| 角色 | 演員 | 備註 |
| Dr. James Kildare (191 episodes, 1961-1966) | 理查德·查伯蘭（Richard Chamberlain） | |
| Dr. Leonard Gillespie (191 episodes, 1961-1966) | 雷蒙德·馬西（Raymond Massey） | |
| Harry Kleber (9 episodes, 1965) | 萊斯利·尼爾森（Leslie Nielsen） | |
| John Kapish, M.D. (8 episodes, 1961-1964) | 肯·巴瑞（Ken Berry） | |
| Nurse Bonnie Mynes (8 episodes, 1963-1965) | 李·麥瑞威瑟（Lee Meriwether） | |
| Bishop (8 episodes, 1961-1965) | Hayden Rorke | |
| Dr. Milton Orliff (7 episodes, 1962-1966) | 馬丁·鮑爾薩姆（Martin Balsam） | |
| Dr. Roger Helvick (7 episodes, 1963-1965) | Andrew Prine | |
| Amy Post (7 episodes, 1963-1966) | 黛安·貝克（Diane Baker） | |
| Anna Perrona (7 episodes, 1965) | Donna Loren | |
| Laura Morrison (7 episodes, 1965) | 瑪琳·麥森（Marlyn Mason） | |
| Steve Perrona (7 episodes, 1965) | Tom Nardini | |
| Fred Kirsh (7 episodes, 1965) | David Opatoshu | |
| Beatrice Fain, RN (6 episodes, 1963-1965) | Jean Inness | |
| Dr. Carl Noyes (6 episodes, 1961-1966) | 威廉·夏特納（William Shatner） | |
| Betty Johnson RN (6 episodes, 1961-1964) | Della Sharman | |
| Lydia McGuire (6 episodes, 1962-1965) | Patricia Barry | |
| Dr. Yates Atkinson MD (6 episodes, 1962-1964) | 詹姆斯·T·卡倫漢（James T. Callahan） | |
| Millie McLean RN (6 episodes, 1962-1965) | Carol Anderson | |
| Mrs. Gast (6 episodes, 1961-1965) | Naomi Stevens | |
| Nurse Whitman (6 episodes, 1963-1966) | Ann Loos | |
| Mac (6 episodes, 1961-1965) | Clegg Hoyt | |
| Dr. Wickens (6 episodes, 1962-1965) | Philip Bourneuf | |
| Andrew Webb (6 episodes, 1964-1966) | 布拉福德·迪爾曼（Bradford Dillman） | |
| Ella Vitnack (6 episodes, 1965-1966) | 奧黛麗·托特（Audrey Totter） | |
| Thomas Hartwood (6 episodes, 1965) | 托尼·比爾（Tony Bill） | |
| Judd Morrison (6 episodes, 1965) | 羅伯特·里德（Robert Reed） | |
| Mitchell Hobart (6 episodes, 1965) | Fred J. Scollay | |
| Dr. Rudy Devereux (6 episodes, 1965) | 迪恩·斯托克維爾（Dean Stockwell） | |
| Frankie Warren (6 episodes, 1965) | Sheilah Wells | |
| Justin Post (6 episodes, 1966) | 傑克·霍金斯（Jack Hawkins） | |
| Bryan Cannon (6 episodes, 1966) | Donald Madden | |
| Quint Lowry, MD (5 episodes, 1963-1965) | Steve Bell | |
| Simon Agurski, M.D. (5 episodes, 1961-1965) | Eddie Ryder | |
| Yvonne Barlow (5 episodes, 1966) | 喬安娜·佩蒂（Joanna Pettet） | |
| Jeannie Orloff (5 episodes, 1966) | 迪安娜·茂道（Diana Muldaur） | |
| John McGinnis (5 episodes, 1965-1966) | Len Wayland | |
| Charles Shannon (5 episodes, 1965) | Burt Brinckerhoff | |
| Norma Hobart (5 episodes, 1965) | 哈澤爾·考特（Hazel Court） | |
| Arnold Vitnack (5 episodes, 1965) | 諾曼·費爾（Norman Fell） | |
| Jill Hartwood (5 episodes, 1965) | Judy Lang | |
| Chris Becker (5 episodes, 1965) | 瑪格麗特·萊頓（Margaret Leighton） | |
| Evelyn Driscoll (5 episodes, 1966) | 傑芙·唐內爾（Jeff Donnell） | |
