郭曉奎

上海交通大學特聘教授，國家級教學名師，全國教育科研先進工作者，全國優秀教師。現任國家熱帶病研究中心副主任；上海交通大學-愛丁堡大學全健康研究中心常務副主任；上海交通大學國家熱帶病研究中心全球健康學院專職副院長；上海渥太華聯合醫學院副院長；生物醫學科學專業管委會主任；致遠學院醫學方向主任。兼任中國微生物學會醫學微生物學免疫學專業委員會主任委員；中國醫藥教育協會微生態與健康分會副主任委員；上海市微生物學會副理事長，秘書長；國家虛擬模擬實驗教學創新聯盟醫學基礎委員會主任；國家高等學校基礎醫學實驗教學中心規範化建設與管理工作組組長。教育部基礎醫學類教指委專業建設工作組特聘專家、拔尖人才培養與實踐教學工作組特聘專家。國家級研究生規劃教材醫學微生物學主編；國家級本科規劃教材病原生物學中文、雙語主編、醫學微生物學英文版主編；國家級精品課程、國家精品共享課程、國家一流課程、上海市混合課程醫學微生物學負責人。

倡導並實踐全人教育，強化課程思政，建立的ASK體系得到全國醫學教育界的認可，2017年校特等獎；積極推動能力導向梯度實驗教學體系建設與實踐，培養學生科創精神和研究素養，2019年校特等獎；作為我國生物醫學科學專業的創立者之一，是專業設立可行報告和培養方案的主要起草人。交醫2016年設立該專業，現已獲批國家強基計劃專業、國家拔尖人才培養基地和國家一流專業。2020年校特等獎；積極推動我國基礎醫學整合課程建設，包括針對醫學相關專業的橫向整合課程體系；具有我國特色的基予系統器官的整合課程體系；北美渥太華大學的整合課程體系和醫學實驗整合課程體系。到業界讚譽，2015年校特等獎；促進以學生為中心的積極的學習：秉承我國“教學有法，教無定法；教有定規，貴在得法”的教學思想，因材施教。與新體系實施相適應，推出以學生為中心的因材施教的多樣性教學模式，減少大班課堂教學，增加小組教學、案例討論、減少授課時數，採用多種學生參與式學習方法。在教學過程中，跳出以往LBL（Lecture based learning）灌輸式教學方式，提倡TBL（Team based learning）、PBL（Problem based learning）、CBL（Case based learning）、RBL（Research based learning）、CAL（Computer assisted learning）相融合的多元模式；推進形成性評價：為全面公平地評價學生，並促進學生自主學習，強化形成性評價，建立了全新的評價體系。如PBL、CBL、實驗、文獻綜述、小論文等考核，以配合整合課程對學生創新精神和能力培養的總體目標；課程建設方面，“醫學微生物學”先後獲國家精品課程、國家精品共享課程和國家級一流課程；作為全球健康學院的創立者之一，為全體醫學生開設全球健康與全健康課程，得到了世界醫學教育聯合會（WFME）高級顧問和我國認證工作委員專家的讚賞；教材建設方面，是國家級本科規劃教材《病原生物學》、《Medical Microbiology》和國家級研究生規劃教材《醫學微生物學》主編；教學學術研究，主持國家、上海市等教學課題20餘項，發表教育教學論文31篇，出版《病原生物學教育教學》和《醫學整合課程實踐與研究》；曾先後獲得全國教育科研優秀教學成果特等獎、國家教學成果一等獎（排名2）、4項省市級教學成果獎、7項校級教學成果特等獎、3次校長獎、2次校教書育人一等獎和1次2等獎。

科學研究主要聚焦微生態學和全健康（One Health）最重要的3個領域：1）鉤端螺旋體病、布魯菌病等人獸共患病，與團隊一起在國際上率先完成鉤端螺旋體基因組序列結構分析和重要功能基因研究，改寫了教科書相關內容，研發了鉤端螺旋體感染診斷試劑盒並成功轉化；2）微生態製劑、益生菌等功能食品藥品安全性，建立了基於基因組的益生菌安全性評價技術服務平台；3）細菌耐藥性的防控，推動了我國首例經倫理審批的噬菌體治療耐藥性細菌感染的臨床實踐。主持包括4項863課題等20多個國家級科研項目，發表400餘篇研究論文，其中151篇SCI論文；已主編出版20多本學術著作和教科書。

獲全國教育科研成果特等獎、國家級教學成果一等獎等省部級以上科研教育獎勵20餘項。

1982年09月至1986年07月四川大學學習

1988年09月至1991年07月哈爾濱醫科大學學習

1997年09月至2000年07月日本愛知學院大學學習

1986年08月2000年06月哈爾濱醫科大學工作

2000年07月至2019年06月上海交通大學醫學院基礎醫學院工作

2019年07月至今上海交通大學醫學院-國家熱帶病研究中心全球健康學院工作

中國微生物學會理事兼醫學微生物學免疫學專業委員會主任委員；中國微生物學會教學工作委員會副主任委員；

中國醫藥教育協會微生態與健康分會副主任委員；

上海市微生物學會副理事長、秘書長；

上海市微生物學會微生物組學專業委員會主任委員；

上海噬菌體與耐葯研究所學術委員會主任委員；

全國公共衛生與預防醫學名詞審定委員會熱帶醫學名詞審定分委員會副主任委員

醫學教育、全健康科學研究、細菌耐葯控制、人獸共患病、食品安全

● ● 郭曉奎，王昊，鈕曉音，胡翊群，洪梅，陳鋒，葉曦，戴佳穎，邵莉，蘇冰，程金科，張健，陳燕，唐華，孫雪青。生物醫學科學人才培養生態體系的構建與實踐，教學成果特等獎。上海交通大學，2020

● ● 章俊良，王維克，鄭杭，陳鋒，俞勇，孫淮，郭曉奎，沈紅斌，錢雪峰，葉曦，夏偉梁，吳曉玲，何峰，汪燕，姚乃嘉。建設榮譽課程體系，培養學術型創新人才教學成果二等獎，上海交通大學，2020

● ● 王兆軍，王昊，許文燮，李峰，王穎，吳健樺，賀明，張帆，吳琛耘，黃旭，王宏林，夏立，支建明，顧鳴敏，郭曉奎。能力為核心、融合為手段重構基礎醫學課程。教學成果一等獎，上海交通大學，2020

● ● 程金科，王昊，郭曉奎，易靜，徐天樂，董艷，王穎，蘇懿，余健秀，童雪梅，蘇冰，鍾清，朱雯佳，鈕曉音，張悅恬。突出學生主體、強化培養過程的研究生培養體系創新與實踐，教學成果特等獎，上海交通大學，2020

● ● 董為人，夏歐東，肖純凌，郭曉奎，胡珍橋，關喆，黃巧冰，仇欣霞，王巧玲，陳英華。基於優質多元信息化平台，構築“智能+”醫學金課堂，第九屆廣東省教育教學成果獎二等獎，2020。廣東省教育廳

● ● 郭曉奎（負責人）國家級一流課程（國家級精品在線開放課程）：醫學微生物學，教育部，2020.

