王慧明

中國整形美容協會委員，浙江省口腔醫學會會長；浙江省抗癌協會口腔頜面腫瘤專委會副主任委員；浙江省抗癌協會頭頸腫瘤專委會副主任委員。2000年入選浙江省151人才。兼任六本專業期刊的編委。

1991年在華西醫科大學口腔醫學院獲博士學位，曾在德國基爾大學臨床進修和博士后研究。從事口腔頜面外科專業26年，注重於臨床治療的個性化、手術的微創化、癒合的功能化、外形的美觀化。在複雜病例人工牙種植；面骨骨折和軟組織外傷的微創整復；大型口腔頜面腫瘤的手術及綜合治療；多種皮瓣或肌皮瓣修復口腔及面部組織缺損；正頜手術矯正頜面部骨組織畸形及發育不良；面部輪廓的改型；唇、齶裂畸形功能性修復；頜骨缺損及缺失修復再造等方面具有較深造詣。對口腔頜面腫瘤；頜面組織修復重建；口腔種植；口腔組織工程技術有較深入的研究，發表相關論文80餘篇，主持國家自然基金和省部重點項目多項，主持項目榮獲省部級科技進步獎4項。

口腔種植；口腔頜面腫瘤；頜面組織修復重建；口腔組織工程技術。

1、《口腔頜面種植修復學》2009 世界圖文出版社 主編

2、《口腔頜面重建修復》 參編

3、《現代顱頜面整復外科》2004 浙江大學出版社 參編

1.Zhou Y, Guan X, Wang H*, Zhu Z, Li C, Wu S, Yu H. Hypoxia stimulates osgteogenic/angiogenic responses of bone marrow-derived mesenchymal stromal cells seeded on bone-derived scaffolds via ERK1/2 and p38 pathways. Biotechnol Bioeng. 2013 Jun;110(6):1794-804. (IF: 3.946)

2.Dong Wei, Jian-hua Liu, Wen-quan Zhao, Hui-yong Zhu, Zhi-yong Li, and Hui-ming Wang*, 'Use of the Versatile Sternocleidomastoid Flap in Oral and Maxillofacial Surgery: Our Experience', British Journal of Oral and Maxillofacial Surgery (2013). SCI 1.95

3.Y Zhou, X Guan, W Zhu, Z Liu, X Wang, H Yu, and H Wang*, 'Capsaicin Inhibits Porphyromonas Gingivalis Growth, Biofilm Formation, Gingivomucosal Inflammatory Cytokine Secretion, and in Vitro Osteoclastogenesis', European Journal of Clinical Microbiology & Infectious Diseases (2013), 1-9. SCI 3.024

4.Ziqiang Kong, Mengfei Yu, Kui Chenga, Wenjian Weng, Huiming Wang*, Jun Lin, Piyi Du, Gaorong Han. Incorporation of chitosan nanospheres into thin mineralized collagen coatings for improving the antibacterial effect.Colloids and Surfaces B: Biointerfaces 111 (2013) 536–541 SCI3.554

5.Yang Liu , Mengfei Yu, Kui Cheng, Wenjian Weng, Jun Lin, Huiming Wang*, Piyi Du, Gaorong Han. Influence of rod-surface structure on biological interactions between TiO2 nanorod films and proteins/cells. Thin Solid Films(2013). SCI1.604

6.Xinhua Wang, Mengfei Yu, Wenyuan Zhu, Tingwei Bao, Liqin Zhu, Wenquan Zhao, Fuyan Zhao, Huiming Wang*. Adenovirus-Mediated Expression of Keratinocyte Growth Factor Promotes Secondary Flap Necrotic Wound Healing in an Extended Animal Model. Aesth Plast Surg (2013) 37:1023–1033 SCI 1.264

7.Jun Lin, Lan Yu, Juan Li, Yan Lu, Junjun Tu, Wenjian Weng, Jinghong Xu, and Huiming Wang*, 'The Cellular Response of Titanium Coated with Calcium Phosphate/Collagen-I Complex in Vitro', Nanoscience and Nanotechnology Letters, 5 (2013), 427-32. SCI 1

8.Ting Ling, Mengfei Yu, Wenjian Weng, Huiming Wang*, Kui Cheng, Jun Lin, and Piyi Du, 'Improvement of Drug Elution in Thin Mineralized Collagen Coatings with Plga‐Peg‐Plga Micelles', Journal of Biomedical Materials Research Part A (2013). SCI2.834

9.Li SY, Hu JA, Wang HM*，Expression of Yes- associated protein 1 gene and protein in oral squamous cell carcinoma. Chin Med J (Engl). 2013 Feb;126(4):655-8. SCI 1.017

10.Tingwei Bao, Huiming Wang*, Dong Wei, and Di Yu, 'Transposition of a Lingual Thyroid to the Submandibular Space Using a Modified Technique', Journal of Laryngology and Otology, 126 (2012), 1287. SCI 0.79

11.Kai Ma, Zhifeng Huang, Jianfeng Ma, Longquan Shao, Huiming Wang*, and Yanliang Wang, 'Perlecan and Synaptophysin Changes in Denervated Skeletal Muscle', Neural Regeneration Research, 7 (2012), 1293-98.SCI 0.216

12.Fang L, Wang H*, Zhou L, Yu D. FOXO3a reactivation mediates the synergistic cytotoxic effects of rapamycin and cisplatin in oral squamous cell carcinoma cells. Toxicol Appl Pharmacol. 2011 Feb 15;251(1):8-15. SCI 3.99

13.

