胡寶洋

2005年赴美國威斯康星大學（University of Wisconsin-Madison)從事博士后研究。

2009年任該校助理科學家（Assistant Scientist）。

2011年1月引入中國科學院動物研究所，組建幹細胞與神經再生研究組。指導研究生3名，博士后2名。

主要從事幹細胞與再生醫學領域的研究，圍繞幹細胞醫學轉化，重點研究全能幹細胞向神經系的分化機制、人類幹細胞生物學的獨特性以及幹細胞醫藥學應用的系統化評估等科學問題。

1.神經分化機制。用多能幹細胞定向分化和細胞重編程為模型，研究神經分化中細胞外信號、轉錄程序、轉錄前後表觀遺傳學因素如何協同指導多能幹細胞向某一特定類型細胞分化。藉助小鼠等動物模型和遺傳學手段在體內進一步驗證。

2.人類發育和細胞分化的獨特性。以人多能幹細胞神經定向分化系統為基礎，利用比較生物學和生物信息學方法發掘決定人類高級功能和獨特性狀的調控元件及調控機制。利用攜帶神經系統疾病表型的人類iPS細胞或重編程細胞，揭示動物模型難以模擬的神經系統疾病發生機制。

3.幹細胞醫學轉化。以定向分化為基礎，完善規模化細胞分化和體細胞直接轉分化為特定細胞類型的方法。與相關領域合作，建立細胞產品應用於細胞替代和藥物篩選的標準評估體系

論文

Li Z, Wan H, Feng G, Wang L, He Z, Wang Y, Wang X, Li W, Zhou Q, Hu B. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells

Jiang Y, Du M, Wu M, Zhu Y, Zhao X, Cao X, Li X, Long P, Li W, Hu B. Phosphatidic Acid Improves Reprogramming to Pluripotency by Reducing Apoptosis

Wan H, Feng C, Teng F, Yang S, Hu B, Niu Y, Xiang A, Fang W, Ji W, Li W, Zhao X, Zhou Q. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system

Zhu H, Tan Y, Gu Q, Han W, Li Z, Meyer J, Hu B. Regulations in the United States for cell transplantation clinical trials in neurological diseases

Chen H, Qian K, Chen W, Hu B, Blackbourn L, Du Z, Ma L, Liu H, Knobel K, Ayala M, Zhang S. Human-derived neural progenitors functionally replace astrocytes in adult mice

Wang S, Li W, Wang S, Hu B. Rapid and efficient assembly of transcription activator-like effector genes by USER cloning

Wu M, Chen G, Hu B. Induced pluripotency for translational research

Jiang Y, Zhang M, Hu B. Specification of functional neurons and glia from human pluripotent stem cells

Ma L, Hu B, Liu Y, Vermilyea S, Liu H, Gao L, Sun Y, Zhang X, Zhang S. Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice

Hu B, Zhang S. Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs

Hu B, Weick J, Yu J, Ma L, Zhang X, Thomson J, Zhang S. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

Hu B, Zhang S. Differentiation of spinal motor neurons from pluripotent human stem cells

Hu B, Du Z, Zhang S. Differentiation of human oligodendrocytes from pluripotent stem cells

Hu B, Du Z, Li X, Ayala M, Zhang S. Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects

Du Z, Hu B, Ayala M, Sauer B, Zhang S. Cre recombination-mediated cassette exchange for building versatile transgenic human embryonic stem cells lines

Li X, Hu B, Jones S, Zhang Y, Lavaute T, Du Z, Zhang S. Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules

專利

Zhang SC, Hu BY, Du ZW. Myelinating Oligodendrocyte Precursor Populations, US patent

Zhang SC, Hu BY, Du ZW. Method of Generating Myelinating Oligodendrocytes from Embryonic Stem Cells

美國神經科學學會(SfN)會員，美國眼科與視覺學會(ARVO)會員。