金梅林

1980.07-1982.02，華中農業大學畜牧獸醫系，助教。

1982.02-1990.01，華中農業大學畜牧獸醫系，講師。

1990.01-2001.01，華中農業大學畜牧獸醫系，副教授。

1998.03-2000.01，香港中文大學醫學院，高級訪問學者、副教授。

2001.01-至今，華中農業大學動物醫學院，教授。

2011.01-至今，華中農業大學預防獸醫學系，主任、教授。培養博士后6人，博士26人，碩士74人。

研究方向

預防獸醫學。

動物流感、豬鏈球菌病等人獸共患病和新發重要動物疫病的病原學、流行病學、致病機制、新型疫苗和診斷製劑等方面的研究並取得重大成果，為提高養殖效益、促進公共衛生安全做出了重要貢獻。

學術成果

1.潛心動物流感病原學與致病機制、系列化診斷製劑盒和新型疫苗研究，實現產業化，打破了國外壟斷，填補了國內空白，為流感防控提供了理論、技術與產品支撐。流感研究發表SCI論文61篇。率先將分子生物學與常規技術相結合，創建快速、現場“欄圈邊”使用的診斷製劑盒16種。研製了國際上首個禽流感病毒乳膠凝集檢測試劑盒，率先開發出商業化膠體金檢測試紙條、通用型ELISA抗原檢測試劑盒和豬流感H1亞型ELISA抗體檢測試劑盒，相關產品列入國家禽流感一線防控計劃。研製出我國首個豬流感H1N1亞型滅活疫苗，可對H1N1、H1N2和甲型H1N1流感提供有效保護，結束了我國無豬流感疫苗的歷史。

2.提出解決多病原共感染的新策略，創製豬鏈球菌等細菌病新型疫苗，為控制細菌感染、保障食品安全提供了重要支撐。研製出首個豬鏈球菌三價滅活疫苗，在全國31個省市推廣，市場佔有率達44%，使用疫苗的區域均無群發性豬鏈球菌病流行，有效阻斷病原向人傳播。原創性發掘豬鏈球菌、副豬嗜血桿菌通用保護功能蛋白，在國際上首創二聯細菌病基因工程亞單位疫苗，推進了動物細菌疫苗從傳統向精準提升。研製出首個副豬嗜血桿菌-豬鏈球菌二聯滅活疫苗、豬鏈球菌弱毒疫苗。提出並實施免疫診斷與凈化的策略，有效控制了豬痢疾流行。

3.著力構建產學研技術創新平台，以第一完成人獲新獸葯註冊證書8項，主要完成人獲新獸葯註冊證書14項，實現成果從實驗室走向市場的跨越。建成國際水準GMP產業化基地，研發新型疫苗和診斷製劑48項，轉化企業23項次。形成具有國際影響力的動物生物製品創製、健康養殖、技術服務“三位一體”的防控技術體系。成果在全國推廣取得重大經濟社會效益。豬偽狂犬疫苗全國銷量第一。

獲國家發明專利授權47項（第一23項，轉化30項）。現已發表論文289篇，SCI論文142篇（IF5.0以上21篇）。SCI總影響因子440，他引1227次。連續三年被Elsevier資料庫評為高被引學者。主參編專著8部。

發表文章

在國內外重要刊物發表論文289篇，其中SCI論文142篇，第一作者和通訊作者SCI論文96篇：

（1）動物流感病原學、致病與免疫機制相關SCI文章61篇，第一作者和通訊作者SCI論文51篇。

（2）豬鏈球菌、副豬嗜血桿菌、豬丹毒等細菌致病機制與免疫機制、疫苗研究相關SCI文章50，第一作者和通訊作者SCI論文36篇。

（3）其他重要病原致病機制、疫苗研究相關SCI文章31篇，其中通訊作者和第一作者文章9篇。

（4）相關研究通訊作者中文文章42篇。

（5）相關研究參與作者中文文章65篇。

動物流感病原學、致病與免疫機制相關SCI文章61篇，第一作者和通訊作者SCI論文51篇

（1）Zhong Zou, Kun Huang, Yanmin Wei, Huanchun Chen, Ziduo Liu, Meilin Jin*. Construction of a highly efficient CRISPR/Cas9-mediated duck enteritis virus-based vaccine against H5N1 avian influenza virus and duck Tembusu virus infection. Scientific Reports. 2017, 3;7(1):1478.

（2）Shengyu Wang, Xin Sun, Chenyang Yi, Dan Zhang, Xian Lin, Xiaomei Sun, Huanchun Chen and Meilin Jin*.AGO2 Negatively Regulates Type I Interferon Signaling via Competition Binding IRF3 with CBP/p300. FrontiersinCellularandInfectionMicrobiology. 2017,

（3）Wei Qian, Xiaoqin Wei, Kelei Guo, Yongtao Li, Xian Lin, Zhong Zou, Hongbo Zhou and Meilin Jin*.The C-Terminal Effector Domain of NS1 Protein of Influenza A Virus blocks IFN-β Production by Targeting TRAF3. Frontiers in Immunology.2017.

（4）Yousong Peng, Xiaodan Li, Hongbo Zhou, Aiping Wu, Libo Dong, Ye Zhang,Rongbao Gao, Hong Bo, Lei Yang, Dayan Wang, Xian Lin, Meilin Jin*, Yuelong Shu* , Taijiao Jiang*,Continual Antigenic Diversification in China Leads to Global Antigenic Complexity of Avian Influenza H5N1 Viruses, Scientific Reports, .2017 Mar 6;7:43566.

（5）Wenting Zhang, Chengzhi Cai, Li Lin, Yizhi Jane Tao, Meilin Jin*. Subcellular localization and interactions of Infectious Salmon Anemia Virus (ISAV) M1 and NEP as well as host Hsc70.Virology Journal. 2017,DOI 10.1186/s12985-017-0702-z.

