張龍

1999-2003：四川大學生物學基地班 學士

2003-2008：清華大學生物科學與技術系 博士

2008-2013：荷蘭萊頓大學醫學中心（LUMC）博士后

2013 : 荷蘭萊頓大學醫學中心（LUMC）研究助理教授

2013年9月至今 : 浙江大學生命科學研究院教授、研究員、博士生導師

2014年獲得浙江省傑出青年科學基金

2016年獲得科技部"蛋白質機器與生命過程調控"重點專項青年科學家項目首席，入選

萬人計劃科技創新領軍人才，科技部創新人才推進計劃中青年科技創新領軍人才。

2018年獲中國細胞生物學學會青年研究員獎

代表性論文（#Corresponding author;*Co-first authors;）

• 2013年底歸國后的工作：

• · Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL,Zhang L*.OTUB2 promotes cancer metastasis via Hippo independent activation of YAP and TAZ.Molecular Cell.2018.

• · Dai T, Wu L, Wang S, Wang J, Xie F, Zhang Z, Fang X, Li J, Fang P, Li F, Jin K, Dai J, Yang B, Zhou F, van Dam H, Cai D, Huang H,Zhang L*. FAF1 regulates antiviral immunity by inhibiting MAVS but is antagonized by phosphorylation upon viral infection.Cell Host & Microbe.2018.

• ·Gao L, Wang L, Dai T, Jin K, Zhang Z, et al., Zhou F*,Zhang L*. Tumor-derived exosome antagonize innate antiviral immunity.Nature Immunology.2018

• · Zhang M, Jin K, Gao L, Zhang Z, Li F,Zhou F*,Zhang L*. Methods and technologies for exosome isolation and characterization.Small Methods. 2018

• · Yan X*,Zhang L*. A special issue onTGF-β signaling: regulation, crosstalk and biology.Acta Biochim Biophy Sin.2018

• · Zhang Q, Han X, Chen J, Xie X, Xu J, Zhao Y, Shen J, Hu L, Xu P, Song H,Zhang L, Zhao B, Wang YJ, Xia Z. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) mediate cell-density-dependent proinflammatory response.J Biol Chem.2018.

• · Loss of Par3 promotes prostatic tumorigenesis by enhancing cell growth and changing cell division models. Zhou PJ, Wang X, An N, Wei L,Zhang L, Huang X, Zhu HH, Fang YX, Gao WQ.Oncogene.2018

• · Clustering-local-unique-enriched-signals (CLUES) promotes identification of novel regulators of ES cell self-renewal and pluripotency. Wu C, Jiao Y, Shen M, Pan C, Cheng G, Jia D, Zhu J,Zhang L, Zheng M, Jia J.Plos one.2018

• ·Wang S, Xie F, Chu F, Zhang Z, Yang B, Dai T, Gao L, Wang L, Ling L, Jia J, van Dam H, Jin J,Zhang L*, Zhou F*. YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through kinase-IKKe mediated phosphorylation.Nature Immunology.2017

• ·Zhang Z, Fan Y, Xie F, Shao L, et al., Jin J, Ding C, Sheng Y,Zhou F,Zhang L*. Breast cancer metastasis suppressor OTUD1 deubiquitylates SMAD7.Nature Communications. 2017

• ·Xie F, Jin K, Shao L, Fan Y, Tu YF, Yang B, van Dam H, Ten Dijke P, Weng HL, Dooley S, Wang S, Jia JL, Jin J, Zhou F*,Zhang L*.FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.Nature Communications. 2017

• ·Zhou F, Xie F, Jin K, Zhang ZK, Clerici M, Gao R, Sixma TK, Huang HZ, van Dinther M,Zhang L*, Ten Dijke P*. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling.EMBO Journal.2017

• ·Jin K*, Li T, van Dam H, Zhou F*,Zhang L*. Molecular insight into tumor metastasis: tracing the dominant events.Journal of Pathology.2017 Jan

• ·Xie F, Ling L, van Dam H, Zhou F*,Zhang L*.TGF-β signaling in cancer metastasis.Acta Biochim Biophy Sin.2017

• ·Zhang L*, Xie F, Ten Dijke P,Zhang J,Zhou F*. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death.Cell Death & Differentiation.2017

• ·Gao Z, Li Y,Wang F, Huang T, Fan K, Zhang Y, Zhong J, Cao Q, Chao T, Jia J, Yang S,Zhang L, Xiao Y, Zhou J, Feng X, J Jin. Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability.Nature Communications. 2017

