金鋒

中國科學院博士生導師

金鋒,男,畢業於東京大學理學部人類學系,中國科學院博士生導師。

人物經歷


1993年畢業於東京大學理學部人類學系,獲得博士學位。
1993年回國后先後供職於中國科學院遺傳研究所。
1994年作為日本學術振興會博士后研究員在京都國際日本文化研究中心研究亞洲人群血緣關係。
1997年以來兼職於天津、內蒙古、西北等師範大學生命科學院客座教授,中國社會科學院考古研究所古代文明中心研究員,中央民族大學人類學學院客座教授,日本JBC生命科學研究所高級研究員,Head Scientist for New Sun Bio Science,Executable Inspector of Quality Assurance International (QAI USA)。

研究方向


涉及人類學、遺傳學、分子醫學以及共生微生物對生存質量的影響等多個領域。

主要貢獻


1. HSPG2 gene C/A polymorphism do not confer susceptibility to Alzheimer’s disease inChinese. Wang B, Jin F,Yang Z,Zheng C,Lu Z. Wang L. Dement. Geriatr Cogn Disord 2007;23⑸:312-315.
⒉ 近視與遺傳,翁蕾鳴、王昕、王瀝、金鋒*,遺傳 2006;28⑷:486-92.
⒊ The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease. Wang B, Jin F,Yang Z,Lu Z,Kan R,Zheng C,Wang L. J Mol Neurosci. 2006;30⑶:267-71.
⒋ Association analysis of NAD (P) H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer’s disease. Binbin Wang, Feng Jin,Yanchen Xie,Ying Tang,Rui Kan,Chenguang Zheng,Ze Yang,Li Wang. Neuroscience Letters 2006;409:79–181.
⒌ Phylogenetic relationship of the populations within and around Japan using 105 short andem repeat polymorphic loci. Li SL,Yamamoto T,Yoshimoto T,Uchihi R,Mizutani M,Kurimoto Y,Tokunaga K, Jin F,Katsumata Y,Saitou N. Human Genetics 2006; 118⑹:695-707.
⒍ Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians. Nakayama K,Soemantri A, Jin F,Dashnyam B,Ohtsuka R,Duanchang P,IsaM,Harihara S,Ishida T. Human Genetics 2006;119⑶:322-30.
⒎ Distribution of the F374 allele of the SLC45A2 (MATP) gene and founder-haplotypeanalysis. Yuasa I,Umetsu K,Harihara S,Kido A,Miyoshi A,Saitou N,Dashnyam B, Jin F,Lucotte G,Chattopadhyay PK,Henke L,Henke J. Ann Human Genetics 2006;70(Pt 6):802-11.
⒏ The Gly482Ser variant of the PPARGC1 gene is associated with Type 2 diabetes mellitus in northern Chinese,especially men.Sun L,Yang Z, Jin F,Zhu XQ,Qu YC,Shi XH,Wang L.Diabet Med. 2006;23⑽:1085-92.
⒐ Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene. Wan C,Zhang T,Wang B,Han,Y,Zhang C,Zhang Y,Gong H, Jin F*,Wang L. Diabetes Obes Metab.2006;8⑹:703-8.
⒑ 廣西巴馬地區長壽老人ApoE基因多態性分析.鄭陳光、楊澤、胡才友、呂澤平、梁積英、龐國防、陳進超、韋俊興、韋勇、王辰、屈彥純、孫亮、楊斯雷、史曉紅、唐雷、鄭衛東、梁永錫、夏寧、潘尚領、王瀝、金鋒、吳森 廣西醫科大學學報 2005;22⑴:5-8.
⒒ 核輔激活因子PGC-1表達的分子調控機制 孫亮、朱小泉、王瀝、金鋒、楊澤 中國生物化學與分子生物學學報 2005; 21⑷:431~439.
⒓ 廣西巴馬地區長壽老人ApoE基因多態性與認知功能的關係 胡才友、楊澤、鄭陳光、呂澤平、梁積英、龐國防、陳進超、韋俊興、韋勇、王辰、屈彥純、孫亮、楊斯雷、史曉紅、唐雷、鄭衛東、王瀝、金鋒、韓布新、吳森、梁永錫 中國心理衛生雜誌 2005;19⑹: 383-386.
⒔ 核輔激活因子PGC-1作用分子機制的研究進展. 孫亮、金鋒、王瀝、楊澤 遺傳 2005; 27⑵:302-308.
⒕ RUS skeletal maturity of children in Beijing. Ashizawa K,Kumakura C,Zhou X, Jin F and Cao J.Ann Hum Biol. 2005;32⑶:316-25.
⒖ Genetic association of BACE 1 gene polymorphism C786G with late-onset Alzheimer`s disease in Chinese. Kan R.,Wang B.,Zhang C., Jin F.,Zheng W.,Lu Z.,Zheng C.,Yang Z. and Wang L. Journal of Molecular Neuroscience 2005;25⑵:127-132.
⒗ Founder SVA retrotransposal insertion in Fukuyama-type congenital muscular dystrophy and its origin in Japanese and Northeast Asian populations. Watanabe M.,Kobayashi K., Jin F.,Park K.,Yamada T.,Tokunaga K.,and Toda T. Am J Med Genet A. 2005;138⑷:344-8.
⒘ Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer`s disease. Wang B., Jin F.,Kan R.,Ji S.,Zhang C.,Lu Z.,Zheng C.,Yang Z.,and Wang L.Journal of Molecular Neuroscience 2005;27⑴:23-27.