（6）Xiaokun Liu, Cha Yang, Yong Hu, Erming Lei1,Xian Lin, Lianzhong Zhao, Zhong Zou, Anding Zhang, Hongbo Zhou, Huanchun Chen, Ping Qian*, Meilin Jin*.HIST1H1C regulates IFN-β and inhibits influenza virus replication by interacting with IRF3.Frontiers in Immunology.2017 Mar 24;8:350.

（7）Cai W, Chen S, Li Y, Zhang A, Zhou H, Chen H, Jin M*. 14-Deoxy-11,12-didehydroandrographolide attenuates excessive inflammatory responses and protects mice lethally challenged with highly pathogenic A(H5N1) influenza viruses.Antiviral Res. 2016,133:95-105.

（8）Zou Z, Chen S, Liu Z, Jin M. *.Identification and genetic analysis of H3N8 subtype influenza viruses isolated from domestic pigeons in Central China.Virus Genes. 2016 Feb;52(1):38-50.

（9）Xian Lin, Ruifang Wang, Wei Zou, Xin Sun, Xiaokun Liu, Lianzhong Zhao, Shengyu Wang, Meilin Jin*.Overexpression of human Cu/Zn superoxide dismutase (SOD1) inhibits the replication of highly pathogenic H5N1 influenza virus in A549 cells.Viruses. 2016.8(1):10.3390/v8010013.

（10）Zhao LZ, Zhu JP, Zhou HB, Zhao ZZ, Zou Z, Liu XK, Lin X, Zhang X, Deng XX, Wang RF, Chen HC, Jin ML*.Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells. Scientific Reports.2015.5:14991.

（11）Cai WT, Li YT, Chen SR, Wang ML, Zhang AD, Zhou HB, Chen HC, Jin ML*.14-Deoxy-11,12-dehydroandrographolide exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export of viral ribonucleoprotein complexes. Antiviral Research.2015.118:82-92.

（12）Lin X, Wang RF, Zhang J, Sun X, Zou Z, Wang SY, Jin ML*.Insights into Human Astrocyte Response to H5N1 Infection by Microarray Analysis. Viruses-Basel.2015.7(5):2618-2640.

（13）Li YT, Wen ZB, Zhou HB, Wu SJ, Jia GM, Qian W, Jin ML*.Porcine interferon-induced protein with tetratricopeptide repeats 3, poIFIT3, inhibits swine influenza virus replication and potentiates IFN-beta production. Developmental & Comparative Immunology. 2015.50(1):49-57.

（14）Lin X, Huang C, Shi J, Wang R, Sun X, Liu X, Zhao L, Jin M*.Investigation of Pathogenesis of H1N1 Influenza Virus and Swine Streptococcus suis Serotype 2 Co-Infection in Pigs by Microarray Analysis.PLoS One. 2015 Apr 23;10(4):e0124086.

（15）Zou Z, Hu Y, Liu ZG, Zhong W, Cao HZ, Chen HC, Jin ML*.Efficient strategy for constructing duck enteritis virus-based live attenuated vaccine against homologous and heterologous H5N1 avian influenza virus and duck enteritis virus infection. Veterinary Research. 2015.46:42.

（16）Hu Y, Liu XK, Zhang AD, Zhou HB, Liu ZD, Chen HC, Jin ML*.CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2. Cellular and Molecular Life Sciences. 2015.72.(5):971-982.

（17）Zhao ZZ, Yi CY, Zhao LZ, Wang SY, Zhou LS, Hu Y, Zou W, Chen HC, Jin ML*.PB2-588I Enhances 2009 H1N1 Pandemic Influenza Virus Virulence by Increasing Viral Replication and Exacerbating PB2 Inhibition of Beta Interferon Expression. Journal of Virology. 2014.88(4):2260-2267.

（18）Li YT, Zou W, Jia GM, Ke JJ, Zhu JP, Lin X, Zhou HB, Jin ML* .The 2009 pandemic (H1N1) viruses isolated from pigs show enhanced pathogenicity in mice. Veterinary Research.2013.44: 41 .

（19）Zou W, Chen DJ, Xiong M, Zhu JP, Lin X, Wang L, Zhang J, Chen LL, Zhang HY, Chen HC, Chen M, Jin ML*.Insights into the increasing virulence of the swine-origin pandemic H1N1/2009 influenza virus. Scientific Reports.2013.3:1601.

（20）Zhao SH, Suo LS, Jin ML*.Genetic Characterization of a Novel Recombinant H5N2 Avian Influenza Virus Isolated from Chickens in Tibet. Journal of Virology.2012.86(24):13836-13837.

（21）Wang N, Zou W, Yang Y, Guo XB, Hua YF, Zhang Q, Zhao ZZ, Jin ML*.Complete Genome Sequence of an H10N5 Avian Influenza Virus Isolated from Pigs in Central China. Journal of Virology. 2012.86(24):13865-13866.

（22）Zou W, Guo XB, Li SY, Yang Y, Jin ML*.Complete Genome Sequence of a Novel Natural Recombinant H5N5 Influenza Virus from Ducks in Central China. Journal of Virology. 2012.86(24):13878.

（23）Hu Y, Liu XK, Li SY, Guo XB, Yang Y, Jin ML* .Complete Genome Sequence of a Novel H4N1 Influenza Virus Isolated from a Pig in Central China. Journal of Virology. 2012.86(24):13879.

（24）Liu C, Zhang AD, Guo J, Yang J, Zhou HB, Chen HC, Jin ML*. Identification of Human Host Proteins Contributing to H5N1 Influenza Virus Propagation by Membrane Proteomics. Journal of Proteome Research. 2012.11(11):5396-5405.

（25）Zou W, Ke JJ, Zhu JP, Zhou HB, Jin ML* .The antigenic property of the H5N1 avian influenza viruses isolated in central China. Journal of Virology.2012.9:10.1186/1743-422X-9-148.

