張曉東

張曉東性別：男職稱：南開大學生命科學學院教授所屬部門：學系生物化學和分子生物招生專業：

生化與分子生物學

研究方向：腫瘤分子生物學，探討乙肝病毒致癌分子機制和乳腺癌轉移分子機制，篩選抗腫瘤藥物

研究領域：腫瘤分子生物學，開展乙肝病毒致癌分子機制和乳腺癌轉移分子機制研究，篩選抗腫瘤藥物

科研成果

國家科技進步獎二等獎：《人原發性肝癌發病機制的免疫病理學和分子病理學研究》

陝西省科技進步獎一等獎：《肝炎、肝硬變和肝癌發病關係的免疫病理學和分子病理學研究》

回國后獲得基金和研究生培養情況

2000年11月回國，先後獲得並參加973計劃項目2項（1項為課題組組長）、主持國家自然科學基金4項，參加國家自然科學基金7項，主持天津市科技發展計劃科技攻關項目4項。目前，培養博士生15人（畢業10人)，碩士生27人（畢業19人）。目前，已獲得國家發明專利2項。回國后在國內外學術刊物上共發表論文70餘篇，其中SCI論文50餘篇(影響因子累計大於180）,影響因子大於10的1篇，大於9的2篇，大於5的8篇。

獲得

1.葉麗虹，張曉東，吳蓮英，朱惠芳。高轉移傾向的人乳腺癌細胞系及其建立方法，獲得國家發明專利.

2.葉麗虹，張曉東，秦宵然，朱惠芳，王洪輝。人肝癌轉移亞克隆細胞系及其建立方法，獲得國家發明專利.

:主要學術論文::

張曉東；東楠；殷麗輝；蔡娜；馬宏濤；尤嘉琮；張航；王洪輝; He, R;. Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues. JOURNAL OF MEDICAL VIROLOGY

張曉東；東楠；張航；尤嘉琮；王洪輝；葉麗虹. Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cel. JOURNAL OF LABORATORY AND CLINICAL MEDICINE

王鳳澤；沙麗；喬玲；吳蓮英；張曉東；葉麗虹. Promotion of transcriptional activity of NF-kappa B mediated by HBXIP in hepatoma cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

秦宵然；張航；周曉雷；王長曄；張惠中；張曉東；葉麗虹. Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells. TRANSLATIONAL RESEARC

張曉東；張偉英；葉麗虹. Pathogenesis of hepatitis B virus infection. FUTURE VIROLOGY

喬玲；徐治立；譚旭；葉麗虹；張曉東. Investigation of inhibition of Wnt/beta-catenin pathway in breast cancer cells mediated by Dkk-1 released from human mesenchymal stem cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

王徠鳳澤；沙麗；張偉應；吳蓮英；喬玲；李楠；張曉東；葉麗虹. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. ACTA PHARMACOLOGICA SINICA

張曉東；張航；吳蓮英；沙麗；劉樹業；邵新華；葉麗虹. Anti-HBx in sera is a potential marker of development from hepatitis B (HB) to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

葉麗虹；蔡娜；東楠；李楠；張偉英；張航；張烜；吳蓮英；張曉東. Interference of RNA targeting hepatitis B virus x (HBx) gene reduces the tumorigenicity of hepatoma cells and HBx-transformed human liver cells. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

張曉東；蔡娜；李楠；張偉英；張航；張烜；吳蓮英；齊眾；葉麗虹. Transformation of human normal liver L-O2 cells induced by hepatitis B virus X protein, enhanced by highly expression level of survivin as a co-factor. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Zhang, XD; Zhang, H; Ye, LH. Effects of hepatitis B virus X protein on the development of liver cancer. JOURNAL OF LABORATORY AND CLINICAL MEDICINE 147-2-58.2006-1-1

Zhang H, Wu LY, Zhang S, Qiu LY, Li N, Zhang X, Zhang XZ, Shan SL, Ye LH, Zhang XD*.Anti-hepatitis B Virus (HBV) X protein (HBx) in sera is one of the markers of development of liver c. J Biomed Biotechnol

Zhang WY, Cai N, Ye LH, Zhang XD. Transformation of human liver L-O2 cells mediated by stable HBx transfection.. Acta Pharmacol Sinica.

Zhang WY, Xu FQ, Shan CL, Xiang R, Ye LH, Zhang XD. Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacologica Sinica

You J, Mi D, Zhou X, Qiao L, Xu S, Zhang X, Ye LH. Positive feedback between activated ERK and COX/LOX contributes to breast cancer cell proliferation . Endocrinology

Zhou X, Liu Y, You J, Zhang X, Ye LH. Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. . Cancer Letters 270--312-327.2008-11-8

Qiao L, Xu ZL, Zhao TJ, Ye LH, Zhang XD. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Letters

張學智，山長亮，葉麗虹，張曉東. RNA干擾在抗乙肝治療中的應用及其研究進展. . 生物化學與生物物理進展

Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye L, Zhang X. Depression of tumorigenesis mediated by human mesenchymal stem cells in a model of hepatoma cells.. Cell Res

Ye LH, Dong N，Wang Q，Xu ZL，Cai N，Wang HH，Zhang X. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology

Zhang H, Shan C, Li N, Zhang X, Zhang X, Xu F, Zhang S, Qiu L, Ye L, Zhang X. Identification of a natural mutant of HBV X protein truncated 27 amino acids at COOH-terminal and it. Acta Pharmacologica Sinica

Qiao L, Zhao T, Wang F, Shan C, Ye L, Zhang X. NF-κB downregulation maybe involved the depression of proliferation of tumor cells mediated by human mesenchymal stem cells. . Acta Pharmacologica Sinica,

Wang F, Sha L, Ye L*, Zhang X. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. . Acta Pharmacologica Sinica

張烜，葉麗虹，張曉東. 骨橋蛋白通過NF-kB上調鈣蛋白酶小亞基1促進肝癌細胞遷移. 生物化學與生物物理進展

Cui WJ, Liu Y, Zhou XL, Wang FZ, Zhang XD, Ye LH. Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway. Acta Pharmacol Sin.

