楊卓

一、教育經歷

1983年天津醫科大學本科畢業，1989年浙江大學醫學院，醫學碩士學位。1998年英國伯明翰大學醫學院，博士學位。

二、工作經歷

1983年天津醫科大學本科畢業，1989年浙江大學醫學院獲醫學碩士學位。1998年英國伯明翰大學醫學院獲博士學位。2003起至今為南開大學教授。

三、學術兼職

天津市生物醫學檢測技術與儀器重點實驗室學術委員會委員

天津市神經損傷變異與再生重點實驗室學術委員會委員

中華醫學研究雜誌專家編輯委員會常務編委

中華臨床醫學雜誌英文版編委

天津醫藥編委及英文編輯

1． 生理學

2． 專業英語

3． 若干研究生及碩士生課程

研究方向：

1圍繞神經系統重大疾病，開發和製備了相關的動物模型，並在動物模型基礎上進行神經電生理、認知、神經細胞的免疫組化及突觸機制等研究。

2納米顆粒在中樞神經系統的作用和毒性的機制。

3 腎發育有關的離子通道機制研究。

4海馬神經通路的交互作用與神經元突觸傳遞效率。

天津市應用基礎與前沿技術研究計劃重點項目（10JCZDJC19100）

科技部973項目(2011CB944003)

國家自然科學基金項目(31070890)

英國皇家工程學院與中國研究交流項目Ref 5502）

1.Dehong Shan,Yongling Xie, Guogang Ren, Zhuo Yang. Inhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neurons. Toxicology Letters. 2012; (209): 129-135

2. Jing Xu, Pengjuan Xu, Zhigui Li, Jie Huang, Zhuo Yang*. Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells. J Biomed Mater Res A. 2012;100(3): 738-745

3. Liu Ye, Guan Wei, Ren G, Yang Zhuo. The possible mechanism of silver nanoparticle impact on hippocampal synaptic plasticity and spatial cognition in rats. Toxicol Lett. 2012;(209): 227-231

4. Yongling Xie, Yiyi Wang, Tao Zhang, Guogang Ren, Zhuo Yang,Effects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviors. The Journal of Biomedical Science. 2012;19(1):14

5. XU Jing, WANG Yiyi, LI Ning, XU Lanju, YANG Hanyu, YANG Zhuo. l-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia. Neuropharmacology. 2012;62(7):2423–2428

6. Liu Z, Zhang T, Ren G, Yang Z. Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons. Nanotoxicology. 2012;6:414-423

7. Xu Pengjuan, Xu Jing, Li Zhigui, Yang Zhuo. Expression of TRPC6 in renal cortex and hippocampus of mouse during postnatal development. PLoS One.2012;7(6):e38503（P1-P8）

8. Jing Xu, Zhigui Li, Pengjuan Xu and Zhuo Yang. Protective effects of leukemia inhibitory factor against oxidative stress during high glucose-induced apoptosis in podocytes. Cell Stress Chaperones. 2012 Jul;17(4):485-93

9. Pengjuan Xu, Jing Xu, Shichang Liu, Guogang Ren, Yang Zhuo. In vitro to xicity of nanosized copper particles in PC12 cells induced by oxidative stress. Journal of Nanoparticle Research. 2012;14(906):1-9

10. Lu Xiao, Zhanyong Li, Pengjuan Xu, Zhigui Li, Jing Xu, Zhuo Yang.The Expression of EPOR in renal cortex during postnatal development. PLoS One. July 2012; 7(7): e41993

11. Han YG, Xu J, Li ZG, Ren GG, Yang Z. In vitro toxicity of multi-walled carbon nanotubes in C6 rat glioma cells. Neurotoxicology. 2012;33( 5): 128-134

12. Jing Xu, Zhigui Li, Pengjuan Xu, Lu Xiao, Zhuo Yang. Nanosized copper oxide induces apoptosis through oxidative stress in podocytes. Arch Toxicol DOI 10.1007/13. Jingxia Zhao, Yang Yao, Shichang Liu, Tao Zhang, Guogang Ren, Zhuo Yang. Involvement of reactive oxygen species and high-voltage-activated calcium currents in nanoparticles zinc oxide-induced cytotoxicity in vitro. J Nanopart Res (2012) 14:1238

14. Pengjuan Xu, Jing Xu, Shichang Liu, Zhuo Yang. Nano copper induced apoptosis in podocytes via increasing oxidative stress. Journal of Hazardous Materials. 2012;241–242:279–286

15．Yang-guang HAN, Shi-chang LIU, Tao ZHANG, Zhuo YANG， Induction of apoptosis by melamine in differentiated PC12 cells. Cell Mol Neurobiol, 2011; 31:65–71