（26）Zhang WT, Tu JG, Zhao ZZ, Chen HC, Jin ML*.The new temperature-sensitive mutation PA-F35S for developing recombinant avian live attenuated H5N1 influenza vaccine. Journal of Virology. 2012.9:97 .

（27）Zhe JP, Zou W, Jia GM, Zhou HB, Hu Y, Peng MY, Chen HC, Jin ML*.Analysis of cellular proteome alterations in porcine alveolar macrophage cells infected with 2009 (H1N1) and classical swine H1N1 influenza viruses. Journal of Proteomics. 2012.75(6):1732-1741.

（28）Tu JG, Guo J, Zhang AD, Zhang WT, Zhao ZZ, Zhou HB, Liu C, Chen HC, Jin ML*.Effects of the C-Terminal Truncation in NS1 Protein of the 2009 Pandemic H1N1 Influenza Virus on Host Gene Expression. PLOS ONE. 2011.6(10): e26175.

（29）Zhou HB, Wang C, Yang Y, Guo XB, Kang C, Chen HC, Jin ML*.Pandemic (H1N1) 2009 Virus in Swine Herds, People's Republic of China. Emerging infectious diseases.2011.17(9):1757-1759.

（30）Li YT, Zhou HB, Wen ZB, Wu SJ, Huang CH, Jia GM, Chen HC, Jin ML*.Transcription analysis on response of swine lung to H1N1 swine influenza virus.BMC GENOMICS.2011.12:398.

（31）Zhou HB, Zhang AD, Chen HC, Jin ML*.Emergence of novel reassortant H3N2 influenza viruses among ducks in China. Archives of Virology. 2011.156(6):1045-1048.

（32）Zhu JP, Zhou HB, Zou W, Jin ML*.Effect of human activated NRAS on replication of delNS1 H5N1 influenza virus in MDCK cells. Virology Journal.2011.9:240.

（33）Zhou HB, Zhu JP, Tu JG, Zou W, Hu Y, Yu ZJ, Yin WS, Li YT, Zhang AD, Wu YR, Yu ZN, Chen HC, Jin ML*.Effect on Virulence and Pathogenicity of H5N1 Influenza A Virus through Truncations of NS1 eIF4GI Binding Domain. Journal of Infectious Diseases. 2010.202(9):1338-1346.

（34）Chen LP, Sheng ZH, Zhang AD, Guo XB, Li JK, Han HY, Jin ML*.Quantum-dots-based fluoroimmunoassay for the rapid and sensitive detection of avian influenza virus subtype H5N1. Luminescence. 2010.25(6):419-423.

（35）Zou W, Ke JJ, Zhang AD, Zhou MG, Liao YH, Zhu JP, Zhou HB, Tu JG, Chen HC, Jin ML*.Proteomics Analysis of Differential Expression of Chicken Brain Tissue Proteins in Response to the Neurovirulent H5N1 Avian Influenza Virus Infection. Journal of Proteome Research .2010.9(8):3789-3798.

（36）Zhou HB, Yu ZJ, Hu Y, Tu JG, Zou W, Peng YP, Zhu JP, Li YT, Zhang AD, Yu ZN, Ye ZP, Chen HC, Jin ML*.The Special Neuraminidase Stalk-Motif Responsible for Increased Virulence and Pathogenesis of H5N1 Influenza A Virus.PLOS ONE.2009.4(7): e6277 .

（37）Luo QP, Huang HL, Zou W, Dan HB, Guo XB, Zhang AD, Yu ZJ, Chen HC, Jin ML*.An indirect sandwich ELISA for the detection of avian influenza H5 subtype viruses using anti-hemagglutinin protein monoclonal antibody. Veterinary Microbiology.2009.137(1-2):24-30.

（38）Tu JG, Zhou HB, Jiang TZ, Li C, Zhang AD, Guo XB, Zou W, Chen HC, Jin ML*.Isolation and molecular characterization of equine H3N8 influenza viruses from pigs in China. Archives of Virology. 2009.154(5):887-890.

（39）Zou W, Yu ZJ, Zhou HB, Tu JG, Jin ML*.Genetic characterization of an H5N1 avian influenza virus with neurovirulence in ducks. Virus Genes .2009.38(2):263-268.

（40）Zhang SL, Xiao LY, Zhou HB, Yu ZJ, Chen HC, Guo AZ, Jin ML*.Generation and characterization of an H5N1 avian influenza virus hemagglutinin glycoprotein pseudotyped lentivirus. Journal of Virological Methods. 2008.154(1-2):99-103.

（41）Xu XJ, Xu GY, Zhou HB, Yu ZJ, Zhang AD, Song YF, Jin ML*, Chen HC.Evolutionary characterization of influenza virus A/duck/Hubei/W1/2004 (H9N2) isolated from central China. Virus Genes .2008.36(1):79-83.

（42）Li XM, Jin ML*, Yu ZJ, Zhang AD, Chen HC, Qian P*. Pathogenicity of a goose isolate of highly pathogenic H5N1 influenza a virus for chickens, mice and pigs. Acta Virologica. 2008.52(1):41-46.

（43）Zhou HB, Jin ML*, Yu ZJ, Xu XJ, Peng YP, Wu HY, Liu JL, Liu H, Cao SB, Chen HC. Effective small interfering RNAs targeting matrix and nucleocapsid protein gene inhibit influenza A virus replication in cells and mice. Antiviral Research .2007.76(2):186-193.

（44）Yu ZJ, Song YF, Zhou HB, Xu XJ, Hu QY, Wu HY, Zhang AD, Zhou YJ, Chen JF, Dan HB, Luo QP, Li XM, Chen HC, Jin ML*.Avian influenza (H5N1) virus in waterfowl and chickens, central China . Emerging Infectious Diseases.2007.13(5):772-775.

