乙二醇二甲醚

乙二醇二甲醚（Dimethoxyethane），也稱作1,2-二甲氧基乙烷，俗稱“二甲基溶纖劑”。分子式為C4H10O2。無色透明液體，略有乙醚氣味，溶於水、乙醇、乙醚和氯仿。化學性質穩定，可用作硝酸纖維素、樹脂、寡糖和多糖的溶劑。

編號	毒性類型	測試方法	測試對象	使用劑量	毒性作用
1	acute	Oral	Human	3380 mg/kg	1.胃腸道毒性Gastrointestinal - gastritis 2.肝毒性Liver - other changes 3.腎、輸尿管和膀胱毒性Kidney, Ureter, Bladder -other changes
2	acute	Inhalation	Human	25 ppm	1.行為毒性Behavioral - tremor 2.行為毒性Behavioral - convulsions or effect on seizure threshold 3.行為毒性Behavioral - changes in motor activity (specific assay)
3	acute	Oral	Rodent - rat	2370 mg/kg	1.行為毒性Behavioral - altered sleep time (including change in righting reflex) 2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration -other changes
4	acute	Inhalation	Rodent - rat	1500 ppm/7H	1.Details of toxic effects not reported other than lethal dose value
5	acute	Intraperitoneal	Rodent - rat	2500 mg/kg	1.Details of toxic effects not reported other than lethal dose value
6	acute	Intravenous	Rodent - rat	2068 mg/kg	1.血液毒性Blood - other hemolysis with or without anemia
7	acute	Oral	Rodent - mouse	2560 mg/kg	1.行為毒性Behavioral - somnolence (general depressed activity) 2.行為毒性Behavioral - changes in motor activity (specific assay) 3.心臟毒性Cardiac - other changes
8	acute	Inhalation	Rodent - mouse	1480 ppm/7H	1.行為毒性Behavioral - analgesia 2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration -dyspnea 3.腎、輸尿管和膀胱毒性Kidney, Ureter, Bladder -hematuria
9	acute	Intraperitoneal	Rodent - mouse	2147 mg/kg	1.腎、輸尿管和膀胱毒性Kidney, Ureter, Bladder -changes in both tubules and glomeruli 2.血液毒性Blood - changes in spleen 3.血液毒性Blood - other changes
10	acute	Oral	Rodent - rabbit	890 mg/kg	1.行為毒性Behavioral - general anesthetic 2.血液毒性Blood - other hemolysis with or without anemia
11	acute	Administration onto the skin	Rodent - rabbit	1280 mg/kg	1.Details of toxic effects not reported other than lethal dose value
12	acute	Oral	Rodent - guinea pig	950 mg/kg	1.行為毒性Behavioral - general anesthetic 2.胃腸道毒性Gastrointestinal - other changes 3.腎、輸尿管和膀胱毒性Kidney, Ureter, Bladder -other changes
13	MutipleDose	Inhalation	Rodent - rat	400 ppm/6H/2W-I	1.大腦毒性Brain and Coverings - other degenerative changes 2.營養和代謝系統毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
14	MutipleDose	Oral	Rodent - rat	10206 mg/kg/21D-C	1.內分泌毒性Endocrine - changes in thymus weight 2.營養和代謝系統毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.慢性病相關毒性Related to Chronic Data - changes in testicular weight
15	MutipleDose	Oral	Rodent - rat	500 mg/kg/10D-I	1.內分泌毒性Endocrine - changes in thymus weight 2.免疫系統毒性Immunological Including Allergic - decreased immune response
16	MutipleDose	Inhalation	Rodent - rat	300 ppm/6H/13W-I	1.血液毒性Blood - changes in leukocyte (WBC) count 2.營養和代謝系統毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.慢性病相關毒性Related to Chronic Data - changes in testicular weight
17	MutipleDose	Inhalation	Rodent - rat	970 mg/m3/7H/5W-I	1.血液毒性Blood - changes in bone marrow (not otherwise specified) 2.血液毒性Blood - changes in spleen
18	MutipleDose	Inhalation	Rodent - rat	1000 ppm/6H/11D-I	1.腎、輸尿管和膀胱毒性Kidney, Ureter, Bladder -other changes in urine composition 2.血液毒性Blood - changes in bone marrow (not otherwise specified) 3.血液毒性Blood - changes in leukocyte (WBC) count
19	MutipleDose	Administration onto the skin	Rodent - rat	20 mg/kg/4W-I	1.血液毒性Blood - changes in other cell count (unspecified) 2.血液毒性Blood - changes in leukocyte (WBC) count 3.慢性病相關毒性Related to Chronic Data - changes in testicular weight
20	MutipleDose	Intraperitoneal	Rodent - rat	450 mg/kg/16D-I	1.血液毒性Blood - changes in other cell count (unspecified) 2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
21	MutipleDose	Oral	Rodent - rat	29484 mg/kg/13W-C	1.內分泌毒性Endocrine - changes in thymus weight 2.血液毒性Blood - changes in platelet count 3.營養和代謝系統毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain
22	MutipleDose	Administration onto the skin	Rodent - rat	3200 mg/kg/4D-I	1.內分泌毒性Endocrine - changes in thymus weight 2.免疫系統毒性Immunological Including Allergic - decrease in humoral immune response
23	MutipleDose	Oral	Rodent - mouse	12110 mg/kg/2W-C	1.內分泌毒性Endocrine - changes in thymus weight 2.慢性病相關毒性Related to Chronic Data - changes in testicular weight
24	MutipleDose	Oral	Rodent - mouse	82 mg/kg/13W-C	1.內分泌毒性Endocrine - effect on menstrual cycle 2.內分泌毒性Endocrine - other changes 3.血液毒性Blood - changes in spleen
25	MutipleDose	Inhalation	Rodent - mouse	1000 ppm/6H/11D-I	1.血液毒性Blood - changes in leukocyte (WBC) count 2.慢性病相關毒性Related to Chronic Data - changes in testicular weight
26	MutipleDose	Inhalation	Mammal - dog	750 ppm/7H/12W-I	1.血液毒性Blood - microcytosis with or without anemia 2.血液毒性Blood - other changes
