王洪根

2011年9月至2013年8月：博士后，德國明斯特大學，合作導師：Prof. Dr. Frank Glorius；

2006年9月至2011年7月：博士，中國科學院廣州生物醫藥與健康研究院，導師：朱強研究員，張健存研究員；

2005年7月至2005年8月：交換生，香港理工大學應用生物及化學科技學系；

2002年9月至2006年7月：理學學士，雙專業：藥學＆計算機科學，中山大學藥學院，中山大學計算機科學系。

1.活性及多樣性導向的新型有機合成方法學；

2.活性導向的天然產物全合成；

3.基於生物靶標的合理藥物設計、合成與生物活性研究；

4.藥物新型合成工藝研究.

中國科學院優秀博士學位論文，2012年

中國科學院院長獎學金優秀獎，2011年

中山大學“百人計劃”啟動經費200萬，2013-2016年，負責人

(1)Wang,H.;Beiring, B.; Yu, D.-G.; Collins, K.; Glorius, F.“Dendralene Synthesis: Rhodium(III)-Catalyzed Alkenyl C–H Activation and Coupling Reaction with Allenyl Carbinol Carbonate.” Angew. Chem. Int. Ed.2013, in press. (IF = 13.5)

(2)Wang, H.;Schröder, N.; Glorius, F.“Mild Rh(III)-Catalyzed Direct C-H Allylation of Arenes with Allyl Carbonates.” Angew. Chem. Int. Ed.2013,52, 5386-5389. (IF = 13.5)

(3)Wang, H.;Grohmann, C; Nimphius, C.; Glorius, F.* “Mild Rhodium(III)-Catalyzed C–H Activation and Annulation with Alkyne MIDA Boronates: Short and Efficient Synthesis of Heterocyclic Boronic Acid Derivatives.”J. Am. Chem. Soc.2012, 134, 19592.(IF = 9.9, highlighted in synfacts)

(4)Wang, H.*;Glorius, F.*“Lending Handedness to the Cyclopentadienyl Ligand.” Science2012,338, 479-480. (Perspective, IF = 32.5)

(5)Wang, H.;Glorius, F.* “Mild Rh(III)-Catalyzed C–H Activation of Aromatic Amide Derivatives and Intermolecular Annulation with Allenes: Efficient Synthesis of 3,4-Dihydroisoquinolin-1(2H)-ones.”Angew. Chem. Int. Ed.2012,51, 7318-7322. (Hot Paper,IF = 13.5)

(6)Wang, H.;Y, Wang, Liang, D.; Zhang, J.*; Zhu, Q.* “Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl-Substituted AromaticN-Heterocycles.”Angew. Chem. Int. Ed.2011, 50,5678-5681(Hot Paper, IF = 13.5)

(7)Wang, H.;Wang, Y.; Peng, C.; Zhang, J.*; Zhu, Q.* “A Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles fromN-Aryl-2-aminopyridines.”J. Am. Chem. Soc.2010,132, 13217-13219. (IF = 9.9)

(8)Wang, H.;Zhao, J.; Zhang, J.; Zhu, Q.* “Brønsted Acid-Promoted Sequential Hydroarylation-Hydroamidation of Arene Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-spiro-3,4-dihydro-2-(1H)-quinazolinones.”Adv. Synth. Catal.2011,353, 2653-2658. (IF =6.0)

(9)Wang, H.;Liu, L.; Wang, Y.; Peng, C.; Zhang, J.*; Zhu, Q.* “An efficient synthesis of 4-alkyl -2(1H)-quinazolinones and 4-alkyl-2-chloroquinazolines from 1-(2-alkynylphenyl)ureas.”Tetrahedron Lett.2009,50, 6841-6843. (IF = 2.7)

(10)Grohmann, C.;Wang, H.;Glorius, F.* “Rh[III]-catalyzed C-H Amidation using Aroyloxycarbamates to give N-Boc protected Arylamines.”Org. Lett.2013,15, 3014-3017. (IF = 5.9)

(11)Grohmann, C.;Wang, H.;Glorius, F.* “Rh[III]-Catalyzed Direct C–H Amination Using N-Chloroamines at Room Temperature.” Org. Lett.2012,14, 656-659.(IF = 5.9)

(12)Wang, Y.;Wang, H.;Peng, J.; Zhu, Q.* “Palladium-Catalyzed Intramolecular C(sp2)-H Amidination by Isonitrile Insertion: Direct Access to 4-Aminoquinazolines fromN-Arylamidines.”Org. Lett.2011, 13,4604-4607.(IF = 5.9)

(13)Peng, L.;Wang, H.;Peng, C.; Ding, K.*; Zhu, Q.* “Sequential Hydration-Condensation-Double Cycloaddition of Pyridine-Substituted 2-Alkynylanilines: an Efficient Approach to Quinoline-Based Heterocycles.”Synthesis.2011,1723-1732.(IF =2.5)

(14)Wencel-Delord, J.; Nimphius, C.;Wang, H.;Glorius, F.* “Rhodium(III) and Hexabromobenzene – A Catalyst System for the Cross-Dehydrogenative Coupling of Simple Arenes and Heterocycles with Arenes Bearing Directing GroupsAngew. Chem. Int. Ed.2012,51, 13001-13005.

(15)Liu, L.; Wang, Y.;Wang, H.;Peng, C.; Zhao, J.; Zhu, Q.* “Tetrabutylammonium chloride-triggered 6-endo cyclization ofo-alkynylisocyanobenzenes: an efficient synthesis of 2-chloro-3-substituted quinolines.”Tetrahedron Lett.2009,50, 6715-6719. (IF = 2.7)

(16)Peng, C.; Wang, Y.; Liu, L.;Wang, H.;Zhao, J.; Zhu, Q.*“p-Toluenesulfonic Acid Promoted Annulation of 2-Alkynylanilines with Activated Ketones: Efficient Synthesis of 4-Alkyl-2,3-Disubstituted Quinolines.”Eur. J. Org. Chem.2010, 818-822.(IF = 3.3)

(17)Liao, Q.; Xie Z.*; Dong D.; Xu, X.;Wang, H.“Determination of Guaifenesin in Human Plasma by LC/MS/MS and Its Pharmacokinetic Study.”CHINA PHARMACY,2007,14, 1068-1071.

(18)Wan, J.*; Luo, X.; Fang, W.;Wang, H.;Chen, Q.; Fang, Z.; Zhang.J. “A Non-equavalent-point Titrimetric Analysis - A Fast Computerizational Titrimetric Method.”CHINESE JOURNAL OF ANALYSIS LABORATORY,2008,27, 13-16.

(1)朱強，王洪根，王勇，梁冬冬，劉蘭英，張健存，“咪唑[1,2-a]吡啶和咪唑醛類化合物的合成方法”中國專利，2012，專利公開號：CN102358739。

(2)王洪根;朱強*天然產物全合成薈萃-萜類，第14章，科學出版社，北京，2010.