（45）Chen JF, Jin ML*, Yu ZJ, Dan HB, Zhang AD, Song YF, Chen HC.A latex agglutination test for the rapid detection of avian influenza virus subtype H5N1 and its clinical application. Journal of Veterinary Diagnostic Investigation. 2007.19(2):155-160.

（46）Huang HL, Dan HB, Zhou YJ, Yu ZJ, Fan HY, Tong TZ, Jin ML*, Chen HC*.Different neutralization efficiency of neutralizing monoclonal antibodies against avian influenza H5N1 virus to virus strains from different hosts. Molecular Immunology. 2007.44(5):1052-1055.

（47）Yu ZJ, Jin ML*, Xu XJ, Zhang RH, Zhou HB, Hu QY, Wu HY, Qin B, Tan Y, Chen HC.Development of a specific latex agglutination test based on a recombinant hemagglutinin protein to detect antibodies to H5 avian influenza viruses. Avian Diseases. 2006.50(2):264-268.

（48）Zhao ST, Jin ML*, Li HC, Tan YD, Wang GH, Zhang RH, Chen HC.Detection of antibodies to the nonstructural protein (NS1) of avian influenza viruses aflows distinction between vaccinated and infected chickens. Avian Diseases. 2005.49(4):488-493.

（49）Xu XJ, Jin ML*, Yu ZJ, Li HC, Qiu DX, Tan YD, Chen HC.Latex agglutination test for monitoring antibodies to avian influenza virus subtype H5N1. Journal of Clinical Microbiology. 2005.43(4):1953-1955.

（50） Jin ML, Wang GH, Zhang RH, Zhao ST, Li HC, Tan YD, Chen HC.Development of enzyme-linked immunosorbent assay with nucleoprotein as antigen for detection of antibodies to avian influenza virus. Avian Diseases. 2004.48(4):870-878.

（51）Zhang AD, Jin ML*, Liu FF, Guo XB, Hu QY, Han L, Tan YD, Chen HC.Development and evaluation of a DAS-ELISA for rapid detection of avian influenza viruses . Avian Diseases.2006.50(3):325-330.

（52）Zhou HB, Jin ML, Chen HC, Huag QF, Yu ZJ .Genome-sequenee analysis of the pathogenic H5N1 avian influenza A virus isolated in China in 2004. VIRUS GENES.2006.32(1):85-95.

（53）Yan Zhang, Nan Wang, Jiyue Cao,Huanchun Chen , Meilin Jin, Hongbo Zhou*. Genetic characterization of H1N2 swine influenza virus isolated in China and its pathogenesis and inflammatory responses in mice. Arch Virol.2013 Sep;158(9):1965-72.

（54）Yan Zhang, Jiping Zhu, Yongtao Li, Konrad C. Bradley, Jiyue Cao, Huanchun Chen, Meilin Jin,Hongbo Zhou*.Glycosylation on Hemagglutinin Affects the Virulence and Pathogenicity of Pandemic H1N1/2009 Influenza A Virus in Mice.Plos ONE.2013,8(4):e61397.

（55）Li Y, Ming F, Huang H, Guo K, Chen H, Jin M, Zhou H.Proteome Response of Chicken Embryo Fibroblast Cells to Recombinant H5N1 Avian Influenza Viruses with Different Neuraminidase Stalk Lengths. Scientific Reports. 2017,7:40698.

（56）LR, Li PW*, Guo XB, Jin ML. Zhang W, Zhang Q. A Chromatographic Strip for Rapid Semi-quantitative Detection of H5 Subtype Avian Influenza Viruses in Poultry. Food Analytical Methods. 2013,6(6): 1712-1717.

（57）Li XP, Lu DL, Sheng Z, Chen K, Guo XB, Jin ML, Han HY*. A fast and sensitive immunoassay of avian influenza virus based on label-free quantum dot probe and lateral flow test strip. Talanta. 2012,100(16): 1-6.

（58）Wu, Q, Fang, LR*, Wu, XB , Li, B , Luo R, Yu ZJ , Jin ML, Chen, HC, Xiao SB. A pseudotype baculovirus-mediated vaccine confers protective immunity against lethal challenge with H5N1 avian influenza virus in mice and chickens. Molecular Immunology. 2009,46(11): 2210-2217.

（59）Wu QF, Xiao SB, Fan HY, Li Y, Xu JF, Li Z, Lu W, Su XY, Zou W, Jin ML, Chen HC, Fang LR*.Protective immunity elicited by a pseudotyped baculovirus-mediated bivalent H5N1 influenza vaccine. Antiviral Research. 2011,92(3): 493-496.

（60）Zhang S, Wang R, Su H, Wang B, Sizhu S, Lei Z, Jin M, Chen H, Cao J, Zhou H.Sus scrofa miR-204 and miR-4331 Negatively Regulate Swine H1N1/2009 Influenza A Virus Replication by Targeting Viral HA and NS, Respectively.Int J Mol Sci. 2017 Apr 3;18(4).

（61）Zhang RH, Li CH, He WX, Wang CL, Xu T*, Jin ML, Chen HC. Development of latex agglutination test with nucleoprotein as antigen for detection of antibodies to swine influenza virus. International Immunopharmacology. 2014, 19(2): 201-205.

豬鏈球菌、副豬嗜血桿菌、豬丹毒等細菌致病機制與免疫機制、疫苗研究相關SCI文章50，第一作者和通訊作者SCI論文36篇

（1）Weifeng Zhu, Chao wu, Chao Kang, Chengzhi Cai, Meilin Jin*.Development of a duplex PCR for rapid detection and differentiation of Erysipelothrix rhusiopathiae vaccine strains and wild type strains.Veterinary Microbiology. 2017, 199: 108–110.

（2）Zhu Weifeng, Ya Wang, Chengzhi Cai, Jingtao Li, Wu Chao,Chao Kang and Meilin Jin*.Erysipelothrix rhusiopathiae recruits host plasminogen via the major protective antigen SpaA. FEMS Microbiology letters. 2017 Mar 1;364(5).

