向文勝

1993- 1995: Assistant。

1996 - 2000: Lecturer。

2001 - 2003: Postdoctoral fellow。

2001-2003中國科學院過程工程所博士后。

2001 - 2003: Associate professor。

2003-2005浙江大學化學系博士后。

2003 - present: Professor。

2007 - present: Longjiang Scholar Professor。

2008 - present: Excellent Talents in University, China。

主講課程

主講本科生課程《工業微生物》，主講碩士研究生課程《儀器分析》《生物化工研究班討論》課程。

學生培養

招收培養碩士研究生58名、博士生31名，指導博士后4名。畢業生中大部分就業於國內知名大學和科研院所，其中13名赴國外深造或工作。1998年被遴選為博士生導師，2000年以來，連續被評為東北農業大學優秀博士生導師，省第三屆和第四屆優秀研究生學位論文指導教師，黑龍江省研究生優秀導師等。

研究方向

Current research interests are about isolating and screening of antibiotic-generating strain, secondary metabolite biosynthesis in microorganisms, gene cloning and expression, enzyme reaction mechanisms, metabolic pathway engineering, and natural product drug discovery and development.

研究課題

(1) 國家科技支撐計劃重點項目——新型抗寄生蟲原料葯的研製與應用，2007-2010。

(2 ) 國家科技支撐計劃重點項目子項目——抗寄生蟲類藥物篩選新技術，2007-2010。

(3) 教育部新世紀優秀人才計劃——農用抗生素米爾貝黴素的生物合成與調控，2009-2011。

(4) 國家自然基金——高選擇性谷氨酸門控氯離子通道篩選體系研究與應用，2008-2010。

(5) 國家自然科學基金——γ-氨基丁酸受體親和篩選模型的構建和獲得新配體方法的建立及應用，2006-2008。

(6) 國家自然科學基金——基於與天門冬醯胺合成酶結合小分子信號的混合篩選及先導化合物的發現，2005-2005。

(7) 國家自然科學基金——P450體外代謝除草劑模型的構建及作用，2003-2005。

(8) 國家自然科學基金——P450催化除草劑代謝速率及羥基化位點與化合物結構的關係，2000-2002。

(9) 國家自然科學基金——抗草甘膦EPSP合酶基因克隆及抗性機理，1997-1999。

(10) 黑龍江省傑出青年基金，冰城鏈黴菌生物合成米爾貝黴素基因簇及調控基因克隆與高產代謝工程菌的構建，2008-2010。

(11) “973”子項目，農藥活性化合物及菌株篩選，2004-2008。

(12) “龍江學者特聘教授”配套基金項目，2008-2010。

(13) 省重點項目，多拉菌素工程菌的構建，2008-2010。

(14) 哈爾濱市科委重點項目，多拉菌素高產優良的選育，2007-2009。

(15) “973”子項目，農藥活性化合物篩選及與靶分子的作用，2010-2014。

論文著作

發表論文

1. Xiang-Jing Wang, Ming Wang, Ji-Dong Wang, Wen-Sheng Xiang. Isolation and Identification of Novel Macrocyclic Lactones from Streptomyces Avermitilis NEAU1069 with Acaricidal and Nematocidal Activity, Journal of Agricultural and Food Chemistry, (publishing)

2. Ming Wang, Xiao-Hu Yang, Ji-Dong Wang, Xiang-Jing Wang, Zheng-Jie Chen, Wen-Sheng Xiang. New β-Class Milbemycin Compound from Streptomyces avermitilis NEAU1069: Fermentation, Isolation and Structure Elucidation, J. Antibiotics, 2009, 62(10):587-591

3. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, Ji Zhang, Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties, J. Antibiotics, 2009, 62(9):501-505

4. Lu Shi-Xiang, Guo Yang-Hui, Wang Ya-Ping, Wang Xiang-Jing, Xiang Wen-Sheng. A novel synthesis of ( R)-4-cyano-3-hydroxybutyric acid ethyl ester, Chinese Journal of Organic Chemistry, 2009，