| Ken Cleveland (5 episodes, 1966) | John Napier | |
| Dr. Thomas Gerson (4 episodes, 1961-1965) | 裘德·泰勒（Jud Taylor） | |
| Dr. Jeff Brenner (4 episodes, 1966) | Bruce Hyde | |
| Lucy Hyde, RN (4 episodes, 1962-1963) | Maxine Stuart | |
| Jaime Angel (4 episodes, 1966) | 傑克·尼科爾森（Jack Nicholson） | |
| Dr. Demerest (4 episodes, 1964-1966) | 巴瑞·阿沃特（Barry Atwater） | |
| Dr. Steve Bardeman (4 episodes, 1963-1965) | William Sargent | |
| Peter De Gravio (4 episodes, 1961-1966) | 艾德·賓斯（Ed Binns） | |
| Dr. Phillip Downey (4 episodes, 1961-1965) | 丹·奧赫里奇（Dan O'Herlihy） | |
| Pappas (4 episodes, 1962-1966) | Eduardo Ciannelli | |
| Mr. Gaffney (4 episodes, 1962-1965) | Alan Hewitt | |
| Mr. Hallerton (4 episodes, 1962-1965) | Edmon Ryan | |
| Rachel Field (4 episodes, 1964-1965) | Sharon Farrell | |
| Joe Quinlen (4 episodes, 1965) | 弗雷德·阿斯泰爾（Fred Astaire） | |
| Sister Benjamin (4 episodes, 1965) | Laura Devon | |
| Tracey Richards (4 episodes, 1965) | Kathy Garver | |
| Rhoda Kirsh (4 episodes, 1965) | 克勞斯·利特曼（Cloris Leachman） | |
| Sister St John (4 episodes, 1965) | Irene Martin | |
| Dr. Maxwell Becker (4 episodes, 1965) | 詹姆斯·梅森（James Mason） | |
| Felix Holman (4 episodes, 1965) | 達倫·麥克加文（Darren McGavin） | |
| Nurse Betty Taylor (4 episodes, 1965) | Lory Patrick | |
| Lois Gibbon (4 episodes, 1965) | Tippy Walker | |
| Katherine West (4 episodes, 1966) | Elizabeth Allen | |
| Judy Cannon (4 episodes, 1966) | Joyce Bulifant | |
| Little Al (4 episodes, 1966) | Richard Elkins | |
| Sugar Man (4 episodes, 1966) | Dilart Heyson | |
| Dr. Vincent Brill (4 episodes, 1966) | Mart Hulswit | |
| Dr. Lou Rush (4 episodes, 1966) | 詹姆斯·厄爾·瓊斯（James Earl Jones） | |
| Snake (4 episodes, 1966) | Kirk Kirksey | |
| Damon West (4 episodes, 1966) | 里卡多·蒙特爾班（Ricardo Montalban） | |
| Irene Rush (4 episodes, 1966) | Diana Sands | |
| Bonda Jo Weaver (4 episodes, 1966) | 萊斯莉·安·華倫（Lesley Ann Warren） | |
| Abby Thompson (3 episodes, 1962-1964) | Brenda Scott | |
| Miss Conant RN (3 episodes, 1963-1964) | Jo Helton | |
| Nurse Zoe Lawton (3 episodes, 1966) | Lee Kurty | |
| Cathy Benjamin (3 episodes, 1961-1964) | 蘇珊娜·普萊薛特（Suzanne Pleshette） | |
| Carol Tredman (3 episodes, 1965) | 安吉·迪金森（Angie Dickinson） | |
| Helen Orloff (3 episodes, 1966) | Debi Storm | |
| Helen Phipps, R.N. (3 episodes, 1962-1964) | Madge Blake | |
| Miss Plessy (3 episodes, 1962-1964) | Dorothy Neumann | |
| Mrs. Gitner (3 episodes, 1963-1965) | Peggy Rea | |
| Miss Roth (3 episodes, 1961-1963) | Josie Lloyd | |
| Dr. Jessie Martel (3 episodes, 1963-1965) | 蘇珊·奧利佛（Susan Oliver） | |
| Annie (3 episodes, 1963-1964) | Jeanette Nolan | |
| Emma Miller (3 episodes, 1962-1965) | Joan Tompkins | |
