張雷

發育過程的組織分化與生長調控

一直從事組織、器官發育的信號轉導調控研究，並在Hippo信號通路、Hh信號通路以及Wg/Wnt等信號通路的調節機制研究中取得過突破性進展，迄今共發表相關研究論文33及綜述4篇。2009年回國建立獨立實驗室以來，主要從事Hippo信號的研究工作，取得了若干突破性進展，以通訊作者或共同通訊作者身份在eLife，PLoS Biol，Cancer Cell，Nat Commun，Cell Res等期刊上發表研究論文17篇及應邀綜述2篇，申請共同專利1項。

1.　Hongling Huang, Shimin Wang, Mengxin Yin,Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao#, Xin-Yuan Liu# andLei Zhang# Par-1 regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association.PLoS Biology2013,11(4) e1001620 (Press released by PLoS Biology)（# corresponding author） 2.　Yunyun Jin, Jinjin Xu, Meng-Xin Yin, Yi Lu, Lianxin Hu, Peixue Li, Peng Zhang, Zengqiang Yuan, Margaret S. Ho, Hongbin Ji, Yun Zhao#,Lei Zhang# Brahma is essential for Drosophila Intestinal Stem Cell proliferation and regulated by Hippo signaling.eLife2013 2: e00999 （# corresponding author） 3.　Tong Guo, Yi Lu, Peixue Li, Meng-Xin Yin, Dekang Lv, Wenjing Zhang, Huizhen Wang, Zhaocai Zhou, Hongbin Ji, Yun Zhao#,Lei Zhang# A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity.Cell Research2013，23:1201-1214（# corresponding author) 4.　Shi Jiao, Huizhen Wang, Zhubing Shi, Aimei Dong, Wenjing Zhang, Xiaomin Song, Feng He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Peixue Li, Yun Zhao, Hongbin Ji#,Lei Zhang#, Zhaocai Zhou#. A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer.Cancer Cell2014, 25: 166-180 （# corresponding author) 5.　Yijun Gao, Wenjing Zhang, Xiangkun Han, Fuming Li, Xujun Wang, Rui Wang, Zhaoyuan Fang, Xinyuan Tong, Shun Yao, Fei Li, Yan Feng, Yihua Sun, Yingyong Hou, Zhongzhou Yang, Kunliang Guan, Haiquan Chen,Lei Zhang# & Hongbin Ji# YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression.Nat Communications2014, 5:4629 （# corresponding author)