張連文

學科方向：糖生物學

招生方向：微生物學

2007年1月畢業於清華大學生物系獲博士學位。同年進入南開大學藥學院工作。講授研究生《糖化學與糖生物學在藥物開發中的應用》課程，並從事糖生物學方面的研究工作，包括糖基轉移酶的基礎及應用研究和O-GlcNAc單糖基化修飾在腫瘤中的作用機制。先後主持或參與國家自然科學基金，國家重大藥物創新專項，973項目多項。發表SCI論文10餘篇，獲授權專利一項。

發表文章及專利

1)Zhang LW*, Ren FF, Li J,et al.A modified coupled-enzyme method for O-linked GlcNAc transferase activity assay. Biological procedures online, 2009,11(1): 171-183

2) Lei Li, Robert Woodward, Xianwei Liu, Yan Ding, Wen Yi, Veer S Bhatt,Lianwen Zhangand Peng George Wang, Overexpression and Topology of Bacterial Oligosaccharyltransferase PglB, Biochemical and Biophysical Research Communications 2010, 394:1069–1074.

3) Rui Shen, Shuai Wang, Junyang Xian, Xiaofeng Ma, Jing Li,Lianwen Zhang* and Peng Wang, An easy colorimetric assay for several glycosyltransferase, Biochemistry-moscow, 2010, 75(7): 944-950.

4) Jing Li, Cailuan Huang,Lianwen Zhang, Lin Lin, Zhonghua Li, Fuwu Zhang, and Peng Wang, Isoforms of Human O-GlcNAcase Show Distinct Catalytic Efficiencies. Biochemistry-moscow, Biochemistry-moscow, 2010, 75(7): 944-950.

5) Sunhong, Ma xiaofeng Ren Feifei,Zhang lianwenand Wang peng.A review on N-aetylgucosamine transferase, Chinese Bulletin of Life Sciences, 2011, 23：643-647

6) Guangxiang Ren, Jingli Hou, Qinghong Fang, Hong Sun, Xiaoyan Liu, Peng George Wang and Lianwen Zhang* Synthesis of flavonol 3-O-glycoside by UGT78D1, Glycoconjugate Journal，2012，29 (5)：425-432

7)Xiaofeng Ma, Hui Yan, Pi Liu, Xiaoyan Liu, Peng Wang &Lianwen Zhang*. Substrate specificity provides insight into the sOGT catalytic mechanism, (submitted)

8)張連文,馬曉峰，王鵬。一種半乳糖基轉移酶修飾黃酮類糖苷化合物的方法.