張奇

張奇 性別：男職稱：南開大學藥學院副教授 學科方向：生物技術藥物

招生方向：微生物與生化藥學

教師簡介

1998年9月至2002年7月就讀於南開大學生命科學學院微生物學系，2002年9月考入南開大學微生物學系攻讀研究生，2007年6月獲得理學博士學位后留校任教，主要從事藥學、免疫學及分子生物學等研究，甘氨酸及其衍生物產業技術創新戰略聯盟專家委員。主持國家自然科學基金2項，天津市自然科學基金1項，橫向基金1項；參加包括“973”、國家科技重大專項、國家自然科學基金、天津市科技支撐計劃、天津市自然科學基金等在內的10餘項自然科學基金項目。主要開展腫瘤糖蛋白相關研究、氨基酸類醫藥中間體的生物合成及病原微生物的檢測技術開發以及微生物代謝產物藥物和肽類藥物的開發工作。共發表國內外學術論文及會議論文60餘篇，其中SCI收錄23篇；申請專利14項，授權2項，參編教材2部。

發表文章

1）Pang Pengwei, Qi Zhang*, Jie Hou, Fang Bai, Mei-rong Cao, Ting Sun, Qian Shi, Gang Bai. Cell surface glycoprotein profiling of cancer cells based on bioorthogonal chemistry, Anal Bioanal Chem (2012) 403(6):1661–1670(通訊作者)

2) Duan Jingjing, Qi Zhang*, Hongzhi Zhao, Jun Du, Fang Bai, Gang Bai. Cloning, expression, characterization and application of atcA, atcB and atcC from Pseudomonas sp. QR-101, Biotechnology Letters, (2012) 34:1101–1106 (通訊作者)

3) Peng Wei Pan, Qi Zhang*, Fang Bai, Jie Hou, and Gang Bai, Profiling and comparative analysis of glycoproteins in Hs578BST and Hs578T and investigation of prolyl 4-hydroxylase alpha polypeptide II expression and influence in breast cancer cells, Biochemistry (Moscow) 2012, 77(5), 539-545 (通訊作者)

4) Jun Du, Qi Zhang*, Jingjing Duan,Chunqin Liu, Yangsheng Yu, Jie Hou, Fang Bai, Ning Chen, Gang Bai, Enzymatic synthesis of L-tryptophan from D,L-2-amino-Δ2-thiazoline-4-carboxylic acid and indole by Pseudomonas sp. TS1138 ATC hydrolase, S-carbamyl- L-cysteine amidohydrolase, and Escherichia coli L-tryptophanase, Applied of Biochemistry and Microbiology,2012,48(2):159-166 (通訊作者)

5) Li Ming, Yang Jie, Qu Han, Qi Zhang*, Fang Bai, Gang Bai. Novel Immobilization of Arginase I via Cellulose Binding Domain and Application in Producing of L-Ornithine, Biotechnology Letters, Applied of Biochemistry and Microbiology (Acceptted)(通訊作者)

6) Zhang Qi, Wang Bin, Li Xia, Hou Jie, Fang Bai, Sun Dan, Bai Gang, Establishment and Application of Immunofluorescence Detection Method Depending on Click Chemistry, Chemical Journal of Chinese Universities, 2011, 32(2): 287-291

7）Jie Hou,Qi Zhang, Xia Li, Yu Tang, Fang Bai, Qian Shi, Mei-rong Cao, Cui-hong Yang, De-ling Kong, Gang Bai Synthesis of novel folate conjugated fluorescent nanoparticles for tumor imaging, J Biomedical Materials Res, Part A , 2011, 99 (4) 684-9

8）Cao Mei-Rong, Hou Jie, Zhang Qi, Fang Bai, Bai Gang, Hyaluronic Acid-Quantum Dot Conjugate for Tumor Imaging, Chemical Journal of Chinese Universities, 2012, 33(03): 437-441

9）Peng Meng, Yuanqiang Guo, Qi Zhang, Jie Hou, Fang Bai, Peng Geng, Gang Bai, A novel amino-oligosaccharide isolated from the culture of Streptomyces strain PW638 is a potent inhibitor of α-amylase, Carbohydrate Research, 2011, 346(13), 1898-1902

