高斌

高斌 研究員，中國科學院微生物研究所研究員，中國科學院病原微生物與免疫學重點實驗室副主任；分子免疫研究中心主任。

1978-1982年　南京醫學院

1984-1987年　北京軍事醫學科學院感染免疫碩士

1990-1993年　London university 生物化學與免疫學博士

1993-1996年　Oxford University 博士后

1996-1997年　Research Leader, Peptide Therapeutics plc (Acambis),Cambridge, UK

1997-2001年　牛津大學分子醫學研究所博士后研究員

2001-2005年　倫敦大學學院(UCL)講師，博士生導師

2005年 - 現在 中科院微生物所研究員、博士生導師，中國科學院“海外知名學者”

免疫系統的特徵是識別自己和非己。細胞毒T淋巴細胞（CTL）通過其細胞表面的受體（TCR）檢查表達在所有人體細胞表面的一種稱作MHC I類複合體的身份標記。假如細胞受到病毒、細菌或寄生蟲侵入，或發生癌變，來自入侵者的蛋白碎片會裝載到MHC I類分子上形成肽複合體（p—MHC），T細胞將識別該變化並殺死攜帶有病原體的宿主細胞或癌變細胞。

研究入侵病原物及癌變細胞蛋白的抗原加工與提呈，抗原表位與MHC I類分子的裝配，MHC－TCR相互作用機制，調控MHC-TCR之間的識別，預防病毒感染，治療癌症。

研究課題包括抗原加工與提呈的理論基礎；人源化TCR-like單鏈抗體的臨床評價；免疫殺傷細胞的特異性調控與應用。

1. Changzhen Liu, Thomas S. Walter, Peng Huang, Shiqian Zhang, Xuekai Zhu, Ying Wu, Lucy R. Wedderburn, Peifu Tang, Raymond J. Owens, David I. Stuart, Jingshan Ren, Bin Gao* (2010); Structural and Functional Insights of RANKL-RANK Interaction and Signalling. J Immunol. 184:6910-9

2. Changzhen Liu, Hongmei Fu, Barry Flutter, Simon J Powis, Bin Gao* (2010). Suppression of MHC class I surface expression by calreticulin s P-domain in a calreticulin deficient cell line BBA - Mol Cell Research 1803(5):544-52

3. Xuekai Zhu, Lei Wang, Rongzhi Liu, Barry Flutter, Shenghua Li, Jie Ding, Hua Tao, Changzhen Liu, Meiyi Sun and Bin Gao (2010). COMBODY: one-domain antibody multimer with improved avidity Immunol and Cell Biol88: 667–675

4. Wu Ying #, Liu Changzhen #, Sun Meiyi, Shen Hexiao, Guo Deyin, Gao Bin *(2010). A Specific Cytotoxic T lymphocyte Epitope Presentation System for Anti-tumor Immunity. Int J Cancer 126(10):2373-86

5. Fu Hongmei #, Liu Changzhen #, Flutter B, TaoHua, Gao Bin*(2009). Calreticulin maintains the low threshold of peptide required for efficient antigen presentation. Mol Immunol 46(16):3198-206

6. Charles Kwok-chong Li, Paul Knopp, Halima Moncrieffe, Bhanu Singh, Sonia Shah, Kanneboyina Nagaraju, Hemlata Varsani, Gao Bin, Lucy R. Wedderburn. (2009). Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis. Am J Pathol. 175(3):1030-40

7. Zhang Shiqian #, Liu Changzhen #, Huang Peng, Zhou Shu, Ren Jingshan, Yoshihiro Kitamura, Tang Peifu,Zhenggang Bi, Gao Bin *(2009) The affinity of human RANK binding to its ligand RANKL. Arch Biochem Biophys. 487(1):49-53

8. Vassiliki Sofra, Salah Mansour, Liu Mengya, Gao Bin, Elisavet Primpido, Wang Ping, Li Suling. (2009) Antigen-loaded ER microsomes from APC induce potent immune responses against viral infection. Eur J Immunol. 39(1):85-95

9. Chu F, Lou Z, Chen YW, Liu Y, Gao B, Zong L, Khan AH, Bell JI, Rao Z, Gao GF. (2007) First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escape. J Immunol. 178(2):944-52.

10. Flutter B, Fu HM, Wedderburn L, Gao B. (2007) An extra molecule in addition to human tapasin is required for surface expression of beta2m linked HLA-B4402 on murine cell. Mol Immunol. 44(14):3528-36.