陳佳

2002年本科畢業於南開大學生命科學學院生物化學系；2009年在中科院上海生命科學研究院生物化學與細胞生物學研究所獲博士學位；2009年至2014年在美國國立衛生研究院（NIH）進行博士后研究工作。2014年11月加入上海科技大學生命科學與技術學院任助理教授（終身教授序列）。

物種繁衍依賴於基因組的穩定性，這在細胞內是由一系列精巧而複雜的DNA修復機制負責維持的。然而在某些生理、病理狀態下細胞會激活錯誤傾向性DNA修復機制。因此DNA修復的精確性和錯誤傾向性之間的平衡對於包括癌症在內的疾病發生、衰老和進化都有著重要的意義。我們實驗室將探索由DNA修復引發的突變在疾病發生、衰老以及基因組主動性去甲基化等過程中所起的作用，主要集中於三個方面： 1）DNA修復在內源基因組水平引發突變的分子機制；2）鑒定並分析參與DNA修復引發突變的新分子和新通路；3）DNA修復引發突變在癌症發生過程中的作用。我們的研究將有助於發現癌症治療的新靶標，完善衰老的DNA損傷學說以及揭示物種進化的分子動力。

1. Chen J, Miller BF, Furano AV. Repair of naturally occurring mismatches can induce mutations in flanking DNA. eLife, 2014, 3: e02001

Featured in Insight Article by Wilson SH. eLife, 2014, 3: e03068

2. Hu GJ*, Chen J*, Zhao XN*, Xu JJ, Guo DQ, Lu M, Zhu M, Xiong Y, Li Q, Chang CC, Song BL, Chang TY, Li BL. Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance gene. Cell Res, 2013, 23: 1007-1024 (*co-first author)

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Featured in Research Highlight Article by Preußer C, Bindereif A. Cell Res, 2013, 23: 1071-1072

3. Lei L, Xiong Y, Chen J, Yang JB, Wang Y, Yang XY, Chang CC, Song BL, Chang TY, Li BL. TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation. J Lipid Res, 2009, 50: 1057-1067

4. Zhao X*, Chen J*, Lei L, Hu G, Xiong Y, Xu J, Li Q, Yang X, Chang CC, Song B, Chang T, Li B. The optional long 5'-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay. Acta Biochim Biophys Sin, 2009, 41: 30-41 (*co-first author)

5. Chen J*, Zhao XN*, Yang L, Hu GJ, Lu M, Xiong Y, Yang XY, Chang CC, Song BL, Chang TY, Li BL.RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform. Cell Res, 2008, 18: 921-936 (*co-first author)

6. Yang L, Lee O, Chen J, Chen J, Chang CC, Zhou P, Wang ZZ, Ma HH, Sha HF, Feng JX, Wang Y, Yang XY, Wang L, Dong R, Ornvold K, Li BL, Chang TY. Human acyl-coenzyme A:cholesterol acyltransferase 1(Acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N-terminal. J Biol Chem, 2004, 279: 46253-46262

7. Li BL, Chang TY, Chen J, Chang CC, Zhao XN. Human ACAT1 gene expression and its involvement in the development of atherosclerosis. Future Cardiol, 2006, 2: 93-99 (Review)

8. Yang L, Yang JB, Chen J, Yu GY, Zhou P, Lei L, Wang ZZ, Cy Chang C, Yang XY, Chang TY, Li BL. Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone. Cell Res, 2004, 14: 315-323

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