共找到29條詞條名為李棟的結果 展開
- 中國內地導演
- 綿陽市人民政府副市長
- 廣西梧州市龍圩區人民政府副區長
- 中南財經政法大學法學院院長助理、教授
- 中國農業工程學會青年科技工作委員會委員
- 北京蛋白質組研究中心研究員
- 杭州市紀委副秘書長、辦公廳主任
- 中科院生物大分子國家重點實驗室研究組長
- 國家稅務總局深圳市坪山區稅務局局長
- 中國科學院計算技術研究所副研究員
- 東北石油大學教授
- 西北工業大學航空學院流體力學系教授
- 精工鋼構聯席總裁
- 互動哥
- 李二幸
- 清朝人士
- 明朝官員
- 濟南市食品藥品檢驗檢測中心副主任
- 四川省基督教協會榮譽會長
- 中南大學冶金與環境學院講師
- 武漢音樂學院音樂教育學院學生輔導員
- 革命烈士
- 鄂爾多斯市人民檢察院檢察員
- 湖北恩施籍涉黑惡犯罪團伙
- 演員
- 90后
- 中國作家、編劇
- 廣西百色市右江區財政局派駐右江區汪甸瑤族鄉長平村工作隊員
- 馬鞍山市公安局楚江分局陶庄派出所四級警長
李棟
北京蛋白質組研究中心研究員
李棟，男，博士。2001年7月在北京大學化學學院獲理學學士學位， 2006年7月在北京大學化學學院獲理學博士學位，之後任北京蛋白質組研究中心（國家蛋白質科學中心北京）助理研究員、副研究員和研究員，現為該中心生物學網路課題組PI。第七批北京市優秀青年人才獎勵對象，國際蛋白質組學核心期刊PROTEOMICS期刊編委。
目錄
研究方向：
主要從事蛋白質組生物信息學研究，致力於從生物醫學大數據中進行知識的發現。承擔國家精準醫學、國家國際科技合作專項和國家自然科學基金等各類項目9項，首次整合多生物學證據進行高通量蛋白質相互作用數據的可靠性分析；建立國際上首個基於蛋白質網路預測信號通路的生物信息演演算法系統；首次揭示蛋白質相互作用網路拓撲上的“保守直徑”現象和為進化上的“蛋白質成簇添加”現象提供模體層次的證據；建立大規模組學數據可視化和分析軟體平台，為國內外提供數據分析服務25000多次；對最大規模組織層次蛋白質網路——肝臟蛋白質相互作用網路進行研究。在Nature Communications, Molecular&Cellular Proteomics, Molecular Systems Biology和J Proteome Res等期刊發表第一/通訊作者（含並列）署名SCI論文19篇，累計影響因子110，發表其他署名SCI論文20篇，獲國家科技進步創新團隊獎等國家和省部級獎勵5次，獲軟體著作權28項。
發表第一/責任作者論文：
Yang Li#, Ping Xie#, Liang Lu#, Jian Wang, Lihong Diao, Zhongyang Liu, Feifei Guo, Yangzhige He, Yuan Liu, Qin Huang, Han Liang, Dong Li* & Fuchu He*. An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.Nature Communications,2017, 8: 347
Dong Li, Wanlin Liu, Zhongyang Liu, Jian Wang, Yunping Zhu, Fuchu He, PRINCESS: a PRotein INteraction Confidence Evaluation System with multiple data Sources.Molecular & Cellular Proteomics, 2008, Jun 7: 1043-1052.
Liu Z, Guo F, Zhang J, Wang J, Lu L, Li D*, He F*. Proteome-wide prediction of self-interacting proteins based on multiple properties.Mol Cell Proteomics. 2013 Jun;12(6):1689-700.
Liu W*, Li D*, Wang J, Xie H，Zhu Y, He F, Proteome-wide prediction of signal flow direction in protein interaction network based on interacting domains.Molecular & Cellular Proteomics, 2009, Sep;8(9):2063-70.
Guo F, Wang D, Liu Z, Lu L, Zhang W, Sun H, Zhang H, Ma J, Wu S, Li N, Jiang Y, Zhu W, Qin J, Xu P, Li D*, He F*. CAPER: a Chromosome-Assembled human Proteome browsER.J Proteome Res.2013 Jan 4;12(1):179-86.
Wang, Dan; Liu, Zhongyang; Guo, Feifei; Diao, Lihong; Li, Yang; Zhang, Xinlei; Huang, Zechi; Li, Dong*; He, Fuchu*, CAPER2.0: an interactive, configurable and extensible workflow-based platform to analyze datasets from the Chromosome-centric Human Proteome Project,J Proteome Res,2014, 13: 99-106.
Shuai Yang , Xinlei Zhang , Hongli Diao , Feifei Guo , Dan Wang , Zhongyang Liu , Honglei Li , Junjie Zheng , Jingshan Pan , Edouard C. Nice , Dong Li* , and Fuchu He*. CAPER 3.0: a scalable cloud-based system for data-intensive analysis of Chromosome-centric Human Proteome Project datasets.J. Proteome Res., 2015, 14: 3720-8.
Jian Wang*, Keke Huo*, Lixin Ma*, Liujun Tang*, Dong Li*, et al., Toward an understanding of the protein interaction network of the human liver.Molecular Systems Biology,2011 7: 536.
Li D, Li J, Ouyang S, Wang J, et al., Protein Interaction Networks of Saccharomyces cerevisiae, Caenorhabditis elegans andDrosophila melanogaster: Large-Scale Organization and Robustness,Proteomics,2006, Jan, 6:456-461.
