楊國華

楊國華：博士、副教授、碩士生導師，系副主任

學科專業：醫學遺傳學

研究方向：單基因病的基因診斷、克隆和功能研究

學習經歷：

1992.9-1995.7 湖北工程學院生物系專科學習；

2001.9-2006.12 武漢大學生命科學學院遺傳學專業碩博連讀。

主要工作經歷與任職

1995.9-1999.7 武鋼九中生物教師；

1999.10-2001.3 武漢科諾生物農藥公司銷售經理；

2007.1-2010.8 武漢大學基礎醫學院講師；

2010.9-2011.10 湖北省隨州市衛生局副局長；

2011.10 –至今 武漢大學基礎醫學院副教授，碩士生導師。

目前主要科學研究領域和興趣

單基因病相關基因的克隆和功能研究，疾病基因診斷新方法的研究。

教學情況：

1)《細胞生物學》（五、七、八年制）；

2)《醫學遺傳學》（五、七、八年制及外語教學班）；

3)《基因組學》（八年制）；

4)《細胞、分子與基因》（本科芝加哥實驗班）；

5)《醫學基因工程》 碩士研究生；

6)《細胞遺傳學實驗技術》（碩士研究生）；

7)《Genetics》 留學生班。

近5年代表性論文

1) Li C, Wang L, Zhang J, Huang M, Wong F, Liu X, Liu F, Cui X, Yang G, Chen J, Liu Y, Wang J, Liao S, Gao M, Hu X, Shu X, Wang Q, Yin Z, Tang Z, Liu M. CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochim Biophys Acta. 2014; 1842(7):1121-9.

2) Changyong Li, Guohua Yang, Jie Ruan, Sphingosine kinase 1/sphingosine-1- phosphate receptor type 1signalling axis is induced by transforming growth factor-β1 and stimulates cell migration in RAW264.7 macrophages, Biochemical and Biophysical Research Communications. 2012; 426(3): 415-420.

3) Risheng Liang, Xiaolei Zhuo,Guohua Yang, Daji Luo, Shan Zhong, Jixing Zou. Molecular phylogenetic relationships of family Haemulidae and the related species based on mitochondrial and nuclear genes. Mitochondrial DNA. 2012, 23(4):264-77.

4) Juan Tian, Guohua Yang, Songshan Wang, Yuanzhen Zhang, Guibo Song, Fang Zheng. Molecular diagnosis of two families with classic congenital adrenal hyperplasia. Gene. 2011, 482(1-2): 8-14.

5) Guohua Yang, Shan Zhong, Xianrong Zhang, Biwen Peng, Jun Li, Tie Ke, Hua Xu. Molecular Genetic Analysis of Autosomal Dominant Late-Onset Cataract in a Chinese Family. J Huazhong Univ Sci Technol. 2010, 30(6):792-6.

6) Yukan Huang, Jing Zhang, Chang Li, GuohuaYang, Mugen Liu, Qing. Wang, Zhaohui Tang. Identification of a novel homozygous nonsense mutation in EYS in a Chinese family with autosomal recessive retinitis pigmentosa. BMC Med Genet. 2010, 11: 121-6.

7) Kun Wang, Ya Gao, Xiaojue Peng, Guohua Yang, Feng Gao, Shaoqing Li, Yingguo Zhu. Using FAM labeled DNA oligos to do RNA electrophoretic mobility shift assay. Molecular Biology Reports. Mol Biol Rep. 2010, 37(6):2871-5.

8) Jie Lin, Xu Lin, Guohua Yang, Yong Wang, Biwen Peng, Jianyin Lin. Toxoplasma gondii: Expression of GRA1 gene in endoplasmic reticulum promotes both growth and adherence and modulates intracellular calcium release in macrophages. Experimental Parasitology. Experimental Parasitology. 2010, 125: 165-8.

9) Shan Zhong*, Guohua Yang*, Cong Xia, Duanlian Zhang, Shengguo Shan. Expression of matrix metalloproteinase and its tissue inhibitor in haemangioma. J Huazhong Univ Sci Technol. 2009, 29(5):614-6.

10) Guo-Hua Yang, Yong-Zhong Xing, Shao-Qing Li, Jing-Zhen Ding, Bing Yue, Kai Deng, Yang-Sheng Li, Ying-Guo Zhu. Molecular dissection of developmental behavior of tiller number and plant height and their relationship in rice (Oryza sativa L.). Hereditas. 2006, 143: 236-10.

11) Guohua Yang, Sansi Tu, Shaoqing Li, Lingling Feng, Jin Kong, Hui Li, Kai Deng, Yangsheng Li. Analysis of QTLs Underlying the Traits Relative to Chlorophyll Content of the Flag Leaf in Rice. Frontiers of biology. 2008, 3 (4):443-6.

12) Shao-Qing Li, Guo-Hua Yang, shao-bo Li, Yang-Sheng Li, Zu-Yu Chen, Ying-Guo Zhu. Distribution of fertility-restorer genes for wild-abortive and Honglian CMS lines of rice in the AA genome species of genus Oryza. Annals of Botany. 2005, 96:461-6.