| Mrs. Holmes (3 episodes, 1964-1965) | Phyllis Hill | |
| Brian Bailey (3 episodes, 1964) | Michel Petit | |
| D.R. Dromley (3 episodes, 1961-1964) | 約翰·菲爾德（John Fiedler） | |
| Dr. Sackley (3 episodes, 1965) | Pauline Meyer | |
| Dr. Vincent (3 episodes, 1961-1962) | Gary Judis | |
| Dr. Dunning (3 episodes, 1961-1966) | Virginia Gregg | |
| Dr. Philip Leland (3 episodes, 1961-1962) | Lew Gallo | |
| Dan Hargrave (3 episodes, 1962-1966) | Murray Hamilton | |
| Henry Harris (3 episodes, 1962-1965) | 埃德·貝格利（Ed Begley） | |
| Dr.Parkinson (3 episodes, 1962-1963) | Andy Clyde | |
| Sgt Hensley (3 episodes, 1963-1966) | 喬治·肯尼迪（George Kennedy） | |
| Mrs. Davis (3 episodes, 1963-1965) | Marjorie Bennett | |
| MacAllister Thane (3 episodes, 1963-1965) | Sorrell Booke | |
| Bruno Rossi (3 episodes, 1964-1966) | Joe De Santis | |
| Francesca Paolini (3 episodes, 1964) | 丹妮拉·碧安琪（Daniela Bianchi） | |
| Dr. Ian MacDuff (3 episodes, 1964) | Donald Harron | |
| Sister Teresa (3 episodes, 1964) | 梅賽德絲·麥坎布雷奇（Mercedes McCambridge） | |
| Armando di Corregio (3 episodes, 1964) | Fabrizio Mioni | |
| Gaspero Paolini (3 episodes, 1964) | 拉蒙·諾瓦羅（Ramon Novarro） | |
| Dr. Guiseppe Muretelli (3 episodes, 1964) | Paul Stewart | |
| Signora Rossi (3 episodes, 1964) | Theresa Tirelli | |
| Luisa Brabante (3 episodes, 1964) | 阿莉達·瓦莉（Alida Valli） | |
| Laurel Colling (3 episodes, 1965-1966) | Shannon Farnon | |
| Receptionist (3 episodes, 1965-1966) | Audrey Larkins | |
| Dr. Lench (3 episodes, 1965) | 詹姆斯·愛德華茲（James Edwards） | |
| Luther Bernstein (3 episodes, 1965) | James Frawley | |
| Francis X Healy (3 episodes, 1965) | 哈里·摩根（Harry Morgan） | |
| Irene Fairly (3 episodes, 1965) | Jeanne Rainer | |
| Dr. Halliman's Orderly (3 episodes, 1965) | Christopher Riordan | |
| Mrs. Canford (3 episodes, 1965) | 安妮·賽默爾（Anne Seymour） | |
| Judge (3 episodes, 1965) | Karl Swenson | |
| Rev Jack Elder (3 episodes, 1966) | 理查德·貝梅爾（Richard Beymer） | |
| Dr. Lilith McGraw (2 episodes, 1963-1965) | Diana Hyland | |
| Pat Holmes (2 episodes, 1964) | 伊薇特·米米亞克斯（Yvette Mimieux） | |
| Aunt Frances (2 episodes, 1962-1963) | 瑪麗·阿斯特（Mary Astor） | |
| Lorena Henty (2 episodes, 1962-1963) | 科林·威克斯·帕斯頓（Collin Wilcox Paxton） | |
| David Burnside (2 episodes, 1962-1965) | 凱勒·歐康納（Carroll O'Connor） | |
| Jody (2 episodes, 1962-1963) | Rory O'Brien | |
| Julie Belmanno (2 episodes, 1962-1963) | 喬伊絲·馮·派特（Joyce Van Patten） | |
| Mr. Hutchinson (2 episodes, 1962-1964) | James Griffith | |
| Jackie Barnett RN (2 episodes, 1962-1964) | Patience Cleveland | |
| Dr. MacDonald (2 episodes, 1962-1964) | Bert Remsen | |
| Chris Priest (2 episodes, 1963-1964) | Joey Scott | |
| Adam Barstow (2 episodes, 1962-1963) | 理查德·本傑明（Richard Benjamin） | |