LI Dong, LI Jian-Qi, OUYANG Shu-Guang, WANG Jian, et al., An Integrated Strategy for Functional Analysis in Large-scale Proteomic Research by Gene Ontology,Progress in Biochemistry and Biophysics,2005, 32: 1026 - 1029.
Zhongyang Liu, Feifei Guo, Jiangyong Gu, Yong Wang, Yang Li, Dan Wang, Liang Lu, Dong Li*, and Fuchu He*. Similarity-based prediction for Anatomical Therapeutic Chemical classification of drugs by integrating multiple data sources,Bioinformatics,2015，31：1788-95.
Liu Z, Liu Q, Sun H, Hou L, Guo H, Zhu Y, Li D*, He F*. Evidence for the additions of clustered interacting nodes during the evolution of protein interaction networks from network motifs.BMC Evol Biol.2011; May, 11(1):133.
Sun H *, Li D*, Wang J, Liu Z, Xie H, Zhu Y, He F, PNmerger: a Cytoscape plugin to merge biological pathways and protein interaction networks.Prog Biochem Biophys,2009, 36: 1613-1616.
Wanlin Liu, Dong Li*, Qijun Liu, Yunping Zhu and Fuchu He, A novel parametric approach to mine gene regulatory relationship from microarray datasets,BMC bioinformatics,2010, 11: S15.
1.
Yang Li#, Ping Xie#, Liang Lu#, Jian Wang, Lihong Diao, Zhongyang Liu, Feifei Guo, Yangzhige He, Yuan Liu, Qin Huang, Han Liang, Dong Li* & Fuchu He*. An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.Nature Communications,2017, 8: 347
2.
Dong Li, Wanlin Liu, Zhongyang Liu, Jian Wang, Yunping Zhu, Fuchu He, PRINCESS: a PRotein INteraction Confidence Evaluation System with multiple data Sources.Molecular & Cellular Proteomics, 2008, Jun 7: 1043-1052.
3.
Liu Z, Guo F, Zhang J, Wang J, Lu L, Li D*, He F*. Proteome-wide prediction of self-interacting proteins based on multiple properties.Mol Cell Proteomics. 2013 Jun;12(6):1689-700.
4.
Liu W*, Li D*, Wang J, Xie H，Zhu Y, He F, Proteome-wide prediction of signal flow direction in protein interaction network based on interacting domains.Molecular & Cellular Proteomics, 2009, Sep;8(9):2063-70.
5.
Guo F, Wang D, Liu Z, Lu L, Zhang W, Sun H, Zhang H, Ma J, Wu S, Li N, Jiang Y, Zhu W, Qin J, Xu P, Li D*, He F*. CAPER: a Chromosome-Assembled human Proteome browsER.J Proteome Res.2013 Jan 4;12(1):179-86.
6.
Wang, Dan; Liu, Zhongyang; Guo, Feifei; Diao, Lihong; Li, Yang; Zhang, Xinlei; Huang, Zechi; Li, Dong*; He, Fuchu*, CAPER2.0: an interactive, configurable and extensible workflow-based platform to analyze datasets from the Chromosome-centric Human Proteome Project,J Proteome Res,2014, 13: 99-106.
7.
Shuai Yang , Xinlei Zhang , Hongli Diao , Feifei Guo , Dan Wang , Zhongyang Liu , Honglei Li , Junjie Zheng , Jingshan Pan , Edouard C. Nice , Dong Li* , and Fuchu He*. CAPER 3.0: a scalable cloud-based system for data-intensive analysis of Chromosome-centric Human Proteome Project datasets.J. Proteome Res., 2015, 14: 3720-8.
8.
Jian Wang*, Keke Huo*, Lixin Ma*, Liujun Tang*, Dong Li*, et al., Toward an understanding of the protein interaction network of the human liver.Molecular Systems Biology,2011 7: 536.
9.
Li D, Li J, Ouyang S, Wang J, et al., Protein Interaction Networks of Saccharomyces cerevisiae, Caenorhabditis elegans andDrosophila melanogaster: Large-Scale Organization and Robustness,Proteomics,2006, Jan, 6:456-461.
10.
LI Dong, LI Jian-Qi, OUYANG Shu-Guang, WANG Jian, et al., An Integrated Strategy for Functional Analysis in Large-scale Proteomic Research by Gene Ontology,Progress in Biochemistry and Biophysics,2005, 32: 1026 - 1029.
11.
Zhongyang Liu, Feifei Guo, Jiangyong Gu, Yong Wang, Yang Li, Dan Wang, Liang Lu, Dong Li*, and Fuchu He*. Similarity-based prediction for Anatomical Therapeutic Chemical classification of drugs by integrating multiple data sources,Bioinformatics,2015，31：1788-95.
12.
Liu Z, Liu Q, Sun H, Hou L, Guo H, Zhu Y, Li D*, He F*. Evidence for the additions of clustered interacting nodes during the evolution of protein interaction networks from network motifs.BMC Evol Biol.2011; May, 11(1):133.
13.
Sun H *, Li D*, Wang J, Liu Z, Xie H, Zhu Y, He F, PNmerger: a Cytoscape plugin to merge biological pathways and protein interaction networks.Prog Biochem Biophys,2009, 36: 1613-1616.
14.
Wanlin Liu, Dong Li*, Qijun Liu, Yunping Zhu and Fuchu He, A novel parametric approach to mine gene regulatory relationship from microarray datasets,BMC bioinformatics,2010, 11: S15.
