袁正宏

1995－1996年獲歐共體居里獎學金在英國帝國理工學院聖瑪麗醫院進修丙型肝炎病毒分子生物學。

1999，2002年作為高級訪問學者分別在美國Washington University （St Louis）及Rockefeller University進行HCV分子生物學及RNA-蛋白相互作用的研究工作。

2001年7月，任部醫學分子病毒學教育部/衛生重點實驗室主任；

2001年7月至2008年4月任復旦大學上海醫學院副院長。

2005年1月起兼任上海市（復旦大學附屬）公共衛生臨床中心副主任。

2006年7月起兼任生物醫學研究院副院長。

2008年4月-2012年10月任上海市（復旦大學附屬）公共衛生臨床中心黨委書記兼副主任。

2012年9月起任復旦大學上海醫學院（大醫口）副院長。

2013年9月，任復旦大學黨委副書記兼紀委書記。

2017年11月起兼任復旦大學基礎醫學院院長。

2019年6月，任復旦大學黨委副書記，復旦大學上海醫學院黨委書記。

2019年12月，袁正宏同志不再擔任復旦大學紀委書記。

主要開展機體天然免疫清除和維持肝炎病毒感染中作用、肝炎病毒基因複製與致病機理等研究工作。

近年代表性學術論文

1. Exosomes mediate the cell-to-cell transmission of IFN-a-induced antiviral activity. Jianhua Li, Kuancheng Liu, Yang Liu, Yan Xu, Fei Zhang,Huijuan Yang, Jiangxia Liu, Tingting Pan, Jieliang Chen, Min Wu, Xiaohui Zhou andZhenghong Yuan*. Nature Immunology, 2013,online DOI:10.1038/ni.2647.

2. Association between adverse clinical outcome in human disease caused by novel influenza AH7N9 virus and sustained viral shedding and emergence of antiviralresistance.Yunwen Hu, Shuihua Lu, Zhigang Song, Wei Wang, Pei Hao, Jianhua Li,Xiaonan Zhang, Hui-Ling Yen, Bisheng Shi, Tao Li, Wencai Guan, Lei Xu, Yi Liu,Sen Wang, Xiaoling Zhang, Di Tian, Zhaoqin Zhu, Jing He, Huang Kai, HuijieChen, Lulu Zheng, Xuan Li, Jie Ping, Bin Kang, Xiuhong Xi, Lijun Zha,Yixue Li,Zhiyong Zhang, Malik Peiris,Zhenghong Yuan*.Lancet, Published Online May 28, 2013 6736(13)61125-3.

3. Human infection with a novel avian-origin influenza A (H7N9) virus. Rongbao Gao, BinCao, Yunwen Hu, Zijian Feng, Dayan Wang, Wanfu Hu, Jian Chen,--- Guizhen Wu, YuWang,Zhenghong Yuan*, and YuelongShu.N Engl J Med2013.DOI: 10.1056.

4. Hepatitis B Virus Surface Antigen Selectively Inhibits TLR2 Ligand-Induced IL-12 Productionin Monocytes/Macrophages by Interfering with JNK Activation. Wang S, Chen Z, HuC, Qian F, Cheng Y, Wu M, Shi B, Chen J,Hu Y,Yuan Z*. J Immunol.2013 May 15;190(10):5142-51.

5. Hepatitis Bvirus polymerase impairs interferon-α-induced STATsactivation through nhibitionof importin-α5 and protein kinase C-δ. Jieliang Chen, Min Wu, Xiaonan Zhang,Wen Zhang, Zhanqing Zhang,Lixiang Chen, Jing He, Ye Zheng, Cuncun Chen, FanWang, Yunwen Hu,Xiaohui Zhou, Cong Wang, Yang Xu, Mengji Lu,Zhenghong Yuan* Hepatology. 2013， 57： 2： 470–482.

6. New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.Zhenghong Yuan*. Antiviral Therapy.2013; 18:1-15.

7徠. Rupintriviris a promising candidate for treating severe cases of enterovirus-71 infection:Evaluation of antiviral efficacy in a murine infection model XiaonanZhang,Zhigang Song,Boyin Qin,Xiaoling Zhang,Lixiang Chen,Yunwen Hu,Zhenghong Yuan*. Antivral Therapy,2013, 97:3:264–269.

8. Flavivirusreplication complex assembly revealed by DNAJC14 functional mapping.Yi Z,Yuan Z, Rice CM, Macdonald MR. J Virol.2012, 86(21):11815-11832.

9. HBsAg Inhibits IFN-a Production in Plasmacytoid Dendritic Cells through TNF-a andIL-10 Induction inMonocytes. Bisheng Shi, Guangxu Ren, Yunwen Hu, Sen Wang,Zhanqing Zhang,Zhenghong Yuan* PLOS ONE.September 2012 | Volume 7 | Issue 9 | e44900.

