毛一雷

1990年在澳大利亞Modbury醫院完成住院醫訓練。

1997年獲北歐最著名的瑞典隆德大學（Lund University）外科博士學位，師從歐洲科學院院士、國際肝膽胰外科協會主席Stig Bengmark和歐洲外科研究協會主席Bengt Jeppsson。

1999年在美國哈佛大學完成博士后訓練，師從哈佛著名科學家Robert J. Smith；同時在美國麻省總醫院（MGH）腫瘤外科完成臨床培訓。

擅長腹部外科，主要是肝、膽疾病的診斷和外科治療，同時對外科疑難和重症疾病的治療、臨床營養支持有較深的研究。

主持美國CMB基金、參與國家863項目、國家科技支撐計劃課題及國家自然科學基金等多個項目。有國家專利兩項。目前主持的“GP73肝癌早期診斷”和“GSA肝臟三維立體肝功能評估”的項目處國內領先、國際先進地位。

主要的方向是研究重症疾病、內毒素血症和激素的拮抗，激素的細胞內信號轉導、作用途徑及其調節因子等。並參與在國際上首先克隆了大鼠SOCS基因，多次在國際會議上發言。從1999年初起，在哈佛大學麻省總醫院（MGH）腫瘤外科（Surgical Oncology，全美同類科室連續三年排名第一）做臨床研究。

1999年回國后，在中國醫學科學院，北京協和醫院外科從事臨床工作。主持多個臨床相關的科研項目，分別申請到國際國內研究基金數百萬，主要研究包括“肝癌早期診斷血清標記物GP73在臨床上的應用及其相關抗體的開發”和“新的肝功能評估方法：GSA三維立體肝功能現象技術”，達國際先進水平。分別獲國家癌症中心臨床科研一等獎，衛生部醫藥衛生青年科技論壇一等獎，2014年中華醫學科技獎三等獎第一完成人。

在國際、國內著名雜誌發表100餘篇論文。

第一作者、通訊作者SCI文章

Shunda Du, Yilei Mao, Xinting Sang, Xin Lu, Zhiying Yang, Shouxian

Zhong, JIefu Huang. Bleeding Ectopics. The Lancet, 2010;375(9732): 21922192.

Yilei Mao, Huayu Yang, Haifeng Xu, et al. Golgi protein 73 (GOLPH2) is

a valuable serum mark for hepatocellular carcinoma. GUT.

2010, 59 (12):1687-1693.

Mao Y, Yu Z, Lu X, Sang X, Yang Z, Zhong S. Survival after 90%

hepatectomy in rat: blocking Jak-Stat or p21-ras signaling. Hepatology, 2004;40 (4 suppl 1): 175A.

Mao Y, Nobaek S, Kasravi B, Adawi D, Stenram U, Molin G, Jeppsson B. The effects ofLactobacillusstrains and oat fiber on methotrexate-induced enterocolitis in rats. Gastroenterology 1996; 111: 334-344.

Xinting Sang, Yongliang Sun, Yilei Mao,Zhiying Yang, Xin Lu, Huayu Yang, Haifeng Xu, Shouxian Zhong, Jiefu Huang. Hepatobiliary Cystadenomas and Cystadenocarcinomas: Report of 33 Cases. Liver International, 2011; 31(9):1337-1344.

Sun YL, Yang H, Mao Y,et al. The Increased GP73 Expression in Hepatocellular Carcinoma Tissue Correlates to the Tumor Aggression but not Survival. J Gastroenterol Hepatol, 2011;26:1207-1212.

Mao Y. Ling P-R, Fitzgibbons TP, McCowen KC, Frick GP, Bistrian BR, Smith RJ. Endotoxin-Induced Inhibition of Growth Hormone Receptor Signaling in Rat Liverin Vivo.Endocrinology 1999, 140: 5505-5515.

Huayu Yang, Yilei Mao, Xin Lu, et al. The Effects of Urinary Trypsin Inhibitor on Liver Function and Inflammatory Factors in Patients Undergone Hepatectomy: a Prospective, Randomized, Controlled Clinical Study. Am J Surg, 2011, 202(2):151-157.