● ● 郭曉奎（負責人）在線開放課程《醫學微生物學》，高教出版社，2019。

● ● 郭曉奎（負責人）上海市高校優質混合式示範課程《醫學微生物學》，上海市教委，2019。

● ● 郭曉奎（成員）基礎醫學整合課程改革團隊，教書育人獎一等獎，上海交通大學，2019

● ● 董為人，夏歐東，肖純凌，郭曉奎，胡珍橋，關喆，黃巧冰，仇欣霞，王巧玲，陳英華。基於多元化信息化優質平台，構築“智能+”醫學金課堂，教育教學成果獎一等獎，南方醫科大學，2019。

● ● 郭曉奎，顧鳴敏，許偉榕，鈕曉音，趙蔚，胡優敏，孫岳平，陳蓀紅，劉慧中，蘇懿，能力導向梯度實驗教學體系建設與實踐，上海交通大學教學成果特等獎，2019

● ● 郭曉奎（負責人）21教育講壇，上海交通大學醫學院，2019

● ● 郭曉奎上海市“為人、為學、為師”先進宣傳典型，中共上海市教育衛生工作委員會，2018

● ● 陳國強，郭曉奎，胡翊群，鈕曉音，邵莉，唐華，梅文翰，朱海燕，郁松，蘇懿。夯實醫教協同，綜合性大學“有靈魂的卓越醫學創新人才培養體系”構建與實踐，高等教育國家級教學成果一等獎，教育部，2018。

● ● 陳國強，郭曉奎，胡翊群，鈕曉音，邵莉，唐華，梅文翰，朱海燕，郁松，蘇懿。深化醫教協同，校院聯動構建有靈魂的卓越醫學創新人才培養體系，上海市教學成果特等獎，上海市，2018。

● ● 郭曉奎（負責人）上海市精品課程《基礎醫學器官系統整合課程》（含《病原生物學》），上海市教委，2018

● ● 郭曉奎（負責人）21教育講壇，上海交通大學醫學院，2018

● ● 郭曉奎（負責人）上海高校課程思政教育教學改革試點項目，上海市教委，2017

● ● 郭曉奎（負責人）聯盟規劃課程《醫學微生物學》，中國醫學教育慕課聯盟，2017。

● ● 郭曉奎，胡翊群，鈕曉音，梅文瀚，郁松，姜敘誠，富冀楓，丁文龍，張君慧，湯雪明，王一飛。基礎醫學ASK全人教育體系的實踐與推廣，上海交通大學教學成果特等獎，2017。

● ● 郭曉奎（成員）深化醫教協同推進卓越醫學人才培養，第五屆全國教育改革創新獎， 2017

● ● 郭曉奎教書育人一等獎，上海交通大學，2017

● ● 郭曉奎（成員）致遠學院項目主任團隊，教書育人二等獎，上海交通大學，2017

● ● 郭曉奎（成員）校長獎（教師發展中心），上海交通大學，2017

● ● 郭曉奎十佳班主任，上海交通大學，2017

● ● 郭曉奎十佳班導師，上海交通大學醫學院，2017

● ● 郭曉奎（負責人）21教育講壇，上海交通大學醫學院，2017

● ● 郭曉奎,唐華,鈕曉音,繆青,郁松,顧鋒,周棟,王甦平。醫學生創新能力培養體系的建設與實踐，上海交通大學教學成果一等獎，2016。

● ● 邵莉,李衛平,陳芳源,陸勤,張勇,王婷,酈憶,梅文瀚,郭曉奎。基於國際化與信息化的北美醫學課程和評估體系及師資隊伍建設的探索與實踐，上海交通大學教學成果一等獎， 2016。

● ● 郭曉奎（負責人）上海市重點課程《醫學導論（含醫學微生物學）》，上海市教委，2016

● ● 郭曉奎（負責人）21教育講壇，上海交通大學醫學院，2016

● ● 郭曉奎（負責人）國家精品共享課程《醫學微生物學》，教育部，2016

● ● 郭曉奎，富冀楓，梅文瀚，郁松，胡翊群，鈕曉音。基於器官系統的整合課程體系的改革與實踐，上海交通大學教學成果特等獎，上海交通大學，2015。

● ● 沈柏用、張勇、富冀楓、邵潔、張文慧、劉志宏、郭曉奎、鄭民華、李宏為醫學法語教學中的多主體、多模式國際合作的創新實踐，上海交通大學教學成果二等獎，上海交通大學，2015。

● ● 郭曉奎醫學院首屆班導師文化創建“十大精品項目”，2015。

● ● 郭曉奎十佳班導師，上海交通大學醫學院，2015

● ● 丁文龍、郭曉奎等以學生創新能力培養為核心的基礎醫學實踐教學模式的構建與應用，上海市教學成果二等獎，2014

● ● 丁文龍、郭曉奎等以學生創新能力培養為核心的基礎醫學實踐教學模式的構建與應用，上海交通大學教學成果一等獎，上海交通大學，2014。

● ● 郭曉奎國家高等學校教學名師獎，2011

● ● 郭曉奎（主編）《病原生物學綱要》，上海交通大學第十三屆優秀教材一等獎，2011

● ● 郭曉奎，徐大剛，趙蔚，吳健樺，張湘燕。病原生物學教育教學體系的建立與完善，全國“十一五”教育科研成果特等獎，2010。

● ● 郭曉奎校長獎，上海交通大學，2010

● ● 郭曉奎，張湘燕，趙蔚，吳健樺，陳洪。融合式教學模式在病原生物學的發展與實踐，上海交通大學教學成果二等獎，上海交通大學，2010

● ● 郭曉奎（負責人）病原生物學教育教學團隊，全國“十一五”教育科研先進集體，2010

● ● 郭曉奎（負責人）病原生物學教學團隊，上海市優秀教學團隊，2010。

● ● 郭曉奎全國“十一五”教育科研先進工作者，2010

● ● 郭曉奎全國優秀教師， 2009

● ● 郭曉奎上海市教學名師,2009

● ● 郭曉奎（負責人）病原生物學教學團隊，上海市教育系統先進集體，2009。

● ● 郭曉奎（負責人）病原生物學教學團隊，上海市文明班組，2009。

● ● 郭曉奎，徐大剛，趙蔚，吳健樺，張湘燕。病原生物學課程與教學模式的創新發展與實踐，上海市教學成果三等獎，上海市政府，2009。

● ● 郭曉奎，徐大剛，趙蔚，吳健樺，張湘燕。病原生物學教育教學體系的建立與完善，校教學成果特等獎，上海交通大學，2008。

● ● 郭曉奎優秀教師，上海交通大學醫學院，2008

● ● 郭曉奎（負責人）病原生物學，雙語示範課程，上海市教委，2008

● ● 郭曉奎寶鋼基金會優秀教師獎，2007

● ● 郭曉奎（病原生物學教學團隊負責人），優秀教學團隊，上海交通大學，2007

● ● 郭曉奎（負責人）雙語示範課程《病原生物學》，上海交通大學醫學院，2006

● ● 郭曉奎（負責人）國家精品共享課程《醫學微生物學》，2005

● ● 郭曉奎（負責人）醫學微生物資料庫及其共享體系的建立，上海市教委，2005

● ● 郭曉奎校長獎，上海第二醫科大學，2004

● ● 郭曉奎優秀青年教師，上海交通大學基礎醫學院，2004

● ● 2004年鉤端螺旋體全基因組測序和部分功能的研究獲上海市科技進步獎二等獎。

● ● 1999年肺炎克雷伯桿菌的分子生物學研究及在院內感染監控中的應用獲黑龍江省醫藥衛生科學技術進步一等獎和1999年獲黑龍江省科學技術進步三等獎。

● ● 1997年克隆識別技術研究及其應用獲獲黑龍江省教育委員會科學技術進步一等獎和1997年獲黑龍江省科學技術進步三等獎。

● ● 1997年住院患者肺炎桿菌感染的分子流行病學研究獲黑龍江省教育委員會科學技術進步一等獎。

● ● 郭曉奎霍英東教育基金會青年教師獎，1996

● ● 1995年淋病的病原學鑒別診斷的研究獲哈爾濱市科學技術進步三等獎。

● ● 1994年柯薩奇病毒性心肌炎診斷的研究獲黑龍江省醫藥衛生科學技術進步一等獎。

● ● 1994年淋球菌基因探針的製備及哈市淋球分子流行病學研究獲黑龍江省科學技術進步二等獎。

● ● 1993年綠膿桿菌質粒圖譜血清型和耐葯譜的研究獲黑龍江省科學技術進步三等獎。

● ● 程志，張鳳民，郭曉奎，凌虹，牛美娟。改革實驗教學、加強學生能力培養，黑龍江省優秀教學成果二等獎，1993

● ● Feng T, Leptihn S, Dong K, Loh B, Zhang Y, Stefan M, Li M, Guo X* and CuiZ*: JD419, a Staphylococcus aureus Phage With a Unique Morphology and Broad Host Range. Frontiers in microbiology 2021, https://doi.org/10.3389/fmicb .2021.602902.

