陳強

陳強 性別：男 職稱：南開大學生命科學院教授 所屬部門：生物化學和分子生物學系

招生專業：生物化學與分子生物學、動物學

研究方向：生物電分析化學、生物醫學感測技術、中藥藥理及藥物分析

1994年3月於日本東北大學藥學部藥品物理化學專業獲得藥學博士學位。現任南開大學特聘教授，博士生導師。

個人學習和工作經歷：

1980.09－1984.07 南開大學化學系物理化學專業，獲得理學學士學位；

1988.04－1994.03 日本東北大學藥學部藥品物理化學專業，獲得藥學碩士、藥學博士學位；

1996.03－2001.04 日本東北大學藥學研究科任教並完成在職博士后研究，成為東北大學藥學部創建以來第一位外籍教員；

2001.05－ 至今 任教於南開大學生命科學學院，並創建生物感測器實驗室。兼任生物活性材料教育部重點實驗室副主任，建立了新型診斷材料領域，開展了分子間相互作用和分子識別的新型分析技術、中藥作用機理及方劑配伍規律研究新方法的構建，功能微生物及其在環保、農業中的應用等跨學科的研究。

目前的主要研究方向：

生物電分析化學、生物醫學感測技術、中藥藥理及藥物分析

研究成果：

在納米新材料光電化學技術、高性能納米結構固定化酶電極製備技術、分子間相互作用和分子識別的新型分析技術、中藥作用機理及方劑配伍規律研究新方法的構建等方向取得了顯著成果。在國內外核心刊物發表論文80餘篇，其中40餘篇被SCI、EI收錄，已授權專利6項，申請中專利1項。主持和分擔了國家自然科學基金、“863”計劃、教育部、天津市等科研項目十餘項，研究成果獲1997年日本文部省獎勵研究A和2005年度天津市自然科學二等獎（編號2005ZR-2-011-R1）。

研究生培養：

獲2006年度南開大學“敬業”獎教金一等獎。指導博士研究生中有兩名分別於2005、2006年獲得“南開十傑”稱號，所指導研究生多次獲得“南開大學優秀碩士畢業論文”及“南開大學優秀畢業生”獎勵。為研究生開設三門課程：“物理化學在生命體系中的應用”（碩士生）、 “生物電化學”（博士生）、“生物感測器的原理與技術” （博士生）。

碩士生、博士生招生專業：生物化學與分子生物學、動物學

代表性文章目錄：

1.Zixia Zhao, Mingqiang Qiao, Feng Yin, Bin Shao, Baoyan Wu, Yanyan Wang, Xinsheng Wang, Xia Qin, Sha Li, Lei Yu, Qiang Chen. Amperometric glucose biosensor based on self-assembly hydrophobin with high efficiency of enzyme utilization. Biosensors & Bioelectronics, 2007,22:3021-3027 (SCI, IF 5.061)

2.Baoyan Wu, Shihua Hou，Feng Yin, Zixia Zhao, Yanyan Wang, Xinsheng Wang, Qiang Chen. Amperometric glucose biosensor based on multilayer films via layer-by-layer self-assembly of multi-wall carbon nanotubes, gold nanoparticles and glucose oxidase on the Pt electrode. Biosensors &Bioelectronics,2007,22:2854-2860 (SCI, IF 5.061)

3.Baoyan Wu, Shihua Hou, Feng Yin, Jing Li, Zixia Zhao, Jiadong Huang, Qiang Chen. Amperometric Glucose Biosensor Based on Layer-by-layer Assembly of Multilayer Films Composed of Chitosan, Gold Nanoparticals and Glucose Oxidase Modefied Pt Electrode. Biosensors &Bioelectronics,2007,22:838-844 (SCI, IF 5.061)

4.Haibin Shi, Yu Yang, Jiadong Huang, Zixia Zhao, Xinhua Xu, Jun-ichi Anzai, Tetsuo Osa, Qiang Chen. Amperometric Choline Biosensors Prepared by Layer-by-layer Deposition of Choline Oxidase on the Prussian Blue-Modified Platinum Electrode. Talanta,2006,70:852-858(SCI, IF 3.374)

