劉昱

北京師範大學化學專業學士，美國韋恩州立大學分析化學博士，美國國立衛生研究院博士后。現任上海交通大學特別研究員，博士生導師。

主要從事RNA研究，開發PLOR方法合成位點選擇性標記的RNA，以核磁共振 (NMR)、X-射線自由電子激光技術 (XFEL)、X-射線晶體衍射、單分子熒光轉移技術 (smFRET)、小角散射技術 (SAXS) 等為主要手段解析非編碼RNA的三維結構，結合生物化學、合成生物學及分子生物學等手段闡明核糖開關RNA調控基因表達及艾滋病毒RNA與蛋白質相互作用機理的分子機制。

位點選擇性標記的RNA的合成

非編碼RNA的結構解析

非編碼RNA的功能機制研究

1.

位點選擇性標記的RNA的合成

2.

非編碼RNA的結構解析

3.

非編碼RNA的功能機制研究

Stagno, J., Y.Liu, et. al. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Nature (2017) 541: 242-246.

Y. Liu*, P. Yu, et. al. Applications of PLOR in labeling large RNAs at specific sites. Methods (2016), 103: 4-10 (*: 通訊作者).

Y. Liu*, R. Sousa, Y-X. Wang. Specific labeling: An effective tool to explore the RNA world. BioEssays (2016), 38: 192-200 (*: 通訊作者).

Y. Liu, E. Holmstrom, et. al. Synthesis and applications of RNAs with position-selective labeling and mosaic composition. Nature (2015), 522: 368-372. Related Highlights: A machine to manage modifications, Nature Methods (2015), 12: 598-599.

X. Fang, et. al., Y. Liu, et. al. An unusual topological structure of the HIV-1 Rev response element. Cell (2013), 155: 594-605.

1.

Stagno, J., Y.Liu, et. al. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Nature (2017) 541: 242-246.

2.

Y. Liu*, P. Yu, et. al. Applications of PLOR in labeling large RNAs at specific sites. Methods (2016), 103: 4-10 (*: 通訊作者).

3.

Y. Liu*, R. Sousa, Y-X. Wang. Specific labeling: An effective tool to explore the RNA world. BioEssays (2016), 38: 192-200 (*: 通訊作者).

4.

Y. Liu, E. Holmstrom, et. al. Synthesis and applications of RNAs with position-selective labeling and mosaic composition. Nature (2015), 522: 368-372. Related Highlights: A machine to manage modifications, Nature Methods (2015), 12: 598-599.

5.

X. Fang, et. al., Y. Liu, et. al. An unusual topological structure of the HIV-1 Rev response element. Cell (2013), 155: 594-605.