10）Fang Bai, Haijin Xu, Qi Zhang, Xizhen Qi, Rui Mou, Gang Bai, and Mingqiang Qiao, Functional characterization of pfm in protein secretion and lung infection of Pseudomonas aeruginosa, Can. J. Microbiol., 2011, 57, 829-837

11) Yu Tang, Qi Zhang, Long Wang, Peng-Wei Pan, Gang Bai. Preparation of cellulose magnetic microspheres with “the smallest critical size” and their application for microbial immunocapture, Langmuir, 2010, 26 (13), 11266–11271

12) Zhihui Gao, Qi Zhang*, Yu Cao, Pengwei Pan, Fang Bai, Gang Bai, Preparation of novel magnetic cellulose microspheres via cellulose binding domain-streptavidin linkage and its use for the isolation of mRNA from eukaryotic cells and tissues, Journal of Chromatography A, 2009, 1216(45): 7670-7676(通訊作者)

13) Peng Geng, Gang Bai, Qian Shi, Lei Zhang, Zhihui Gao, Qi Zhang, Taxonomy of the Streptomyces strain ZG0656 that produces acarviostatin α-amylase inhibitors and analysis of their effects on blood glucose levels in mammalian systems, Journal of AppliedMicrobiology, 2009, 106: 525–533

14) Zhihui Gao, Gang Bai, Jiaqi Chen, Qi Zhang, Pengwei Pan, Fang Bai, Peng Geng, Development, Characterization, and Evaluation of a Fusion Protein of a Novel Glucagon-like Peptide-1 (GLP-1) Analogue and Human Serum Albumin in Pichia pastoris, Biosci. Biotechnol. Biochem., 2009, 73(3): 688-694

15) Wang Bin, Wang Shuai, Zhang Zhen-Xin, Yang Pin, Tian Ye, Zhang Qi, Bai Gang, Chen Ru-Yu, Alkynyl-Modified Naphthalimide: Synthesis, Crystal Structure and Fluorescence Spectrum, Chinese Journal of Structural Chemistry, 2009, 28(8):1008-1012

16) Qian Shi, Ze Liu, Yang Yang, Peng Geng, Yuan-yuan Zhu, Qi Zhang, Fang Bai, Gang Bai, Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects, Acta Pharmacol Sin, 2009, 30(5): 567-567

17) Zhihui Gao, Yu Tang, Jiaqi Chen, Ru Bai, Qi Zhang, Yuanyuan Hou, Yaxin Lu, Gang Bai, A novel DPP-IV-resistant analog of glucagon-like peptide-1 (GLP-1): KGLP-1 alone or in combination with long-acting PLGA microspheres, peptide, 2009, 30: 1874–1881

18) Gang Bai, Yang Yang, Qian Shi, Ze Liu, Qi Zhang, Yuan-yuan Zhu, Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist, Acta Pharmacol Sin, 2008, 29 (10): 1187–1194

19) Qi Zhang, Gang Bai, Jiaqi Chen, et al. Identification of antiviral mimetic peptides with interferon α-2b like activity from a random peptide library using a novel functional bio-panning method. Acta Pharmacologica Sinica, 2008, 29(5): 634-640

20) Zhang Qi, Bai Gang, Li Haiyan, et al. The Pathogenic Cellulase Assay of the Pine Wilt Disease and the Immunological Localization, Biosci. Biotechnol. Biochem., 2006, 70(11): 2727-2732

21) Zhang Qi, Bai Gang, Chen Jiaqi, et al. Use of an Enhanced Green Fluorescence Protein linked to a Single Chain Fragment Variable Antibody to Localize Bursaphelenchus xylophilus Cellulase, Biosci. Biotechnol. Biochem., 2007, 71 (6): 1514-1520

22) Cao Yu, Zhang Qi, Wang Chao, et al. Preparation of novel immunomagnetic cellulose microspheres via CBD-protein A linkage and its use for the isolation of interferon alpha-2b, Journal of Chromatography A, 2007, 1149(2): 228-235

23) Jiaqi Chen, Gang Bai, Yu Cao, Zhihui Gao, Qi Zhang, et al. One-Step Purification of a Fusion Protein of Glucagon-Like Peptide-1 and Human Serum Albumin Expressed in Pichia pastoris by an Immunomagnetic Separation Technique, Biosci. Biotechnol. Biochem., 2007, 71(11): 2655-2662