吳長鋒

吳長鋒

吳長鋒,南方科技大學徠教授,博士生導師,生物醫學工程系副系主任,國家首批青年特聘教授,國家自然科學優秀青年科學基金獲得者,中國生物醫學工程學會生物光子學分會委員。在國際上率先開展半導體聚合物熒光量子點 (Polymer Dot) 的研究,近十年來在聚合物點的製備表徵、能量傳遞、單粒子熒光、性能調控、和生物醫學應用等方面取得了多項原創性學術成果。迄今在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., Nano Lett.等期刊上共發表SCI收錄論文100餘篇,被包括Nature、Science、Nature 子刊、Chemical Reviews、Chemical Society Reviews在內的學術期刊總共引用7000多次,當前H 因子為43,研究成果已申請國際PCT專利7項。

人物簡介


青年千人吳長鋒
青年千人吳長鋒
吳長鋒,物理學和化學雙博士學位,2011年入選國家首批“青年”。任吉林大學教授,博士生導師。2004年獲中國科學院長春光機所凝聚態物理博士學位,2008年獲美國克萊姆森大學化學博士學位,隨後在華盛頓大學從事博士后研究。2011年入選國家首批青年,入職吉林大學電子科學與工程學院工作,被聘為教授、博士生導師。2012年獲得國家自然科學優秀青年科學基金,2013年獲得國家自然科學基金重點項目資助。主要研究方向:生物光子學;分子探針及成像技術;光電功能高分子材料;生物分 析檢測與生物感測器。
2004年在中科院長春光機與物理研究所獲得“凝聚態物理”理學博士,攻讀博士期間在國際上首次製備出Y2O3:Eu納米管,用高分辨激光光譜學探測稀土離子在納米管中的不同格位,發表在Appl. Phys. Lett.上的學術論文已被SCI引用140多次。博士畢業后赴美國Clemson大學物理系從事博士后研究,並於2005年在Clemson大學攻讀化學博士學位。在此期間,與導師Dr. Jason McNeill合作在國際上率先開展了半導體聚合物作為熒光量子點的研究,系統研究了半導體聚合物量子點的製備表徵、能量傳遞、及單粒子熒光等性質。2008年獲Clemson大學化學博士學位,隨後赴美國華盛頓大學Dr. Daniel Chiu研究組從事博士后研究,博士後期間實現了聚合物量子點的生物功能化、生物細胞的特異性標記及對活體動物腫瘤組織的靶向性輸送等多方面的突破,為聚合物量子點的生物醫學應用奠定了基礎。 2011年入選國家首批“青年”,入職吉林大學電子科學與工程學院工作,被聘為教授、博士生導師。2012年受聘為齊魯工業大學客座教授。任電子學院生物醫學工程系主任,吉林省青聯委員。
迄今在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., Nano Lett.等期刊上共發表SCI收錄論文100餘篇,被包括Nature、Science、Nature 子刊、Chemical Reviews、Chemical Society Reviews在內的學術期刊總共引用7000多次,當前H 因子為43,研究成果已申請國際PCT專利7項。
教育和工作經歷
1994-1998 齊魯工業大學材料科學與工程學院 本科
1998-2001 吉林大學材料科學與工程學院 碩士
2001-2004 中科院長春光機與物理研究所 凝聚態物理博士
2004-2005 美國Clemson 大學物理系 生物光學博士后
2005-2008 美國Clemson 大學化學系 物理化學博士
2008-2012 美國華盛頓大學化學系 生物分析博士后
2012-2016 吉林大學電子科學與工程學院 教授、博士生導師
2016年-至今 南方科技大學生物醫學工程系 教授
項目負責人
2011 年 國家青年項目
2012 年 國家自然科學優秀青年基金項目“生物醫學光子學”
2013 年 國家自然科學基金重點項目“開關/閃爍可控聚合物量子點的設計製備及納米分辨動態光學成像研究”

代表性論文


Zhang, B.; Wang, F.; Zhou, H.; Gao, D.; Yuan, Z.; Wu, C.*; Zhang, X.*, Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy.Angew. Chem. Int. Ed.2019, 58(9), 2744-2748.
Chen, H.; Wang, F.; Liu, M.; Qian, M.; Men, X.; Yao, C.; Xi, L.; Qin, W.; Qin, G.*; Wu, C.*, Near-Infrared Broadband Polymer-Dot Modulator with High Optical Nonlinearity for Ultrafast Pulsed Lasers.Laser Photonics Rev.2019, 13(2), 1800326.