（3）Zhu W, Zhang Q, Li J, Wei Y, Cai C, Liu L, Xu Z, Jin M.Glyceraldehyde-3-phosphate dehydrogenase acts as an adhesin in Erysipelothrix rhusiopathiae adhesion to porcine endothelial cells and as a receptor in recruitment of host fibronectin and plasminogen.Vet Res. 2017 Mar 21;48(1):16.

（4）Ya Wang, Jingtao Li, Anding Zhang, Weifeng Zhu, Qiang zhang; Zhongmin Xu, Shuxian Yan, Xiaomei Sun, Huanchun Chen, Meilin Jin*. iTRAQ-based quantitative proteomics analysis reveals potential virulence factors of Erysipelothrix rhusiopathiae. Journal of Proteomics. 2017. JPROT-D-16-00573R3.

（5）Zhu W, Li J, Wang Y, Kang C, Jin M*, Chen H.Evaluation and improvement of a single nucleotide polymorphism-based PCR assay for rapid differentiation of live attenuated vaccine strains from field isolates of Erysipelothrix rhusiopathiae.J Vet Diagn Invest..2016 ,28(6):714-717.

（6）Huang K, Song Y, Zhang Q, Zhang A, Jin M*. Characterisation of a novel integrative and conjugative element ICESsD9 carrying erm(B) and tet(O) resistance determinants in Streptococcus suis, and the distribution of ICESsD9-like elements in clinical isolates..J Glob Antimicrob Resist. 2016 Jul 28;7:13-18.

（7）Huang K, Zhang Q, Song Y, Zhang Z, Zhang A, Xiao J, Jin M*.Characterization of Spectinomycin Resistance in Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism Antimicrob Agents Chemother. 2016,23;60(10):6390-2.

（8）Zhang Q, Yang YJ, Yan SX, Liu JT, Xu ZM, Yu JP, Song YJ, Zhang AD, Jin ML*.A novel pro-inflammatory protein of Streptococcus suis 2 induces the Toll-like receptor 2-dependent expression of pro-inflammatory cytokines in RAW 264.7 macrophages via activation of ERK1/2 pathway. Frontiers in Microbiology.2015.6:178.

（9）Huang KS, Yuan ZZ, Li JT, Zhang Q, Xu ZM, Yan SX, Zhang AD, Jin ML*.Identification and characterisation a surface-associated arginine peptidase in Streptococcus suis serotype 2. Microbiological Research. 2015.170:168-176.

（10）Zhu WF, Wu C, Sun XM, Zhang AD, Zhu J, Hua YF, Chen HC, Jin ML*.Characterization of Streptococcus suis serotype 2 isolates from China. Veterinary Microbiology. 2013.166(3-4):527-534.

（11）Zhang Q, Zhou MG, Song DS, Zhao JP, Zhang AD, Jin ML*.Molecular characterisation of resistance to fluoroquinolones in Haemophilus parasuis isolated from China. International Journal of Antimicrobial Agents. 2013.42(1):87-89.

（12）Zhang Q, Liu JT, Yan SX, Yang YJ, Zhang AD, Jin ML*.Fluoroquinolone-Resistant Haemophilus parasuis Isolates Exhibit More Putative Virulence Factors than Their Susceptible Counterparts. Journal of Clinical Microbiology. 2013.51(9):3130-3131.

（13）Chen L, Song YJ, Wei ZG, Hei HK, Zhang AD, Jin ML*. Antimicrobial Susceptibility, Tetracycline and Erythromycin Resistance Genes, and Multilocus Sequence Typing of Streptococcus suis Isolates from Diseased Pigs in China. JournalofVeterinaryMedicalScience. 2013.75(5):583-587.

（14）Yuan ZZ, Yan XJ, Zhang AD, Chen B, Shen YQ, JinML*.Molecular Mechanism by Which Surface Antigen HP0197 Mediates Host Cell Attachment in the Pathogenic Bacteria Streptococcus suis. Journal of Biological Chemistry. 2013.288(2):956-963.

（15）Zhang AD, Chen B, Yuan ZZ , Li R, Liu C, Zhou HB, Chen HC, Jin ML*.HP0197 Contributes to CPS Synthesis and the Virulence of Streptococcus suis via CcpA.PLOS ONE.2012.7(11):e50987.

（16）Zhou MG, Zhang Q, Zhao JP, Jin ML*.Haemophilus parasuis Encodes Two Functional Cytolethal Distending Toxins: CdtC Contains an Atypical Cholesterol Recognition/Interaction Region.PLOS ONE. 2012.7(3):e32580.

（17）Chen B, Zhang AD, Xu ZM, Li R, Chen HC, Jin ML*.Large-Scale Identification of Bacteria-Host Crosstalk by Affinity Chromatography: Capturing the Interactions of Streptococcus suis Proteins with Host Cells. Journal of Proteome Research. 2011.10(11):5163-5174.

（18）Zhang AD, Yang M, Hu P, Wu JY, Chen B, Hua YF, Yu J, Chen HC, Xiao JF, Jin ML*.Comparative genomic analysis of Streptococcus suis reveals significant genomic diversity among different serotypes.BMC Genomics.2011.12:523.

（19）Hu P, Yang M, Zhang AD, Wu JY, Chen B, Hua YF, Yu J, Xiao JF, Jin ML*.Complete Genome Sequence of Streptococcus suis Serotype 14 Strain JS14. Journal of Bacteriology. 2011.193(9):2375-2376.

（20）Hu P, Yang M, Zhang AD, , Hua YF, Yu J, Chen HC, Xiao JF, Jin ML*.Complete Genome Sequence of Streptococcus suis Serotype 3 Strain ST3.Journal of Bacteriology. 2011.193(13):3428-3429.

