MAF

MAF（Minor Allele Frequency）：最小的等位基因頻率

Hapmap計劃將MAF>0.05的SNPs作為首要研究目標，MAF廣泛應用於複雜疾病的全基因組關聯研究。在關聯研究中，較小的MAF將會使統計效能降低，從而造成假陰性的結果。為了研究人群中罕見突變與疾病的關聯，通常通過加大樣本量的方法來彌補MAF降低所帶來的統計效能的損失。在研究中，這一突變位點往往屬於同一基因或同一通路上一組罕見突變中的一個。

此外，已知MAF還可以估算樣本量或檢驗效能，並可以確定基因型的頻率。

eg.G is a MAF=0.40 , freq(A)=1-freq(G)=1-0.40=0.60

so,

freq_(AA)=0.60*0.60

freq_(AG)=2*0.40*0.60

freq_(GG)=0.40*0.40

MAF（Maximum Aerobic Function ）

著名的《The Big Book of Endurance Training and Racing》一書提出的耐力訓練方法。

3.MAF（紐西蘭農林部）

4.Medical Device Master File (MAF)

U.S. FDA Medical Device Master File RequirementsA Medical Device Master File (MAF) is a way to preserve trade secrets of medical device companies and their suppliers. A medical device company often needs to submit information about their supplier's product, facility or process. The MAF allows each company to submit its own confidential data to FDA without it being disclosed to anyone outside FDA. A Medical Device Master File is a submission of information to the U.S. Food and Drug Administration by the Medical Device Master File holder.