding,* PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo. Breast Cancer Research and Treatment. 2011, 130, 85-96. (IF=4.564)

21. Jing Deng , Enguang Feng, Sheng Ma, Yan Zhang, Xiaofeng Liu, Honglin Li*, Huang Huang, Jin Zhu, Weiliang Zhu, Xu Shen, Liyan Miao*, Hong Liu, Hualiang Jiang, Jian Li*. Design and Synthesis of First-in-Class Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases? Journal of Medicinal Chemistry.2011, 54, 4508-4522. (IF=5.614)

22. Yu Zhou, Chunyi Jiang, Yaping Zhang, Zhongjie Liang, Wenfeng Liu, Liefeng Wang, Cheng Luo, Tingting Zhong, Yi Sun, Linxiang Zhao, Xin Xie, Hualiang Jiang, Naiming Zhou,* Dongxiang Liu* and Hong Liu*. Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as β-Amyloid Peptide Aggregation Inhibitors. Journal of Medicinal Chemistry 2010, 53, 5449-5466. (IF=5.614)

23. Yu Zhou,Yun Zhai, Jian Li, Deju Ye, Hualiang Jiang and Hong Liu.* Metal-free Tandem Reaction in Water: An Efficient and Regioselective Synthesis of 3-Hydroxyisoindolin-1-ones. Green Chemistry. 2010, 12，1397-1404. (IF=6.828).

24. He Huang, Qin Chen，Xin Ku, Linghua Meng*, Liping Lin, Xiang Wang, Caihua Zhu, Yi Wang, Zhi Chen, Ming Li, Hualiang Jiang, Kaixian Chen, Jian Ding , Hong Liu.* A series of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity. Journal of Medicinal Chemistry 2010, 53, 3048-3064. (IF=5.614)

25. Yu Feng, Xiao Ding, Tao Chen, Lili Chen , Fang Liu, Xu Jia, Xiaomin Luo,Xu Shen, Kaixian Chen, Hualiang Jiang, Hui Wang*, Hong Liu*, Dongxiang Liu.* Design, Synthesis and Interaction Study of Quinazoline-2(1H)-Thione Derivatives as Novel Bcl-xL Inhibitors. Journal of Medicinal Chemistry 2010, 53, 3465-3479. (IF=5.614)