5. Xiang-Jing Wang, Suo-Lian Guo, Wan-Qian Guo, Wen-Sheng Xiang. Role of nsdA in Negative Regulation of Antibiotic Production and Morphological Differentiation in Streptomyces bingchengensis, J. Antibiotics, 2009, 62(6):329-13

6. Xiang-Jing Wang, Xiao-Chong Wang, Wen-Sheng Xiang. Improvement of milbemycin-producing Streptomyces bingchenggensis by rational screening of ultraviolet- and chemically induced mutants, World Journal of Microbiology and Biotechnology, 2009, 25:1051-1056

7. Xiang-Jing Wang, Ji-Dong Wang, Wen-Sheng Xiang. Three new milbemycin derivatives from Streptomyces bingchenggensis, Journal of Asian Natural Products Research, 2009, 11 (7), 597-603

8. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, A novel macrolide compound from the Streptomyces bingchenggensis, Fermentation, Isolation, Structure Elucidation and Biological Properties, J. Antibiotics, 2009, 62(4):229-31

9. Hai Bo Sun, Guo Jun Zheng , Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang. Novel synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde: A key intermediate of Losartan, Chinese Chemical Letters, 20 (2009) 269-270

10. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Optimization of culture conditions for hydrogen production by Ethanoligenens harbinense B49 using response surface methodology. Bioresource Technology, 2009, 100 (3): 1192-6

11. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, New Seco-milbemycins from Streptomyces bingchenggensis: Fermentation, Isolation and Structure Elucidation, J.Antibiotics, 2008, 61 (1): 27-32

12. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, Two new components from Gnetum pendulum, J. of Asian Natural Products Research, 2008, 10: 1-5

13. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Biohydrogen production from ethanol-type fermentation of molasses in an expanded granular sludge bed (EGSB) reactor. Int J Hydrogen Energy, 2008, 33(19): 4981~4988

14. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Simultaneous biohydrogen production and starch wastewater treatment in an acidogenic expanded granular sludge bed reactor by mixed culture for long-term operation. Int J Hydrogen Energy, 2008, 33: 7397-7404

15. Nan-Qi Ren, Wan-Qian Guo, Xiang-Jing Wang, Wen-Sheng Xiang. Effects of different pretreatment methods on fermentation types and dominant bacteria for hydrogen production. Int J Hydrogen Energy, 2008, 33 (16): 4318~4324

16.Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang. Two new milbemycins from Streptomycesbingchenggensis Fermentation, Isolation, Structure Elucidation and Biological properties, J. Antibiotics, 2007, 60 (6):351-356

17. iangjing Wang, Nanqi Ren, Wensheng Xiang. Influence of Gaseous End-products Inhibition and Nutrient Limitations on the Growth and Hydrogen Production by Hydrogen-producing Fermentative Bacterial B49, International Journal of hydrogen Energy, 2007(32):748-754

18. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang. Further New Milbemycin Antibiotics from Streptomyces bingchenggensis,J .Antibiotics, 2007, 60 (10): 608-613

19. Wensheng Xiang, Xiangjing Wang, Expression of a wheat cytochrome P450 monooxygenase cDNA in yeast catalyzes the metabolism of sulfonylurea herbicide. Pest . Biochem. Physio, 2006, 85(1):1-6

20. Xiang Wensheng, Wang Xiangjing, Purification of recombinant wheat cytochrome P450 monooxygenase expressed in yeast and its properties, Protein Expression and Purification, 2006(1):54-59

21. Wensheng Xiang, Xiangjing Wang, Expression of a wheat cytochrome P450 monooxygenase cDNA in yeast catalyzes the metabolism of sulfonylurea herbicide. Pest . Biochem. Physio, 2006, 85(1):1~6

著作、教材

(1) “十一五”規劃教材《儀器分析》，主編，哈爾濱工業大學出版社。

(2) 《現代農業儀器分析應用技術》 主編，東北林業大學出版社。

(3) 《生物化學過程工程學》 副主編，科學出版社。