10. Plasma microRNA profile as a predictor of early virological response to interferontreatment in chronic hepatitis B patients. Xiaonan Zhang, Cuncun Chen, Min Wu,Liang Chen, Jiming Zhang, Xinxin Zhang ,Zhanqin Zhang, Jingdi Wu, Jiefei Wang,Xiaorong Chen, Tao Huang，Lixiang Chen,ZhenghongYuan*. Antiviral Therapy. 2012.;17(7):1243-53.

11. Viperin inhibits Hepatitis C Virus replication 3 by interfering with thebinding of NS5Ato host protein hVAP-33 Shanshan Wang, Xianfang Wu,Tingting Pan, Wuhui Song,YaohuiWang, Fei Zhang,Zhenghong Yuan*. Journal of General Virology(2012), 93, 83–92.

12. Inhibition of hepatitis B virus replication by cIAP2 involves accelerating theubiquitin-proteasome-mediated destruction of polymerase.Zekun Wang, Jinjing Ni,Jianhua Li, Bisheng Shi, Yang Xu, andZhenghongYuan*. J. Virol. published 24 August 2011, 10.1128/JVI.00879-11.

13. Hepatitis C virus NS5B delays S-phase progression in humanhepatocyte-derived cells byrelocalizing the cyclin-dependent kinase2-interacting protein (CINP). YaohuiWang, Yuchan Wang, Yan Xu, Wenyan Tong, TingTing Pan, Jianhua Li, Shuhui Sun,Junjie Shao, Huanping Ding,Zhenghong Yuan*. JBC.2011 286: 26603-26615.

14. Hepatitis C Virus Co-Opts Ras-GTPase-Activating Protein-Binding Protein 1 for ItsenomeReplication Zhigang Yi, Tingting Pan, Xianfang Wu, Wuhui Song, ShanshanWang, Yan Xu,Charles M. Rice, Margaret R. MacDonald,* andZhenghong Yuan*. Journal of Virology.July 2011, p. 6996–7004.

15. Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment JianhuaLi, Yinghui Liu, Zekun Wang, Kuancheng Liu, Yaohui Wang,Jiangxia Liu,HuanpingDing, andZhenghong Yuan* . Journal of Virology, July 2011, p. 6319–6333.

16. Identification and Characterization of the Host ProteinDNAJC14 as a Broadly Active FlavivirusReplicationModulator .Zhigang Yi1, Lindsey Sperzel1, Cindy Nu rnberger1, PeterJ. Bredenbeek1, Kirk J. Lubick, Sonja M.Best, Cristina T. Stoyanov1, Lok Man J.Law1,Zhenghong Yuan, Charles M.Rice, Margaret R.MacDonald1* PLoS Pathogens.January 2011 | Volume 7| Issue 1 | e1001255.

17. Inhibition ofhepatitis B virus replication by MyD88 involves accelerated degradation of pregenomicRNA and nuclear retention of preS/S RNAs，Jianhua Li, Shanshan Lin, Qiying Chen, Lu Peng, JianweiZhai Yinghui Liu,Zhenghong Yuan*. Journal of Virology, July 2010, p.6387–6399.

18. HCV NS5A Activates the Mammalian Target of Rapamycin (mTOR) Pathway and Contributes toCell Survival by Disrupting the Interaction between FK506-binding Protein 38(FKBP38) and mTOR. Lu Peng, Dongyu Liang, Wenyan Tong, Jianhua Li, andZhenghong Yuan* The Journal of BiologicalChemistry.July2,2010.285,NO.27,pp. 20870–20881.

19. Hepatitis B virus polymerase inhibits RIG-I andToll-like receptor 3-mediated interferon-binductionin human hepatocytes through interference withinterferon regulatoryfactor 3 activation anddampening of the interaction between TBK1/IKKeand DDX3.，Shiyan Yu，Jieliang Chen, MinWu, Hui ChenandYuan Z*. Journal ofGeneral Virology(2010), 91, 2080-2090.

20. Whole recombinant Hansenula polymorpha expressing hepatitis B virus surface antigen (yeast-HBsAg) induces potent HBsAg-specific Th1 and Th2 immune responses. Guanglin Bian, Yuming Cheng, Zekun Wang, Yunwen Hu, Xiaonan Zhang, Min Wu,Zhiao Chen, Bisheng Shi, Shuhui Sun, Yan Shen, Er jia Chen, Xin Yao,Yumei Wen,Zhenghong Yuan* Vaccine28 (2010) 187–194.

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