孫之榮
孫之榮
孫之榮 博導,現任清華大學教授現任生物科學與技術系生物信息學研究室負責人,任教育部生物信息學重點實驗室副主任、學術秘書
目前正圍繞功能基因組信息學開展基礎和應用研究。研究課題: 包括從基因到蛋白質結構和功能的分子生物學遺傳信息中心法則的多層次研究,以及從分子到細胞的綜合分析的系統生物學研究。目前實驗室具有代表性的課題有:
■ 幾種主要的分子網路及Pathway拓撲結構分析及動力學研究;
■ 幾種常見腫瘤的分子標識譜以及Pathway層次上的腫瘤機理研究。
Selected Publications Hua SJ & Sun ZR*.(2001). A Novel Method of Protein Secondary Structure Prediction with High Segment Overlap Measure: Support Vector Machine Approach. J. Mol. Biol., 308:397-407.
■ Hua SJ & Sun ZR*. (2001). Support Vector Machine Approach for Protein Subcellular Localization Prediction. Bioinformatics, 17:721-728.
■ Hua SJ, Guo T, Gough J & Sun ZR*. (2002). Proteins with Class Alpha/Beta Fold Have High-level Participation in Fusion Events. J. Mol. Biol., 320:713-719.
■ Zheng JS, Wu JJ, and Sun ZR* An Approach to Identify Over-represented Cis-elements in Related Sequences. Nucleic Acids Research, 2003, V31, N7, 1-11.
■ Guo T, Hua SJ, Ji XL & Sun ZR*, DBSubLoc: database of protein subcellular localization. Nucleic Acids Research, 2004, V32, Database issue D122-D124.
■ Ji XL, Y Y, Li L, Li YD & Sun ZR*, HMMGEP: clustering gene expression data using hidden Markov models. Bioinformatics, 2004. Feb 26.
■ Zi Z, Cho KH, Sung MH, Xia X, Zheng J, Sun ZR*., In silico identification of the key components and steps in IFN-gamma induced JAK-STAT signaling pathway. FEBS Lett., 2005 Feb 14;579(5):1101-8.