27	MutipleDose	Inhalation	Rodent - rabbit	300 ppm/6H/13W-I	1.內分泌毒性Endocrine - changes in thymus weight 2.血液毒性Blood - changes in erythrocyte (RBC) count 3.慢性病相關毒性Related to Chronic Data - changes in testicular weight
28	MutipleDose	Administration onto the skin	Rodent - guinea pig	65 mg/kg/13W-I	1.血液毒性Blood - changes in erythrocyte (RBC) count 2.營養和代謝系統毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.慢性病相關毒性Related to Chronic Data - changes in testicular weight
29	SkinEyeIrrition	Administration onto the skin	Rodent - rabbit	483 mg/24H	1.Mild
30	SkinEyeIrrition	Administration into the eye	Rodent - rabbit	97 mg
31	SkinEyeIrrition	Administration into the eye	Rodent - rabbit	500 mg/24H	1.Mild
32	SkinEyeIrrition	Administration into the eye	Rodent - guinea pig	10 ug	1.Mild
33	Mutation		Human Lymphocyte	150 mmol/L
34	Mutation	Oral	Rodent - rat	500 mg/kg
35	Mutation	Oral	Rodent - rat	500 mg/kg
36	Mutation	Oral	Rodent - mouse	500 mg/kg
37	Reproductive	Oral	Rodent - rat	175 mg/kg,female 7-13 day(s) after conception	1.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system
38	Reproductive	Oral	Rodent - rat	175 mg/kg,female 7-13 day(s) after conception	1.生殖毒性Reproductive - Maternal Effects - parturition 2.生殖毒性Reproductive - Effects on Newborn -biochemical and metabolic
39	Reproductive	Oral	Rodent - rat	15015 mg/kg,male 13 week(s) pre-mating	1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, andcount)
40	Reproductive	Oral	Rodent - rat	100 mg/kg,male 1 day(s) pre-mating	1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct
41	Reproductive	Oral	Rodent - rat	350 mg/kg,female 9-15 day(s) after conception	1.生殖毒性Reproductive - Fertility -litter size (e.g. # fetuses per litter; measured before birth) 2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 3.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system
42	Reproductive	Inhalation	Rodent - rat	68 mg/kg/4H,female 1-19 day(s) after conception	1.生殖毒性Reproductive - Fertility -pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) 2.生殖毒性Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
43	Reproductive	Inhalation	Rodent - rat	30 ppm/6H,male 65 day(s) pre-mating	1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct
44	Reproductive	Inhalation	Rodent - rat	100 ppm/6H,female 6-17 day(s) after conception	1.生殖毒性Reproductive - Maternal Effects - parturition 2.生殖毒性Reproductive - Fertility -female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # femalesmated) 3.生殖毒性Reproductive- Effects on Newborn -live birth index (measured after birth)
45	Reproductive	Inhalation	Rodent - rat	100 ppm/6H,female 6-17 day(s) after conception	1.生殖毒性Reproductive - Effects on Newborn -viability index (e.g., # alive at day 4 per # bornalive) 2.生殖毒性Reproductive - Effects on Newborn -growth statistics (e.g.%, reduced weight gain)
46	Reproductive	Inhalation	Rodent - rat	30 ppm/6H,male 13 week(s) pre-mating	1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
47	Reproductive	Administration onto the skin	Rodent - rat	11592 mg/kg,female 6-17 day(s) after conception	1.生殖毒性Reproductive - Fertility -female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # femalesmated) 2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetaldeath
48	Reproductive	Administration onto the skin	Rodent - rat	4375 mg/kg,male 7 day(s) pre-mating	1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, andcount) 2.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct 3.生殖毒性Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
49	Reproductive	Administration onto the skin	Rodent - rat	2 mg/kg,female 10 day(s) after conception	1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
50	Reproductive	Administration onto the skin	Rodent - rat	1 mg/kg,female 12 day(s) after conception	1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -craniofacial (including nose andtongue) 3.生殖毒性Reproductive - Specific Developmental Abnormalities -gastrointestinal system
51	Reproductive	Intraperitoneal	Rodent - rat	330 mg/kg,female 12 day(s) after conception	1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system 2.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system
52	Reproductive	Intraperitoneal	Rodent - rat	190 mg/kg,female 14 day(s) after conception	1.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System 2.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system
53	Reproductive	Intraperitoneal	Rodent - rat	190 mg/kg,female 12 day(s) after conception	1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system
54	Reproductive	Intraperitoneal	Rodent - rat	190 mg/kg,female 8 day(s) after conception	1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