● ● Wu N, Dai J, Guo M, Li J, Zhou X, Li F, Gao Y, Qu H, Lu H, Jin J, Li T, Shi L, Wu Q, Tan R, Zhu M, Yang L, Ling Y, Xing S, Zhang J, Yao B, Le S, Gu J, Qin J, Li J, Cheng M, Tan D, Li L, Zhang Y, Zhu Z, Cai J, Song Z, Guo X, Chen LK*, Zhu T*: Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients. Emerging microbes & infections 2021, 10:612-8.

● ● Li T, Lyu L, Zhang Y, Dong K, Li Q*, Guo X*, Zhu Y*: A newly isolated E. thailandicus strain d5B with exclusively antimicrobial activity against C. difficile might be a novel therapy for controlling CDI. Genomics 2021, 113:475-83.

● ● Chen Q, Ma X, Li C, Shen Y, Zhu W, Zhang Y, Guo X, Zhou J*, Liu C*: Enteric Phageome Alterations in Patients With Type 2 Diabetes. Frontiers in cellular and infection microbiology 2020, 10:575084.

● ● Wu C, Du X, Tang L, Wu J, Zhao W, Guo X, Liu D, Hu W, Helmby H, Chen G*, Wang Z*: Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE). Frontiers in immunology 2020, 11:1767.

● ● Tan D, Zhang Y, Qin J, Le S, Gu J, Chen LK, Guo X, Zhu T*: A Frame shift Mutation in wcaJ Associated with Phage Resistance in Klebsiella pneumoniae. Microorganisms 2020, 8.

● ● Qin J, Wu N, Bao J, Shi X, Ou H, Ye S, Zhao W, Wei Z, Cai J, Li L, Guo M, Weng J, Lu H, Tan D, Zhang J, Huang Q, Zhu Z, Shi Y, Hu C, Guo X*, Zhu T*: Heterogeneous Klebsiella pneumoniae Co-infections Complicate Personalized Bacteriophage Therapy. Frontiers in cellular and infection microbiology 2020, 10:608402.

● ● Li T, Zhang Y, Dong K, Kuo CJ, Li C, Zhu YQ, Qin J, Li QT, Chang YF*, Guo X*, Zhu Y*: Isolation and Characterization of the Novel Phage JD032 and Global Transcriptomic Response during JD032 Infection of Clostridioides difficile Ribotype 078. mSystems 2020, 5.

● ● Ji J, Liu Q, Wang R, Luo T, Guo X, Xu M, Yin Q, Wang X, Zhou M, Li M*, He P*: Identification of a novel phage targeting methicillin-resistant Staphylococcus aureus In vitro and In vivo. Microbial pathogenesis 2020, 149:104317.

● ● Bao J, Wu N, Zeng Y, Chen L, Li L, Yang L, Zhang Y, Guo M, Li L, Li J, Tan D, Cheng M, Gu J, Qin J, Liu J, Li S, Pan G, Jin X, Yao B, Guo X, Zhu T*, Le S: Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant Klebsiella pneumoniae. Emerging microbes & infections 2020, 9:771-4.

● ● Zhang C, Xu J, Zhang T, Qiu H, Li Z, Zhang E, Li S, Chang YF, Guo X, Jiang X*, Zhu Y*: Genetic characteristics of pathogenic Leptospira in wild small animals and livestock in Jiangxi Province, China, 2002-2015. PLoS neglected tropical diseases 2019, 13:e0007513.

● ● Tan D, Zhang Y, Cheng M, Le S, Gu J, Bao J, Qin J, Guo X, Zhu T*: Characterization of Klebsiella pneumoniae ST11 Isolates and Their Interactions with Lytic Phages. Viruses 2019, 11.

● ● Sun Y, Chen Q, Lin P, Xu R, He D, Ji W, Bian Y, Shen Y, Li Q, Liu C, Dong K, Tang YW, Pei Z, Yang L, Lu H, Guo X*, Xiao L*: Characteristics of Gut Microbiota in Patients With Rheumatoid Arthritis in Shanghai, China. Frontiers in cellular and infection microbiology 2019, 9:369.

● ● Li XM, Kang YX, Lin L, Jia EH, Piao DR, Jiang H, Zhang CC, He J, Chang YF*, Guo XK*, Zhu Y*: Genomic Characterization Provides New Insights for Detailed Phage- Resistant Mechanism for Brucella abortus. Frontiers in microbiology 2019, 10:917.

● ● Du X, Zhang Y, Li X, Li Q, Wu C, Chen G, Guo X, Weng Y*, Wang Z*: PRL2 serves as a negative regulator in cell adaptation to oxidative stress. Cell & bioscience 2019, 9:96.

● ● Cui Z, Guo X, Feng T, Li L*: Exploring the whole standard operating procedure for phage therapy in clinical practice. Journal of translational medicine 2019, 17:373.

● ● Zhu L, Luo F, Hu W, Han Y, Wang Y, Zheng H, Guo X*, Qin J*: Bacterial Communities in the Womb During Healthy Pregnancy. Frontiers in microbiology 2018, 9:2163.

● ● Yin C, Wu C, Du X, Fang Y, Pu J, Wu J, Tang L, Zhao W, Weng Y, Guo X, Chen G*, Wang Z*: PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS. Frontiers in immunology 2018, 9:2609.

● ● Wei Y, Yang F, Wu Q, Gao J, Liu W, Liu C, Guo X, Suwal S, Kou Y, Zhang B, Wang Y, Zheng K*, Tang R*: Protective Effects of Bifidobacterial Strains Against Toxigenic Clostridium difficile. Frontiers in microbiology 2018, 9:888.

● ● Wang J, Teng Z, Cui X, Li C, Pan H, Zheng Y, Mao S, Yang Y, Wu L, Guo X, Zhang X, Zhu Y: Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012-2016. Emerging microbes & infections 2018, 7:8.

● ● Wang J, Teng Z, Chu W, Fang F, Cui X, Guo X, Zhang X*, Thorley BR*, Zhu Y*: The emergence and spread of one Coxsackievirus A16 Genogroup D novel recombinant strain that caused a clustering HFMD outbreak in Shanghai, China, 2016. Emerging microbes & infections 2018, 7:131.

● ● Ding B, Li Q, Guo M, Dong K, Zhang Y, Guo X, Liu Q, Li L*, Cui Z*: Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice. Frontiers in microbiology 2018, 9:1553.

● ● Zhou K, Xie L, Han L, Guo X, Wang Y*, Sun J*: ICESag37, a Novel Integrative and Conjugative Element Carrying Antimicrobial Resistance Genes and Potential Virulence Factors in Streptococcus agalactiae. Frontiers in microbiology 2017, 8:1921.

● ● Zhang F, Wang X, Xie L, Zheng Q, Guo X, Han L, Sun J*: A novel transposon, Tn6306, mediates the spread of blaIMI in Enterobacteriaceae in hospitals. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2017, 65:22-6.