16. Shichang Liu, Yangguang Han, Tao Zhang, Zhuo Yang, Protective effect of trifluoperazine on hydrogen peroxide-induced apoptosis in PC12 cells. Brain Research Bulletin, 2011;84:183–188

17. Xiaofan Yang, Yucheng Wang, Jia Luo, Shichang Liu and Zhuo Yang，Protective effects of YC-1 against glutamate induced PC12 cell apoptosis. Cell Mol Neurobiol. 2011;31(2):303-11

18. Quan MN, Zhang N, Wang YY, Zhang T, Yang Z. Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model. Neuroscience. 2011;182: 88–97

19. Quan M, Zheng C, Zhang N, Han D, Tian Y, Zhang T, Yang Z. Impairments of behavior, information flow between thalamus and cortex, and prefrontal cortical synaptic plasticity in an animal model of depression. Brain Research Bulletin，2011; 85 109–116

20. Dadong Han, Yutao Tian, Tao Zhang, Guogang Ren, Zhuo Yang. Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats. International Journal of Nanomedicine.2011;6: 1453-1461

21. Yi-Yi Wang, Ning Li，Jie Huang，Zhuo Yang, Tao Zhang. Effects of ionic products from silicon-substituted hydroxyapatite on the rat brain activity: Morris water maze studies and long term potentiation in hippocampal CA1. Materials Science & Engineering: C (Materials for Biological Applications).2011;31:1558–1566

22. Liu Zhaowei, Ren Guogang, Zhang Tao, Yang Zhuo. The inhibitory effects of nano-Ag on voltage-gated potassium currents of hippocampal CA1 neurons, Environmental Toxicology, 2011;26(5):552-8

23. Liu Zhaowei, Liu Shichang, Ren Guogang , Zhang Tao, Yang Zhuo，Nano-CuO inhibited voltage-gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G-proteins pathway. J. Appl. Toxicol. 2011; 31: 439–445

24. Y. Yao, D.D. Han, T. Zhang, Z. Yang, Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 pyramidal neurons, Phytotherapy Research,2010;24: 136–140

25. Shichang Liu, Lanju Xu, Tao Zhang, Guogang Ren, Zhuo Yang, Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells，Toxicology,2010;267:172–177

26. Yinguo ZHANG, Ning LI, Zhuo YANG，Perinatal food restriction impaired spatial learning and memory behaviour and decreased the density of nitric oxide synthase neurons in the hippocampus of adult male rat offspring，Toxicology Letters，2010；193：167-172

27. Mei-Na Quan, Yu-Tao Tian, Kun-Han Xu, Tao Zhang, Zhuo Yang. Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats, Neuroscience；2010;169:214–222

28. Z Yang, ZW Liu, R Allaker, P Reip, J Oxford, Z Ahmad, and G Ren, A review of nanoparticle functionality and toxicity on the central nervous system, J R Soc Interface. 2010; 7: S411–S422

29. ZHANG Yinguo, LI Ning,YANG Jiajia，ZHANG Tao，YANG Zhuo, Effects of maternal food restriction on physical growth and neurobehavior in newborn Wistar rats, Brain Research Bulletin; 2010：83: 1-8

30. Yinguo ZHANG, Jingxia ZHAO, Tao ZHANG , Zhuo YANG，In vitro assessment of the effect of methylene blue on voltage-gated sodium channels and action potentials in rat hippocampal CA1 pyramidal neurons, Neurotoxicology. 2010;31(6):724-9

31. ZHAO Jingxia, XU Lanju, ZHANG Tao, REN Guogang，YANG Zhuo，Influences of nanoparticle zinc oxide on acutely isolated rat hippocampal CA3 pyramidal neurons，Neurotoxicology,2009;30:220-230

32. Yang Z, Han D, Coote JH. Cardiac sympatho-excitatory action of PVN-spinal oxytocin neurones. Autonomic Neuroscience: Basic and Clinical, 2009; 147:80-85

33. Lan-ju XU, Jing-Xia ZHAO, Tao ZHANG, Guo-gang REN, Zhuo YANG, In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents, Environmental Toxicology, 2009; 24(3):211-217

34. Liu Zhaowei, Ren Guogang, Zhang Tao, Yang Zhuo.Action potential changes associated with the inhibitory effects on voltage-gated sodium current of hippocampal CA1 neurons by silver nanoparticles. Toxicology,2009;264:179-184

35. Zhangjie Su，Dadong Han, Bo Sun, Jiaheng Qiu, Ying Li, Mu Li, Tao Zhang, Zhuo Yang. Heat Stress Preconditioning Improves Cognitive Outcome following Diffuse Axonal Injury in Rats.Journal of Neurotrauma，2009, 26(10): 1695-1706