⒙ 廣西紅水河流域長壽老人相關基因研究 楊澤、鄭陳光、呂澤平、陳進超、韋俊興、韋勇、王辰、屈彥純、孫亮、楊斯雷、史曉紅、唐雷、鄭衛東、梁永錫、夏寧、王瀝、金鋒、梁積英、胡才有、吳森中國老年保健醫學雜誌 2004;2⑵:7-11
⒚ 內皮型一氧化氮合酶3 基因多態性與晚發性阿爾茨海默病的關聯 楊澤、李曙、金鋒、呂澤平、鄭陳光、唐雷、鄭衛東、史曉紅、王瀝、梁積英、胡才友 中華老年醫學雜誌 2004;23⑺:468-471.
⒛ 心血管危險因子與廣西漢族遲發性阿爾茨海默病之間的相關性研究 鄭衛東、鄭懷競、楊澤、鄭陳光、呂澤平、金鋒、王瀝、史曉紅、唐雷、胡才有 中國神經免疫學和神經病學雜誌 2004; 11⑵68-71
21. 體能相關基因研究張濤、張傳芳、金鋒、王瀝 遺傳 2004;26⑵:219-226.
22. 體能與遺傳 張傳芳、王瀝、張濤、金鋒* 遺傳學報2004,31⑶:317-324.
23. Natural selection and population history in the human angiotensinogen gene (AGT): 736complete AGT sequences in chromosomes from around the world. Nakajima T,Wooding S,Sakagami T,Emi M,Tokunaga K,Tamiya G,Ishigami T,Umemura S,Munkhbat B, Jin F,G Jia,Hayasaka I,Ishida T,Saitou N,Pavelka K,Lalouel JM,Jorde LB,Inoue I. American Journal of Human Genetics 2004;74⑸: 898-916. SCI 12.65
24. Evolution of the O alleles of the human ABO blood group gene. F. Roubinet,S. Despiau,F. Calafell, F. Jin,N. Saitou,A. Blancher. Transfusion 2004;44⑸:707-15. SCI 3.16
25. Expression analysis of an FGFR2 Ⅲc 5` splice site mutation (1084+3A→G). Kan R,TwiggSR,Berg J,Wang L, Jin F,Wilkie AO. J Medical Genetics 2004;41⑻:e108. SCI 4.33
26. Association of the HTR6 polymorphism C267T with late-onset Alzheimer’s disease inChinese. R. Kan,B. Wang,C. Zhang,Z. Yang,W. Zheng,Z. Lu,C. Zheng, F. Jin* and L.Wang. Neuroscience Letter 2004;372(1-2): 27-29.
27. Neither the Tumor Necrosis Factor a-308 A/G Polymorphism nor the a2-MacroglobulinPolymorphism was Associated with Late-onset Alzheimer’s disease in Chinese. Zhang P.,Yang Z.,Wan C.,Zheng W.,Zhang C.,Zheng C., Jin F.*,and Wang L. Acta Genetica Sinica2004;31⑴:1-6.
28. Characteristic β-Globin Gene Cluster Haplotypes of Evenkis and Orunchuns in North China.K. Shimizu,A. Marubayashi,K. Tokimasa,S. Harihara,K. Omoto,T. Imanishi,L. Hao and F. Jin*. Human Biology 2004;76⑸,765-778.
29. Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase geneand Alzheimer`s disease in Chinese. B. Wang,C. Zhang,W. Zheng,Z. Lu,Z. Yang,L. Wangand F. Jin*. Neuroscience Letter 2004; 369⑵:104-107.
30. 廣西紅水河流域長壽老人遺傳特徵分析 楊澤、鄭陳光、呂澤平、史曉紅、唐雷、王辰、屈彥純、金鋒、王瀝、韋勇、胡才友、陳進超、梁永錫、韋俊興 中國老年保健醫學 2003;1⑵: 30-34.
31. 偶聯蛋白與肥胖及2型糖尿病發病的關係. 萬春玲、張鐵梅、王瀝、楊澤、金鋒* 遺2003;25⑵:211-220.
32. 老年痴獃關聯基因的研究進展張鵬、王瀝、楊澤、金鋒*遺傳 2003; 25⑷:445-449.
33. 晚發性Alzheimer病的遺傳病因學研究. 李曙、楊澤、金鋒*國外醫學遺傳學分冊 2003,26⑷:242-245.
34. Y-chromosomal DNA haplogroups and their implications for the dual origins of the Koreans.Jin HJ,Kwak KD,Hammer MF,Nakahori Y,Shinka T,Lee JW, Jin F,Jia X,Tyler-Smith C,Kim W. Human Genetics. 2003; 114⑴:27-35.
35. Association study between late-onset Alzheimer`s disease and the transferrin genepolymorphisms in Chinese. Zhang P.,Yang Z.,Zhang C.,Lu Z.,Shi X.,Zheng W.,Wan C.,Zhang D.,Zheng C.,Li S., Jin F.*,Wang L. Neuroscience Letter. 2003;349⑶:209-11.
36. 張瑩,王瀝,賈旭明,張端陽,宣世偉,金鋒* 中國人ABO血型分泌型岩藻糖轉移酶基因多態性研究 遺傳學報 2002;29⑾:949-952.
37. Extreme mtDNA Homogeneity in Continental Asian Populations. H. Oota,T. Kitano, F. Jin,I. Yuasa,L. Wang,S. Ueda,N. Saitou,and M. Stoneking. American Journal of PhysicalAnthropology 2002;118:146–153.
科普文章
[自殺與人類共生菌] 牛頓科學世界 2006年 第三期。
[關注人類與微生物的自然平衡] 牛頓科學世界 2006年 第五期。