| Dr. Nicholas Keefe (2 episodes, 1962-1964) | 雷普·湯恩（Rip Torn） | |
| Ted Gallahad (2 episodes, 1962-1963) | Jack Carter | |
| Jesse Hartwood MD (2 episodes, 1963-1965) | 羅伯特·考普（Robert Culp） | |
| Harvey Gruboldt MD (2 episodes, 1963-1965) | 凱文·麥卡錫（Kevin McCarthy） | |
| Lily Prentice (2 episodes, 1963-1964) | 魯思·羅曼（Ruth Roman） | |
| Joan Cartwright (2 episodes, 1963-1964) | 簡妮絲·魯爾（Janice Rule） | |
| Hildy Pochek (2 episodes, 1964-1965) | 洛伊絲·內特爾頓（Lois Nettleton） | |
| Dr. Brown (2 episodes, 1961-1962) | Frank Kiliman | |
| Dr. Andrew Bennett (2 episodes, 1962-1966) | 西德尼·布萊克默（Sidney Blackmer） | |
| John Doe IV (2 episodes, 1963-1964) | J. Pat O'Malley | |
| Dr. Norman Gaye (2 episodes, 1964) | 克魯·古拉格（Clu Gulager） | |
| Dr. Norman Hutchens (2 episodes, 1961-1962) | Warren J. Kemmerling | |
| Ben Ballard (2 episodes, 1962-1964) | Max Showalter | |
| Arthur Jansen (2 episodes, 1963-1965) | 萊斯·崔梅恩（Les Tremayne） | |
| Harry Buford (2 episodes, 1964-1965) | Robert Karnes | |
| Mrs. Martinez (2 episodes, 1964-1965) | 雪莉·莫里森（Shelley Morrison） | |
| Clara McCloskey (2 episodes, 1964-1965) | Marge Redmond | |
| Paul Montgomery (2 episodes, 1964) | John Newland | |
| Dr. John Connor (2 episodes, 1962-1964) | Robert Brubaker | |
| Maya Lajos RN (2 episodes, 1962-1963) | Lisabeth Hush | |
| Earl McCloskey (2 episodes, 1963-1965) | 海爾德·高德（Harold Gould） | |
| Eleanor Quayle (2 episodes, 1961-1963) | Gertrude Flynn | |
| Barbara (2 episodes, 1962-1963) | Adrienne Marden | |
| Russ (2 episodes, 1964) | Robert Logan | |
| Dr. Bellaman (2 episodes, 1961-1965) | Noah Keen | |
| Mr. Holmes (2 episodes, 1964) | George Petrie | |
| Emergency Intern (2 episodes, 1965) | Robert Jacquin | |
| Betty Alcott, RN (2 episodes, 1961-1962) | Elizabeth Perry | |
| Dr. William Coombs (2 episodes, 1962-1964) | Charles Alvin Bell | |
| Dunleavy (2 episodes, 1963-1966) | Clancy Cooper | |
| Dr. Cassidy (2 episodes, 1963-1964) | Wilton Graff | |
| Carl Victor (2 episodes, 1963-1964) | Paul Newlan | |
| B.R. Liebman, M.D. (2 episodes, 1961-1962) | 哈維·科曼（Harvey Korman） | |
| Nurse Jackie Barnett (2 episodes, 1964) | 貝弗莉·亞當斯（Beverly Adams） | |
| Cavelli (2 episodes, 1966) | Michael Panaieff | |
| Arthur Norris (2 episodes, 1962-1964) | David Sheiner | |
| Fred Payson (2 episodes, 1963-1964) | Leonard Stone | |
| David Coburn MD (2 episodes, 1961-1966) | William Swan | |
| Mrs. Koenig (2 episodes, 1963-1965) | Viola Harris | |
| Dr. Kenneth Kline (2 episodes, 1965) | Whit Bissell | |
| Gage (2 episodes, 1961-1966) | Tony Monaco | |
| Dr. Anne Warner (2 episodes, 1961-1965) | Gail Kobe | |
| Alan Burnside (2 episodes, 1961-1965) | Roger Mobley | |