5.WU Bao-Yan, LI Jing, HUANG Jia-Dong, Wang Yanyan, Yin Huijun, Chen Keji, CHEN Qiang. Real time kinetic analysis of the interaction between interleukin-1α and soluble interleukin-1 receptor using a resonant mirror biosensor. Analytica Chimica Acta, 2006, 557: 106-110(SCI, IF 3.186)

主要徠學術論文

韓松岩, 劉東波, 黃亮, 王深琪, 劉清平, 陳強. Monitoring adsorption in situ and kinetic studies of low-density lipoprotein onto cholesterol modified dextran using qua. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 26-6-1166. 2005-1-1

李靜，黃加棟，吳寶艷，陳強. Effects of propyl gallate on interaction between TNF-alpha and sTNFR-I using an affinity biosensor. ACTA PHARMACOLOGICA SINICA 26-10-1212. 2005-1-1

史海濱，趙紫霞，宋昭，黃加棟，楊鈺，陳強. Fabricating of acetylcholine biosensor by a layer-by-layer deposition technique for determining trichlorfon. ELECTROANALYSIS 17-14-1285. 2005-1-1

陳強, 韓君, 史海濱，吳寶艷, 許鑫華. Use of Chitosan for developing layer-by-layer multilayer thin films containing glucose oxidase for biosensor applications. Sensor Letters v 2-n 2-p 102-105. 2005-1-1

史海濱, 宋昭, 黃加棟，楊鈺，趙紫霞, 陳強. Effects of the type of polycation in the coating films prepared by a layer-by-layer deposition technique on the properties of amperometric choline sensors. Sensors and Actuators, B: Chemical v 109-n 2-p 341-347. 2005-1-1

史海濱, 宋昭, 黃加棟，楊鈺，趙紫霞, 陳強. Effects of the type of polycation on the amperometric response of choline biosensors prepared by a layer-by-layer deposition technique. Materials Science and Engineering C v 25-n 4-p 433-435. 2005-1-1

吳寶艷, 許鑫華, 史海濱, 韓松岩，宋岩、黃亮, 陳強. Effect of cellulose acetate diffusion restricting membrane on the glucose biosensor. Tianjin Daxue Xuebao (Ziran Kexue yu Gongcheng Jishu Ban)/Journal of Tianjin University Science and Technology v 38-n 6-p 513-517. 2005-1-1

尹峰；趙紫霞; 吳寶艷；王新勝; 王艷艷；陳強. Glucose biosensor based on layer-by-layer assembly of multi-walled carbon nanotubes and polyallylamine. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 35-7-1021-1024. 2007-1-1

劉強; 許鑫華；張春懷; 陳強. Electrochemical deposition of composite films composed of polyaniline and chitosan for biosensor applications. SENSOR LETTERS 5-2-459-462. 2007-1-1

趙紫霞; 喬明強; 尹峰; 邵兵; 吳寶艷; 王艷艷; 王新勝; 秦霞; 李莎; 於雷; 陳強. Amperometric glucose biosensor based on self-assembly hydrophobin with high efficiency of enzyme utilization. BIOSENSORS & BIOELECTRONICS 22-12-3021-3027. 2007-1-1

吳寶艷；侯識華; 尹峰; 趙紫霞; 王艷艷; 王新勝; 陳強. Amperometric glucose biosensor based on multilayer films via layer-by-layer self-assembly of multi-wall carbon nanotubes, gold nanoparticles and glucose oxidase on the Pt electrode. BIOSENSORS & BIOELECTRONICS 22-12-2854-2860. 2007-1-1

劉東波; 賀秉軍；韓松岩; 王申奇; 劉清平; Jun-ichi, A; Osa, T; 陳強. An adsorption behavior of low-density lipoprotein onto cholesterol-modified dextran studied by a quartz crystal microbalance. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 27-4-665-669. 2007-1-1

黃加棟; 宋昭; 李靜; 楊鈺; 史海濱; 吳寶艷; Anzai, JI; Osa, T; 陳強. A highly-sensitive L-lactate blosensor based on sol-gel film combined with multi-walled carbon nanotubes (MWCNTs) modified electrode. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 27-1-29-34. 2007-1-1