● ● Zeng L, Wang D, Hu N, Zhu Q, Chen K, Dong K, Zhang Y, Yao Y*, Guo X*, Chang YF*, Zhu Y*: A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens against leptospirosis. Frontiers in microbiology 2017, 8:396.

● ● Xie L, Dou Y, Zhou K, Chen Y, Han L, Guo X, Sun J*: Coexistence of blaOXA-48 and Truncated blaNDM-1 on Different Plasmids in a Klebsiella pneumoniae Isolate in China. Frontiers in microbiology 2017, 8:133.

● ● Xiao SZ, Wang S, Wu WM, Zhao SY, Gu FF, Ni YX, Guo XK, Qu JM*, Han LZ*: The Resistance Phenotype and Molecular Epidemiology of Klebsiella pneumoniae in Bloodstream Infections in Shanghai, China, 2012-2015. Frontiers in microbiology 2017, 8:250.

● ● Xia B, Sun L, Fan X, Xiao H, Zhu Y, Qin J, Cai C, Zhao W, Chang YF, Zhang Y*, Guo X*, He P*: A new model of self-resolving leptospirosis in mice infected with a strain of Leptospira interrogans serovar Autumnalis harboring LPS signaling only through TLR4. Emerging microbes & infections 2017, 6:e36.

● ● Wang S, Xiao SZ, Gu FF, Tang J, Guo XK, Ni YX, Qu JM*, Han LZ*: Antimicrobial susceptibility and molecular epidemiology of clinical Enterobacter cloacae bloodstream isolates in Shanghai, China. PloS one 2017, 12:e0189713.

● ● Song Z, Gu FF, Guo XK, Ni YX, He P*, Han LZ*: Antimicrobial Resistance and Molecular Characterization of Staphylococcus aureus Causing Childhood Pneumonia in Shanghai. Frontiers in microbiology 2017, 8:455.

● ● Lin P, Ding B, Feng C, Yin S, Zhang T, Qi X, Lv H, Guo X, Dong K, Zhu Y, Li Q*: Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder. Journal of affective disorders 2017, 207:300-4.

● ● Hua Y, Luo T, Yang Y, Dong D, Wang R, Wang Y, Xu M, Guo X, Hu F*, He P*: Phage Therapy as a Promising New Treatment for Lung Infection Caused by Carbapenem-Resistant Acinetobacter baumannii in Mice. Frontiers in microbiology 2017, 8:2659.

● ● Guo M, Feng C, Ren J, Zhuang X, Zhang Y, Zhu Y, Dong K, He P, Guo X*, Qin J*: A Novel Antimicrobial Endolysin, LysPA26, against Pseudomonas aeruginosa. Frontiers in microbiology 2017, 8:293.

● ● Cui Z, Guo X, Dong K, Zhang Y, Li Q, Zhu Y, Zeng L, Tang R, Li L*: Safety assessment of Staphylococcus phages of the family Myoviridae based on complete genome sequences. Scientific reports 2017, 7:41259.

● ● Cui Z*, Feng T, Gu F, Li Q, Dong K, Zhang Y, Zhu Y, Han L, Qin J, Guo X*: Characterization and complete genome of the virulent Myoviridae phage JD007 active against a variety of Staphylococcus aureus isolates from different hospitals in Shanghai, China. Virology journal 2017, 14:26.

● ● Chen Q, Ren Y, Lu J, Bartlett M, Chen L, Zhang Y, Guo X, Liu C*: A Novel Prebiotic Blend Product Prevents Irritable Bowel Syndrome in Mice by Improving Gut Microbiota and Modulating Immune Response. Nutrients 2017, 9.

● ● Zhao SY, Zhang J, Zhang YL, Wang YC, Xiao SZ, Gu FF, Guo XK, Ni YX, Han LZ*: Epidemiology and risk factors for faecal extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) carriage derived from residents of seven nursing homes in western Shanghai, China. Epidemiology and infection 2016, 144:695-702.

● ● Zhang Q, Wan H, Huang S, Zhang Y, Wang Y, Guo X, He P*, Zhou M: Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease. The clinical respiratory journal 2016, 10:22-31.

● ● Zhang F, Xie L, Wang X, Han L, Guo X, Ni Y, Qu H*, Sun J*: Further Spread of bla NDM-5 in Enterobacteriaceae via IncX3 Plasmids in Shanghai, China. Frontiers in microbiology 2016, 7:424.

● ● Xu Y*, Zhu Y*, Wang Y*, Chang YF, Zhang Y, Jiang X, Zhuang X, Zhu Y, Zhang J, Zeng L, Yang M, Li S, Wang S, Ye Q, Xin X, Zhao G, Zheng H, Guo X, Wang J: Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira. Scientific reports 2016, 6:20020.

● ● Xie L, Wu J, Zhang F, Han L, Guo X, Ni Y, Sun J*: Molecular Epidemiology and Genetic Characteristics of Various blaPER Genes in Shanghai, China. Antimicrobial agents and chemotherapy 2016, 60:3849-53.

● ● Wei Y, Ye L, Li Y, Yang F, Liu D, Guo X, Tang R*, Liu C*: Functional characterization of RelBE toxin-antitoxin system in probiotic Bifidobacterium longum JDM301. Acta biochimica et biophysica Sinica 2016, 48:741-9.

● ● Wang Y, Li R, Zhou Y, Ling Z, Guo X, Xie L, Liu L*: Motif-Based Text Mining of Microbial Metagenome Redundancy Profiling Data for Disease Classification. BioMed research international 2016, 2016:6598307.

● ● Wang Y, Ding X, Chen Y, Guo M, Zhang Y, Guo X*, Gu H*: Antibiotic-loaded, silver core-embedded mesoporous silica nanovehicles as a synergistic antibacterial agent for the treatment of drug-resistant infections. Biomaterials 2016, 101:207-16.

● ● Wang S, Zhao SY, Xiao SZ, Gu FF, Liu QZ, Tang J, Guo XK, Ni YX, Han LZ*: Antimicrobial Resistance and Molecular Epidemiology of Escherichia coli Causing Bloodstream Infections in Three Hospitals in Shanghai, China. PloS one 2016, 11:e0147740.

● ● Shi SF, Jia JF, Guo XK, Zhao YP, Chen DS, Guo YY, Zhang XL*: Reduced Staphylococcus aureus biofilm formation in the presence of chitosan-coated iron oxide nanoparticles. International journal of nanomedicine 2016, 11:6499-506.

● ● Gu FF, Zhang J, Zhao SY, Yang ZR, Zhang YL, Xiao SZ, Wang S, Guo XK, Qu JM, Ni YX, Han LZ*: Risk factors for methicillin-resistant Staphylococcus aureus carriage among residents in 7 nursing homes in Shanghai, China. American journal of infection control 2016, 44:805-8.

● ● Gu FF, Chen Y, Dong DP, Song Z, Guo XK, Ni YX, Han LZ*: Molecular Epidemiology of Staphylococcus aureus among Patients with Skin and Soft Tissue Infections in Two Chinese Hospitals. Chinese medical journal 2016, 129:2319-24.

● ● Zhu W, Wang J, Zhu Y, Tang B, Zhang Y, He P, Zhang Y, Liu B, Guo X*, Zhao G*, Qin J*: Identification of three extra-chromosomal replicons in Leptospira pathogenic strain and development of new shuttle vectors. BMC genomics 2015, 16:90.

● ● Zhou Y, Lin F, Cui Z, Zhang X, Hu C, Shen T, Chen C, Zhang X*, Guo X*: Correlation between Either Cupriavidus or Porphyromonas and Primary Pulmonary Tuberculosis Found by Analysing the Microbiota in Patients' Bronchoalveolar Lavage Fluid. PloS one 2015, 10:e0124194.

