袁直

1989年獲博士學位后留南開大學高分子所任講師，1992年晉陞為副教授，1996年晉陞為教授。2000年7月，任南開大學化學院副院長，高分子所所長。

現任南開大學化學院副院長，高分子所所長，民盟天津市委副主任委員。

2017年6月，民盟天津市第十一屆委會召開第一次全體會議，選舉袁直為副主任委員。

1、吸附分離材料的結構設計及吸附機制研究

2、納米肝靶向給葯系統研究

3、誘導抗凝血生物化表面的設計和構建

國家自然科學基金重點項目及多項面上項目，“973項目”課題，天津市科技支撐重點項目，天津市自然科學基金重點項目。

部分論文（原文）

(1) Zhi Yuan*. Doxorubicin-loadedglycyrrhetinicacid-modified alginate nanoparticles for liver tumor chemotherapy.Biomaterials, 2012,33, 2187–2196.

(2) ZhiYuan*. Self-assembly and liver targeting of sulfatedchitosan nanoparticlesfunctionalized with glycyrrhetinic acid.Nanomedicine: nanotechnology, biology, and medicine, 2012,8, 870–9.

(3) ZhiYuan*. Synthetic receptor and its association with CTDpeptides.Tetrahedron, 2012,68, 2357–2362.

(4) ZhiYuan*. In vitro evaluation of polymeric micelles basedonhydrophobically-modified sulfated chitosan as a carrier of doxorubicin.Journal of Materials Science: Materials in Medicine, 2012,23,1663–1674.

(5) ZhiYuan*. Selective removal of caffeine from tea extracts using macroporouscrosslinked polyvinyl alcohol adsorbents.Journal of Separation Science, 2012,35, 36–44.

(6) ZhiYuan*. Effects of oligopeptide’s conformational changes on itsadsorption.Colloids andsurfaces. B,Biointerfaces, 2011,83,229–236.

(7) ZhiYuan*. HUVEC cell affinity evaluation and integrin-mediated mechanismstudy on PHSRN-modified polymer.Colloidsand surfaces B Biointerfaces, 2011,84,6–12.

(8) ZhiYuan*. A comparison study between polymeric ligand and monomeric ligandfor oligopeptide adsorption.Journalofcolloid and interface science, 2011,355, 478–85.

(9) ZhiYuan*. Glycyrrhetinic acid-functionalized degradable micelles asliver-targeted drug carrier.Journalof Materials Science-Materials in Medicine, 2011,22, 853–863.

(10) ZhiYuan*. An efficient molecular docking method for adsorbentscreening.Journal OfChromatography B, 2011,879,1605–1609.

(11) Wang, J.; Wang, W.;Wei, Q.; Zhang, S.;Yuan, Z. New method for affinity adsorbent screening usinggold colloids.Langmuir, 2011,27, 11457–65.

(12) ZhiYuan*. Understanding the role of the C3-hydroxyl group inglycyrrhetinicacid on liver targeting.Journalof controlled release, 2011,152, 237–239.

(13) ZhiYuan*. Antitumor activity of drug loaded glycyrrhetinicacid modifiedalginate nanoparticles on mice bearing orthotopic liver tumor.Journal of controlled release, 2011,152, 111–113.

(14) ZhiYuan*. The potential for blood vessel engineering of PHSRN-modifiedpolymer:HUVEC cell affinity evaluation and integrin-mediated mechanismstudy.Journal of controlledrelease, 2011,152, 243–245.

(15) ZhiYuan*. Blood compatibility evaluation of poly(D,L-lactide-co-beta-malicacid) modified with the GRGDS sequence.Colloids and surfaces. B, Biointerfaces, 2010,75, 370–6.

(16) Tian, Q.; Zhang,C.-N.; Wang, X.-H.; Wang,W.; Huang, W.; Cha, R.-T.; Wang, C.-H.; Yuan, Z.; Liu,M.; Wan, H.-Y.; Tang, H.Glycyrrhetinic acid-modified chitosan/poly(ethyleneglycol) nanoparticles for liver-targeted delivery.Biomaterials, 2010,31, 4748–4756.

(17) ZhiYuan*. Adsorbents with high selectivity for uremic middle molecularpeptides containing the Asp-Phe-Leu-Ala-Glusequence.Langmuir, 2010,26, 7181–7187.

