王斌貴

2002年入選中國科學院“百人計劃”，曾先後在日本、德國、美國等留學、合作研究。主要從事海洋天然藥物化學、海洋生物活性物質研究。以海洋生物（海洋動、植物和海洋微生物）為主要研究對象，以海洋天然產物化學、海洋天然藥物化學研究為基礎，以海洋生物中防治重要疾病創新藥物先導結構的發現與優化為主要研究方向。

已發表論文100餘篇（其中SCI論文70餘篇），申請國家發明專利6項，參編專著3部。近年來主持完成中國科學院“百人計劃”項目、國家自然科學基金重點項目、中國科學院知識創新工程前沿領域項目等課題。課題組目前承擔國家自然科學基金重大國際合作項目、科技部“863計劃”項目、山東省科技發展計劃重點項目等課題的執行。

曾獲中國科學院“百人計劃”（2003）、國家人事部“新世紀百千萬人才工程”（2007）、國務院“政府特殊津貼”（2008）、青島市“專業技術拔尖人才”（2008）及中國科學院“優秀研究生導師”（2008）等榮譽稱號。

1.中國科學院“百人計劃”項目“海洋生物活性先導化合物的發現”（2003-2006）；

2.國家自然科學基金重點項目“松節藻科海洋紅藻若干重要屬、種的化學、生物活性與經典分類學基礎研究”（2005-2009）；

3.科技部“863計劃”目標導向課題“海洋共生菌活性物質的高效利用”（2007-2010）；

4.國家自然科學基金重大國際合作項目“海洋特殊環境中紅樹林植物內生真菌生物多樣性、活性成分及化學生態學意義”（2010-2012）；

1． Cui C M, Li X M, Li C S, Proksch P, Wang B G*, Cytoglobosins A–G, Seven New Cytochalasans from a Marine Derived Endophytic Fungus Chaetomium globosum QEN-14, Journal of Natural Products

2．Yan H J, Gao S S, Li C S, Li X M, Wang B G*, Chemical Constituents of a Marine-derived Endophytic Fungus Penicillium commune G2M, Molecules

3．Li C S, Li X M, Cui C M, Wang B G*,Brominated Metabolites from the Marine Red Alga Laurencia similis,Zeitschrift für Naturforschung

4． Wang B G*, Zhang W W, Duan X J, Li X M, In vitro antioxidative activities of extract and semi-purified fractions of the marine red alga Rhodomela confervoides (Rhodomelaceae). Food Chemistry

5． Li D L, Li X M, Wang B G*, Natural Anthraquinone Derivatives from a Marine Mangrove Plant-derived Endophytic Fungus Eurotium rubrum: Structural Elucidation and DPPH Radical-scavenging Activity. Journal of Microbiology and Biotechnology

6． Ji N Y, Li X M, Li K, Wang B G*, Halogenated Sesquiterpenes from the Marine Red Alga Laurencia saitoi (Rhodomelaceae), Helvetica Chimica Acta

7．Cui C M, Li X M, Li C S, Sun H F, Gao S S, Wang B G*, Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus, Helvetica Chimica Acta

8．Liang Y, Li X M, Cui C M, Li C S, Wang B G*,A new rearranged chamigrane sesquiterpene from Laurencia okamurai, Chinese Chemical Letters

9．Gao S S, Li X M, Wang B G*, Perylene Derivatives Produced by Alternaria alternate, an Endophytic Fungus Isolated from Algal Species of Laurencia sp., Natural Product Communications

10．Li K, Li X M, Ji N Y, Gloer J B, Wang B G*,Urceolatin, a Structurally Unique Bromophenol from Polysiphonia urceolata, Organic Letters

11．Li K, Li X M, Ji N Y, Wang B G*, Bromophenols from the Marine Red Alga Polysiphonia urceolata (Rhodomelaceae) with DPPH Radical Scavenging Activity, Journal of Natural Product

12．Ji N Y, Li X M, Xie H, Ding J, Li K, Ding L P, Wang B G*, Highly Oxygenated Triterpenoids from the Marine Red Alga Laurencia mariannensis (Rhodomelaceae). Helvetica Chimica Acta

13．Li D L, Li X M, Li T G, Dang H Y, Wang B G*, Dioxopiperazine Alkaloids Produced by the Marine Mangrove Derived Endophytic Fungus Eurotium rubrum. Helvetica Chimica Acta

14．Ji N Y, Li X M, Li K, Ding L P, Gloer, J B, Wang B G*, Diterpenes, Sesquiterpenes, and a C15-Acetogenin from the Marine Red Alga Laurencia mariannensis, Journal of Natural Products