Sun, K.; Yang, Y.; Zhou, H.; Yin, S.; Qin, W.; Yu, J.; Chiu, D.T.; Yuan, Z.; Zhang, X.; Wu, C.*, Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone,ACS Nano2018, 12 (6), 5176–5184
Chen, H.; Fang, X.; Jin, Y.; Hu, X.; Yin, M.; Men, X.; Chen, N.; Fan, C.; Chiu, D. T.; Wan Y.*; Wu, C.*, Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery.Small2018, 14(21), 1800239.
Chang, K.; Liu, Z.; Fang, X.; Chen, H.; Men, X.; Yuan, Y.; Sun, K.; Zhang, X.; Yuan, Z.; Wu, C.*, Enhanced Phototherapy by Nanoparticle-Enzyme via Generation and Photolysis of Hydrogen Peroxide.Nano Lett.2017, 17 (7), 4323-4329.
Chen, X.; Liu, Z.; Li R.; Shan, C.; Zeng, Z.; Xue, B.; Yuan, W.; Mo, P.; Xi, P.*; Wu, C.*; Sun, Y.*, Multicolor Super-resolution Fluorescence Microscopy with Blue and Carmine Small Photoblinking Polymer Dots.ACS Nano2017, 11 (8), 8084-8091.
Chen, X.; Li R.; Liu, Z.; Sun, K.; Sun, Z.; Chen, D.; Xu, G.; Xi, P.; Wu, C.*; Sun, Y.*, Small Photoblinking Semiconductor Polymer Dots for Fluorescence Nanoscopy.Adv. Mater.2017, 29 (5), 1604859.
Chen, D.; Wu, I. C.; Liu, Z.; Tang, Y.; Chen, H.; Yu, J.; Wu, C.*; Chiu, D. T.*, Semiconducting Polymer Dots with Bright Narrow-Band Emission at 800 nm for Biological Applications.Chem. Sci.2017, 8 (5), 3390-3398.
Chen, H.; Zhang, J.; Chang, K.; Men, X.; Fang, X.; Zhou, L.; Li, D.; Gao, D.; Yin, S.; Zhang, X.; Yuan, Z.; Wu C.*;Biomaterials.2017, 144, 42-52.
Che徠n, D.; Li, Q.; Meng, Z.; Guo, L.; Tang, Y.; Liu, Z.; Yin, S.; Qin, W.; Yuan, Z.; Zhang, X.; Wu. C.*, Bright Polymer Dots Tracking Stem Cell Engraftment and Migration to Injured Mouse Liver.Theranostics2017, 7(7), 1820-1834.
Sun, K.; Tang, Y.; Li, Q.; Yin, S.; Qin, W.; Yu, J.; Chiu, D. T.; Liu, Y.; Yuan, Z.; Zhang, X.; Wu, C.*, In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer.ACS Nano2016, 10 (7), 6769-6781.
Wu, C.; Chiu, D. T., Highly Fluorescent Semiconducting Polymer Dots for Biology and Medicine.Angew. Chem. Int. Ed.2013, 52 (11), 3086-3109.
Yu, J.; Wu, C.; Zhang, X.; Ye, F.; Gallina, M. E.; Rong, Y.; Wu, I. C.; Sun, W.; Chan, Y. H.; Chiu, D. T., Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross‐Linking and Their Application for Specific Cellular Imaging.Adv. Mater.2012, 24 (26), 3498-3504.
Wu, C.; Hansen, S. J.; Hou, Q.; Yu, J.; Zeigler, M.; Jin, Y.; Burnham, D. R.; McNeill, J. D.; Olson, J. M.; Chiu, D. T., Design of Highly Emissive Polymer Dot Bioconjugates for in Vivo Tumor Targeting.Angew. Chem. Int. Ed.2011, 50 (15), 3430-3434.
Wu, C.; Schneider, T.; Zeigler, M.; Yu, J.; Schiro, P. G.; Burnham, D. R.; McNeill, J. D.; Chiu, D. T., Bioconjugation of Ultrabright Semiconducting Polymer Dots for Specific Cellular Targeting.J. Am. Chem. Soc.2010, 132 (43), 15410-15417.