Liang Fang, HuiMng Wang*, Lin Zhou, and Da Yu, 'Akt-Foxo3a Signaling Axis Dysregulation in Human Oral Squamous Cell Carcinoma and Potent Efficacy of Foxo3a-Targeted Gene Therapy', Oral oncology, 47 (2011), 16-21. SCI 2.85

14.Jun Lin, Yi-jing Fan, Christian Mehl, Jia-jun Zhu, Hong Chen, Ling-yan Jin, Jing-hong Xu, and Hui-ming Wang*, 'Eucommia Ulmoides Oliv. Antagonizes H2o2-Induced Rat Osteoblastic Mc3t3-E1 Apoptosis by Inhibiting Expressions of Caspases 3, 6, 7, and 9', Journal of Zhejiang University SCIENCE B, 12 (2011), 47-54.SCI 1.679

15.Lin J, Zhu J, Gu X, Wen W, Li Q, Fischer-Brandies H, Wang H*, Mehl C. Effects of bonding with complex adhesives containing fluorapatite or fluorohydroxyapatite to enamel. Acta biomaterialia，2011 Mar;7(3):1346-53. SCI 4.865

16.Xin‐Hua Gu, Cai‐Yun Mao, Cong Liang, Hui‐Ming Wang*, and Matthias Kern, 'Does Endodontic Post Space Irrigation Affect Smear Layer Removal and Bonding Effectiveness?', European journal of oral sciences, 117 (2009), 597-603. SCI 2.07

17.Xin-Hua Gu, Cai-Yun Mao, Cong Liang, Hui-Ming Wang, Matthias Kern. Dose endodontic post space irrigation affect smear layer removal and bongding effectiveness. European Journal Oral Sciences, 2009; 117 : 597-603. IF 2.07

18.Lin Jun, Xu Jinghong, Chen Hong, Dong Chen, Wang Huiming. Study on CPC Carried by rhBMP-2. Rare Metal Materials and Engineering. 2008;5 (37) 626-670 IF 0.251

19.Huiming Wang, Liqin Zhu, et al. Effects of Titanium Implant Surface Coated with Natural Nacre on MC3T3E1 Cell Line in Vitro. Progress in Biochemistry Biophysics, 2008, 35 (6) : 671-675. IF 0.193

20.Hua Yao, Huiming Wang, Zhuo Zhang, Bing-Hua Jiang, Jia Luo and Xianglin Shi. Sulforaphane inhibited expression of hypoxia-inducible factor-1a in human tongue squamaous cancer cells and prostate cancer cells. Int. J. Cancer. 2008; 123, 1255-1261. IF 10.3

21.王慧明，徐俊華等. 骨移植同期種植體植入和二期種植體植入的比較研究. 中國口腔種植學雜誌, 2008, 13(3): 151-153.

22.賀俊，王慧明等. 骨形態發生蛋白-7真核表達載體的構建及其在MC3T3-E1細胞中的表達. 華西口腔醫學雜誌, 2008, 26(5): 479-481

23.王慧明，徐俊華等. 納米羥基磷灰石/I型膠原複合人工骨組成結構及成骨活性的實驗研究. 生物醫學工程學雜誌, 2008, 25 (03) : 567-570.

24.Huiming Wang, Cheng Luo, etal. Simulated Growth of CaCO3 Crystals on Nacreous Surface. Chinese Journal of Inorganic Chemistry, 2007 23 (6) : 1107-1110. SCI IF 0.531

25.賀俊，王慧明等. VEGF165和VEGF121在MC3T3-E1細胞中的表達及生物學功能. 浙江大學學報(醫學版), 2006, 35 (3) : 281-286

26.魏棟，王慧明等. 99^mTc-MDP動態骨顯像在定量監測組織工程骨修復兔顱骨缺損中的應用. 中華放射醫學與防護雜誌, 2006, 26 (5) : 498-500一級雜誌

27.劉治慧，王慧明等. 自體髂骨遊離移植同期種植體植入修復骨量不足區牙缺失的動物實驗研究. 中國口腔種植學雜誌，2006，11（3）：104-109

28.. Kui Cheng, Wenjian Weng, Huiming Wang, Sam Zhang. In vitro behavior of osteoblast-like cells on fluoridated hydroxyapatite coatings. Biomaterials, 2005 :26 (3) 6288-6295. SCI IF 4.64 2/4

29.王慧明，徐俊華等. 牛肌腱膠原蛋白的提取及多孔支架的製作. 中國口腔種植學雜誌, 2005, 10(3): 108-110,142

30.姚華，王慧明等. 茶多酚對舌鱗狀細胞癌細胞增殖和端粒酶催化亞基的抑制作用. 中華口腔醫學雜誌 2005, 40(6); 451-454 一級雜誌

31.劉治慧，王慧明等. 無引導膜狀況下自體髂骨遊離移植同期種植的骨結合強度測試分析及臨床應用. 中國口腔種植學雜誌，2005，10（4）172-174

1、人胚成骨細胞體外培養在生料骨相容性檢測中的應用 第一。

浙江省科技進步二等獎(1998)。

2、生物材料種植界面骨基質基因表達及調控 第一。

浙江省科技進步三等獎(2001)。

3、下唇缺損即刻修復術式設計及數學優選分析 第三。

浙江省科技進步三等獎(2002)。

4、血管化預成組織工程肌骨瓣修復下頜複合缺損的研究 第一。

浙江省科技進步二等獎(2006)。