丁丹

南開大學生命科學學院教授

丁丹,男,博士,南開大學生命科學學院生物化學和分子生物學系教授、博士生導師。主要從事新型分子影像材料與納米藥物的設計、製備與生物醫學應用。

教育和工作經歷


2013.03 – 今 副教授、教授
南開大學,生命科學學院
2010.08 – 2013.02 博士后
新加坡國立大學,化學與生物分子工程系
2005.09 – 2010.07 博士學位
南京大學,化學化工學院高分子科學與工程系
2001.09 – 2005.07 學士學位
南京大學,化學化工學院化學系

研究方向


1)新型分子影像材料(聚集誘導發光材料、半導體共軛高分子等)
2)納米藥物

主要論著


1. Song, Z.; Mao, D.; Sung, S. H. P.; Kwok, R. T. K.; Lam, J. W. Y.; Kong, D.;Ding, D.;* Tang, B. Z.* Activatable Fluorescent Nanoprobe with Aggregation-Induced Emission Characteristics for Selective In Vivo Imaging of Elevated Peroxynitrite Generation,Adv. Mater.2016, 28, 7249-7256.
2. Yu, C. Y. Y.; Xu, H.; Ji, X.; Kwok, R. T. K.; Lam, J. W. Y.; Li, X.;* Krishnan, S.;Ding, D.;* Tang, B. Z.*Mitochondrion-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics Synergistically Boosts the Radiosensitivity of Cancer Cells to Ionizing Radiation,Adv. Mater.2017, DOI: 10.1002/adma.201606167.
3. Liu, J.; Chen, C.; Ji, S.; Liu, Q.;*Ding, D.;*Zhao, D.; Liu, B.* Long Wavelength Excitable Near-Infrared Fluorescent Nanoparticles with Aggregation-Induced Emission Characteristics for Image-Guided Tumor Resection,Chem. Sci.2017, DOI: 10.1039/c6sc04384d.
4. Chen, C.; Song, Z.; Zheng, X.; He, Z.; Liu, B.;* Huang, X.; Kong, D.;Ding, D.;* Tang, B. Z.* AIEgen-based Theranostic System: Targeted Imaging of Cancer Cells and Adjuvant Amplification of Antitumor Efficacy of Paclitaxel,Chem. Sci.2017,8, 2191-2198.
5. Feng, G.; Fang, Y.; Liu, J.; Geng, J.;Ding, D.;* Liu, B.* Multifunctional Conjugated Polymer Nanoparticles for Image-Guided Photodynamic and Photothermal Therapy,Small2017, DOI: 10.1002/smll.201602807.
6. Wang, H.; Liu, J.; Han, A.; Xiao, N.; Xue, Z.; Wang, G.; Long, J.; Kong, D.; Liu, B.;* Yang, Z.;*Ding, D.* Self-Assembly-Induced Far-Red/Near-Infrared Fluorescence Light-up for Detecting and Visualizing Specific Protein-Peptide Interactions,ACS Nano2014,8, 1475-1484.
7.Ding, D.; Mao, D.; Li, K.; Wang, X.; Qin, W.; Liu, R.; Chiam, D. S.; Tomczak, N.; Yang, Z.; Tang, B. Z.;* Kong, D.;* Liu, B.* Precise and Long-Term Tracking of Adipose-Derived Stem Cells and Their Regenerative Capacity via Superb Bright and Stable Organic Nanodots,ACS Nano2014,8, 12620-12631.
8. Jin, G.; Mao, D.; Cai, P.; Liu, R.; Tomczak, N.; Liu, J.; Chen, X.; Kong, D.;Ding, D.;* Liu, B.;* Li, K.* Conjugated Polymer Nanodots as Ultrastable Long-Term Trackers to Understand Mesenchymal Stem Cell Therapy in Skin Regeneration.Adv. Funct. Mater.2015,25, 4263-4273.
9. Han, A.; Wang, H.; Kwok, R. T. K.; Ji, S.; Li, J.; Kong, D.; Tang, B. Z.; Liu, B.;* Yang, Z.;*Ding, D.* Peptide-Induced AIEgen Self-Assembly: A New Strategy to Realize Highly Sensitive Fluorescent Light-Up Probes,Anal. Chem.2016,88, 3872-3878.
10. Zhu, H.; Fang, Y.; Zhen, X.; Wei, N.; Gao, Y.; Luo, K. Q.; Xu, C.; Duan, H.;Ding, D.;* Chen, P.;* Pu, K.* Multilayered Semiconducting Polymer Nanoparticles with Enhanced NIR Fluorescence for Molecular Imaging in Cells, Zebrafish and Mice.Chem. Sci.2016,7, 5118-5125.
11.Ding, D.; Kwok, R. T. K.; Yuan, Y.; Feng, G.; Tang, B. Z.;* Liu, B.* A Fluorescent Light-Up Nanoparticle Probe with Aggregation-Induced Emission Characteristics and Tumor-Acidity Responsiveness for Targeted Imaging and Selective Suppression of Cancer Cells,Mater. Horiz.2015,2, 100-105.
12.Ding, D.; Li, K.; Liu, B.;* Tang, B. Z.* Bioprobes Based on AIE Fluorogens,Accounts Chem. Res.2013,46, 2441-2453.
13.Ding, D.; Goh, C. C.; Feng, G. X.; Zhao, Z. J.; Liu, J.; Liu, R. R.; Tomczak, N.; Geng, J. L.; Tang, B. Z.; Ng, L. G.;* Liu, B.* Ultrabright Organic Dots with Aggregation-Induced Emission Characteristics for Real-TimeTwo-Photon Intravital Vasculature Imaging,Adv. Mater.2013,25, 6083-6088.
14.Ding, D.; Zhu, Z. S.; Li, R. T.; Li, X. L.; Wu, W.; Jiang, X. Q.;* Liu, B. R. Nanospheres-Incorporated Implantable Hydrogel as a Trans-Tissue Drug Delivery System,ACS Nano2011,5, 2520-2534.
15. Qin, W.;Ding, D.; Liu, J. Z.; Yuan, W. Z.; Hu, Y.; Liu, B.;* Tang, B. Z.* BiocompatibleNanoparticles with Aggregation-Induced Emission Characteristics as Far-Red/Near-Infrared Fluorescent Bioprobes for In Vitro and In Vivo Imaging Applications,Adv. Funct. Mater.2012,22, 771-779. contributed equally
16.Ding, D.; Liu, J.; Feng, G. X.; Li, K.; Hu, Y.; Liu, B.* Bright Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for In Vivo Bioimaging,Small2013,9, 3093-3102.
17.Ding, D.; Wang, G.; Liu, J. Z.; Li, K.; Pu, K. Y.; Hu, Y.; Ng, J. C. Y.; Tang, B. Z.; Liu, B.* Hyperbranched Conjugated Polyelectrolyte for Dual-Modality Fluorescence and Magnetic Resonance Cancer Imaging,Small2012,8, 3523-3530.