向浩
向浩
向浩 武漢大學公共衛生學院流行病與衛生統計學系副教授、碩導、全球健康系主任,武漢大學珞珈青年學者,主要研究方向為環境流行病學、腫瘤分子流行病學和全球健康學。
1. 腫瘤的分子流行病學:研究遺傳變異及環境暴露因素與腫瘤易感性的關係,重點探討GH-IGF基因家族、MiRNA結合位點的基因多態性與結直腸癌發病的易感性,並深入探討其發病機制。
2. 環境與全球健康:重點關注空氣污染物(PM2.5、PM10、CO、O3、NO2和SO2等)與各種心血管疾病和呼吸系統疾病急性發作和死亡的短期效應和長期影響。
3. 教學研究:探討公共衛生與預防醫學本科專業人才培養改革,全球健康學本科人才培養體系建設
1. 國家自然科學基金青年基金項目“BER通路基因miRNA結合位點基因多態性與結直腸癌易感性的關聯及功能研究”(81402743),起止時間:2015.1-2017.12;
2. 武漢大學自主創新項目“MiRNA 結合位點基因多態性與高血壓易感性的流
行病學研究”(4101039), 起止時間:2011.9-2013.9;
3. 武漢大學公共衛生學院青年基金項目“生物鐘基因多態性與大腸癌關係的
分子流行病學研究”(GW1345323), 起止時間:2010.11-2013.11
4.衛生部縱向項目“大流行不同階段急性呼吸道感染患病情況和流感知識態度、行為水平電話調查”(305153253),起止時間:2009.11-2011.11
5. 美國中華醫學基金會(CMB)教學研究項目“基於勝任力的全球健康人才培養實踐和理論探索”(13-134),起止時間:2013.01-2016.01
1. 國家自然基金課題“脂聯素家族基因多態性與大腸癌易感性的分子流行病學
研究”(30972534),起止時間:01/01/2010-12/31/2012;
2. 國家自然基金課題“大腸癌飲食及相關因素暴露與GH 家族多態性的分子流
行病學研究”(30571598),起止時間:01/01/2006-12/31/2008;
3. 國 家 自 然 基 金 課 題“飲食因素與大腸癌相關基因交互作用的研究”
(30371239),起止時間:01/01/2004-12/31/2005。
4. 武漢大學課程體系改革試點基地項目“全球健康學專業課程體系建設”,起止時間:2013.7-2016.7
1. Hao Xiang, Li Liu, Guang-di Chu, Sheng Wei, Jian-ping Liu, Yi-hua Xu, Ji-gui Chen, Chong-jian Wang, Qing-Yi Wei, Shao-fa Nie*. Association between two functional polymorphisms of insulin-like growth factor binding protein 3 and colorectal cancer risk in a Chinese population.Journal of Toxicology and Environmental Health, Part A. 72(11-12): 706-711, 2009
2. Hao Xiang*, Ying Wang, Shaofa Nie. Meta-analysis of the association between insulin-like growth factor binding protein 3 genetic polymorphisms and colorectal cancer susceptibility,PLOS ONE, 8(3):e59665, 2013
3. Xiang H, Mertz KJ, Arena VC, Brink LL, Xu X, Bi Y, Talbott EO. Estimation of short-term effects of air pollution on stroke hospital admissions in Wuhan, China.PLoS One. 12;8(4):e61168, 2013
4. Zhang F, Xiang H(Co-first Author), Fan Y, Ganchuluun TA, Kong W, Ouyang Q, Sun J, Cao B, Jiang H, Nie S*. The effects of sulfonylureas plus metformin on lipids, blood pressure, and adverse events in type 2 diabetes: a meta-analysis of randomized controlled trials.Endocrine. 44(3):648-58,2013
5. Zhong R, Liu L, Zou L, Sheng W, Zhu B, Xiang H, Chen W, Chen J, Rui R, Zheng X, Yin J, Duan S, Yang B, Sun J, Lou J, Liu L, Xie D, Xu Y, Nie S*, Miao X. Genetic variations in the TGFβ signaling pathway, smoking and risk of colorectal cancer in a Chinese population.Carcinogenesis.34(4):936-42, 2013
6. Liu L,Zhong R,Wei S,Yin JY,Xiang H,Zou L,Chen W,Chen JG,Zheng XW,Huang LJ,Zhu BB,Chen Q,Duan SY,Rui R,Yang BF,Sun JW,Xie DS,Xu YH, Miao XP,Nie SF*. Interactionsbetweengeneticvariantsin theadiponectin,adiponectinreceptor1 and environmentalfactorson theriskofcolorectalcancer.PLOS ONE. 6(11):e27301, 2011
7. Hao Xiang, Ying Wang, Shaofa Nie*. Meta Analysis On The Associations Between Insulin-like Growth Factor Binding Protein 3 Genetic Polymorphisms And Colorectal Cancer Susceptibility. UICC 2012 WorldCancer Congress. Aug. 27-30, 2012, pp 244, Montreal, QC,Canada, poster
8. Hao Xiang, Shaofa Nie*. Association Between IGF-IR Gene Polymorphisms And Colorectal Cancer Risk: A Case-Control Study In A Chinese Population. UICC 2012 WorldCancer Congress. Aug. 27-30, 2012, pp 268, Montreal, QC, Canada, poster
9. Evelyn Talbott*, Hao Xiang, Luann Brink, Kristen Mertz, Xiaohui Xu, Vincent Arena. Association of Air Pollution and Cerebrovascular Hospitalization from 2006-2008 in Wuhan, China. 2012 International Stroke Conference,Feb.1-3,2012,pp 223, New Orleans, L.A., U.S, poster