Mao Y, Nobaek S, Adawi D, Molin G, Jeppsson B. Comparison of the effects of different strains ofLactobacillusin reducing bacterial translocation on methotrexate induced-enterocolitis in rats. Digestive surgery 1997; 14: 284-291.

Mao Y,Huang J. Commentary on: Aspartate transaminase to platelet ratio index (APRI): A simple noninvasive index assessing liver fibrosis in patients with chronic liver diseases. Hepat Mon. 2011;11(5):376-377.

Mao Y, Yu J-L, Ljungh Å, Molin G, Jeppsson B. Intestinal immune response to oral administration ofLactobacillus reuteriR2LC,Lactobacillus plantarumDSM 9843, pectin and oatbase on methotrexate-induced enterocolitis in rats. Microbial Ecology in Health and Disease 1996; 9: 261-270.

Mao Y, Kasravi B, Nobaek S, Wang L-Q, Adawi D, Roos G, Stenram U, Molin G, Bengmark S, Jeppsson B. Pectin-supplemented enteral diet reduces the severity of methotrexate-induced enterocolitis in rats. Scand J Gastroenterology 1996; 31: 558-567.

Shunda Du, Yilei Mao, Xin Lu, Xinting Sang, Shouxian Zhong, Jiefu Huang. Hepatic Metastatic Melanoma: Diagnosis and Treatment. Brazilian Journal of Medical and Biological Research 2012XU Haifeng, MAO Yilei,DU Shunda, CHI Tianyi, LU Xin, YANG Zhiying, SANG Xinting, ZHONG Shouxian, HUANG Jiefu. Adult primary undifferentiated embryonal sarcoma of the liver: A case report. Chin Med J, 2010, 123(2): 250-252.

Liu Liguo, Xu Yiyao, Mao Yilei, Sang Xinting, Yang Zhiying, Lu Xin, Zhong Shouxian, Huang Jiefu. Adult congenital diaphragmatic hernia of the liver: a rare case report. Science China-Life Sciences, 2010; 53 (2): 204-206.

Ge PL, Du SD, Mao YL. Advances in preoperative assessment of liver function. HBPD INT, 2014;13(4):361-370.

Mao Y, Du S, Ba J, Li F, Yang H, Lu X, Sang X, Li S, Che L, Tong J, Xu Y, Xu H, Zhao H, Chi T, Liu F, Du Y, Zhang X, Wang X, Dong J, Zhong S, Huang J, Yu Y, Wang J. Using Dynamic99mTc-GSA SPECT/CT Fusion Images for Hepatectomy Planning and Postoperative Liver Failure Prediction.Ann Surg Oncol, 2014 Oct 8.

Du S, Wang Z, Sang X, Lu X, Zheng Y, Xu H, Xu Y, Chi T, Zhao H, Wang W, Cui Q, Zhong S, Huang J, Mao Y. Surgical resection improves the outcome of the patients with neuroendocrine tumor liver metastases: large data from Asia. Medicine. (Dec 2, 2014 Accept)

GE P, DU S, MAO Y: Advances in preoperative assessment of liver function. Hepatobiliary Pancreat Dis Int 2014; 13(4): 361-370

PAN J, ZHANG Y, YANG H, XU H, LU X, SANG X, ZHONG S, MAO Y: The response of Golgi protein 73 to transcatheter arterial chemoembolization in patients with hepatocellular carcinoma may relate to the influence of certain chemotherapeutics. Hepatobiliary Pancreat Dis Int 2015; 14(4): 406-412

LIAO W, MAO Y, GE P, YANG H, XU H, LU X, SANG X, ZHONG S: Value of quantitative and qualitative analyses of circulating cell-free DNA as diagnostic tools for hepatocellular carcinoma. Medicine 2015; 94(14): e722

YANG H, FU Q, LIU C, LI T, WANG Y, ZHANG H, LU X, SANG X, ZHONG S, HUANG J, MAO Y: Hepatitis B virus promotes autophagic degradation but not replication in autophagosome. BioScience Trends 2015; 9(2): 111-116

DU S, WANG Z, SANG X, LU X, ZHENG Y, XU H, XU Y, CHI T, ZHAO H, WANG W, CUI Q, ZHONG S, HUANG J, MAO Y: Surgical resection improves the outcome of the patients with neuroendocrine tumor liver metastases. Medicine 2015; 94(2): e388