（21）Hu P, Yang M, Zhang AD, Wu JY, Chen B, Hua YF, Yu J, Chen HC, Xiao JF, Jin ML*.Comparative Genomics Study of Multi-Drug-Resistance Mechanisms in the Antibiotic-Resistant Streptococcus suis R61 Strain.PLOS ONE.2011.6(9):e24988.

（22）Zhang AD, Mu XF, Chen B, Liu C, Han L, Chen HC, Jin ML*.Identification and characterization of IgA1 protease from Streptococcus suis. Veterinary Microbiology. 2010.140(1-2):171-175.

（23）Li R, Zhang AD, Chen B, Teng L, Wang Y, Chen HC, Jin ML*.Response of swine spleen to Streptococcus suis infection revealed by transcription analysis. BMC Genomics.2010.11:556.

（24）Chen B, Zhang AD, Li R, Mu XF, He HK, Chen HC, Jin ML*.Evaluation of the protective efficacy of a newly identified immunogenic protein, HP0272, of Streptococcus suis .FEMS Microbiology Letters. 2010.307(1):12-18.

（25）Hu QY, Liu P, Yu ZJ, Zhao G, Li J, Teng L, Zhou MG, Bei WC, Chen HC, Jin ML*.Identification of a cell wall-associated subtilisin-like serine protease involved in the pathogenesis of Streptococcus suis serotype 2. Microbial Pathogenesis.2010.48(3-4):103-109.

（26）Zhang AD, Mu XF, Chen B, Han L, Chen HC, Jin ML*.IgA1 protease contributes to the virulence of Streptococcus suis. Veterinary Microbiology. 2010.148(2-4):436-439.

（27）Liao YH, Deng JH, Zhang AD, Zhou MG, Hu Y, Chen HC, Jin ML*.Immunoproteomic analysis of outer membrane proteins and extracellular proteins of Actinobacillus pleuropneumoniae JL03 serotype 3. BMC Genomics.2009.9:172.

（28）Zhang AD, Chen B, Mu XF, Li R, Zheng P, Zhao YX, Chen HC, Jin ML*.Identification and characterization of a novel protective antigen, Enolase of Streptococcus suis serotype 2. VACCINE. 2009.27(9):1348-1353.

（29）Zhou MG, Zhang AD, Guo Y, Liao YH, Chen HC, Jin ML*.A comprehensive proteome map of the Haemophilus parasuis serovar 5. Proteomics. 2009.9(10):2722-2739.

（30）Zhang A, Chen B, Mu XF, Zhao YX, Zheng P, Chen HC, Jin ML*.Identification of three novel in vivo-induced expressed antigens during infection with Streptococcus suis serotype 2. FEMS Microbiology Letters. 2009.295(1):17-22.

（31）Wei ZG, Li R, Zhang AD, He HK, Hua YF, Xia J, Cai XH, Chen HC, Jin ML*.Characterization of Streptococcus suis isolates from the diseased pigs in China between 2003 and 2007.Veterinary Microbiology. 2009.137(1-2):196-201.

（32）Zhou MG, Guo Y, Zhao JP, Hu QY, Hu Y, Zhang AD, Chen HC, Jin ML*.Identification and characterization of novel immunogenic outer membrane proteins of Haemophilus parasuis serovar 5.VACCINE. 2009.27(38):5271-5277.

（33）Zheng P, Zhao YX, Zhang AD, Kang C, Chen HC, Jin ML*.Pathologic Analysis of the Brain from Streptococcus suis Type 2 Experimentally Infected Pigs. Veterinary pathology. 2009.46(3):531-535.

（34）Zhang AD, Chen B, Li R, Mu XF, Han L, Zhou HB, Chen HC, Jin ML*.Identification of a surface protective antigen, HP0197 of Streptococcus suis serotype 2.VACCINE.2009.27(38):5209-5213.

（35）Zhang AD, Xie CY, Chen HC, Jin ML*.Identification of immunogenic cell wall-associated proteins of Streptococcus suis serotype 2. Proteomics. 2008.8(17):3506-3515.

（36）Yang JX, Jin ML*, Chen JF, Yang Y, Zheng P, Zhang AD,Song YF, Zhou HB, Chen HC.Development and evaluation of an immunochromatographic strip for detection of Streptococcus suis type 2 antibody. Journal of Veterinary Diagnostic Investigation. 2007.19(4):355-361.

（37）Fu L, Zhao J, Lin L, Jin, M，Zhang, A*,et al. Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2. Microbes and Infection . 2016;18:285-9.

（38）Lin, L., Pan, S., Zhao, J., Liu, C., Wang, P., Fu, L., Xu, X., Jin, M. & Zhang, A*. HSPD1 interacts with IRF3 to facilitate interferon-beta induction. PLoS One, 2014, 9: e114874.

（39）Yang, C., Chen, B., Zhao, J., Lin, L., Han, L., Pan, S., Fu, L.,., Chen, H. & Zhang, A. TREM-1 signaling promotes host defense during the early stage of infection with the highly pathogenic Streptococcus suis. Infection and Immunity, 2015, 83: 3293-301.

（40）Yang, C., Zhao, J., Lin, L., Pan, S., Fu, L., Han, L., Jin, M., Zhou, R. & Zhang, A. Targeting TREM-1 Signaling in the Presence of Antibiotics is Effective Against Streptococcal Toxic-Shock-Like Syndrome (STSLS) Caused by Streptococcus suis. Frontiers in Cellular and Infection Microbiology, 2015, 5: 79.

（41）Zhao, J., Pan, S., Lin, L., Fu, L., Yang, C., Xu, Z., Wei, Y., Jin, M. & Zhang, A. Streptococcus suis serotype 2 strains can induce the formation of neutrophil extracellular traps (NETs) and evade trapping. FEMS Microbiology Letters, 2015, 362: pii: fnv022.

（42）Liu J, Tian ZY, Xiao YC, Wang XL, Jin ML , Shi DS*. The Role of Porcine Monocyte Derived Dendritic Cells (MoDC) in the Inflammation Storm Caused by Streptococcus suis Serotype 2 Infection. PLOS ONE. 2016,11(3): e0151256.

