高榮

四川大學生命科學學院教授

高 榮 博士,四川大學生命科學學院教授,博士生導師 四川省學術和技術帶頭人。研究方向包括:分子遺傳和基因工程、分子免疫學、生物技術、微生物學和動物傳染病;主要開展動物表觀遺傳學、動物分子免疫、動物生長發育和代謝調節、新疫苗研製、免疫應答調節和新型抗感染免疫分子製劑的研究探索;已承擔主持歐盟國際合作項目、科技部國際合作專項、國家自然科學基金、國家863計劃、國家支撐計劃、重大基礎研究項目、教育部、四川省等20多項重點科研課題研究;已在國內外核心學術刊物發表科研論文90多篇,其中SCI、EI論文40多篇,部分成果已獲省級科技進步二等獎4項,省教委科技進步一等獎1項、二等獎1項;已獲得或申請技術發明專利共計17項;培養、指導碩士生、博士生和博士后32人。

學習工作


1981.09-1985.07:動物醫學本科畢業,學士;
1985.9-1988.6:免疫病理碩士研究生, 碩士;
1988.07-1991.07: 碩士,參加工作;助教、講師;
1991.09-1994.12: 講師;在職博士研究生,博士;
1995.01-1996.02:東北農業大學,副教授;
1996.03-至今:四川大學生命科學學院,副教授,教授;
2004.11:訪問美國Missouri University、Stanford University、Kansas University,California University in Los Angeles and San Francisco,California Institute of Technology、
2005-2006年:到澳大利亞Melbourne University、Victoria University、Monash University、美國Harvard University、Massachusetts Institute of Technology、Boston University、Washington University 、Maryland University訪問與學術交流;;
2007-2008年:丹麥Denmark Technical University訪問學者、到Copenhagen University、英國Cambridge University、Oxford University學術交流與合作研究;
2009.06-09:到比利時Veterinary and Agrochemical research Centre、德國Hannover University和新加坡國立大學訪問和學術交流;
2010年:到德國Leipzig University、法國的ONCFS研究所、美國 California University of Berkley、California University of San Diego、Chicago University、Massachusetts Institute of Technology訪問與學術交流;
2011.11:訪問西班牙Barcelona University 、Olot Pfizer company和瑞士IVI(Institute of Virology and Immunoprophylaxis)和學術交流;

主要研究


研究方向包括:分子遺傳和基因工程、分子免疫學、生物技術、微生物學和動物傳染病;主要開展動物表觀遺傳學、動物分子免疫、動物生長發育和代謝調節、新疫苗研製、免疫應答調節和新型抗感染免疫分子製劑的研究探索;
著重利用我國豐富的生物基因資源,克隆分離免疫抗感染、生長發育和代謝調控相關功能基因和分子,鑒定其功能活性;以現代分子生物學、遺傳學、分子免疫學、生物信息學和結構生物學等理論為指導,用生物工程技術修飾和改造生物分子結構,提高其生物調節活性;結合納米生物材料技術,研製協調增強動物免疫防禦、抗應激和促進動物生長發育和代謝調節的系列新型分子製劑;防治傳染性疾病,控制微生物感染,調節動物生長發育、保障和促進動物健康生長,並改善動物營養成分,提高其營養價值。