● ● Zhao SY, Wang YC, Xiao SZ, Jiang XF, Guo XK, Ni YX, Han LZ*: Drug susceptibility and molecular epidemiology of Escherichia coli in bloodstream infections in Shanghai, China, 2011-2013. Infectious diseases 2015, 47:310-8.

● ● Zhang Y, Sun J, Mi C, Li W, Zhao S, Wang Q, Shi D, Liu L, Ding B, Chang YF, Guo H*, Guo X, Li Q*, Zhu Y*: First report of two rapid-onset fatal infections caused by a newly emerging hypervirulent K. Pneumonia ST86 strain of serotype K2 in China. Frontiers in microbiology 2015, 6:721.

● ● Zhang J, Gu FF, Zhao SY, Xiao SZ, Wang YC, Guo XK, Ni YX, Han LZ*: Prevalence and Molecular Epidemiology of Staphylococcus aureus among Residents of Seven Nursing Homes in Shanghai. PloS one 2015, 10:e0137593.

● ● Zhang C, Yang H, Li X, Cao Z, Zhou H, Zeng L, Xu J, Xu Y, Chang YF, Guo X*, Zhu Y*, Jiang X*: Molecular Typing of Pathogenic Leptospira Serogroup Icterohaemorrhagiae Strains Circulating in China during the Past 50 Years. PLoS neglected tropical diseases 2015, 9:e0003762.

● ● Zeng LB, Zhuang XR, Huang LL, Zhang YY, Chen CY, Dong K, Zhang Y, Cui ZL, Ding XL, Chang YF*, Guo XK*, Zhu YZ*: Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants. Journal of proteomics 2015, 112:27-37.

● ● Wei YX, Ye L, Liu DB, Zhang ZY, Liu C*, Guo XK*: Activation of the chromosomally encoded mazEF(Bif) locus of Bifidobacterium longum under acid stress. International journal of food microbiology 2015, 207:16-22.

● ● Wang Y, Zhuang X, Zhong Y, Zhang C, Zhang Y, Zeng L, Zhu Y, He P, Dong K, Pal U*, Guo X*, Qin J*: Distribution of Plasmids in Distinct Leptospira Pathogenic Species. PLoS neglected tropical diseases 2015, 9:e0004220.

● ● Wang XF, Tian F, Cao RM, Li J, Wu SM, Guo XK*, Chen TX*: Antimicrobial activity of human beta-defensins against lactic acid bacteria. Natural product research 2015, 29:2164-6.

● ● Scaria J, Suzuki H, Ptak CP, Chen JW, Zhu Y, Guo XK, Chang YF: Comparative genomic and phenomic analysis of Clostridium difficile and Clostridium sordellii, two related pathogens with differing host tissue preference. BMC genomics 2015, 16:448.

● ● Kang YX, Li XM, Piao DR, Tian GZ, Jiang H, Jia EH, Lin L, Cui BY*, Chang YF*, Guo XK*, Zhu YZ*: Typing Discrepancy Between Phenotypic and Molecular Characterization Revealing an Emerging Biovar 9 Variant of Smooth Phage-Resistant B. abortus Strain 8416 in China. Frontiers in microbiology 2015, 6:1375.

● ● Gu FF, Hou Q, Yang HH, Zhu YQ, Guo XK, Ni YX, Han LZ*: Characterization of Staphylococcus aureus Isolated from Non-Native Patients with Skin and Soft Tissue Infections in Shanghai. PloS one 2015, 10:e0123557.

● ● Fang Y, Wu C, Chen Q, Wu J, Yang Y, Guo X, Chen G*, Wang Z*: SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development. Acta tropica 2015, 149:49-58.

● ● Fan J, Zhang Y, Xiong H, Wang Y, Guo X*: Nucleotide analogue-resistant mutations in hepatitis B viral genomes found in hepatitis B patients. The Journal of general virology 2015, 96:663-70.

● ● Zhu WN, Huang LL, Zeng LB, Zhuang XR, Chen CY, Wang YZ, Qin JH, Zhu YZ, Guo XK*: Isolation and characterization of two novel plasmids from pathogenic Leptospira interrogans serogroup Canicola Serovar Canicola strain Gui44. PLoS neglected tropical diseases 2014, 8:e3103.

● ● Zhao JW, Sun ZQ, Zhang XY, Zhang Y, Liu J, Ye J, Chen CC, Samten B, Wang HH, Guo XK*, Zhang SL*: Mycobacterial 3-hydroxyacyl-l-thioester dehydratase Y derived from Mycobacterium tuberculosis induces COX-2 expression in mouse macrophages through MAPK-NF-kappaB pathway. Immunology letters 2014, 161:125-32.

● ● Yuan L, Cui Z, Wang Y, Guo X*, Zhao Y*: Complete genome sequence of virulent bacteriophage SHOU24, which infects foodborne pathogenic Vibrio parahaemolyticus. Archives of virology 2014, 159:3089-93.

● ● Yu XL, Wen ZL, Chen GZ, Li R, Ding BB, Yao YF, Li Y, Wu H, Guo XK, Wang HH, Zhang SL*: Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated from south-central in China. The Journal of antibiotics 2014, 67:291-7.

● ● Wu J, Lin K, Zeng J, Liu W, Yang F, Wang X, Xiao Y, Guo X, Nie H, Zhou T, Xu C*: Role of DC-SIGN in Helicobacter pylori infection of gastrointestinal cells. Frontiers in bioscience 2014, 19:825-34.

● ● Wu J, Lin K, Zeng J, Liu W, Yang F, Wang X, Xiao Y, Guo X, Nie H, Zhou T, Xu C*: Role of DC-SIGN in Helicobacter pylori infection of gastrointestinal cells. Frontiers in bioscience 2014, 19:825-34.

● ● Wu C, Chen Q, Fang Y, Wu J, Han Y, Wang Y, Yang Y, Chu M, Feng Y, Tan L, Guo X, Hu W, Wang Z*: Schistosoma japonicum egg specific protein SjE16.7 recruits neutrophils and induces inflammatory hepatic granuloma initiation. PLoS neglected tropical diseases 2014, 8:e2703.

● ● Wang YL, Qin JH, Zhang CC, Guo XK, Jiang XG*, He P*: An outbreak of leptospirosis in Lezhi County, China in 2010 may possibly be linked to rainfall. Biomedical and environmental sciences : BES 2014, 27:56-9.

● ● Wang Y, Zhao S, Han L, Guo X, Chen M, Ni Y, Zhang Y, Cui Z, He P*: Drug resistance and virulence of uropathogenic Escherichia coli from Shanghai, China. The Journal of antibiotics 2014, 67:799-805.

● ● Liu B*, Wang Y*, Guo X*, Zhu W*, Zhang Y*, He P*: Carboxyfluorescein diacetate succinimidyl ester labeling method to study the interaction between Leptospira and macrophages. Journal of microbiological methods 2014, 107:205-13.

● ● Huang L, Zhu W, He P, Zhang Y, Zhuang X, Zhao G, Guo X, Qin J*, Zhu Y*: Re-characterization of an extrachromosomal circular plasmid in the pathogenic Leptospira interrogans serovar Lai strain 56601. Acta biochimica et biophysica Sinica 2014, 46:605-11.

● ● Fan J, Wang Y, Xiong H, Guo X*, Cheng YC*: Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility. The Journal of general virology 2014, 95:2523-30.

● ● Zhao J, Sun Z, Pei H, Ye J, Chen C, Samten B, Zhang S*, Guo X*: Immunological evaluation of a novel Mycobacterium tuberculosis antigen, Rv3117, absent in Mycobacterium bovis BCG. Molecular medicine reports 2013, 8:1587-93.

