王曉晨

1988.09 - 1992.07 山東大學 本科 微生物學

1994.09 - 1999.07 北京大學生命科學學院 植物基因工程和蛋白質工程國家重點實驗室 博士 細胞生物學

1998 - 1999年 比利時根特大學/佛蘭德斯生物科技研究所訪問學生

1999 - 2006年 美國科羅拉多大學分子與細胞發育生物學系博士后

2006 - 2011年 北京生命科學研究所研究員

2011年-至今 北京生命科學研究所高級研究員

1.由於遺傳上的冗餘性，傳統的正向遺傳學篩選可能會“漏掉”一些參與凋亡細胞吞噬過程的基因，我們將運用特異的正向遺傳學篩選手段來獲得這些基因

徠2.運用反向遺傳學尋找參與凋亡細胞清除過程的新基因

3.對所鑒定的吞噬相關基因展開凋亡細胞吞噬過程調節機制的研究

Wu, Y.W., Cheng, S.Y., Zhao, H.Y., Zou, W., Yoshina, S., Mitani, S.,Zhang, H., *Wang, X.C.(2014)PI3P phosphatase activity is required for autophagosome maturation and autolysosomeformation. EMBO Rep.15(9):973-81.2014/09

Wang H,Lu Q,Cheng S, *Wang X,*Zhang H(2013).Autophagy activity contributes to programmed cell death in Caenorhabditis elegans. Autophagy.9(12):1975-82

Cheng S , Wu Y , Lu Q , Yan J, Zhang H， *Wang X(2013).Autophagy genes coordinate with the class II PI3 kinase PIKI-1 to regulate apoptotic cell clearance in C. elegans. Autophagy.9(12):2022-32,2013/12

Li X, Chen B, Yoshina S, Cai T, Yang F, Mitani S, *Wang X(2013).Inactivation of C. elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants， Mol Biol Cell.24(8):1163-75.

Huang J, Wang H, Chen Y, Wang X*, and Zhang H*(2012). Residual body removal during spermatogenesis inC. elegansrequires genes that mediate cell corpse clearance. Development139(24), 4613-4622.(*Co-corresponding author)

Zhang Y, Wang H, Kage-Nakadai E, Mitani S, and Wang X*(2012).C. eleganssecreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment. Curr Biol22(14), 1276-1284.

Liu B, Du H, Rutkowski R, Gartner A, and Wang X*(2012). LAAT-1 is thelysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science337, 351-354.

Kang Y, Zhao D, Liang H, Liu B, Zhang Y, Liu Q, Wang X*, and Liu Y* (2012).Structural study of TTR-52 reveals the mechanism by which a bridging moleculemediates apoptotic cell engulfment. Genes Dev.26(12), 1339-1350.(*Co-corresponding author)

Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, Tian D, Wang X*, Vale RD*, and Ou G* (2012). Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell.J Cell Biol197(1), 27-35.(Co-corresponding author)

Wu YC, Wang Xand Xue D (2012). Methods for Studying Programmed Cell Death inC. elegans.inCAENORHABDITIS ELEGANS: CELL BIOLOGY AND PHYSIOLOGY, SECOND EDITION, ELSEVIER ACADEMIC PRESS INC,USA, 297-320.

Guo P, and Wang X*(2010). Rab GTPases act in sequential steps to regulatephagolysosome formation. Small GTPases1(3), 1-4 (Invited Extra view).

Chen B, Jiang Y, Zeng S, Yan J, Li X, Zhang Y, Zou W, and Wang X*(2010).Endocytic sorting and recycling require membrane phosphatidylserine asymmetrymaintained by TAT-1/CHAT-1. PLoS Genet6(12), e1001235.

Guo P, Hu T, Zhang J, Jiang S, and Wang X*(2010). Sequential action ofCaenorhabditis elegansRab GTPases regulates phagolysosome formation duringapoptotic cell degradation. Proc Natl Acad Sci U S A107, 18016-18021.

Wang X*, Li W, Zhao D, Liu B, Shi Y, Chen B, Yang H, Guo P, Geng X, Shang Z,Peden E, Kage-Nakadai E, Mitani S, and Xue D* (2010).Caenorhabditis eleganstransthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor.Nat Cell Biol12,655-664.(Co-corresponding author)

Tian Y, Li Z, Hu W, Ren, H, Tian, E, Zhao Y, Lu Q, Huang X, Yang P, Li X, Wang X, Kovacs A L, Yu L and Zhang H (2010)C. elegansScreen Identifies Autophagy Genes Specific to Multicellular Organisms. Cell141(6),1042-1055.

Zou W, Lu Q., Zhao D, Li W, Mapes J, Xie Y, and Wang X*(2009).Caenorhabditis elegansmyotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet5, e1000679.

Li W, Zou W, Zhao D, Yan J, Zhu Z, Lu J, and Wang X*(2009).C. elegansRabGTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5. Development136, 2445-2455.

Lu Q, Zhang Y, Hu T, Guo P, Li W, and Wang X*(2008).C. elegansRab GTPase 2 is required for the degradation of apoptotic cells. Development135, 1069-1080.