• ·Liu K, Xie F, Gao A, Zhang R,Zhang L, Xiao Z, Hu Q, Huang W, Huang Q, Lin B, Zhu J, Wang H, Que J, Lan X. Sox2 regulates multiple malignant processes of breat cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis.Molecular Cancer2017

• ·Li Y, Jin K, Gabi W van Pelt, Hans van Dam, Yu X, Wilma E. Mesker, Peter ten Dijke, Zhou F*, Zhang L*. c-Myb enhances breast cancer invasion and metastasis through Wnt/β-catenin/Axin2 pathway.Cancer Res.2016

• ·Zhou F*, Li F, Fang PF, Dai T, Yang B, van Dam H, Jia jl, Zheng M,Zhang L*. Ubiquitin-specific Protease 4 Antagonize Osteoblast Differentiation through Dishevelled.J Bone Miner Res.2016

• ·Jin K*, Li T, Sanchez-Duffhues G, Zhou F*,Zhang L*. Involvement of inflammation and its related microRNAs in hepatocellular carcinoma.Oncotarget. 2016

• ·Zhang L, Zhou F, van Dinther M, Ten Dijke P. Determing TGF-βReceptor levels in the Cell MembraneMethods Mol Biol.2016

• ·Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Klionsky DJ, et al.,Zhang L, et al.,Autophagy. 2016

• ·Li Y, Drabsch Y, Pujuquet P, Ren J, van Laar T,Zhang L, van Dam H, Clement-Lacroix P, Ten Dijke P. Genetic depletion and pharmacological targeting of alphav integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models.Breast Cancer Res.2015 Feb 25

• ·Chen F, Chen J, Lin J, Cheltsov AV, Xu L, Chen Y, Zeng Z, Chen L, Huang M, Hu M, Ye X, Zhou Y, Wang G, Su Y,Zhang L, Zhou F, Zhang XK, Zhou H. NSC-640358 acts as RXRα ligand to promote TNFα-mediated apoptosis of cancer cell.Protein Cell.2015 Sep

• ·Xie F, Zhang Z, van Dam H,Zhang L*, Zhou F*. Regulation of TGF-βSuperfamily Signaling by SMAD Mono-Ubiquitination.Cells.2014 Oct

• ·Zhou F, Li F, Xie F, Zhang Z, Huang H,Zhang L*. TRAF4 mediates activation ofTGF-β signaling and is a biomarker for oncogenesis in breast cancer.Sci China Life Sci.2014 Dec

• ·Zhang J, Zhang X, Xie F, Zhang Z, van Dam H,Zhang L*, Zhou F*. The regulation of TGF-β/SMAD signaling by protein deubiquitination.Protein Cell.2014 Apr 23

• ·Zhou F, Drabsch Y, Dekker TJ, de Vinuesa AG, Li Y, Hawinkels LJ, Sheppard KA, Goumans MJ, Luwor RB, de Vries CJ, Mesker WE, Tollenaar RA, Devilee P, Lu CX, Zhu H,Zhang L*, Dijke PT*. Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling. Nat Communications. 2014 Mar

• ·Zhang L*, Zhou F*, Ten Dijke P*. Signaling interplay between TGF-β receptor and PI3K/AKT pathway in cancer.Trends in Biochemical Sciences.2013 Nov.14

• 國外的工作：

• ·Drabsch Y, He S,Zhang L,Snaar-Jagalska BE,Ten Dijke P. Transforming growth factor beta signalling controls human breast cancer metastasis in a zebrafish xenograft model.Breast Cancer Research.2013 Nov

• ·Zhang L#, Zhou F#, García de Vinuesa A, de Kruijf EM, Mesker WE, Hui L, Drabsch Y, Li Y, Bauer A, Rousseau A, Sheppard KA, Mickanin C, Kuppen PJ, Lu CX, Ten Dijke P. TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis.Molecular Cell.2013 Sep

• ·Zhang X, Zhang J, Bauer A,Zhang L, Selinger DW, Lu CX, and ten Dijke P. Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.EMBO Journal.2013

• ·Zhang X, Zhang J,Zhang L, van Dam H, Ten Dijke P. UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination.Cell Research.2013

• ·Zhang L#, Zhou F#, Drabsch Y, Snaar-Jagalska E, Mickanin C, Huang H, Sheppard KA, Lu C, and ten Dijke P. USP4 is regulated by Akt phosphorylation and directly deubiquitinates TGF-βtype I receptor.Nature Cell Biology2012;

