趙剛

1980年和1987年曾分別就讀於四川大學化學系和蘭州大學化學系,1999年在香港中文大學獲博士學位。1987年至1996年在四川大學任教。1999年赴法國在法國國家科學研究中心從事博士后研究。2000年任美國俄亥俄州立大學研究員助理。2003年在世界500強企業之一的日東電工集團生物製藥部任技術總監。

多年來一直致力於有機合成、有機合成方法學、藥用高分子材料等領域的研究工作，近年來在不對稱有機合成、核糖核酸和脫氧核糖核酸的合成、金屬有機化學、配位化學、晶體學、生物學等領域也有重要的研究成果。

主要從事抗腫瘤藥物的設計、合成、不對稱催化、手性識別、納米運載體系和生物活性等領域的研究。

曾在《Nature》、《J. Am. Chem. Soc.》、《Chemistry & Biology》、《Molecular Microbiology》、《Chem. Eur. J.》、《Organic Letters》、《Organometallics》等上發表論文近五十篇，引用次數超過800次。並申請美國、歐洲專利六十項。作為主要參加者在《Nature》雜誌、作為共同第一作者在《Chemistry & Biology》雜誌上發表了關於新型氨基酸吡咯賴氨酸的全合成與生物活性研究的文章，這兩篇文章被國際著名雜誌和媒體廣泛報道。被譽為解決了近半個多世紀以來遺傳基因編碼中的一個難題並擴展了遺傳基因編碼的規則。曾作為項目技術負責人承擔了加州大學重大科研項目和日東電工與北京製藥集團抗腫瘤藥物的合作開發項目。2011年作為“四川省百人計劃”入選者和“四川省特聘專家”到四川大學從事製藥工程領域的研究與開發工作。

代表性成果：

ZhonglingFeng, Gang Zhao*, Lei Yu*, David Gough, Stephen B. Howell,“Preclinical efficacystudies of a novel nanoparticle-based formulation of paclitaxel thatout-performs Abraxane”,Cancer Chemotherapy and Pharmacology,2010, 65, 923-930. (*reprint author)。

cokinetics and tissue distribution of PGGA-paclitaxel, a novel macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460 lung cancer xenografts”,Cancer Chemotherapy and Pharmacology, 2010, 65, 515-526. (*reprint author) 。

Changxing Liu, Gang Zhao*, Jian Liu, Nianchun Ma, Zongyou Chen, David Gough, and Lei Yu*, “Novel biodegradable lipid nano complex for siRNA delivery significantly improving thechemosensitivity of human colon cancer stem cells to paclitaxel”J. Controlled Release, 2009, 140(3), 277-283. (corresponding author) 。

Wen-Tai Li, Anirban Mahapatra, David G. Longstaff,Jonathan Bechte, Gang Zhao, Patrick T. Kang, Michael K. Chan and Joseph A.Krzycki, “Specificity of Pyrrolysyl-tRNA Synthetase for Pyrrolysine andPyrrolysine Analogs”,J. Mol. Biol.2009, 385, 1156–1164.

Carine Bughin, Gang Zhao, Hugues Bienaym, Jieping Zhu, “5-Aminooxazole as an Internal Traceless Activator of C-Terminal Carboxylic Acid: Rapid Access to Diversely Functionalized Cyclodepsipeptides”,Chem. Eur. J.2006,4, 1174-1184.

Sherry K. Blight, Ross C. Larue, Anirban Mahapatra,David G. Longstaff, Edward Chang, Gang Zhao, Patrick T. Kang, Kari B.Green-Church, Michael K. Chan and Joseph A. Krzycki, “Direct charging of tRNACUAwith pyrrolysinein vitroandin vivo”, Nature(London, United Kingdom), 2004, 431 (7006), 333-335.

Gang Zhao*, Bing Hao*, Patrick T. Kang, Jitesh A. Soares, Tsuneo K. Ferguson, Judith Gallucci, Joseph A. Krzycki, Michael K. Chan, ”Reactivity and chemical synthesis of L-pyrrolysine - the 22(nd) genetically encoded amino acid”, Chemistry & Biology2004,11 (9): 1317-1324.(* co-first author)。

Gang Zhao, Carine Bughin, Hugues Bienaymé, Jieping Zhu“Synthesis of Isocyano Peptides by Dehydration of theN-Formyl Derivatives”,Synlett,2003, 1153-1154.

Gang Zhao, Xiaowen Sun, HuguesBienaymé, and Jieping Zhu, “Activation of a Terminal Carboxylic Acid by anInternal Oxazole: A Novel Synthesis of Macrocyclodepsipeptide”,J. Am. Chem. Soc.,2001,123, 6700.

Gang Zhao, Qingchuan Yang, and Thomas C. W. Mak,"Cyclic ether induced asymmetric cyclopalladation: synthesis, structural determination and alkyne insertion reaction of enantiopure planar chiral cyclopalladated derivatives of ferrocenylimines",Organometallics,1999,18, 3626.

1.

Cancer Chemotherapy and Pharmacology

2.

Cancer Chemotherapy and Pharmacology

3.

J. Controlled Release

4.

J. Mol. Biol.

5.

Chem. Eur. J.

6.

Sherry K. Blight, Ross C. Larue, Anirban Mahapatra,David G. Longstaff, Edward Chang, Gang Zhao, Patrick T. Kang, Kari B.Green-Church, Michael K. Chan and Joseph A. Krzycki, “Direct charging of tRNACUAwith pyrrolysinein vitroandin vivo”, Nature(London, United Kingdom), 2004, 431 (7006), 333-335.

7.

Chemistry & Biology

徠8.

Gang Zhao, Carine Bughin, Hugues Bienaymé, Jieping Zhu“Synthesis of Isocyano Peptides by Dehydration of theN-Formyl Derivatives”,Synlett,2003, 1153-1154.

9.

J. Am. Chem. Soc.,

10.

Organometallics,