徐曉明

1975年畢業於上海第二醫科大學。

1985年獲上海第二醫科大學醫學碩士、1990年於美國俄亥俄州立大學獲理學博士。

1991至1994年在美國邁阿密大學醫學院從事博士后研究。

1994至2001年任美國聖路易斯大學醫學院解剖和神經生物學系副教授。

2001年6月至今任美國路易維爾大學醫學院神經外科系副教授, James R. Petersdorf 講座教授及路易維爾大學傑出學者。

1999年起任上海第二醫科大學神經生物學實驗室客座教授、博士生導師。

主要從事脊髓發育、損傷和再生的研究。現有課題包括：1）雪旺氏細胞和神經幹細胞移植在脊髓修復中的作用；2）神經營養因子及基因治療；3）脊髓二次損傷（如炎症和細胞程序性死亡）的機理和治療；4）脊髓發生和再生時與軸突生長相關分子的表達。

曾獲俄亥俄州立大學校長獎學金、Daniel Heumann 國際學者、美國神經創傷學會Michael Goldberger獎、Christopher Reeve自由研究獎等。近十年來，連續獲得美國National Institutes of Health (NIH) 及國際脊髓損傷研究基金會等多項政府及民間機構的資助。目前任美國NIH基金評審委員會委員。迄今為止，已在國內外有影響的雜誌，包括Journal of Comparative Neurology, Experimental Neurology, Journal of Neuroscience, Nature Neuroscience 等雜誌上，發表論文六十餘篇。

1．Liu NK, Zhang YP, Titsworth WL, Jiang X, Han S, Lu PH, Shields CB and Xu X-M: A Novel Role of Phospholipase A2 in Mediating Spinal Cord Secondary Injury. Annal Neurol 59:606-619, 2006 (Editorial Comment by Linda J. Nobel entitled “Phospholipase A2 and spinal cord injury: A novel target for therapeutic intervention” on the same issue)。

2． Hsu J-YC, Stein SA, and Xu X-M: Development of the corticospinal tract in the mouse spinal cord: A quantitative ultrastructural analysis. Brain Res 1084:16-27, 2006。

3． Jiang X-Y, Fu S-L, Nie B-M, Li Y, Lin L, Yin L, Wang YX, Lu P-H, Xu X-M: Methods for isolating highly-enriched embryonic spinal cord neurons: A comparison between enzymatic and mechanical dissociations. J Neurosci Meth 158:13-18, 2006。

4． Oudega M, Xu X-M: Schwann cell transplantation for repair of the adult spinal cord. J Neurotrauma 23:453-467, 2006。

5． Hsu J-Y, Stein SA, and Xu X-M: Temporal and spatial distributions of growth-associated molecules and astroglial cells in the rat corticospinal tract during development. J Neurosci Res 80:330-340, 2005。

6． Fu S, Ma Z, Yin L, Iannotti C, Lu P, and Xu X-M: Region-specific growth properties and trophic requirements of brain- and spinal cord-derived embryonic neural precursor cells. Neurosci 135:851-862, 2005。

7 ． Hsu J-YC and Xu X-M: Early profiles of axonal growth and astroglial response after spinal cord hemisection and implantation of Schwann cell-seeded guidance channels in adult rats. J Neurosci Res 82:472-483, 2005。

8． Chau, C.H., Shum, D.K.Y., Li, H., Pei, J., Lui, Y.Y., Wirthlin, L., Chan, Y.S. and Xu, X.M.: Chondroitinase treatment enhances axonal regrowth through Schwann cell-seeded guidance channels after spinal cord injury. FASEB J. 18: 194-196, 2004。

9． Sivasankaran, R., Pei, J., Wang, K.C., Zhang, Y.P., Shields, C.B., Xu, X.-M.* and He, Z.*: Protein kinase C mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. Nat. Neurosci. 7:261-268, 2004 (* co-corresponding authors)。

10. Liu NK, Han S, Lu P-H, Xu X-M: Upregulation of annexins I, II and V following traumatic spinal cord injury in adult rats J Neurosci Res 77:391-401, 2004。

11. Iannotti C, Zhang YP, Shields CB, Han Y, Burke DA, Xu X-M: A novel neuroprotective role for glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury. Exp Neurol 189:317-332, 2004。

12. Zhang KH, Xiao H-S, Lu P-H, Shi J, Li G-D, Wang Y-T, Zhang X, Xu X-M: Differential gene expression after complete spinal cord transection in adult rats: An analysis focused on a sub-chronic post-injury stage. Neuroscience 128:375-388, 2004。

13. Chau CH, Shum DKY, Xu X-M: Combinatorial strategies towards spinal cord repair: enhancement of the Schwann cell bridge and modification of the graft-host interface. Preclinica (Invited review) 2:409-415, 2004。

14. Hu J-G, Fu S-L, Zhang K-H, Li Y, Ying L, Lu P-H, Xu X-M: Differential gene expression in neural stem cells and oligodendrocyte precursor cells: A cDNA microarray analysis. J Neurosci Res 78:637-646, 2004。