TANG G, YANG H, ZHANG J, REN J, SANG X, LU X, ZHONG S, MAO Y: Magnesium isoglycyrrhizinate inhibits inflammatory response through STAT3 pathway to protect remnant liver function. World Journal of Gastroenterology 2015; 21(43): 12370-12380

DU S, NI J, WENG L, MA F, LI S, WANG W, SANG X, LU X, ZHONG S, MAO Y: Aggressive locoregional treatment improves the outcome of liver metastases from grade 3 gastroenteropancreatic neuroendocrine tumors. Medicine 2015; 94(34): e1429

HUANG J, MILLIS J, MAO Y, MILLIS M, SANG X, ZHONG S: Voluntary organ donation system adapted to Chinese cultural values and social reality. Liver Transplantation 2015; 21: 419-422

MAO Y, DU S, BA J, LI F, YANG H, LU X, SANG X, LI S, CHE L, TONG J, XU Y, XU H, ZHAO H, CHI T, LIU F, DU Y, ZHANG X, WANG X, DONG J, ZHONG S, HUANG J, YU Y, WANG J: Using dynamic Tc-GSA SPECT/CT fusion images for hepatectomy planning and postoperative liver failure prediction. Ann Surg Oncol 2015; 22: 1301-1307

Liao W, Yang H, Xu H, Wang Y, Ge P, Ren J, Xu W, Lu X, Sang X, Zhong S, Zhang H, Mao Y. Noninvasive detection of tumor-associated mutations from circulating cell-free DNA in hepatocellular carcinoma patients by targeted deep sequencing. Oncotarget. 2016; 7(26): 40481-40490.

Xu W, Xu H, Yang H, Liao W, Ge P, Ren J, Sang X, Lu X, Zhong S, Mao Y. Continuous Pringle maneuver does not affect outcomes of patients with hepatocellular carcinoma after curative resection. Asia Pac J Clin Oncol. 2016 Aug 12. doi: 10.1111/ajco.12585. [Epub ahead of print]

Xu W, Liao W, Ge P, Ren J, Xu H, Yang H, Sang X, Lu X, Mao Y. Multiple Primary Malignancies in Patients With Hepatocellular Carcinoma: A Largest Series With 26-Year Follow-Up. Medicine (Baltimore). 2016; 95(17): e3491.

Xu W, Ge P, Liao W, Ren J, Yang H, Xu H, Sang X, Lu X, Zhong S, Mao Y. Edmondson grade predicts survival of patients with primary clear cell carcinoma of liver after curative resection: A retrospective study with long-term follow-up. Asia Pac J Clin Oncol. 2016 Apr 21. doi: 10.1111/ajco.12494. [Epub ahead of print]

Du S, Liu G, Cheng X, Li Y, Wang Q, Li J, Lu X, Zheng Y, Xu H, Chi T, Zhao H, Xu Y, Sang X, Zhong S, Mao Y. Differential Diagnosis of Immunoglobulin G4-associated Cholangitis From Cholangiocarcinoma. J Clin Gastroenterol. 2016; 50(6): 501-5.

非第一作者SCI文章：

Huang JF, Mao YL, Millis JM. Government policy and organ

transplantation in China. The Lancet; 2008; 372(9654): 1937-1938.

Jiefu Huang, J. Michael Millis, Yilei Mao, M. Andrew Millis, Xinting Sang,

Shouxian Zhong. China’s Pilot Program of Organ Donation from Patients

following Cardiac Death.The Lancet; 2011; in press

Miao RY, Zhao HT, Yang HY,Mao YL, Lu X, Zhao Y, Liu CN, Zhong SX, Sang XT, Huang JF. Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma: A meta-analysis. World J Gastroenterol, 2010;16(23): 2931-2942.

Sang XT, Zhao HT, Lu X, Mao YL, Miao RY, Yang HY, Yang YF, Huang JF, Zhong SX. Prediction and identification of tumor-specific noncoding RNAs from human UniGene. Med Oncol, 2010;27(3):894-898

Millis JM, Huang J, Millis MA, Liu Y, Y. Mao, and M. Simmerling. 2007: The Year of Regulatory Change. Transplantation Proceedings, 2009;41:25–26.