(18) ZhiYuan*. Colorimetric detection of bis-phosphorylated peptides usingzinc(ii) dipicolylamine-appended gold nanoparticles.Sensors and Actuators B: Chemical, 2010,147, 687–690.

(19) ZhiYuan*. Glycyrrhetinicacid-modified poly(ethylene glycol)-b-poly(gamma-benzyll-glutamate) micelles for liver targeting therapy.Acta biomaterialia, 2010,6,3927–3935.

(20) ZhiYuan*. Silk fibroin/montmorillonite nanocomposites: effect of pH on theconformational transition and clay dispersion.Biomacromolecules, 2010,11, 1796–1801.

(21) ZhiYuan*. Insight into glycyrrhetinic acid: the role of the hydroxyl group onliver targeting.Internationaljournal of pharmaceutics, 2010,400, 153–7.

(22) ZhiYuan*. Design, optimization and evaluation of specific affinity adsorbent foroligopeptides.Journal ofChromatography A, 2010,1217, 7539–7546.

(23) ZhiYuan*. A novel copolymer poly(lactide-co-beta-malic acid) with extendedcarboxyl arms offering better cell affinity and hemacompatibility for bloodvessel engineering.Tissue engineeringPart A, 2009,15, 65–73.

(24) ZhiYuan*. Affinity adsorption mechanis mstudies of adsorbents foroligopeptides using model polymer.Polymer,2009,50, 1602–1608.

(25) ZhiYuan*. Rapid and efficient screening of adsorbent for oligopeptide usingmolecular docking and isothermal titration calorimetry.Journal of Separation Science, 2009,32, 2462–2468.

(26) ZhiYuan*. Synthesis, degradability, and cell affinity ofpoly(DL-lactide-co-RS-hydroxyethyl-beta-malolactonate).Journal of Biomedical Materials Research Part A, 2008,87, 459–469.

(27) ZhiYuan*. Studies on adsorption isotherms of endotoxin and BSA using anaffinity column.ProcessBiochemistry, 2007,42, 285–288.

(28) ZhiYuan*. Studies on endotoxin removal mechanism of adsorbents with aminoacid ligands.Journal OfChromatography B, 2007,852, 288–292.

(29) ZhiYuan*. Adsorption mechanism at the molecularlevel between polymers anduremic octapeptide by the 2D 1H NMR Technique.Biomacromolecules, 2006,7, 1811–1818.

(30) ZhiYuan*. Synthesis and characterization of a functionalized amphiphilicdiblock copolymer: MePEG-b-poly(DL-lactide-co-RS-β-malic acid).Colloid and Polymer Science, 2006,285, 273–281.

(31) ZhiYuan*. Synthesis and characterization of novel functionalized polylactideswith pendent hydroxyl arms.Polymer,2006,47, 6978–6985.

(32) ZhiYuan*. Endotoxin adsorbent using dimethylamine ligands.Biomaterials,2005,26, 2741–7.

(33) ZhiYuan*. Separation, identification of uremic middle molecules, andpreliminary study ontheir toxicity.Clinica chimica acta,2004,350,89–98.

專利

1. 袁直等, 中國發明專利, ZL 93107357.x。

2. 袁直等, 中國發明專利, ZL 93107356.1。

3. 袁直等, 中國發明專利, ZL 03 144231.5。

4. 袁直等, 中國發明專利, ZL 03 144383.4。

5. 袁直等, 中國發明專利, ZL200510015172.7。

6. 袁直等, 中國發明專利, ZL 200810052636.5。

7. 袁直等, 中國發明專利, ZL 200810052635.0,。

8. 袁直等, 中國發明專利, CN101444720。

9. 袁直等, 國際專利, 申請號PCT/CN2009/000150。

10. Zhi Yuan et al, US Patent, Application Number 12338966。

11. 袁直等, 中國發明專利, 申請號200910068769.6。

12. 袁直等, 中國發明專利, 申請號200910070231.9。

曾獲中國化學會青年化學獎、國家科技進步二等獎，天津青年科技獎、科技部杜邦科技創新獎、天津市科技進步二等獎、教育部科技進步三等獎；榮獲全國先進女職工稱號。