主要論文


Dong Li, Jian-Lin Chen, Huan Zhang,Xiao Yang, Xiao-Ping Wan, Chi Cheng, Yue Li, Ze-Zhou Wang, Xue-Bin Lv, Hong-Ning Wang, Jiang-Ling Li, Rong Gao,Improvement of the immunity of pig to Hog cholera vaccine by recombinant plasmid with porcine interleukin-6 gene and CpG motifs,Vaccine,2011,29,3888–3894 (corresponding author)
Yuanyuan Yu, Zheng Wang, Lin Cai, Gang Wang, Xiao Yang, Xiao Pin Wan, Xin Hua Xu,Ying Li, Rong Gao. Synthesis and characterization of methoxy poly(ethylene glycol)-O-chitosan-polyethylenimine for gene delivery,Carbohydrate Polymers ,2010,81 (2): 269-274(corresponding author)
Yang, X; Sun, WK; Chen, WL; Chen, JL; Wan, XP; Zhang, H; Cai, L; Wang, ZZ; Lv, XB; Wang, HN; Li, JL; Gao, R. Promotion of the immunity of piglets to Hog cholera vaccine induced by shuffled pig interleukin-2 gene and CpG immunostimulatory sequences encapsulated in chitosan nanoparticles,Procedia in Vaccinology,2010, 2 (1): 51-59(corresponding author)
Zhong-Zhong Zhao, Hua-Bing Zhang , Qian Chen, Zhao Xie, Ying-Yu Wang, Yi Yang, Ze-Zhou Wang , Jiang-Ling Li, Kai-Yuan Wu , Hong-Ning Wang, Min-Jie Meng , Rong Gao, Promotion of immunity of mice to Pasteurella multocida and Hog cholera vaccine by pig interleukin-6 gene and CpG motifs, Comparative Immunology, Microbiology & Infectious Diseases, 2009,32:191-205(corresponding author)
Zhigang Xu , Xiaoping Wan, Wei Zhang, Zheng Wang , Lin Cai , Ying Li, Qing Jiang, Rong Gao, Synthesis of biodegradable polycationic methoxy poly(ethylene glycol)–polyethylenimine–chitosan and its potential as gene carrier, Carbohydrate Polymers, 2009,78(1):46-53(corresponding author)
Baofeng Song, Wei Zhang, Rong Peng , Jie Huang , Ting Nie, Ying Li*, Qing Jiang, Rong Gao, Synthesis and cell activity of novel galactosylated chitosan as a gene carrier, Colloids and Surfaces B:Biointerfaces, 2009, 70:181-186(corresponding author)
Tao Zhang,Yuan Yuan Yu, Dong Li,Rong Peng,Ying Li,Qing Jiang,Ping Dai,Rong Gao*,Synthesis and properties of a novel methoxy poly(ethylene glycol)- modified galactosylated chitosan derivative,J Mater Sci: Mater Med,2009,20(3): 673-680(corresponding author)
Qian Chen, Zhong-Zhong Zhao, Rong Peng,Ying-Yu Wang, Zhao Xie, Ze-Zhou Wang, Rong Gao* ,Enhancement of immunity and resistance in mice by pig IL-6 gene and CpG motifs encapsulated in chitosan nanoparticle,Biotechnology Journal , 2008, 3(2):264-273(corresponding author)
Zhao Xie , Hui Li, Jianlin Chen, Hua-bing Zhang, Qian Chen, Zhong-Zhong Zhao, Chi Cheng, Huan Zhang, Yi Yang, Rong Gao, Shuffling of pig interleukin-2 gene and its enhancing of immunity in mice to Pasteurella multocida vaccine, Vaccine, 2007 25 :8163–8171(corresponding author)
Huan Zhang, Chi Cheng, Min Zheng, Zhao Xie, Jiang Ling Li, Yi Yang, Yi Shen, Hong-Ning Wang,Zezhou Wang, Rong Gao, Enhancement of immunity to an Escherichia coli vaccine in mice orally inoculated with a fusion gene encoding porcine interleukin 4 and 6, Vaccine, 2007, 25: 7094–7101(corresponding author)
Yi Yang, Jianlin Chen, Hui Li, Yingyi Wang, Zhao Xie, Huan Zhang, Cheng Chi, Hongning Wang, Rong Gao, Porcine interleukin-2 gene encapsulated in chitosan nanoparticles enhances immune response of mice to piglet paratyphoid vaccine, Comparative Immunology, Microbiology & Infectious Diseases, 2007,30(1):19-32 (corresponding author)
Wu Kaiyuan, Wu Mei, Fu Manliang, Gao Rong, A novel CpG chitosan nanoparticles to regulate the cellular and humoral immunity of mice. Biomedical and Environmental Sciences,2006,19(2):87-95(corresponding author)
Man-Liang FU, Sancheng Ying, Mei Wu, Hui Li, Rong Gao, Regulating effects of a novel CpG Chitosan-nanoparticles on immune responses to porcine paratyphoid vaccines in mice, Biomedical and Environmental Sciences,2006,19(4):315-322 (corresponding author)
Hui Li, Shigui Liu, Lihuan Wang, Rong Gao et al. Molecular Cloning and Expression of IL2 cDNA from Tibet Pig,Veterinary Research communication, 2005, 29:395-405 (corresponding author)
Mei Wu, Shigui Liu, Bing Shen, Minjie Meng, Rong Gao et al. Regulating effects of porcine interleukin-6 gene and CpG motifs on immune responses to porcine trivalent vaccines in mice. Res. Vet .Sci. 2004,77:49-57(corresponding author)
Jinling Li, Shigui Liu, Bing Shen, Minjie Meng, Rong Gao et al. The immunoregulation of mice by somatic transgenic expression of porcine interleukin-6 and CpG sequence. Veterinary Research Communication,2004,28:33-46 (corresponding author)
Mei Wu,Lin Shu,Rong Gao,Shigui Liu et al, The Effect of Entrapment of Murine Interleukin 2 Gene with Chitosan Nanoparticles on the Expression and Its Regulation of Immune Response of Mice, Journal of biomedical engineering,2004,6:947-952
Manliang Fu, Hui Li, Kaiyuan Wu, Rong Gao et al. Molecular Cloning and Expression of IL2 cDNA from Yak, Sichuan Journal of Zoology, 2005, 24:507-512(corresponding author)
Shen Bin, Gao Rong, Men Mingjie, Shigui Liu et al, Immune response of mice to inoculation with TS11 antigenic gene of Taenia Solium, Chinese J. Veterinary Medicine, 2004,1:3-6
Li Hui,Gao Rong*,Wu Mei, Shigui Liu et al,Cloning and sequence analysis of γ-interferon gene from Tibet pig, Chinese Vet. Science and Technology, 2003,5:48-51
Shen Bin, Gao Rong, Men Mingjie, Shigui Liu et al, The eukaryotic expression of TS11 antigenic gene from cysticircus cellulosae, Chinese J.Vet. Medicine,2003,4: 6-9
Li Hui,Gao Rong*,Wu mei,Ding Xiaotao, Shigui Liu et al, Cloning and Analyzing of interleukin-4 cDNA from the lymphocyte of Tibet Pig, Chinese J. Immunology, 2003,6:475-478
Long Zhangfu, Gao Rong, Men Mingjie, et al, Effect of porcine interleukin gene 6 entrapped with cationic liposome on the immune responses of mice inoculated with the antigenic gene vaccine of Taenia Solium, High Technology Letters, 2003.3:25-29
Lv Xuebing, Li Jianglin, Gao Rong, et al, Effect of transgenic expression of PIFN-γgene on the immune responses of mice immunization with paratyphoid vaccine, High technology letter,2003.4:236
Ning Hong, Gao Rong, Qin Zhen, Shigui Liu et al, Analysis of the protein electrophoresis patterns of Curvularia lunata in maize and immunological detection of the pathogenic culture, High technology Communication,2002.3:11-15
Mei Wu, Rong Gao, Jiangling Li, Minjie Meng, Shigui Liu et al. Regulating Effect of CpG Motifs and Cationic Liposome on Immune Responses to Antigenic Gene of Taenia solium in Mice, High Technology Letters, 2002, 7: 39-44
Jiangling Li, Rong Gao, Mei Wu , Mingjie Meng, Shigui Liu et al., The effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of mice inoculated with the gene vaccine of Taenia solium of pig. High Technology Letters, 2002, 6: 26-30
Wang Zezhou, Gao Rong, Yang Lin, Shigui Liu et al, Construction and Expression of fusion gene of somatostatin and Hepatitis B surface antigen gene in Yeast Pichia Pastoris, Journal of biomedical engineering (EI), 2002,3:483
Meng Minjie, Gao Rong, Tang Manshu, Li Jiang, et al, Cloning and sequencing of porcine interleukin –6 gene from lymphocyte, J. Sichuan University ( natural science edition), 2002, 3:557-560