（43）Tan, C , Liu, M , Jin, M, Liu, J , Chen, Y, Wu, T, Fu, T , Bei, W *,Chen, H. The key virulence-associated genes of Streptococcus suis type 2 are upregulated and differentially expressed in vivo. FEMS Microbiology Letters. 2008,278(1): 108-114.

（44）Tan, C , Fu, SL, Liu, ML, Jin, ML, Liu, JL, Bei, WC*, Chen, HC . Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate-dehydrogenase, of Streptococcus suis serotype 2. Veterinary Microbiology. 2008,130(34): 363-370.

（45）Wu, HM*,Han, HY, Jin, ML,Zhang, AD.A Novel Method to Detect Muramidase Released Protein(MRP) Antigen of Streptococcus sui Serotype 2 Based on CdSe/ZnS Quantum Dot Probe. Acta Chimica Sinica . 2009, 67(10):1087-1092.

（46）Yue, M , Yang, F, Yang, J, Bei, WC*, Zhou, R, Jin, ML, Jin, Q, Chen, HC, Complete Genome Sequence of Haemophilus parasuis SH0165. Journal of Bacteriology. 2009,191(4): 1359-1360.

（47）Tan C, Liu ML , Liu JL , Yuan FY , Fu SL , Liu Y, Jin ML, Bei, WC*, Chen HC.Vaccination with Streptococcus suis serotype 2 recombinant 6PGD protein provides protection against S-suis infection in swine. FEMS Microbiology Letters. 2009,296(1): 78-83.

（48）Tan C,Liu ML, Li JQ , Jin ML, Bei WC*, Chen HC. SsPep contributes to the virulence of Streptococcus suis. Microbial Pathogenesis.2011,51(5): 319-324.

（49）Cai, XW, Chen, HC, Blackall, PJ , Yin, ZY, Wang, L , Liu, ZF , Jin, ML. Serological characterization of Haemophilus parasuis isolates from China. Veterinary Microbiology. 2005,111(34): 231-236.

（50）Gaur U, Wu HY, Feng Z, Yang XH, Guo R, Wu JJ, Li K, Jin ML, Mei SQ, Liu GS*.Gene Expressions in Major Organs between Enshi Black and Landrace Pigs after Streptococcus suis Infection. Pakistan Veterinary Journal. 2014,34(4): 432-437.

其他重要病原致病機制、疫苗研究相關SCI文章31篇，其中通訊作者和第一作者文章9篇

（1） Zhong Zou, Ji Ma, Kun Huang, Ziduo Liu and Meilin Jin*.Live Attenuated Vaccine Based on Duck Enteritis Virus against Duck Hepatitis A Virus Types 1 and 3.Frontiers in Microbiology. 2016 , 7 :1613.

（2） Sun X, Wang S, Lin X, Zhao L, Zhang D, Yi C, Sun X, Chen H, Jin M*..Proteome analysis of Duck Tembusu virus (DTMUV)-infected BHK-21 cells.Proteomics. 2017 May, doi: 10.1002/pmic.201700033.

（3） Qian W, Wei X, Zhou H, Jin M*.Molecular cloning and functional analysis of duck ubiquitin-specific protease 18 (USP18) gene. Developmental & Comparative Immunology. 62 (2016) :39-47.

（4） Zou Z, Liu ZG, Jin ML*.Efficient Strategy to Generate a Vectored Duck Enteritis Virus Delivering Envelope of Duck Tembusu Virus. Viruses-Basel.2014.6(6):2428-2443.

（5） Hu Y, Liu XK, Zou Z, Jin ML*.Glycoprotein C plays a role in the adsorption of duck enteritis virus to chicken embryo fibroblasts cells and in infectivity. Virus Research. 2013.174(1-2):1-7.

（6） Yu XL, Xiao SB, Jiang YB, Fang LR, Chen HC, Jin ML*.A DNA vaccine encoding the FMDV capsid precursor polypeptide P1 and the enhancing effect of bovine herpesvirus 1 VP22 protein as molecular adjuvant . Acta Virologica. 2012.56(2):111-117.

（7） Hu Y, Zhou HB, Yu ZJ, Chen HC, Jin ML*.Characterization of the genes encoding complete US10, SORF3, and US2 proteins from duck enteritis virus. Virus Genes. 2009.38(2):295-301.

（8） Yunfeng Song, Meilin Jin* , Songlin Zhang, Xiaojuan Xu, Shaobo Xiao, Shengbo Cao, Huanchun Chen.Generation and immunogenicity of a recombinant pseudorabies virus expressing cap protein of porcine circovirus type 2.Veterinary Microbiology . 2007,119(24): 97–104.

（9） Jin ML, Zhang P, Ding MX, Yun JP, Chen PF, Chen YH, Chew YQ .Altered expression of nuclear matrix proteins in etoposide induced apoptosis in HL-60 cells. Cell Research.2001.11(2):125-134.

（10） Wei X, Qian W, Sizhu S, Shi L, Jin M, Zhou H*.Molecular cloning and functional analysis of the duck TIR domain-containing adaptor inducing IFN-β (TRIF) gene. Developmental & Comparative Immunology. 2016 Dec;65:369-76.

（11） Yun JP, Chew EC, Liew CT, Chan JY, Jin ML, Li HK, Liang XM, Wu QL. Nucleophosmin/B23 is a proliferate shuttle protein associated with nuclear matrix. J Cell Biochem. 2003 Dec 15;90(6):1140-8.

（12） Yun JP, Liew CT, Chew EC, Yin XY, Lai PB, Fai YH, Li HK, Jin ML, Ding MX, Li MT, Lin HL, Lau WY. Nuclear matrix protein expressions in hepatocytes of normal and cirrhotic rat livers under normal and regenerating conditions. J Cell Biochem. 2004 Apr 15;91(6):1269-79.

