張劍波

理學博士（生物有機化學），1999.12.

中國科學院上海有機化學研究所生命有機化學國家重點實驗室

理學碩士（生物有機化學），1996.12.

中國科學院上海有機化學研究所生命有機化學國家重點實驗室

理學學士（藥物化學），1993.6.

復旦大學藥學院（原上海醫科大學藥學院）

2003 年至今 華東師範大學化學系任特聘副教授

2002 － 2003 年 美國韋恩州立大學化學系任助理研究員

2000 – 2002 年 美國韋恩州立大學化學系任博士后研究員

1）化學生物學（糖化學和糖生物學），包括：

生物活性寡糖、多糖及糖綴合物的分離、純化、結構測定及高效合成。

2）有機合成及合成方法學

3）藥物合成

1、華東師範大學“大夏杯”本科科研基金

2、“對硝基苯酚 α -L-鼠李糖苷的綠色合成”（劉偉、劉念平、朱思敏）

參與撰寫 2 本學術專著，發表論文近40 篇，其中研究論文26 篇、會議論文13 篇， 17 篇發表於 J. Am. Chem. Soc.,Chem. Commun .,Org. Lett.,Appl. Environ. Microbiol. 等國際高水平 SCI 核心專業期刊上。

A. 研究論文

1. Hai Yu,Harshal Chokhawala,Rebekah Karpel,Hui Yu,Bingyuan Wu,Jianbo Zhang,Xi Chen ， A Multifunctional Pasteurella multocida Sialyltransferase: A Powerful Tool for the Synthesis of Sialoside Libraries J. Am. Chem. Soc. 2005,127,17618-17619;

2. 張劍波，時春娟，付傑，“茁霉多糖的研究進展”《醫藥化工》2005，（12），36-38;

3. 張劍波，邵軍，劉子夜，Przemek Kowal，沈傑，王鵬，C. Allen Bush，“腫瘤相關抗原六糖的化學酶促合成”《中國實用新醫學》，2005,2（9）,78;

4. Jianbo Zhang,Przemys aw Kowal,Xi Chen and Peng George Wang，“Large-scale synthesis of globotriose derivatives through recombinant E. coli. ” Org. Biomol. Chem . 2003,1,3048-3053;

5. Jianbo Zhang,Bingyuan Wu,Yingxin Zhang,Przemyslaw Kowal and Peng George Wang，“Creatine phosphate – creatine kinase in enzymatic synthesis of glycoconjugates.” Org. Lett. ” 2003,5,2583-2586;

6. Jun Shao,Jianbo Zhang,Przemek Kowal,Yuquan Lu and Peng George Wang，“ Efficient synthesis of globoside and isogloboside tetrasaccharides by using β （1→3） N-acetylgalactosaminyltransferase / UDP-N-acetylglucosamine C4 epimerase fusion protein” Chem. Commun . 2003,（12）,1422-23.

7. Ziye Liu,Yuquan Lu,Jianbo Zhang,Keith Pardee and Peng George Wang，“P1 trisaccharide (Gal α 1,4Gal β 1,4GlcNAc) synthesis by enzyme glycosylation reactions using recombinant Escherichia coli. ” Appl. Environ. Microbiol. 2003,69 （4）,2110-5;

8. Jun Shao,Jianbo Zhang,Przemek Kowal and Peng George Wang，“Donor substrate regeneration for efficient synthesis of globotetraose and isoglobotetraose.” Appl. Environ. Microbiol. 2002,68 （11）,5634-40;

9. Jun Shao,Jianbo Zhang,Jozef Nahálkab and Peng George Wang，“Biocatalytic synthesis of uridine 5'-diphosphate N-acetylglucosamine by multiple enzymes co-immobilized on agarose beads.” Chem. Comm. 2002,2586-2587.

