周源

個人簡介周源，1990年從北京醫科大學畢業以後，在北京首都醫科大學附屬宣武醫院臨床免疫科工作3年。1994年赴美攻讀博士學位。主攻生長激素在體內外細胞生物學信號傳導。1998年獲博士學位。1998年至2001年，在美國life technology生命技術公司產品研發部門工作。歷任助理科學家，科學家，資深科學家，產品研發部經理.2001年至2005年，就職於Eurogentec美國分部，領導抗體的研發和市場化管理。2007年至2010年，就職於美國Amunix醫藥公司任臨床醫藥產品開發部高級經理，參與研製治療兒童侏儒症的長效生長激素藥品VRS-317，其衍生公司VERSARTIS於2014年3月在NASDAQ成功上市(NASDAQ:VSAR)。2010年至現在，創立美國AbboMax生物醫藥公司，從事並領導相關醫藥產品的科研和臨床應用產業化。教育程度:1990年，中國北京醫科大學基礎醫學專業，醫學學士。1998年，美國賓夕法尼亞州立大學生物醫學專業，博士。科研活動：美國細胞生物學協會會員（ASCB#38985)美國癌症研究協會資深會員(AACR#110600)美國科學促進協會會員（AAAS#12817503)獲獎情況：1998年，美國USDA科學基金(TheUSDAGrantreward, Graduate Student Program atthe Penn State Univ. Title: The signaling of chronic administration of growthhormone in vivo).1994年，北京市科技進步獎二等獎(TheSecond Prize of Science and Technology Improvement, awarded by Beijing HealthBureau, 1994: Title: Detection of anti-double-stranded DNA (ds-DNA)antibodies by Polymerase Chain Reaction (PCR) Method).1993年，北京市科技進步獎二等獎(TheSecond Prize of Science and Technology Improvement, awarded by Beijing HealthBureau,1993: Title: A fast, sensitive ELISA method for detecting hiddenrheumatoid factors (hRF) in the patients with autoimmune disease).專利情況:延長並維持近期發現的有治療功用的蛋白質在急性T淋巴白血病治療中的生物活性（Prolong thebiological activity of the recently discovered potential protein in TALL patients (in Preparation).相關的發表論文：·HongWang, Charles Owens, Nidhi Chandra, Mark R. Conaway, David L. Brautigan, andDan Theodorescu (2010), Phosphorylationof RalB is important for bladder cancer cell growth and metastasis. CancerRes. 70(21):8760-9. ·ClaudiaP. Hernandez, Kevin Morrow, Lluis A. Lopez-Barcons, Jovanny Zabaleta, RosaSierra, Cruz Velasco, John Cole, and Paulo C. Rodriguez (2010). Pegylated arginase I: a potentialtherapeutic approach in T-ALL. Blood.115(25): 5214–5221.·ZhouYuan, Xin Wang, Hongzhi Liu (2008), A Novel Method of Developing aHigh-Affinity Monoclonal Antibodies to Capture Native or Pegylated HumanGranulocyte Colony-Stimulating Factor (G-CSF), Proceedings of the 99th AnnualMeeting of the American Association for Cancer Research; 2008 Apr 12-16. ·ZhouY.Xu, H etal (2006) Midkine, Apotential Tumor Biomarker is Enhanced in Huh7 And HepG2 Human Hepatoma Cells. Proceedings of the 46thAnnual Meeting of the American Society for Cell Biology; 2006; December 9-13.·ZhouY.WangX, Hadley J,CoreySJ,Vasilatos-Younken R (2005) Regulation of JAK2 protein expressionby chronic, pulsatile GH administration in vivo: a possible mechanism forligand enhancement of signal transduction.Gen Comp Endocrinol. 144(2): 128. ·Zhou Y. SungJ,HongA(2005) The enhancement of serine/threonine kinaseactivity is associated with the p53-PUMA apoptotic pathway. Proceeding of the AmericanAssociation for Cancer Research. Volume 46(S): 1286.·ZhouY,CeciliaPo,VeronicaWei,AnitaHong,Yun-JuanChoi,Lindy Kauffman (2004) A Study of Fluorophore Labeled Cell-Permeable Peptides inCancer Research.ProcAmerAssocCancer Research, 45(s): 1011.·Zhou Y. Sung J, Po C, Hong A, Zhihe Liu, Chien-an Andy Hu,(2004) Phosphorylation of PUMA isAssociated with Apoptotic induced Leukemia Cells, Mol Bio Cell, 15(s):737.·Zhou Y, SungJ, Hong, A, (2003) The development and application of monoclonal antibodies tophospherine and phosphothreonine. MolBio Cell, 14(s): 154.·Zhou Y, Sung J, Hong, A,Chen,K,ShihJC,Cases O,VitalisT(2003) A New Tool to RevealTrace amine signaling pathway: An antibody to b-phenethylamine. MolBio Cell, 14(s): 128.·Hong, A,Zhou,Y.Diwu, Z.(2003) Phosphopeptides and their biological applications.CHIMICAOGGI,Chemistry today. June 2003, 57.·Vasilatos-Younken R, Zhou Y, Wang XH, McMurtry JP,Rosebrough RW, Decuypere E, Buys N, Darras V, Geyten SVD and Tomas F (2000)Altered thyroid hormone metabolism with chronic growth hormone (GH) enhacement in vivo: Consequences for skeletalmuscle growth.J.Endocrinol. 166(3): 609.·Wang XH, Zhou Y, Day JR, Beard JL, Vasilatos-Younken R.(2000) Evidence of a role for neuropeptide Y and monoamines in mediating theappetite-suppressive effect of GH. J Endocrinol. 166(3): 621-630.·Ashwell CM, McMurtry JP, Wang XH, Zhou Y,Vasilatos-Younken R (1999) Effects of growth hormone and pair-feeding on leptinmRNA expression in liver and adipose tissue. DomestAnimEndocrinol.17(1): 77.·Zhou Y,WangXH, McMurtry JP, Vasilatos-YounkenR (1998) Induction and activation of JAK2 protein occur with chronic exposureto GH, despite lack of an anabolic response in chicken skeletal muscle. J PoultSci 77(1): 33.·Vasilatos-Younken R, Wang XH, Zhou Y, Day JR, McMurtryJP, Rosebrough RW, Decuypere E, Buys N, Darras V, Beard JL, Tomas F (1999) Newinsight into the mechanism and actions of growth hormone (GH) in poultry.DomestAnimEndocrinol. 17 (2-3), 181-190, Review.·YuNai-ChangandZhouYuan(1998) Detection of anti-double-stranded DNA (ds-DNA) antibodies by PCRmethod. Chinese Journal of Immunology,14(1): 43。·余乃昌，徐陸亭，周源，等。應用PCR技術檢測血清抗雙鏈DNA抗體。中國免疫學雜誌. 1998年01期·劉恕，劉桂榮，周源，等. .隱性類風濕因子的測定方法及臨床意義。中華內科雜誌，1993，32:531-533