Wu, C.; Jin, Y.; Schneider, T.; Burnham, D. R.; Smith, P. B.; Chiu, D. T., Ultrabright and Bioorthogonal Labeling of Cellular Targets Using Semiconducting Polymer Dots and Click Chemistry.Angew. Chem. Int. Ed.2010, 49 (49), 9436-9440.
Wu, C.; Bull, B.; Christensen, K.; McNeill, J., Ratiometric Single‐Nanoparticle Oxygen Sensors for Biological Imaging.Angew. Chem. Int. Ed.2009, 48 (15), 2741-2745.
Yu, J.; Wu, C.; Sahu, S. P.; Fernando, L. P.; Szymanski, C.; McNeill, J., Nanoscale 3D tracking with conjugated polymer nanoparticles.Journal of the American Chemical Society2009, 131(51), 18410-18414.
Wu, C.; Zheng, Y.; Szymanski, C.; McNeill, J., Energy transfer in a nanoscale multichromophoric system: fluorescent dye-doped conjugated polymer nanoparticles.J. Phys. Chem. C2008, 112(6), 1772-1781.
Wu, C.; Bull, B.; Szymanski, C.; Christensen, K.; McNeill, J., Multicolor Conjugated Polymer Dots for Biological Fluorescence Imaging.ACS Nano2008, 2 (11), 2415-2423.
Wu, C.; Szymanski, C.; Cain, Z.; McNeill, J., Conjugated Polymer Dots for Multiphoton Fluorescence Imaging.J. Am. Chem. Soc.2007, 129 (43), 12904-12905.
Wu, C.; Peng, H.; Jiang, Y.; McNeill, J., Energy transfer mediated fluorescence from blended conjugated polymer nanoparticles.J. Phys. Chem. B2006, 110(29), 14148-14154.
Wu, C.; Szymanski, C.; McNeill, J., Preparation and encapsulation of highly fluorescent conjugated polymer nanoparticles.Langmuir2006, 22(7), 2956-2960.
1.
Zhang, B.; Wang, F.; Zhou, H.; Gao, D.; Yuan, Z.; Wu, C.*; Zhang, X.*, Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy.Angew. Chem. Int. Ed.2019, 58(9), 2744-2748.
2.
Chen, H.; Wang, F.; Liu, M.; Qian, M.; Men, X.; Yao, C.; Xi, L.; Qin, W.; Qin, G.*; Wu, C.*, Near-Infrared Broadband Polymer-Dot Modulator with High Optical Nonlinearity for Ultrafast Pulsed Lasers.Laser Photonics Rev.2019, 13(2), 1800326.
3.
Sun, K.; Yang, Y.; Zhou, H.; Yin, S.; Qin, W.; Yu, J.; Chiu, D.T.; Yuan, Z.; Zhang, X.; Wu, C.*, Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone,ACS Nano2018, 12 (6), 5176–5184
4.
Chen, H.; Fang, X.; Jin, Y.; Hu, X.; Yin, M.; Men, X.; Chen, N.; Fan, C.; Chiu, D. T.; Wan Y.*; Wu, C.*, Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery.Small2018, 14(21), 1800239.
5.
Chang, K.; Liu, Z.; Fang, X.; Chen, H.; Men, X.; Yuan, Y.; Sun, K.; Zhang, X.; Yuan, Z.; Wu, C.*, Enhanced Phototherapy by Nanoparticle-Enzyme via Generation and Photolysis of Hydrogen Peroxide.Nano Lett.2017, 17 (7), 4323-4329.
6.
Chen, X.; Liu, Z.; Li R.; Shan, C.; Zeng, Z.; Xue, B.; Yuan, W.; Mo, P.; Xi, P.*; Wu, C.*; Sun, Y.*, Multicolor Super-resolution Fluorescence Microscopy with Blue and Carmine Small Photoblinking Polymer Dots.ACS Nano2017, 11 (8), 8084-8091.
7.
Chen, X.; Li R.; Liu, Z.; Sun, K.; Sun, Z.; Chen, D.; Xu, G.; Xi, P.; Wu, C.*; Sun, Y.*, Small Photoblinking Semiconductor Polymer Dots for Fluorescence Nanoscopy.Adv. Mater.2017, 29 (5), 1604859.
8.
Chen, D.; Wu, I. C.; Liu, Z.; Tang, Y.; Chen, H.; Yu, J.; Wu, C.*; Chiu, D. T.*, Semiconducting Polymer Dots with Bright Narrow-Band Emission at 800 nm for Biological Applications.Chem. Sci.2017, 8 (5), 3390-3398.