| Andy Meadows MD (2 episodes, 1961-1965) | Ford Rainey | |
| Mabel Volk (2 episodes, 1961-1965) | Evelyn Ward | |
| Dr. Lois Bower (2 episodes, 1961-1964) | Carol Eve Rossen | |
| Carl Temple (2 episodes, 1961-1964) | Peter Whitney | |
| Judge Haines (2 episodes, 1961-1963) | 約翰·馬利（John Marley） | |
| Mitchell (2 episodes, 1961-1963) | Ross Martin | |
| Dr. Kenneth Hasker (2 episodes, 1961-1963) | 查爾斯·麥格勞（Charles McGraw） | |
| Nick Nirchos (2 episodes, 1961-1963) | Charles H. Radilak | |
| Nathan Agurski (2 episodes, 1961-1962) | Herschel Bernardi | |
| Susan (2 episodes, 1961-1962) | 貝弗利·加蘭（Beverly Garland） | |
| Little Girl (2 episodes, 1961-1962) | Gina Gillespie | |
| Dr. Galmeir (2 episodes, 1961-1962) | Laurence Haddon | |
| Dr. William Galdi (2 episodes, 1961-1962) | Sandy Kenyon | |
| Dr. Dan Shanks (2 episodes, 1961) | Sammy Reese | |
| Ma McConnell (2 episodes, 1962-1965) | Ellen Attenbury | |
| Director (2 episodes, 1962-1965) | Bert Freed | |
| Instructor (2 episodes, 1962-1965) | Bill Quinn | |
| Ethel Belan (2 episodes, 1962-1964) | 簡妮·庫珀（Jeanne Cooper） | |
| Claire Sutton (2 episodes, 1962-1964) | 帕特·克勞蕾（Pat Crowley） | |
| Detective (2 episodes, 1962-1964) | Ivan Dixon | |
| Adam Ross (2 episodes, 1962-1964) | Lauren Gilbert | |
| Andrea Gaer (2 episodes, 1962-1964) | Georgann Johnson | |
| Charles Bishop (2 episodes, 1962-1964) | 李·馬文（Lee Marvin） | |
| Emily Buchanan (2 episodes, 1962-1964) | 菲伊·斯潘（Fay Spain） | |
| Max (2 episodes, 1962-1964) | Anthony Spinelli | |
| Claire Gebhardt (2 episodes, 1962-1963) | Jean Allison | |
| Dr. Frank Williams (2 episodes, 1962-1963) | 愛德華·阿斯納（Edward Asner） | |
| Dr. Mahmel Homatka (2 episodes, 1962-1963) | 西奧多·拜克（Theodore Bikel） | |
| Ben Mollenhauer (2 episodes, 1962-1963) | 比爾·貝克比（Bill Bixby） | |
| Hertzog (2 episodes, 1962-1963) | John Bleifer | |
| Judge Manning (2 episodes, 1962-1963) | 埃德加·巴詹南（Edgar Buchanan） | |
| Mrs. Gerard (2 episodes, 1962-1963) | Charity Grace | |
| Edward Swader (2 episodes, 1962-1963) | 帕特·亨格爾（Pat Hingle） | |
| Irv Forman (2 episodes, 1962-1963) | Bernard Kates | |
| Judy (2 episodes, 1962-1963) | Mary LaRoche | |
| Mamie Delaney (2 episodes, 1962-1963) | Nora Marlowe | |
| Eleanor Corbin (2 episodes, 1962-1963) | 瑪麗·墨菲（Mary Murphy） | |
| Jonesy (2 episodes, 1962-1963) | Dan Tobin | |
| Pilar (2 episodes, 1962) | Miriam Colon | |
| Intern (2 episodes, 1962) | Frank Mahony | |
| Inspector (2 episodes, 1962) | William Schallert | |
| Lucy Webber RN (2 episodes, 1962) | Helen Wallace | |
| Captain Childs (2 episodes, 1963-1966) | Bill Zuckert | |
| Mr. Baker (2 episodes, 1963-1965) | Ben Wright | |
| Ann Fredericks (2 episodes, 1963-1964) | Susan Brown | |
| Dr. Gault (2 episodes, 1963-1964) | Brendan Dillon | |