吳寶艷; 侯識華; 尹峰; 李靜; 趙紫霞; 黃加棟; 陳強. Amperometric glucose biosensor based on layer-by-layer assembly of multilayer films composed of chitosan, gold nanoparticles and glucose oxidase modified Pt electrode. BIOSENSORS & BIOELECTRONICS 22-6-838-844. 2007-1-1

宋昭; 黃加棟; 史海濱; 吳寶艷; 趙紫霞；陳強. Highly sensitive choline biosensor based on nanotube modified pt electrode combined with sol-gel immobilization. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 34-7-910-914. 2007-1-1

Li, J; Huang, JD; Wu, BY; Song, Z; Chen, Q. Optical biosensor analysis in studying propyl gallate binding to endothelin-1. SENSOR LETTERS 3-4-296. 2006-1-1

Chen, Q; Huang, JD; Yin, HJ; Chen, KJ; Osa, T. The applications of affinity biosensors: IAsys biosensor and quartz crystal microbalance to the study on interaction between Paeoniae radix 801 and endothelin-1. SENSORS AND ACTUATORS B-CHEMICAL 115-1-116. 2006-1-1

Huang, JD; Yang, Y; Shi, HB; Song, Z; Zhao, ZX; Anzai, J; Osa, T; Chen, Q. Multi-walled carbon nanotubes-based glucose biosensor prepared by a layer-by-layer technique. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 26-1-113. 2006-1-1

Song, Z; Huang, JD; Wu, BY; Shi, HB; Anzai, JI; Chen, Q. Amperometric aqueous sol-gel biosensor for low-potential stable choline detection at multi-wall carbon nanotube modified platinum electrode. SENSORS AND ACTUATORS B-CHEMICAL 115-2-626. 2006-1-1

Shi, H; Yang, Y; Huang, JD; Zhao, ZX; Xu, XH; Anzai, J; Osa, T; Chen, Q. Amperometric choline biosensors prepared by layer-by-layer deposition of choline oxidase on the Prussian blue-modified platinum electrode. TALANTA 70-4-852. 2006-1-1

Wu, BY; Wang, YY; Li, J; Song, Z; Huang, JD; Wang, XS; Chen, Q. An optical biosensor for kinetic analysis of soluble Interleukin-1 receptor I binding to immobilized Interleukin-1 alpha. TALANTA 70-3-485. 2006-1-1

Xu, XH; Ren, GL; Cheng, J; Liu, Q; Li, DG; Chen, Q. Layer by layer self-assembly immobilization of glucose oxidase onto chitosan-graft-polyaniline polymers. JOURNAL OF MATERIALS SCIENCE 41-10-3147. 2006-1-1

Wu, Bao-Yan; Li, Jing; Huang, Jia-Dong; Wang, Yan-Yan; Yin, Hui-Jun; Chen, Ke-Ji; Chen, Qiang. Real time kinetic analysis of the interaction between interleukin-1α and soluble interleukin-1 receptor I using a resonant mirror biosensor. Analytica Chimica Acta v 557-n 1-2-p 106-110. 2006-1-1

Wu, Baoyan; Li, Jing; Shi, Haibin; Huang, Jiadong; Anzai, Junichi; Osa, Tetsuo; Chen, Qiang. Ferrocene-mediated anti-interfering glucose biosensor based on glutin and cellulose acetate. High Technology Letters v 12-n 3-p 263-266. 2006-1-1

Yanyan Wang, Xinsheng Wang, Baoyan Wu, Zixia Zhao, Feng Yin, Sha Li, Xia Qin, Qiang Chen. Dispersion of single-walled carbon nanotubes in poly(diallyldimethylammonium chloride) for prepara. Sensors and Actuators B

