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王均
華南理工大學教授
王均,1971年出生於湖北,男,畢業於武漢大學,教授,博士生導師,現任華南理工大學教授。
研究領域為生物醫用高分子材料、蛋白質和核酸的高分子傳遞體系、基因治療和組織工程。2006年獲“百人計劃”擇優支持;2004年12月入選中國科學院“引進國外傑出人才”。
時間 | 院校 | 專業 | 學位 |
xx-1993 | 武漢大學 | 化學專業和細胞生物學 | 學士 |
xx-1999 | 武漢大學 | 高分子化學和物理 | 博士 |
1994年在北京大學醫學部(原北京醫科大學)藥學院天然與仿生藥物國家重點實驗室從事高分子免疫佐劑的開放課題研究。
1999年5月至2004年6月先後在約翰霍普金斯醫學院新加坡生命醫學中心(JohnsHopkinsSingapore)、美國約翰霍普金斯大學醫學院生物醫學工程系從事博士后研究。
2004年9月任中國科學技術大學高分子科學與工程系教授,博士生導師。
2006年7至8月德國羅斯托克大學醫學院訪問教授;12月起任中國科學技術大學生命科學學院教授、博士生導師,合肥微尺度物質科學國家實驗室研究員。
現任華南理工大學教授。
研究領域
1.生物醫用高分子材料
2·蛋白質和核酸的高分子傳遞體系
3·基因治療和組織工程
課題
1·聚磷酸酯高分子生物材料的合成方法學及性能評價
2·生物可降解納米材料的製備及其細胞轉運調節和機制
3·可注射生物可降解高分子水凝膠的製備及生物醫用
4·藥物控制釋放及靶向輸送載體的構建及生物學功效
5·RNA干擾及siRNA藥物靶向輸送及關鍵技術
6·癌症基因治療新型傳輸載體、細胞轉運機制及功效
7·組織工程“人工骨”支架材料及組織工程新方法
承擔科技部“973”項目子課題;國家自然科學基金委傑出青年科學基金;教育部博士點優先支持領域課題;科技部“863”課題;“重大新葯創製”科技重大專項課題等。
論文
1.Xiao CS, Wang YC, Du JZ, Chen XS, Wang J*, Kinetics and Mechanism of 2-Ethoxy-2-oxo-1,3,2-dioxaphospholane Polymerization Initiated by Stannous Octoate, MACROMOLECULES 2006, in press
2.Du JZ, Chen DP, Wang YC, Xiao CS, Lu YJ, Wang J*, Zhang GZ, Synthesis and Micellization of Amphiphilic Brush-Coil Block Copolymer Based on Poly(ε-caprolactone) and PEGylated Polyphosphoester, BIOMACROMOLECULES 2006, 7(6): 1898-1963
3.Chen DP, Wang J*, Synthesis and characterization of block copolymer of polyphosphoester and poly(epsilon-caprolactone), MACROMOLECULES 2006, 39 (2): 473-475
4.Li Q, Wang J, Shahani S, Sun DDN, Sharma B, Elisseeff JH, Leong KW, Biodegradable and photocrosslinkable polyphosphoester hydrogel, BIOMATERIALS 2006, 27 (7): 1027-1034
5.Zou JH, Shi WF, Wang J, Jun B, Encapsulation and controlled release of a hydrophobic drug using a novel nanoparticle-forming hyperbranched polyester, MACROMOLECULAR BIOSCIENCE 2005, 5 (7): 662-668
6.Zhang PC, Wang J, Leong KW, Mao HQ, Ternary complexes comprising polyphosphoramidate gene carriers with different types of charge groups improve transfection efficiency, BIOMACROMOLECULES 2005, 6 (1): 54-60
7.Wan ACA, Mao HQ, Wang S, Phua SH, Lee GP, Pan JS, Lu S, Wang J, Leong KW, Poly(phosphoester) ionomers as tissue-engineering scaffolds, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 2004, 70B (1): 91-102
8.Wang J, Lee IL, Lim WS, Chia SM, Yu H, Leong KW, Mao HQ, Evaluation of collagen and methylated collagen as gene carriers, INTERNATIONAL JOURNAL OF PHARMACEUTICS 2004, 279 (1-2): 115-126
9.Wang J, Gao SJ, Zhang PC, Wang S, Mao MQ, Leong KW, Polyphosphoramidate gene carriers: effect of charge group on gene transfer efficiency, GENE THERAPY 2004, 11 (12): 1001-1010
10.Huang SW, Wang J, Zhang PC, Mao HQ, Zhuo RX, Leong KW, Water-soluble and nonionic polyphosphoester: Synthesis, degradation, biocompatibility and enhancement of gene expression in mouse muscle, BIOMACROMOLECULES 2004, 5 (2): 306-311
11.Wang J, Sun DDN, Shin-ya Y, Leong KW, Stimuli-responsive hydrogel based on poly(propylene phosphate), MACROMOLECULES 2004, 37 (2): 670-672
12.Li Q, Williams CG, Sun DDN, Wang J, Leong K, Elisseeff JH, Photocrosslinkable polysaccharides based on chondroitin sulfate, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH 2004, 68A (1): 28-33
13.Li Y, Wang J, Lee CGL, Wang CY, Gao SJ, Tang GP, Ma YX, Yu H, Mao HQ, Leong KW, Wang S, CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexes, GENE THERAPY 2004, 11 (1): 109-114
14.Lu HF, Lim WS, Wang J, Tang ZQ, Zhang PC, Leong KW, Chia SM, Yu H, Mao HQ, Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance, BIOMATERIALS 2003, 24 (27): 4893-4903
15.Wang J, Huang SW, Zhang PC, Mao HQ, Leong KW, Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoesters, INTERNATIONAL JOURNAL OF PHARMACEUTICS 2003, 265 (1-2): 75-84
16.Fang N, Wang J, Mao HQ, Leong KW, Chan V, BHEM-Chol/DOPE liposome induced perturbation of phospholipid bilayer, COLLOIDS AND SURFACES B-BIOINTERFACES 2003, 29 (4): 233-245
17.Zhao Z, Wang J, Mao HQ, Leong KW, Polyphosphoesters in drug and gene delivery ADVANCED DRUG DELIVERY REVIEWS 2003, 55 (4): 483-499
18.Wang J, Zhang PC, Lu HF, Ma N, Wang S, Mao HQ, Leong KW, New polyphosphoramidate with a spermidine side chain as a gene carrier, JOURNAL OF CONTROLLED RELEASE 2002, 83 (1): 157-168
19.Wang J, Zhang PC, Mao HQ, Leong KW, Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier, GENE THERAPY 2002, 9 (18): 1254-1261
20.Wang J, Mao HQ, Leong KW, A novel biodegradable gene carrier based on polyphosphoester, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2001, 123 (38): 9480-9481
任中國生物材料協會理事、中國化學會化學生物學專業委員會委員、中國微納協會納米生物與醫藥技術專業委員會委員,BiomaterialsScience雜誌(英國皇家化學會)編委。
時間 | 獎項全稱 | 具體獎項 | 頒獎機構 |
2012 | 教育部自然科學獎一等獎 | 一等獎 | 教育部 |
2006 | “百人計劃”擇優支持 | ||
2004-12 | 引進國外傑出人才 | 引進國外傑出人才 | 中國科學院 |