● ● Zhang ZY*, Sun ZQ, Wang ZL, Hu HR, Wen ZL, Song YZ, Zhao JW, Wang HH, Guo XK, Zhang SL: Identification and pathogenicity analysis of a novel non-tuberculous mycobacterium clinical isolate with nine-antibiotic resistance. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2013, 19:91-6.

● ● Zhang Y, Dong K, Zeng L, Li Q, Liu C, Wang J, Guo X*, Zhao GP*: Genetic and molecular biological characterization of two homologous cheR genes from Leptospira interrogans. Acta biochimica et biophysica Sinica 2013, 45:806-16.

● ● Zeng L, Zhang Y, Zhu Y, Yin H, Zhuang X, Zhu W, Guo X*, Qin J*: Extracellular proteome analysis of Leptospira interrogans serovar Lai. Omics : a journal of integrative biology 2013, 17:527-35.

● ● Kang Y, Jia E, Lin L, Duan X, Xiao P, Peng J, Gao W, Zhang C, Guo X*, Cui B*, Li X*: Simultaneous emergence of several biotypes of Brucella among Baotou's brucellosis patients by combined diagnostic strategy. Acta biochimica et biophysica Sinica 2013, 45:893-5.

● ● He P, Deng C, Liu B, Zeng L, Zhao W, Zhang Y, Jiang X, Guo X, Qin J*: Characterization of a bifunctional enzyme with (p)ppGpp-hydrolase/synthase activity in Leptospira interrogans. FEMS microbiology letters 2013, 348:133-42.

● ● Gong L, Han Y, Chen L, Liu F, Hao P, Sheng J, Li XH, Yu DM, Gong QM, Tian F, Guo XK, Zhang XX*: Comparison of next-generation sequencing and clone-based sequencing in analysis of hepatitis B virus reverse transcriptase quasispecies heterogeneity. Journal of clinical microbiology 2013, 51:4087-94.

● ● Chen C, Shen T, Tian F, Lin P, Li Q, Cui Z, Zhang Y, Xue M, Ye J, Guo X, Zhou Y*: New microbiota found in sputum from patients with community-acquired pneumonia. Acta biochimica et biophysica Sinica 2013, 45:1039-48.

● ● Zhou Y, Tao J, Yu H, Ni J, Zeng L, Teng Q, Kim KS, Zhao GP, Guo X*, Yao Y*: Hcp family proteins secreted via the type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Infection and immunity 2012, 80:1243-51.

● ● Zheng LL, Li YX, Ding J, Guo XK, Feng KY, Wang YJ, Hu LL, Cai YD*, Hao P*, Chou KC: A comparison of computational methods for identifying virulence factors. PloS one 2012, 7:e42517.

● ● Zhang ZY, Liu C, Zhu YZ, Wei YX, Tian F, Zhao GP, Guo XK*: Safety assessment of Lactobacillus plantarum JDM1 based on the complete genome. International journal of food microbiology 2012, 153:166-70.

● ● Zhang Y, Lou XL, Yang HL, Guo XK, Zhang XY, He P*, Jiang XC*: Establishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route. BMC infectious diseases 2012, 12:20.

● ● Zhang MM, Zhao JW, Sun ZQ, Liu J, Guo XK, Liu WD*, Zhang SL*: Identification of RD5-encoded Mycobacterium tuberculosis proteins as B-cell antigens used for serodiagnosis of tuberculosis. Clinical & developmental immunology 2012, 2012:738043.

● ● Wei YX, Zhang ZY, Liu C, Malakar PK, Guo XK*: Safety assessment of Bifidobacterium longum JDM301 based on complete genome sequences. World journal of gastroenterology 2012, 18:479-88.

● ● Wang Y, Zhou Y, Li Y, Ling Z, Zhu Y, Guo X*, Sun H*: An improved dimensionality reduction method for meta-transcriptome indexing based diseases classification. BMC systems biology 2012, 6 Suppl 3:S12.

● ● Shi SF, Jia JF, Guo XK, Zhao YP, Chen DS, Guo YY, Cheng T, Zhang XL*: Biocompatibility of chitosan-coated iron oxide nanoparticles with osteoblast cells. International journal of nanomedicine 2012, 7:5593-602.

● ● Peng N, Zhong Y, Zhang Q, Zheng M, Zhao W, Jiang H, Yang C, Guo X, Zhao G*: Characterization of acetyl-CoA and propionyl-CoA carboxylases encoded by Leptospira interrogans serovar Lai: an initial biochemical study for leptospiral gluconeogenesis via anaplerotic CO(2) assimilation. Acta biochimica et biophysica Sinica 2012, 44:692-702.

● ● Li Q, Huang J, Guo H, Guo X, Zhu Y*, Dong K*: Bactericidal activity against meticillin-resistant Staphylococcus aureus of a novel eukaryotic therapeutic recombinant antimicrobial peptide. International journal of antimicrobial agents 2012, 39:496-9.

● ● Cui Z, Zhou Y, Li H, Zhang Y, Zhang S, Tang S*, Guo X*: Complex sputum microbial composition in patients with pulmonary tuberculosis. BMC microbiology 2012, 12:276.

● ● Cui Z, Song Z, Wang Y, Zeng L, Shen W, Wang Z, Li Q, He P, Qin J*, Guo X*: Complete genome sequence of wide-host-range Staphylococcus aureus phage JD007. Journal of virology 2012, 86:13880-1.

● ● Cui Z, Shen W, Wang Z, Zhang H, Me R, Wang Y, Zeng L, Zhu Y, Qin J, He P*, Guo X*: Complete genome sequence of Klebsiella pneumoniae phage JD001. Journal of virology 2012, 86:13843.

● ● Zhong Y*, Chang X*, Cao XJ*, Zhang Y, Zheng H, Zhu Y, Cai C, Cui Z, Zhang Y, Li YY, Jiang XG, Zhao GP, Wang S*, Li Y*, Zeng R*, Li X*, Guo XK*: Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601. Cell research 2011, 21:1210-29.

● ● Zhang ZY, Sun ZQ, Wang ZL, Wen ZL, Sun QW, Zhu ZQ, Song YZ, Zhao JW, Wang HH, Zhang SL*, Guo XK*: Complete genome sequence of a novel clinical isolate, the nontuberculous Mycobacterium strain JDM601. Journal of bacteriology 2011, 193:4300-1.

● ● Zhang SM*, Tian F*, Huang QF, Zhao YF, Guo XK, Zhang FQ: Bacterial diversity of subgingival plaque in 6 healthy Chinese individuals. Experimental and therapeutic medicine 2011, 2:1023-9.

● ● Zhang SM*, Tian F*, Huang QF, Zhao YF, Guo XK, Zhang FQ: Bacterial diversity of subgingival plaque in 6 healthy Chinese individuals. Experimental and therapeutic medicine 2011, 2:1023-9.

● ● Zhang Q, Zhang Y, Zhong Y, Ma J, Peng N, Cao X, Yang C, Zeng R, Guo X, Zhao G*: Leptospira interrogans encodes an ROK family glucokinase involved in a cryptic glucose utilization pathway. Acta biochimica et biophysica Sinica 2011, 43:618-29.

● ● Yalin W, Lingbing Z, Hongliang Y, Jianmin X, Xiangyan Z, Xiaokui G, Utpal P, Jinhong Q*: High prevalence of pathogenic Leptospira in wild and domesticated animals in an endemic area of China. Asian Pacific journal of tropical medicine 2011, 4:841-5.

● ● Ning RD, Zhang XL*, Li QT, Guo XK: The effect of Staphylococcus aureus on apoptosis of cultured human osteoblasts. Orthopaedic surgery 2011, 3:199-204.

● ● Ning R, Zhang X*, Guo X, Li Q: Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2011, 15:189-94.