（13） Wu JY*,Si FS, Jiang CY, Li T, Jin ML.Molecular detection of hepatitis E virus in sheep from southern Xinjiang, China. Virus Genes. 2015,50(3):410-.

（14） Li, YM, Ye, J , Cao*, SB, Xiao, SB, Zhao, Q, Liu, XQ, Jin, ML, Chen, HC . Immunization with pseudotype baculovirus expressing envelope protein of Japanese encephalitis virus elicits protective immunity in mice. Journal of Gene Medicine. 2009,11(1): 57-65.

（15） Jiang SJ*, Zhong X, Zhai C, Chen LA , Ma LX, Jin ML, Chen HC. Constructing recombinant herpesvirus BAC vectors with mating-assisted genetically integrated clone method. Biotechnology Letters. 2010,32(7): 903-907.

（16） Yang JX, Hua QY*, Chen HC, Lv JQ, Qin, ZF, Jin ML, Tao H, Zeng SL , Zhou XL. Development and evaluation of an immune chromatographic strip for the detection of serum antibodies against bluetongue virus. Journal of Virological Methods. 2010,163(1): 68-73.

（17） Zhao, ZQ , Xue, Y, Tang, XB, Wu, B, Cheng, XC, He, QG , Zhang, CJ , Guo, AZ, Jin, ML, Chen, H. Immunogenicity of recombinant protective antigen and efficacy against intranasal challenge with Bordetella bronchiseptica. Vaccine. 2009 ,27(18): 2523-2528.

（18） Li YM, Hou LD, Ye J, Liu XQ, Dan HB, Jin ML,Chen HC, Cao SB*. Development of a convenient immunochromatographic strip for the diagnosis of infection with Japanese encephalitis virus in swine. Journal of Virological Methods.2010,168(12): 51-56.

（19） Li, YM, Ye, J , Cao, SB, Xiao, SB*, Zhao, Q , Liu, XQ, Jin ML, Chen, HC. Immunization with pseudotype baculovirus expressing envelope protein of Japanese encephalitis virus elicits protective immunity in mice. Journal of Gene Medicine. 2009,11(2): 150-159.

（20） Li, XM, Qian, P, Shi, DS, Jin, ML, Lan, SY, Chen, HC*. Induction or inhibition of apoptosis by pseudorabies virus Ea strain in suckling piglets. Acta Biochimica et Biophysica Sinica. 2003,35(4): 325-330.

（21） He YN, Qian P, Zhang KH, Yao QX, Wang D , Xu ZF, Wu B, Jin ML , Xiao SB*, Chen HC. Construction and immune response characterization of a recombinant pseudorabies virus co-expressing capsid precursor protein (P1) and a multiepitope peptide of foot-and-mouth disease virus in swine. Virus Genes.2008,36(2): 393-400.

（22） Liu, JL, Chen, X, Lin, LW, Tan, C, Chen, Y , Guo, Y, Jin, ML, Guo, AZ , Bei, WC*,Chen, HC. Potential use an Actinobacillus pleuropneumoniae double mutant strain Delta apxIIC Delta apxIVA as live vaccine that allows serological differentiation between vaccinated and infected animals. Vaccine. 2007, 25（44）: 7696-7705.

（23） Li, XM, Xu, ZF, He, YN , Yao, QX , Zhang, KS, Jin, ML, Chen, HC, Qian, P*. Genome comparison of a novel classical swine fever virus isolated in China in 2004 with other CSFV strains .Virus Genes. 006,33(2): 133-142.

（24） Peng, B, Chen, HY , Tan, YD, Jin, ML, Chen, HC, Guo, AZ* . Identification of one peptide which inhibited infectivity of avian infectious bronchitis virus in vitro. Science in China Series C:Life Sciences.2006,49(2): 158-163.

（25） Bei WC*, He QG, Yan L, Fang LR , Tan YD , Xiao SB, Zhou R, Jin ML. Construction and characterization of a live, attenuated apxIICA inactivation mutant of Actinobacillus pleuropneumoniae lacking a drug resistance marker. FEMS Microbiology Letters. 2005,243(1): 21-27.

（26） Qian, P, Li, XM , Jin ML, Peng, GQ, Chen, HC*. An approach to a FMD vaccine based on genetic engineered attenuated pseudorabies virus: one experiment using VP1 gene alone generates an antibody responds on FMD and pseudorabies in swine. Vaccine.2004,22(17): 2129-2136.

（27） Li, XM, Li, RF, Jin, ML, Qian, P* .Induction of protective immunity in swine by immunization with live attenuated recombinant pseudorabies virus expressing the capsid precursor encoding regions of foot-and-mouth disease virus. Vaccine. 2008,26(22): 2714-2722.

（28） Z.H.Wang, M.X.Ding, ML Jin Chew EC. Association of EGFR gene fragments with nuclear matrix proteins in high and low metastatic melanoma lines. Anticancer Research,1999,19:4349-4352.

（29） Z.H.Wang, M.X.Ding, J.P.Yuan, M.L.Jin Chew EC. Expression of Bcl-2 and Bax in EGFR-Antisense Tansfected and Untransfected Glioblastoma Cells. Anticancer Research,1999,19:4167-4170.

（30） Sheng, ZH, Han, HY*, Hu, DH , Liang, JG, He, QG, Jin, ML, Zhou, R , Chen, HC. Quantum dots-gold(III)-based indirect fluorescence immunoassay for high-throughput screening of APP. Chemical Communications.2009,18: 2559-2561.

（31） Zhang Q, Hu RM, Hu JY, He H, Tang XB, Jin ML, Chen HC, Wu B*. aroA deleted Bordetella bronchiseptica inspiring robust mucosal immune response and provide full protection against intranasal challenge. Research in Veterinary Science. 2013,94(1): 55-61.

主講課程

《細胞生物學》《禽病學進展》《家畜傳染病》《豬病學進展》。