Zhang X, Ye LH, Zhang XD. A mutant of hepatitis B virus X protein (HBx?127) enhances cell migration via osteopontin (OPN) invo. Acta Pharmacol Sin.

Zhang F, Wang Q, Ye LH, Feng YM, Zhang XD. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kap. J Med Virol.

Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH, Zhang XD. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res.

Wang Q, Zhang WY, Ye LH, Zhang XD. A mutant of HBx (HBxΔ127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin.

Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye L, Zhang XD. A Mutant of Hepatitis B Virus X Protein (HBxDelta127) Promotes Cell Growth through A Positive Feedba. Neoplasia

Zhou XL, Qin XR, Zhang XD, Ye LH. Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/β-catenin signaling. Acta Pharmacol Sin.

Cui WJ, Zhang YW, Hu N, Shan CL, Zhang S, Zhang WY, Zhang XD, Ye LH. MiRNA-520b and miR-520e sensitize breast cancer cells to complement attack via directly targeting 3′. Cancer Biol Ther.

張烜，葉麗虹，張曉東. 乙肝病毒X蛋白通過骨橋蛋白OPN促進肝癌細胞遷移. 中國生化與分子生物學學報26-4-

周曉雷，張曉東，葉麗虹. DKK-1通過上調nm23表達抑制乳腺癌細胞遷移。. 中國生化與分子生物學學報 26-2-

Wang Q, Zhang T, Ye LH*, Wang WH, Zhang XD.. Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma inChina. Cancer Epidemiology --.

Zhang S, Shan CL, Kong GY, Du YM, Ye LH*, Zhang XD*. MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-κB-inducing kinase (NIK). Oncogene

Kong G, Zhang J, Zhang S, Shan C, Ye LH*, Zhang XD*. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targetin. PLoS One 6-5

Kong GY, Zhang JP, Zhang S, Shan CL, Ye LH*, Zhang XD*.. Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin.

張煊；葉麗虹*;張曉東*. Osteopontin(OPN) Upregulates Calpain Small Subunit 1(Capn4) via Nuclear Facter-kappa B in Promotion of Hepatoma Cell Migration. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 37-5-534.2010-1-1

尤嘉琮，米達，周曉雷，喬玲，張航，張曉東*，葉麗虹*. A Positive Feedback between Activated Extracellularly Regulated Kinase and Cyclooxygenase/Lipoxygenase Maintains Proliferation and Migration of Breast Cancer Cells. ENDOCRINOLOGY 150-4-1607-1617.2009-1-1

Zhang Xue-Zhi; Shan Chang-Liang; Ye Li-Hong; Zhang Xiao-Dong. Advantages of RNA interference in anti-hepatitis B virus therapy. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 35-6-631.2008-1-1

Nan HU, Yu LI, Yu ZHAO, Qi WANG, Jia-cong YOU, Xiao-dong ZHANG, Li-hong YE. A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. ACTA PHARMACOLOGICA SINICA?? 32--921-929.2011-1-1

Changliang Shan, Shuai Zhang, Wenjing Cui, Xiaona You, Guangyao Kong, Yumei Du, Liyan Qiu, Lihong Yeand Xiaodong Zhang. Hepatitis B virus X protein activates CD59 involving DNA binding and let-7i in protection of hepatoma and hepatic cells from complement attack. Carcinogenesis

Hu N, Zhang J, Cui W, Kong G, Zhang S, Yue L, Bai X, Zhang Z, Zhang W, Zhang X, Ye L.. miR-520b Regulates Migration of Breast Cancer Cells by Targeting Hepatitis B X-interacting Protein and Interleukin-8. J Biol Chem

張濤，張俊萍，由曉娜，劉遷，杜玉梅，高玉恩，山長亮，孔光耀，葉麗虹，張曉東.Hepatitis B Virus X Protein (HBx) Modulates OncogeneYAPvia CREB to Promote Growth of Hepatoma Cells. . Hepatology

杜玉梅，孔光耀由曉娜，張帥，張濤，葉麗虹，張曉東. Up-regulated long non-coding RNA HULC by HBx enhances growth of hepatoma cells via down-regulating p18.. J Biol Chem.

Zhang X, You X, Wang Q, Zhang T, Du Y, Lv N, Zhang Z, Zhang S, Shan C, Ye LH, Zhang XD. Hepatitis B virus X protein promotes cell migration via multiple cross-talk cascade loops involving . PLoS One 2012;7(2):e

Zhang W, Kong G, Zhang J, Wang T, Ye LH, Zhang XD. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1. PLoS One 2012;7(2):

Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, Zhang S, Zhang W, Zhang XD, Ye LH. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells . FEBS Letters

Zhao Y, Wang W, Wang Q, Zhang XD, Ye LH. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor. Biochem Biophys Res Commun.

Zhang X, You XN, Li N, Zhang WY, Gagos S, Wang Q, Banos A, Cai N, Zhang HK, Zhang H, Zhang XZ, Shan CL, Qiu LY, Zhang S, Lv N, Chen MS, Du YM, Xia JC, Ye LH*, Zhang XD*. Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx/Alu core sequence/subtelomeric DNA. FEBS Letters

Liu SP, Li LL, Zhang YY, Zhang YW, Zhao Y, Lin ZH, Zhang XD*, Ye LH*. HBXIP upregulates s100a4 via stat4 and pten to promote growth and migration of breast cancer cells. J Biol Chem