● ● Cheng Z, Zhao JW, Sun ZQ, Song YZ, Sun QW, Zhang XY, Zhang XL, Wang HH, Guo XK, Liu YF*, Zhang SL*: Evaluation of a novel fusion protein antigen for rapid serodiagnosis of tuberculosis. Journal of clinical laboratory analysis 2011, 25:344-9.

● ● Zhu YZ, Cai CS, Zhang W, Guo HX, Zhang JP, Ji YY, Ma GY, Wu JL, Li QT, Lu CP, Guo XK*: Immunoproteomic analysis of human serological antibody responses to vaccination with whole-cell pertussis vaccine (WCV). PloS one 2010, 5:e13915.

● ● Zhou Y, Lin P, Li Q, Han L, Zheng H, Wei Y, Cui Z, Ni Y, Guo X*: Analysis of the microbiota of sputum samples from patients with lower respiratory tract infections. Acta biochimica et biophysica Sinica 2010, 42:754-61.

● ● Yang J, Xu J, Chen X, Zhang Y, Jiang X, Guo X, Zhao G*: Decrease of plasma platelet-activating factor acetylhydrolase activity in lipopolysaccharide induced mongolian gerbil sepsis model. PloS one 2010, 5:e9190.

● ● Wu CY*, Feng Y*, Qian GC, Wu JH*, Luo J, Wang Y, Chen GJ, Guo XK*, Wang ZJ*: alpha-Galactosylceramide protects mice from lethal Coxsackievirus B3 infection and subsequent myocarditis. Clinical and experimental immunology 2010, 162:178-87.

● ● Wei YX, Zhang ZY, Liu C, Zhu YZ, Zhu YQ, Zheng H, Zhao GP, Wang S, Guo XK*: Complete genome sequence of Bifidobacterium longum JDM301. Journal of bacteriology 2010, 192:4076-7.

● ● Ning R, Zhang X*, Guo X, Li Q: Attachment of Staphylococcus aureus is required for activation of nuclear factor kappa B in human osteoblasts. Acta biochimica et biophysica Sinica 2010, 42:883-92.

● ● Liu C, Zhang ZY, Dong K, Guo XK*: Adhesion and immunomodulatory effects of Bifidobacterium lactis HN019 on intestinal epithelial cells INT-407. World journal of gastroenterology 2010, 16:2283-90.

● ● Dong K, Li Q, Liu C, Zhang Y, Zhao G, Guo X*: Cloning and characterization of three cheB genes in Leptospira interrogans. Acta biochimica et biophysica Sinica 2010, 42:216-23.

● ● Cao XJ, Dai J, Xu H, Nie S, Chang X, Hu BY, Sheng QH, Wang LS, Ning ZB, Li YX, Guo XK, Zhao GP*, Zeng R*: High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans. Cell research 2010, 20:197-210.

● ● Cai CS, Zhu YZ, Zhong Y, Xin XF, Jiang XG, Lou XL, He P, Qin JH, Zhao GP, Wang SY*, Guo XK*: Development of O-antigen gene cluster-specific PCRs for rapid typing six epidemic serogroups of Leptospira in China. BMC microbiology 2010, 10:67.

● ● Zhao W, Chen CY, Zhang XY, Lai WQ, Hu BY, Zhao GP, Qin JH*, Guo XK*: Molecular characterization of the pL40 protein in Leptospira interrogans. Canadian journal of microbiology 2009, 55:739-49.

● ● Zhang ZY, Liu C, Zhu YZ, Zhong Y, Zhu YQ, Zheng HJ, Zhao GP, Wang SY, Guo XK*: Complete genome sequence of Lactobacillus plantarum JDM1. Journal of bacteriology 2009, 191:5020-1.

● ● Zhang SM*, Tian F, Jiang XQ*, Li J*, Xu C*, Guo XK, Zhang FQ*: Evidence for calcifying nanoparticles in gingival crevicular fluid and dental calculus in periodontitis. Journal of periodontology 2009, 80:1462-70.

● ● Yuan J*, Li P, Tao J, Shi X, Hu B, Chen H, Guo X*: H. pylori escape host immunoreaction through inhibiting ILK expression by VacA. Cellular & molecular immunology 2009, 6:191-7.

● ● Yao Y, Xie Y, Perace D, Zhong Y, Lu J, Tao J, Guo X, Kim KS*: The type III secretion system is involved in the invasion and intracellular survival of Escherichia coli K1 in human brain microvascular endothelial cells. FEMS microbiology letters 2009, 300:18-24.

● ● Yang R*, Guo X, Yang J, Jiang Y, Pang B, Chen C, Yao Y, Qin J, Li Q: Genomic research for important pathogenic bacteria in China. Science in China Series C, Life sciences 2009, 52:50-63.

● ● Yang J, Zhang Y, Xu J, Geng Y, Chen X, Yang H, Wang S, Wang H, Jiang X, Guo X, Zhao G*: Serum activity of platelet-activating factor acetylhydrolase is a potential clinical marker for leptospirosis pulmonary hemorrhage. PloS one 2009, 4:e4181.

● ● Lu Q, Yu DH, Fang C, Liu F, Ye X, Zhao Y, Qin J, Guo XK, Liang M, Hu F, Chen HZ*: Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells. Cancer biology & therapy 2009, 8:1125-32.

● ● Liu C, Zhang ZY, Dong K, Yuan JP, Guo XK*: Antibiotic resistance of probiotic strains of lactic acid bacteria isolated from marketed foods and drugs. Biomedical and environmental sciences : BES 2009, 22:401-12.

● ● Feng CY, Li QT*, Zhang XY, Dong K, Hu BY, Guo XK: Immune strategies using single-component LipL32 and multi-component recombinant LipL32-41-OmpL1 vaccines against leptospira. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2009, 42:796-803.

● ● Zhu YZ*, Li QT*, Wang L, Zhong Y, Ding GH, Li G, Jia PL, Shi TL, Guo XK: Gene expression profiling-based in silico approach to identify potential vaccine candidates and drug targets against B. pertussis and B. parapertussis. Omics : a journal of integrative biology 2008, 12:161-9.

● ● Zhang YX, Geng Y, Yang JW, Guo XK, Zhao GP*: Cytotoxic activity and probable apoptotic effect of Sph2, a sphigomyelinase hemolysin from Leptospira interrogans strain Lai. BMB reports 2008, 41:119-25.

● ● Qin JH, Zhang Q, Zhang ZM, Zhong Y, Yang Y, Hu BY, Zhao GP*, Guo XK*: Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar Lai. Infection and immunity 2008, 76:2411-9.

● ● Zou Y, Guo X, Picardeau M, Xu H, Zhao G*: A comprehensive survey on isoleucine biosynthesis pathways in seven epidemic Leptospira interrogans reference strains of China. FEMS microbiology letters 2007, 269:90-6.

● ● He P, Sheng YY, Shi YZ, Jiang XG, Qin JH, Zhang ZM, Zhao GP*, Guo XK*: Genetic diversity among major endemic strains of Leptospira interrogans in China. BMC genomics 2007, 8:204.

● ● Yang HL, Zhu YZ, Qin JH, He P, Jiang XC, Zhao GP*, Guo XK*: In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans. BMC genomics 2006, 7:293.

● ● Yang HL, Jiang XC*, Zhang XY, Li WJ, Hu BY, Zhao GP, Guo XK*: Thrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation. BMC infectious diseases 2006, 6:19.

● ● Qin JH, Sheng YY, Zhang ZM, Shi YZ, He P, Hu BY, Yang Y, Liu SG, Zhao GP*, Guo XK*: Genome-wide transcriptional analysis of temperature shift in L. interrogans serovar lai strain 56601. BMC microbiology 2006, 6:51.