10. Jun Shao,Jianbo Zhang,Przemek Kowal,Yuquan Lu and Peng George Wang，“ Overexpression and biochemical characterization of β -1,3-N-acetylgalactosaminyl-transferase LgtD from Haemophilus influenzae strain Rd.” Biochem. Biophys. Res. Commun . 2002,295 （1）,1-8;

11. Jianbo Zhang,Przemek Kowal,Jianwen Fang,Peter Andreana and Peng George Wang，“Efficient chemoenzymatic synthesis of globotriose and its derivatives with a recombinant α （1→4）-galactosyltransferase.” Carbohydr. Res. 2002,337 （11）,969-976;

12. Ziye Liu,Jianbo Zhang,Xi Chen and Peng George Wang，“Combined biosynthetic pathway for de novo production of UDP-Galactose: Catalyzed with multiple enzymes immobilized on agarose beads.” ChemBioChem . 2002,3,348-355;

13. Xi Chen,Ziye Liu,Jianbo Zhang,Wei Zhang,Przemek Kowal and Peng George Wang，“Reassemble biosynthetic pathways for large-scale carbohydrate synthesis: α -Gal epitope producing ‘superbug'.” ChemBioChem,2002,3,47-53;

14. Jianbo Zhang,Bingyuan Wu,Ziye Liu,Przemyslaw Kowal,Xi Chen,Jun Shao and Peng George Wang，“Large-scale synthesis of carbohydrates for pharmaceutical development.” Curr. Org. Chem. 2001,5,1169-1176;

15. Xi Chen,Jianbo Zhang,Przemek Kowal,Ziye Liu,Peter R. Andreana,Yuquan Lu and Peng George Wang，“Transferring a biosynthetic cycle into a productive E. coli strain: large-scale synthesis of galactosides.” J. Am. Chem. Soc. 2001,123,8866-8867;

16. Xi Chen,Jianwen Fang,Jianbo Zhang,Ziye Liu,Jun Shao,Przemyslaw Kowal,Peter Andreana and Peng George Wang，“Sugar nucleotide regeneration beads (superbeads): A versatile tool for the practical synthesis of oligosaccharides.” J. Am. Chem. Soc. 2001,123,2081-2082;

17. Peng George Wang,Xi Chen,Ziye Liu and Jianbo Zhang，“Large scale production of oligosaccharides through superbug and superbeads technology”. Glycobiology 2001,11,34;

18. Biao Yu,Jianchun Liao,Jianbo Zhang and Yongzheng Hui，“The first synthetic route to furostan saponins.” Tetrahedron Lett. 2001,42,77-79;

19. Jianbo Zhang,Biao Yu and Yongzheng Hui，“Recent progresses in research of furostanol saponins.” Chinese J. Org. Chem. 2000,20,663-688;

20. Biao Yu,Jianbo Zhang,Shoufu Lu and Yongzheng Hui，“A novel and efficient deprotection of the allyl group at the anomeric oxygen of carbohydrates.” Synlett . 1998,29-30;

21. Biao Yu,Bing Li,Jianbo Zhang and Yongzheng Hui，“A novel cleavage of allyl protection”. Tetrahedron Lett. 1998,39,4871-4874;

22. Jianbo Zhang and Gengyuan Tian，“ High performance capillary electrophoresis of carbohydrates.” Chinese J. Org. Chem. 1998,18,88-96;

23. Jianbo Zhang and Gengyuan Tian，“Progress in isolation and structural analysis of oligosaccharides.” Prog. Biochem. Biophys. 1998,25,114-119.

B. 學術專著

24. Jianbo Zhang et al,In: “ Carbohydrate-Based Drug Discovery（糖類的藥物開發）” C.-H. Wong,Ed,Wiley-VCH Press,Weinheim,2003; p 137-167.

25. Jianbo Zhang et al,In: Methods in Enzymology （酶學方法），Vol 362，“ Recognition of Carbohydrates in Biological Systems”，Y.-C. Li,Reiko T. Lee,Eds,Elsevier Science (USA),2003; p 106-124.

中國生物化學與分子生物學會複合糖專業委員會秘書長。