| Mrs. Silber (2 episodes, 1963-1964) | 伊索貝爾·埃爾索姆（Isobel Elsom） | |
| Mr. Chapman (2 episodes, 1963-1964) | Jason Johnson | |
| Joseph Patrick Burns (2 episodes, 1963-1964) | Harold Stone | |
| Nurse (2 episodes, 1963) | Susan Davis | |
| Myra Krolik (2 episodes, 1963) | Zohra Lampert | |
| Dr. Pauline Stewart (2 episodes, 1963) | Mary Webster | |
| Bob (2 episodes, 1964-1966) | Steve Mitchell | |
| Tobra (2 episodes, 1964) | Anna Bruno-Lena | |
| Carol Montgomery (2 episodes, 1964) | 安賈妮特·科默（Anjanette Comer） | |
| Patsy Carey (2 episodes, 1964) | 金·達比（Kim Darby） | |
| Dibbedee (2 episodes, 1964) | Burt Mustin | |
| Capt Lindsay (2 episodes, 1964) | Nelson Olmsted | |
| Big Green (2 episodes, 1964) | Robert Sorrells | |
| Dr. Max Gunther (2 episodes, 1965-1966) | Robert Cornthwaite | |
| Gerald (2 episodes, 1965-1966) | Harry Townes | |
| Dr. Friedkin (2 episodes, 1965) | Jan Arvan | |
| Ulysses 'The Burglar' Jackson (2 episodes, 1965) | Harold Baker | |
| Dr. Bernard Krantz (2 episodes, 1965) | William Bramley | |
| Mother Caritas (2 episodes, 1965) | 斯普林·白靈頓（Spring Byington） | |
| Morgan Bannion (2 episodes, 1965) | James Daly | |
| Kathy Calvert (2 episodes, 1965) | Charla Doherty | |
| John Dolan (2 episodes, 1965) | James Flavin | |
| Philip Foray (2 episodes, 1965) | David Frankham | |
| Garcia (2 episodes, 1965) | Rodolfo Hoyos Jr. | |
| Emily Field (2 episodes, 1965) | 金·亨特（Kim Hunter） | |
| Frederick Foray (2 episodes, 1965) | 巴茲爾·雷斯伯恩（Basil Rathbone） | |
| Emmy Foray (2 episodes, 1965) | Frances Reid | |
| Miss Trilling (2 episodes, 1965) | Elizabeth Rogers | |
| Wylie Hamilton (2 episodes, 1965) | Tim Rooney | |
| Madge Bannion (2 episodes, 1965) | 芭芭拉·拉什（Barbara Rush） | |
| Dr. Brantell (2 episodes, 1965) | Robert F. Simon | |
| Peace (2 episodes, 1965) | Will Tynan | |
| Mark (2 episodes, 1965) | 薩姆·沃特森（Sam Waterston） | |
| Ginny Elder (2 episodes, 1966) | Melanie Alexander | |
| Landlady (2 episodes, 1966) | Mona Bruns | |
| Paul Lee Weaver (2 episodes, 1966) | Steve Carlson | |
| Dahla Rossi (2 episodes, 1966) | Angela Clarke | |
| George Parker (2 episodes, 1966) | 魯珀特·克羅斯（Rupert Crosse） | |
| Margaret (2 episodes, 1966) | Kym Karath | |
| Charlene Rossi (2 episodes, 1966) | 瓊·馬歇爾（Joan Marshall） | |
| (2 episodes, 1966) | Gloria McMillan | |
| Raymond Rossi (2 episodes, 1966) | Lawrence Montaigne | |
| Joe Belasco (2 episodes, 1966) | Alan Reed | |
| Alice (2 episodes, 1966) | 比尤拉·理查茲（Beah Richards） | |
| Richard Ross (2 episodes, 1966) | 約翰·薩克松（John Saxon） | |
| Angie (2 episodes, 1966) | Susan Silo | |
| Nurse Claire Hanson (2 episodes, 1966) | 黛安·瓦西（Diane Varsi） | |
| Tad (2 episodes, 1966) | Bill Walker | |