15．Li K, Li X M, Ji N Y, Wang B G*, Natural Bromophenols from the Marine Red Alga Polysiphonia urceolata (Rhodomelaceae): Structural Elucidation and DPPH Radical-scavenging Activity. Bioorganic & Medicinal Chemistry

16．Ji N Y, Li X M, Li K, Wang B G*, Laurendecumallenes A-B and Laurendecumenyns A-B, Halogenated Nonterpenoid C15-Acetogenin from the Marine Red Alga Laurencia decumbens, Journal of Natural Products,

17．Duan X J, Li X M, Wang B G*, Highly Brominated Mono- and Bis-phenols form the Marine Red Alga Symphyocladia latiuscula with Radical-scavenging Activity, Journal of Natural Products

18．Zhang Y, Li X M, Peter Proksch, Wang B G*, Ergosterimide, a New Natural Diels-Alder Adduct of a Steroid and Maleimide in the Fungus Aspergillus niger, Steroids

19．Wang S, Li X M, Teuscher F, Li D L, Diesel A, Ebel R, Proksch P, Wang B G*, Chaetopyranin, a Benzaldehyde Derivative and Other Related Metabolites from Chaetomium globosum,an Endophytic Fungus Derived from Marine Red Alga Polysiphonia urceolata. Journal of Natural Products

20．Duan X J, Zhang W W, Li X M, Wang B G*, Evaluation of Antioxidant Property of Extract and Fractions Obtained from a Red Alga, Polysiphonia urceolata, Food Chemistry

21. Wang B G*, Gloer J B, Ji N Y, Zhao J C, Halogenated Molecules of Rhodomelaceae Origin: Chemistry and Biology,Chemical Reviews, 2013, 113(5), 3632-3685.

22. Zhang Z, Miao L, Lv C, Sun H, Wei S, Wang B G*, Huang C G*, Jiao B H*, Wentilactone B Induces G2/M Phase Arrest and Apoptosis via the Ras/Raf/MAPK Signaling Pathway in Human Hepatoma SMMC-7721 Cells.Cell Death & Disease, 2013, 4, e657.

23. Lv C, Hong Y, Miao L, Li C S, Xu G M, Wei S, Wang B G*, Huang C G*, Jiao B H*, Wentilactone A as a Novel Potential Antitumor Agent Induces Apoptosis and G2/M Arrest of Human Lung Carcinoma Cells, and is Mediated by HRas-GTP Accumulation to Excessively Activate the Ras/Raf/ERK/p53-p21 Pathway.Cell Death & Disease, 2013, 4, e952.

24. Du F Y, Zhang P, Li X M, Li C S, Cui C M, Wang B G*, Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived FungusBeauveria felina EN-135,Journal of Natural Products, 2014, 77(4), 1164−1169.

25. Meng L H, Li X M, Liu Y, Wang B G*, Penicibilaenes A and B, Sesquiterpenes with a Tricyclo[6.3.1.01,5]dodecane Skeleton from the Marine Isolate ofPenicillium bilaiaeMA-267,Organic Letters, 2014, 16(23), 6052−6055.

26. Zhang P, Mándi A, Li X M, Du F Y, Wang J N, Li X, Kurtán T*, Wang B G*, Varioxepine A, a 3H-Oxepine-Containing Alkaloid with a New Oxa-Cage from the Marine Algal-Derived Endophytic FungusPaecilomyces variotii,Organic Letters, 2014, 16(18), 4834−4837.

27. Zhao J C, Li, X M, Gloer J B, Wang B G*, First Total Syntheses and Antimicrobial Evaluation of Penicimonoterpene, a Marine-Derived Monoterpenoid, and Its Various Derivatives,Marine Drugs, 2014, 12(6), 3352-3370.

28. Meng L H, Liu Y, Li X M, Xu G M, Ji N Y*, Wang B G*, Citrifelins A and B, Citrinin Adducts with a Tetracyclic Framework from Cocultures of Marine-derived Isolates ofPenicillium citrinum andBeauveria felina.Journal of Natural Products, 2015, 78(9), 2301−2305.

29. Li X D, Li X M, Li X, Xu G M, Liu Y, Wang B G*, Aspewentins D−H, 20-Nor-isopimarane Derivatives from the Deep Sea Sediment-Derived FungusAspergillus wentii SD-310.Journal of Natural Products, 2016, 79(5), 1347−1353.

30. Ji N Y*, Wang B G*, Mycochemistry of Marine Algicolous Fungi.Fungal Diversity, 2016, online published, doi:10.1007/s13225-016-0358-9.