Lu X, Zhao HT, Yang HY, Mao YL, Sang MT, Miao RY, Xu YY, Du SD, Xu HF, Chi TY, Yang ZY, Zhong SX, Huang JF. A Prospective Clinical Study on Early Recurrence of Hepatocellular Carcinoma After Hepatectomy. J Surg Oncol, 2009;100(6):488-493.

Lu X, Zhao H, Yang H, Mao Y, Sang X, Miao R, Xu Y, Du S, Xu H, Chi T, Yang Z, Zhong S, Huang J. A prospective clinical study on early recurrence of hepatocellular carcinoma after hepatectomy. J Surg Oncol 2009；Jiefu Huang, Yilei Mao, Yu Wang, Zongjiu Zhang, Minggang Zhao, Yong Liu. Modernazation of the organ transplantation program in China. Transplantaion, 2008;86(12):1649-1652.

Shao Y, Sun ZY, Sun SW, Zhao Y, Sin WY, Yuan YH, Simpson, AJ, Old LJ, Sang XT, Mao YL,Xie Y, Huang JF, Zhao HT. Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients. J Cancer Res Clin Oncol. 2008; 134(4): 495-502.

Ni XG, Bai XF, Mao YL, Shao YF, Wu JX, Shan Y, Wang CF, Wang J, Tian YT, Liu Q, Xu DK, Zhao P. The clinical value of serum CEA, CA19-9, and CA242 in the diagnosis and prognosis of pancreatic cancer. Eur J Surg Oncol, 2005; (2)31:164-169.

Ling PR, Smith RJ, Mueller C, Mao Y,Bistrian BR. Inhibition of interleukin-6-activated janus kinases/signal transducers activators of transcription but not mitogen-activated protein kinase signaling in liver of endotoxin-treated rats. Crit Care Med 2002;30:202-211.

McCowen KC, Ling P, Ciccarone A, Mao Y, Chow JC, Bistrian BR, Smith RJ. Sustained endotoxemia leads to marked down-regulation of early steps in the insulin-signaling cascade. Critical Care Medicine, 2001;29:839-846.

Liu Q, Nobaek S, Adawi D, Mao Y,Wang M, Molin G, Ekelund M, Jeppsson B. Aministration of Lactobacillus plantarum 299v reduces side-effects of external radiation on colon anastomotic healing in an experimental model. Colorectal Disease. 2001;3:245-252.

非醫學作品

2008年底隨中國南極科考隊前往南極探險。著有《冰雪世界的遠征》一書。

2013年在美國Xlibris出版社出版了《TheTop of the Bottom of the World》。

2001年獲美國“Li-foundation Heritage Prize”傑出成就獎，成為該年度生物醫學界唯一獲獎者；曾連續三次（第五、第六、第七屆）獲全國普外科中青年優秀論文一等獎，成為該獎項唯一一個連續三次獲一等獎者；從2000年至今多次獲北京協和醫院醫療成果獎和優秀論文獎。

2010年和2011年又分別榮獲得衛生部第十屆醫藥衛生青年科技論壇一等獎、中國國家癌症中心研究論文一等獎。

2014年獲中華醫學科技獎三等獎；同年被評為北京協和醫院十大最佳外科教授。

榮獲2017年全國衛生計生系統先進工作者。

現為中國醫師協會肝臟外科醫師委員會副主任委員，全國衛生產業企業管理協會外科技術創新與推廣分會會長，中華外科協會肝臟學組委員，中華腫瘤學會肝癌學組委員，中國抗癌協會肝癌專業委員會委員，衛生部肝癌規範診療專家組專家，海峽兩岸衛生交流協會普通外科專家委員會常務委員，美國營養協會（ASN）會員，國際肝膽胰協會中國分會委員。

國內期刊編委：中華醫學雜誌，HBPD INT（SCI），Chinese Medical Sciences Journal，Gastroenterology Report，中華普通外科雜誌，中國醫學科學院學報，中華消化外科雜誌，中華內分泌外科雜誌，中華臨床營養雜誌，中國實用外科雜誌，中華臨床醫師雜誌，中國普外基礎與臨床雜誌，基礎醫學與臨床，中國現代醫生雜誌編委。

國際編委：Journal of Gastrointestinal Surgery。