● ● Li ZH, Dong K, Yuan JP, Hu BY, Liu JX, Zhao GP*, Guo XK*: Characterization of the cheY genes from Leptospira interrogans and their effects on the behavior of Escherichia coli. Biochemical and biophysical research communications 2006, 345:858-66.

● ● Li ZH, Dong K, Sun JC, Yuan JP, Hu BY, Liu JX, Zhao GP*, Guo XK*: Characterization of cheW genes of Leptospira interrogans and their effects in Escherichia coli. Acta biochimica et biophysica Sinica 2006, 38:79-88.

● ● Li QT, Zhu YZ, Chu JY*, Dong K, He P, Feng CY, Hu BY, Zhang SM, Guo XK*: Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine. Acta pharmacologica Sinica 2006, 27:1487-94.

● ● Li Q, Zhu Y, Chu J, Wang Y, Xu Y, Hou Q, Zhang S, Guo X*: Protective immunity against Bordetella pertussis by a recombinant DNA vaccine and the effect of coinjection with a granulocyte-macrophage colony stimulating factor gene. Microbiology and immunology 2006, 50:929-36.

● ● Guo XK, Zhao WQ, Kondo C, Shimojo N, Yamashita K, Aoki T, Hayakawa T*: Tissue inhibitors of metalloproteinases-1 (TIMP-1) and -2(TIMP-2) are major serum factors that stimulate the TIMP-1 gene in human gingival fibroblasts. Biochimica et biophysica acta 2006, 1763:296-304.

● ● Zhang YX, Geng Y, Bi B, He JY, Wu CF, Guo XK, Zhao GP*: Identification and classification of all potential hemolysin encoding genes and their products from Leptospira interrogans serogroup Icterohae-morrhagiae serovar Lai. Acta pharmacologica Sinica 2005, 26:453-61.

● ● Zhang XY, Yu Y, He P, Zhang YX, Hu BY, Yang Y, Nie YX, Jiang XG, Zhao GP, Guo XK*: Expression and comparative analysis of genes encoding outer membrane proteins LipL21, LipL32 and OmpL1 in epidemic leptospires. Acta biochimica et biophysica Sinica 2005, 37:649-56.

● ● Wang HT, Li ZH, Yuan JP, Zhao W, Shi XD, Tong SQ, Guo XK*: Effect of Helicobacter pylori VacA on gene expression of gastric cancer cells. World journal of gastroenterology 2005, 11:109-13.

● ● Zhang YX, Li J, Guo XK, Wu C, Bi B, Ren SX, Wu CF, Zhao GP*: Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome. Cell research 2004, 14:208-16.

● ● Yuan JP, Li T, Li ZH, Yang GZ, Hu BY, Shi XD, Shi TL, Tong SQ, Guo XK*: mRNA expression profiling reveals a role of Helicobacter pylori vacuolating toxin in escaping host defense. World journal of gastroenterology 2004, 10:1528-32.

● ● Yuan JP, Li T, Chen HB, Li ZH, Yang GZ, Hu BY, Shi XD, Tong SQ, Li YX, Guo XK*: Analysis of gene expression profile in gastric cancer cells stimulated with Helicobacter pylori isogenic strains. Journal of medical microbiology 2004, 53:965-74.

● ● Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G*: Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway. Journal of bacteriology 2004, 186:5400-9.

● ● Li ZH, Nie BM, Chen H, Chen SY, He P, Lu Y, Guo XK, Liu JX*: In vitro anti-coxsackievirus B(3) effect of ethyl acetate extract of Tian-hua-fen. World journal of gastroenterology 2004, 10:2263-6.

● ● He P, Zhang XY, Guo XK*, Hu BY, Huang XT, Yang Y, Zhao GP*: Identification and analysis of genes present in Leptospira interrogans serovar lai but absent in L. biflexa serovar monvalerio. Acta biochimica et biophysica Sinica 2004, 36:832-9.

● ● Yuan JP, Zhao W, Wang HT, Wu KY, Li T, Guo XK*, Tong SQ: Coxsackievirus B3-induced apoptosis and caspase-3. Cell research 2003, 13:203-9.

● ● Yuan JP, Li T, Shi XD, Hu BY, Yang GZ, Tong SQ, Guo XK*: Deletion of Helicobacter pylori vacuolating cytotoxin gene by introduction of directed mutagenesis. World journal of gastroenterology 2003, 9:2251-7.

● ● Ren SX, Fu G, Jiang XG, Zeng R, Miao YG, Xu H, Zhang YX, Xiong H, Lu G, Lu LF, Jiang HQ, Jia J, Tu YF, Jiang JX, Gu WY, Zhang YQ, Cai Z, Sheng HH, Yin HF, Zhang Y, Zhu GF, Wan M, Huang HL, Qian Z, Wang SY, Ma W, Yao ZJ, Shen Y, Qiang BQ, Xia QC, Guo XK, Danchin A, Saint Girons I, Somerville RL, Wen YM, Shi MH, Chen Z, Xu JG, Zhao GP*: Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 2003, 422:888-93.

● ● Zhao WQ, Li H, Yamashita K, Guo XK, Hoshino T, Yoshida S, Shinya T, Hayakawa T*: Cell cycle-associated accumulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) in the nuclei of human gingival fibroblasts. Journal of cell science 1998, 111 ( Pt 9):1147-53.

● ● 主編《醫學微生物學》，人民衛生出版社，2021

● ● 主編《病原生物學，第3版》，科學出版社，2021

● ● 主編《醫學微生物學（英文改編版），第2版》，科學出版社，2021

● ● 主編《基礎醫學實驗示範教程》，人民衛生出版社，2020

● ● 主編《Medical Microbiology》，人民衛生出版社，2019

● ● 主編《醫學微生物學》，人民衛生出版社，2019

● ● 總主編《病原生物學實驗教程》，人民衛生出版社，2019

● ● 副主編《噬菌體學：從理論到應用》，科學出版社上海分社，2019

● ● 總主編《細胞與分子物學實驗教程》，人民衛生出版社，2018

● ● 總主編《醫學形態學實驗教程》，人民衛生出版社，2018

● ● 總主編《醫學功能學實驗教程》，人民衛生出版社，2018

● ● 總主編《醫用化學實驗教程》，人民衛生出版社，2018

● ● 副主編《醫學微生物學 第九版》，人民衛生出版社，2018

● ● 副主編《醫學微生物學學習指導與習題集》，人民衛生出版社，2018

● ● 主編《人體微生物組》，人民衛生出版社，2017

● ● 主編《醫學整合課程的實踐與研究》，上海交通大學出版社，2017

● ● 名譽主編《人體微生物組與健康》，上海科學普及出版社，2017

● ● 副主編《醫學微生物學》，全國高等教育醫學數字化規劃教材，2014

● ● 主編《病原生物學 第2版》，科學出版社，2013

● ● 主編《醫學微生物學》，人民衛生出版社，2013

● ● 主編《醫學微生物學實驗技術》，人民衛生出版社，2010

● ● 主審《病原生物學實驗》，上海交通大學醫學院，2009

● ● 主編《感染與優生優育》，第二軍醫大學出版社，2009

● ● 主編《醫學微生物學教育教學》，第二軍醫大學出版社，2008

● ● 主編《病原生物學綱要》，科學出版社，2008

● ● 主編《病原生物學 第1版》，科學出版社，2007

● ● 主編《細胞微生物學》，第二軍醫大學出版社，2004

● ● 主編《感染與優生優育》，黑龍江科技出版社，1996

● ● 主編《克隆識別》，北京協和大學出版社，1994

鉤端螺旋體兩個疫苗候選的外膜蛋白 ZL 2007 1 0042222.X

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