科研項目


科技部國際合作項目,豬瘟防控新疫苗免疫機理及其免疫調控研究
European Commission, SEVENTH FRAMEWORK, PROGRAMME Grant agreement no.: 227003 CP-FP(歐盟國際合作項目),Improve tools and strategies for the prevention and control of classical swine fever;
國家863計劃,家禽重要病毒病基因工程疫苗研究和創製;
國家科技支撐計劃,動物產品獸葯殘留安全控制技術研究;
國家科技支撐計劃,豬瘟及口蹄疫流行病學和快速診斷技術集成研究;
國家重大項目前期基礎研究,生物技術篩選高原植物活性分子及消除細菌耐藥性的研究;
國家自然科學基金,豬白細胞介素-23基因克隆表達及其對豬免疫記憶的效應研究;
國家自然科學基金,豬新型免疫基因轉體細胞表達的免疫調節效應;
國家自然科學基金,豬白細胞介素2和6基因的改組研究;
國家自然科學基金,雞傳染性貧血的免疫機理;
國家自然科學基金,雞馬立克氏病及疫苗的免疫機理;
四川省重點科技項目,豬高效分子免疫調節劑研究及應用;
四川省重點科技項目,抗奶牛乳房炎新型抗菌肽基因分子製劑的研製;
四川省重點科技攻關,動物高效營養分子代謝調節製劑的研製和應用;
四川省重點科技項目,新型動物免疫基因製劑的研製和應用;
四川省傑出青年科技基金,動物新型抗病融合基因的構建及應用研究;
四川省重點科技攻關,新型高效抗感染分子製劑的研究與開發;
四川省重大科技項目,畜用DNA免疫增強劑研究及應用;
國家教育部重點科技項目,畜用核酸免疫增強劑的基礎及應用研究;
四川省重點科技攻關,豬囊蟲病防治關鍵技術研究;
西藏自治區重大科技攻關項目,藏葯及藏藥材現代化新標準示範研究;

工作獲獎


1994:雞傳染性法氏囊病的免疫機理,省科技進步二等獎,省教委科技進步一等獎,
1996:雞馬立克氏病及其疫苗的免疫機理,省科技進步二等獎,省教委科技進步一等獎;
1997:小日齡火雞新城疫免疫機理研究,省教委科技進步一等獎;
2000:囊蟲病防治關鍵技術研究,省科技進步二等獎;
2010:豬用DNA分子免疫調節新技術研究,省科技進步二等獎;
2004-2006:四川大學展虹獎研金二等獎;
2003-2005:四川大學青年骨幹教師獎;
2003年:入選四川大學“214人才”計劃第三層次人才;
2004年:入選“四川省傑出青年學科帶頭人培養計劃;
2008年:四川省學術和技術帶頭人