文波

2005年起在約翰。霍普金斯大學醫學系及表觀遺傳學中心從事博士后研究，

並於2009年晉陞為講師(Instructor)。

2010年被聘為復旦大學生物醫學研究院研究員。

研徠究方向

1.以多能幹細胞定向分化、精子發生為模型研究細胞身份轉換的表觀遺傳機制。

2.長非編碼RNA（LncRNA）與染色質相互作用機制。

論文

在Nature、Nature Genetics、American Journal of Human Genetics、Genome Research 等國際學術期刊上發表論文20餘篇，被引2800多次。

1.Wen B, Wu H, Loh YH, Briem E, Daley GQ, Feinberg AP*. Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions. BMC Genomics. 2012; 13:566.

2.Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, Daley GQ*. Epigenetic memory in induced pluripotent stem cells. Nature 2010 ;16 (7313):285-90.

3.Wen B, Wu H, Shinkai Y, Irizarry R and Feinberg AP*. Large histone H3 lysine-9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nature Genetics 2009;41: 246-50.

4.Doi A, Park IH, Wen B, Murakami P, Aryee M, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J, Schlaeger T, Daley GQ and Feinberg AP*. Differential methylation of tissue- and cancer specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nature Genetics 2009; 41(12):1350-3.

5.Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, Cui H, Gabo K, Rongione M, Webster M, Ji H, Potash JB, Sabunciyan S, Feinberg AP*. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nature Genetics 2009; 41:178-186.

6.Wen B, Wu H, Bjornsson H, Green RD, Irizarry R, Feinberg AP. Overlapping euchromatin/heterochromatin- associated marks are enriched in imprinted gene regions and predict allele-specific modification. Genome Research 2008; 18:1806-13.