徐亮

四川大學華西藥學院副教授

徐亮,男,四川大學華西藥學院副教授。

人物經歷


1993~1997 華西醫科大學藥學院 獲理學學士學位。
1997~2000 華西醫科大學藥學院 獲藥物化學碩士學位。
2000~2003 四川大學華西藥學院 獲藥物化學博士學位。
2003~2005 中科院上海有機化學研究所博士后, 師從林國強院士。
2005~2007 美國科羅拉多州立大學化學系博士后, 師從Yian Shi 教授。
2007~ 四川大學華西藥學院副教授。

研究方向


1. 不對稱合成新方法學的建立及其在藥物分子合成中的應用。
2. 天然含氮有機物的合成研究。

主要貢獻


目前承擔課題

新型手性氮雜環卡賓配體的合成及其在鈀催化不對稱反應中的應用(國家自然科學基金 起止日期2010.1-2012.12, 負責人)

代表論著

1. Liang Xu, Yian Shi, Chiral N-Heterocyclic Carbene-Pd(0) Catalyzed Asymmetric Diamination of Conjugated Dienes and Triene. J. Org. Chem. 2008,73,749
2. Liang Xu, Haifeng Du, and Yian Shi, Diamination of Conjugated Dienes and Trienes Catalyzed by N-Heterocyclic Carbene-Pd(0) Complexes. J. Org. Chem. 2007, 72, 7038.
3. Liang Xu, Jian-li Wang, Feng-peng Wang, Novel Rearrangement Products of the Degrated Derivative of Maoecrystal A, An ent-Kaurane-Type Diterpene, J. Asia Nat. Prod. Res., 2007, 9 (3), 239.
4. Liang Xu, Feng-peng Wang, An Attempt to Enlarge the B ring of Maoecrystal B, an ent-Kaurane-type Diterpene, J. Asia Nat. Prod. Res., 2006, 8(6), 545.
5 Liang Xu, and Feng-Peng Wang, Exhaustive Degradation of the Ring D of 3,20-Epoxy ent-Kaurane-Type Diterpene Maoecrystal A. Tetrahedron, 2005, 61 (18), 4467.
6. Feng-Peng Wang, and Liang Xu, To Seek an Approach Toward the Chemical Conversion of C19- diterpenoid Alkaloids to Taxoids. Tetrahedron, 2005, 61(8), 2149.
7. Liang Xu, Qiao-hong Chen, Feng-peng Wang, A Novel Skeletal Rearrangement of the A Ring of the Immonium Salt Derived from Norditerpenoid Alkaloid Yunaconitine, Tetrahetron, 2002, 58(21), 4267.
8. Qiao-hong Chen, Liang Xu, Feng-peng Wang, A Novel Conversion of Norditerpenoid Alkaloids into Aconane-Type Diterpenes, Tetrahetron, 2002, 58(21), 9431.
9. Qiao-hong Chen, Liang Xu, Feng-peng Wang, A New Access to the Cleavage of the N,19-Bond of Norditerpenoid Alkaloids and Their Derivatives by Formation of Oxaziridines, heterocycles, 2002, 57(12), 2357.
10. Zheng-bang Li, Liang Xu, Xi-xian Jian and Feng-peng Wang, New Norditerpenoid alkaloids from the roots of Aconitum geniculatum. J. Asia Nat. Prod. Res., 2001, 3(2), 131.
11. Qiao-Hong Chen, Liang Xu, Feng-peng Wang, Preparation of the N,19-seco norditerpenoid alkaloids from norditerpenoid alkaloid yunaconitine, Chin .Chem. Lett, 2003, 14, 147.
12.Hong-Fu Lu, Xun Sun, Liang Xu, Li-Guang Lou, Guo-Qiang Lin, Design, synthesis and biological evaluation of novelfluorinated docetaxel analogues,Eur. J. Med. Chem. 2008, doi:10.1016 /j.ejmech.2008.04.004.
研究生及博士後期間:
0.Jiang Long, Liang Xu, Haifeng Du, Kai Li and Yian Shi Organic. Letters.,2009, 11, 5226–5229.
1.Hong-Fu Lu, Xun Sun, Liang Xu, Li-Guang Lou, Guo-Qiang Lin, Design, synthesis and biological evaluation of novelfluorinateddocetaxel analogues,Eur. J. Med. Chem.2008, doi:10.1016 /j.ejmech.2008.04.004.
2.Liang Xu, Yian Shi, Chiral N-Heterocyclic Carbene-Pd(0) Catalyzed Asymmetric Diamination of Conjugated Dienes and Triene. J. Org. Chem.2008, 73, 749
3.Liang Xu, Haifeng Du, and Yian Shi, Diamination of Conjugated Dienes and Trienes Catalyzed by N-Heterocyclic Carbene-Pd(0) Complexes. J. Org. Chem. 2007, 72, 7038.
4.Liang Xu, Jian-li Wang, Feng-peng Wang, Novel Rearrangement Products of the Degrated Derivative of Maoecrystal A, An ent-Kaurane-Type Diterpene, J. Asia Nat. Prod. Res.2007, 9, 239.
5.Liang Xu,Feng-peng Wang, An Attempt to Enlarge the B ring of Maoecrystal B, an ent-Kaurane-type Diterpene, J. Asia Nat. Prod. Res.2006, 8, 545.
6.Liang Xu, and Feng-Peng Wang, Exhaustive Degradation of the Ring D of 3,20-Epoxy ent-Kaurane-Type DiterpeneMaoecrystalA. Tetrahedron, 2005, 61, 4467.
7.Feng-Peng Wang, and Liang Xu, To Seek an Approach Toward the Chemical Conversion of C19- diterpenoid Alkaloids to Taxoids. Tetrahedron, 2005, 61, 2149.
8.Liang Xu, Qiao-hong Chen, Feng-peng Wang, A Novel Skeletal Rearrangement of the A Ring of the Immonium Salt Derived from Norditerpenoid Alkaloid Yunaconitine, Tetrahetron, 2002, 58, 4267.
9.Qiao-hong Chen, Liang Xu, Feng-peng Wang, A Novel Conversion of Norditerpenoid Alkaloids into Aconane-Type Diterpenes, Tetrahetron, 2002, 58, 9431.
10.Qiao-hong Chen, Liang Xu, Feng-peng Wang, A New Access to the Cleavage of the N,19-Bond of Norditerpenoid Alkaloids and Their Derivatives by Formation of Oxaziridines, Heterocycles, 2002, 57, 2357.
11.Zheng-bang Li, Liang Xu, Xi-xianJian and Feng-peng Wang, New Norditerpenoid alkaloids from the roots of Aconitum geniculatum. J. Asia Nat. Prod. Res.2001, 3, 131.
12.Qiao-Hong Chen, Liang Xu,Feng-peng Wang, Preparation of the N,19-seco norditerpenoid alkaloids from norditerpenoid alkaloid yunaconitine, Chin .Chem. Lett, 2003, 14, 147