宋淳

1. 藥物化學：基於計算機靶標模擬的小分子和大分子藥物的設計合成與修飾

2. 藥理學研究：藥物效應動力學，研究藥物對機體的作用，包括藥物的作用和效應、作用機制及臨床應用等。

藥物代謝動力學，研究藥物在機體的作用下所發生的變化及其規律，包括藥物在體內的吸收、分佈、代謝和排泄過程，特別是血葯濃度隨時間變化的規律、影響藥物療效的因素等。

3. 生物分析學研究：用來測定臨床前/臨床藥物動力學參數的生物分析技術研究、方法驗證及標準實驗室管理系統。

4. 新葯開發：開展針對婦科腫瘤、消化道腫瘤的抗腫瘤原創藥物（一類新葯）的研發。

1990.9-1993.7 理學碩士 山東大學 化學系

1998.2-2001.11哲學博士 Brigham Young University 有機化學

2009.9-2012.7 哲學博士 天津大學 藥學院

1993.7-1995.12 工程師 山東華魯科技公司

1996.1-1997.9 工程師 山東省科學院

2001.11-2007.5 高級科學家 輝瑞製藥

2008.3-2010.5 首席科學家 日東電工

2010.8-2011.4 資深科學家 諾華製藥

2011.5-至今教授 山東大學藥物製劑與釋葯系統研究中心

研究生2名，博士生2名

論文

1.Enantioselectiveβ-Boration of Acyclic Enones by a [2.2] Paracyclophane -Based N-HeterocyclicCarbene Copper(I) Catalyst. J. Org. Chem. 2013, 78, 1677−1681.

2.Synthesis of planar chiral[2.2]paracyclophane-based amino thioureas andtheir application in asymmetric aldol reactions of ketones with isatins.Tetrahedron: Asymmetry. 2013,24:1082–1088.

3.Synthesis of novel planar chiral Ag and RhN-heterocyclic carbene complexes derived from [2.2]paracyclophane and theirapplication in ultrasound assisted asymmetric addition reactions oforganoboronic acids to aldehydes. Tetrahedron: Asymmetry .24 (2013) 241–248.

4.Synthesis of newalkoxy/sulfonate-substituted carbene precursors derived from[2.2]paracyclophane and their application in the asymmetric arylation ofaldehydes. Tetrahedron: Asymmetry.2012,23 :1369–1375.

5.Planar Chirality Change in DediazoniationReactions of Paracyclophanes and Mechanistic Implication. Organicletters.2012,14:5436–5439.

6.Asymmetric β-Boration ofr,β-UnsaturatedN-Acyloxazolidinones by [2.2]Paracyclophane-Based Bifunctional Catalys .Organicletters. 2012,14:5780–5783.

7.Benzophenone imine paracyclophane amination.Tetrahedron Lett. 2012, (submitted).

8.Novel effecinet NCH ligands ascross-coupling catalyst and in chiral organocatalysis. Acc.Chem.Res2012,(submitted).

9.Synthesis of cyclophanes with planarandhelical chirelity. J. Org. Chem. 2011, 76, 1953–1956.

10.Synthesis of planar chiral imidazo [1,5-α]pyridinium salts based on [2.2] paracyclophane for asymmetric β-borylation ofenones. Tetrahedron: Asymmetry. 22 (2011) 1055–1062.

11.A new chapter: hematopoietic stem cells aredirect players in immunity. Cell &Bioscience. 2011, 1: 33-37.

12.Synthesis of planar chiral imidazo [1,5-α]pyridinium salts based on [2.2] paracyclophane for asymmetric β-borylation ofenones. Tetrahedron: Asymmetry 2011, 22. 1055.

13.Synthesis of cyclophanes with planarandhelical chirelity. J. Org. Chem. 2011, 76(6), 1953.

14.Planar chiral imidazolium salts based on[2.2]paracyclophane in the asymmetric rhodium-catalyzed 1,2-addition ofarylboronic acids aldehydes. Tetrahedron: Asymmetry. 2010, 21(3), 292.

15.An efficient catalyst system forPd-catalyzed amination of [2.2]paracyclophanyl bromides. J. Org. Chem. 2009,74(17), 6867.

16.Asymmetric allylation of aldehydes withalltrichlorosilane using aza-paracyclophane -oxazoline-N-oxide catalysts.Tetrahedron. Lett. 2006, 47, 8611- 861.

17.Rapid homogeneous-phase sonogashiracoupling reaction using controlled microwave heating in water (invited paper).Green Chemistry, 2005.

18.Palladium catalyzed Suzuki-Miyaura couplingwith aryl chlorides using a bulky phenanthryl N-heterocyclic carbeneligand.Tetrahedron. 2005, 61(31), 7438-7446.

19.Bis-paracyclophane N-heterocycliccarbene-ruthenium catalyzed asymmetric ketone hydrosilylation. TetrahedronLett. 2005, 46(18), 3241-3244.

20.Asymmetric imidazolium catalyzed conjugateaddition. Angew. Chem. Inter. Eng.2003, 42, 5871-5874.

專利

1.PCT/CN2013/077729:Lanthanide labeled peptide and use thereof

2.US2013/882,797 :PEGYLATED CYCLOPAMINEANALOGUE, PREPARATION METHOD AND USES THEREOF

3.PCT/CN2011/000303: PEGYLATED CYCLOPAMINEANALOGUE, PREPARATION METHOD AND USES THEREOF

4.擴增造血幹細胞的化合物及其應用

1.21310004011267防治放化療造成的白細胞減少症的一類新葯KEM0977023 臨床前研究 山東省科技廳

2.23110371611014新型婦科腫瘤化學治療體系及其評價系統的建立 教育部創新基金

3.21310005081323新型熱休克蛋白90抑製劑的設計合成及抗癌檢測 濟南市科技局

4.21310005201301 新型大取代基的N-雜環卡賓配體（NHC）配體設計，合成及應用的研究 山東省自然科

2011 泰山學者海外特聘專家