• ·Zhang L#*, Huang H#, Zhou F#, Pardo CG, Zhang T, Barakat TS, Sheppard KA, van Dam H, Gribnau J, Lu C, and ten Dijke P*. RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation.Molecular Cell2012;

• ·Zhou F, Kai Gong, Yandao Gong andZhang L*. APP intracellular domain (AICD) inhibits Wnt signaling and promotes neurite outgrowth.BBA-Molecular Cell Research2012;

• ·Zhang, J, Zhang X-f,Zhang L, Zhou F, van Dinther M, ten Dijke P. LRP8 mediates Wnt/β-catenin signaling and controls osteoblast differentiation.J. Bone Min Res.2012;

• ·Zhang L#,Zhou F#, Li Y, Drabsch Y, Zhang J, van Dam H, Ten Dijke P.Fas-associated factor 1 is a scaffold protein that promotesβ-TrCP mediated β-catenin ubiquitination and degradation.J Biol Chem. 2012;

• ·Gong K, Zhou F, Huang HZ, Gong YD,Zhang L*.Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling.Protein Cell.2012;

• ·Zhou F#,Zhang L#*, van Laar T, van Dam H, ten Dijke P*. GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb.Mol Biol Cell. 2011;

• ·Zhou F, Zhang XF, van Dam H, ten Dijke P, Huang HZ*,Zhang L*.Ubiquitin-specific protease 4 mitigates Toll-like/Interleukin-1 receptor signaling and regulates innate immune activation.J Biol Chem.2012;

• ·Zhang L#, Shi S, Zhang J, Zhou F, ten Dijke P. Wnt/β-catenin signaling changes C2C12 myoblast proliferation and differentiation by inducing Id3 expression.Biochem Biophys Res Commun. 2012:

• ·Zhou F, Huang H,Zhang L*. Bisindoylmaleimide I enhances osteogenic differentiation.Protein Cell.2012;

• ·Guidelines for the use and interpretation of assays for monitoring autophagy.Klionsky DJ,Zhang L　et al.Autophagy.2012;

• ·Zhang L#, Zhou F#, van Laar T, Zhang J, van Dam H, ten Dijke P. Fas-associated factor 1 antagonizes Wnt signaling by promotingβ-catenin degradation.Mol Biol Cell.2011;

• ·Zhou F, van Laar T, Huang HZ,Zhang L*. APP and APLP1 are degradated through autophagy in response to proteasome inhibition in neuronal cells.Protein Cell. 2011;

• ·Zhou F; Gong K; van Laar T; Gong Y,Zhang L*. Wnt/β-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity.Biochem Biophys Res Commun.2011;

• 博士期間的工作：

• ·Yan X, Zhang J, Pan L, Wang P, Xue H,Zhang L, Gao X, Zhao X, Ning Y, Chen YG TSC-22 promotes TGF-β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.Mol Cell Biol. 2011;

• ·Geng Y, Dong Y, Yu M,Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang D, Ning W. Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development.Proc Natl Acad Sci USA. 2011;

• ·Zhou F#,Zhang L#, Gong K, Lu G, Sheng B, Wang A, Zhao N, Zhang X, Gong Y. LEF-1 activates the transcription of E2F1.Biochem Biophys Res Commun. 2008;

• ·Zhou F#,Zhang L#, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong. The association of GSK3β with E2F1 facilitates nerve growth factor-induced neural cell differentiation.J Biol Chem. 2008;

• ·Gao X, Wen J,Zhang L, Li X, Ning Y, Meng A, Chen YG. Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus.J Biol Chem. 2008;

• ·Su Y#,Zhang L#, Gao X, Meng F, Wen J, Zhou H, Meng A, Chen YG. The evolutionally conserved activity of Dapper2 in antagonizing TGF-β signaling.FASEB J.2007;

• ·Chen YG, Wang Z, Ma J,Zhang L, Lu Z. Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-β signaling.J Biol Chem. 2007;

• ·Zhang L, Zhang SP, Gao X, Wen J, Chen YG. Modulation of TGFβ -signaling in thecytoplasm and the nucleus.Cell Research16:S131-S157; (Meeting Abstract)

• ·Zhang L, Gao X, Wen J, Ning Y, Chen YG. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation.J Biol Chem. 2006;

• ·Gu Y, Jin P,Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG. Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia.Blood. 2006;

• ·Zhang L, Zhou H, Su Y, Sun Z, Zhang H,Zhang L, Zhang Y, Ning Y, Chen YG, Meng A. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors.Science2004;