55	Reproductive	Subcutaneous	Rodent - rat	600 mg/kg,female 6-20 day(s) after conception	1.生殖毒性Reproductive- Effects on Newborn -live birth index (measured after birth) 2.生殖毒性Reproductive - Effects on Newborn -viability index (e.g., # alive at day 4 per # bornalive)
56	Reproductive	Subcutaneous	Rodent - rat	440 mg/kg,female 7-17 day(s) after conception	1.生殖毒性Reproductive- Effects on Newborn -live birth index (measured after birth)
57	Reproductive	Oral	Rodent - rat	250 mg/kg,female 13 day(s) after conception	1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system
58	Reproductive	Oral	Rodent - mouse	175 mg/kg,female 11 day(s) after conception	1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system
59	Reproductive	Oral	Rodent - mouse	2 mg/kg,female 7-14 day(s) after conception	1.生殖毒性Reproductive - Fertility -litter size (e.g. # fetuses per litter; measured before birth) 2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetaldeath 3.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System
60	Reproductive	Oral	Rodent - mouse	500 mg/kg,female 9 day(s) after conception	1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) 2.生殖毒性Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) 3.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus)
61	Reproductive	Oral	Rodent - mouse	250 mg/kg,female 11 day(s) after conception	1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system
62	Reproductive	Oral	Rodent - mouse	6250 mg/kg,male 25 day(s) pre-mating	1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct
63	Reproductive	Inhalation	Rodent - mouse	1000 ppm/6H,male 11 day(s) pre-mating	1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct
64	Reproductive	Inhalation	Rodent - mouse	500 ppm/7H,male 5 day(s) pre-mating	1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, andcount)
65	Reproductive	Inhalation	Rodent - mouse	50 ppm/6H,female 6-15 day(s) after conception	1.生殖毒性Reproductive - Fertility -litter size (e.g. # fetuses per litter; measured before birth) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system
66	Reproductive	Inhalation	Rodent - mouse	50 ppm/6H,female 6-15 day(s) after conception	1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system 2.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system
67	Reproductive	Subcutaneous	Rodent - mouse	1200 mg/kg,female 7-13 day(s) after conception	1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus)
68	Reproductive	Subcutaneous	Rodent - mouse	3200 mg/kg,female 7-14 day(s) after conception	1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
69	Reproductive	Subcutaneous	Rodent - mouse	250 mg/kg,female 8 day(s) after conception	1.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System 2.生殖毒性Reproductive - Specific Developmental Abnormalities -craniofacial (including nose andtongue)
70	Reproductive	Intravenous	Rodent - mouse	250 mg/kg,female 8 day(s) after conception	1.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System
71	Reproductive	Oral	Primate - monkey	930 mg/kg,female 20-45 day(s) after conception	1.生殖毒性Reproductive - Fertility -abortion 2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetaldeath
72	Reproductive	Oral	Primate - monkey	633 mg/kg,female 20-45 day(s) after conception	1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus)
73	Reproductive	Inhalation	Rodent - rabbit	300 ppm/6H,male 65 day(s) pre-mating	1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct
74	Reproductive	Inhalation	Rodent - rabbit	50 ppm/6H,female 6-18 day(s) after conception	1.生殖毒性Reproductive - Specific Developmental Abnormalities -body wall 2.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system 3.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system
75	Reproductive	Inhalation	Rodent - rabbit	50 ppm/6H,female 6-18 day(s) after conception	1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -body wall 3.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system
76	Reproductive	Inhalation	Rodent - rabbit	10 ppm/6H,female 6-18 day(s) after conception	1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) 2.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system
77	Reproductive	Oral	Rodent - guinea pig	6250 mg/kg,male 25 day(s) pre-mating	1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct
78	Reproductive	Administration onto the skin	Rodent - guinea pig	65 mg/kg,male 65 day(s) pre-mating	1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct
79	Reproductive	Oral	Rodent - hamster	1562 mg/kg,male 25 day(s) pre-mating	1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct

乙二醇二甲醚

無色透明液體

理化常數

術語分類

安全性

危險性

基本內容

物質毒性

基本信息