9.
Chen, H.; Zhang, J.; Chang, K.; Men, X.; Fang, X.; Zhou, L.; Li, D.; Gao, D.; Yin, S.; Zhang, X.; Yuan, Z.; Wu C.*;Biomaterials.2017, 144, 42-52.
10.
Chen, D.; Li, Q.; Meng, Z.; Guo, L.; Tang, Y.; Liu, Z.; Yin, S.; Qin, W.; Yuan, Z.; Zhang, X.; Wu. C.*, Bright Polymer Dots Tracking Stem Cell Engraftment and Migration to Injured Mouse Liver.Theranostics2017, 7(7), 1820-1834.
11.
Sun, K.; Tang, Y.; Li, Q.; Yin, S.; Qin, W.; Yu, J.; Chiu, D. T.; Liu, Y.; Yuan, Z.; Zhang, X.; Wu, C.*, In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer.ACS Nano2016, 10 (7), 6769-6781.
12.
Wu, C.; Chiu, D. T., Highly Fluorescent Semiconducting Polymer Dots for Biology and Medicine.Angew. Chem. Int. Ed.2013, 52 (11), 3086-3109.
13.
Yu, J.; Wu, C.; Zhang, X.; Ye, F.; Gallina, M. E.; Rong, Y.; Wu, I. C.; Sun, W.; Chan, Y. H.; Chiu, D. T., Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross‐Linking and Their Application for Specific Cellular Imaging.Adv. Mater.2012, 24 (26), 3498-3504.
14.
Wu, C.; Hansen, S. J.; Hou, Q.; Yu, J.; Zeigler, M.; Jin, Y.; Burnham, D. R.; McNeill, J. D.; Olson, J. M.; Chiu, D. T., Design of Highly Emissive Polymer Dot Bioconjugates for in Vivo Tumor Targeting.Angew. Chem. Int. Ed.2011, 50 (15), 3430-3434.
15.
Wu, C.; Schneider, T.; Zeigler, M.; Yu, J.; Schiro, P. G.; Burnham, D. R.; McNeill, J. D.; Chiu, D. T., Bioconjugation of Ultrabright Semiconducting Polymer Dots for Specific Cellular Targeting.J. Am. Chem. Soc.2010, 132 (43), 15410-15417.
16.
Wu, C.; Jin, Y.; Schneider, T.; Burnham, D. R.; Smith, P. B.; Chiu, D. T., Ultrabright and Bioorthogonal Labeling of Cellular Targets Using Semiconducting Polymer Dots and Click Chemistry.Angew. Chem. Int. Ed.2010, 49 (49), 9436-9440.
17.
Wu, C.; Bull, B.; Christensen, K.; McNeill, J., Ratiometric Single‐Nanoparticle Oxygen Sensors for Biological Imaging.Angew. Chem. Int. Ed.2009, 48 (15), 2741-2745.
18.
Yu, J.; Wu, C.; Sahu, S. P.; Fernando, L. P.; Szymanski, C.; McNeill, J., Nanoscale 3D tracking with conjugated polymer nanoparticles.Journal of the American Chemical Society2009, 131(51), 18410-18414.
19.
Wu, C.; Zheng, Y.; Szymanski, C.; McNeill, J., Energy transfer in a nanoscale multichromophoric system: fluorescent dye-doped conjugated polymer nanoparticles.J. Phys. Chem. C2008, 112(6), 1772-1781.
20.
Wu, C.; Bull, B.; Szymanski, C.; Christensen, K.; McNeill, J., Multicolor Conjugated Polymer Dots for Biological Fluorescence Imaging.ACS Nano2008, 2 (11), 2415-2423.
21.
Wu, C.; Szymanski, C.; Cain, Z.; McNeill, J., Conjugated Polymer Dots for Multiphoton Fluorescence Imaging.J. Am. Chem. Soc.2007, 129 (43), 12904-12905.
22.
Wu, C.; Peng, H.; Jiang, Y.; McNeill, J., Energy transfer mediated fluorescence from blended conjugated polymer nanoparticles.J. Phys. Chem. B2006, 110(29), 14148-14154.
23.
Wu, C.; Szymanski, C.; McNeill, J., Preparation and encapsulation of highly fluorescent conjugated polymer nanoparticles.Langmuir2006, 22(7), 2956-2960.