李莎 王艷艷 趙紫霞 秦霞 王新勝 吳寶艷 陳強. 基於納米材料、聚電解質製備高性能乙醇生物感測器. 分析化學 36-2-227-230. 2008-2-1

秦霞　王艷艷　趙紫霞　王新勝　李莎　于敏　黃楠　苗智穎　陳強. 層層自組裝製備基於多壁碳納米管的膽鹼生物感測器. 分析化學 36-6-827-830. 2008-6-1

Bao-Yan Wu, Shi-Hua Hou, Liang Huang, Feng Yin, Zi-Xia Zhao, Jun-Ichi Anzai, Qiang Chen. Oriented immobilization of immunoglobulin G onto the cuvette surface of the resonant mirror biosenso. Materials Science and Engineering C 28-7-1065-1069. 2008-8-1

Jiadong Huang, Jing Li, Yu Yang, Xinsheng Wang, Baoyan Wu, Qiang Chen. Development of an amperometric L-lactate biosensor based on L-lactate oxidase immobilized through silica sol-gel film on multi-walled carbon nanotubes/platinum nanoparticle modified glassy carbon electrode. Materials Science and Engineering C 28-7-1070-1075. 2008-8-1

Bao-Yan Wu, Shi-Hua Hou, Min Yu, Xia Qin, Sha Li, Qiang Chen. Layer-by-layer assemblies of chitosan/multi-wall carbon nanotubes and glucose oxidase for amperometric glucose biosensor applications. Materials Science and Engineering C 29-1-346-349. 2009-1-1

于敏，王會才，秦 霞，王新勝，昊寶艷，陳 強. 納米銀/半胱氨酸修飾葡萄糖生物感測器的研究. 感測器與微系統 27-10-24-26. 2008-10-1

Xia Qin, Huicai Wang, Xinsheng Wang, Sha Li, Zhiying Miao, Nan Huang, Qiang Chen. Amperometriccholinebiosensorsbased on multi-wallcarbonnanotubes and layer-by-layer assembly of multilayer films composed of Poly(diallyldimethylammonium chloride) and choline oxidase . Materials Science and Engineering: C

Zi-Xia Zhao, Hui-CaiWang, Xia Qin, Xin-ShengWang, Ming-Qiang Qiao, Jun-ichi Anzaib, Qiang Chen. Self-assembled film of hydrophobins on gold surface and its application to electrochemical biosensing. Colloids and Surfaces B: Biointerfaces

Wei Zhao, Huicai Wang, Xia Qin, Xinsheng Wang, Zixia Zhao, Zhiying Miao, Lili Chen, Miaomiao Shan, Yuxin Fang, Qiang Chen. A novel nonenzymatic hydrogen peroxide sensor based on multi-wall carbon nanotube/silver nanoparticle nanohybrids modified gold electrode. Talanta

HuicaiWang, XinshengWang, Xiaoqing Zhang, Xia Qin, Zixia Zhao, Zhiying Miao, Nan Huang, Qiang Chen. A novel glucose biosensor based on the immobilization of glucose oxidase onto gold nanoparticles-modified Pb nanowires. Biosensors and Bioelectronics

Sha Li, Yanyan Wang, Zixia Zhao, Xia Qin, Xinsheng Wang, Min Yu, Zhiying Miao, Baoyan Wu, Qiang Chen. Amperometric Ethanol Biosensor Based on Layer-by-Layer Deposition of Alcohol Oxidase on the Platinum. Sensor letters

Xia Qin, Huicai Wang, Xinsheng Wang, Zhiying Miao, Lili Chen, Wei Zhao, Miaomiao Shan, Qiang Chen. Amperometric biosensors based on gold nanoparticles-decorated multiwalled carbon nanotubes poly(diallyldimethylammonium chloride) biocomposite for the determination of choline. Sensors and Actuators B

陳麗麗, 王會才, 秦霞, 王新勝, 趙紫霞, 苗智穎, 趙薇, 單苗苗, 陳強. 層層自組裝技術製備PDDA-多壁碳納米管-膽鹼生物感測器. 分析化學

Zixia Zhao, Qiang Chen, Jun-ichi ANZAI. Horseradish peroxidase microcapsules based on layer-by-layer polyelectrolyte deposition. Journal of Environmental Sciences 21- supplement 1-

Yanyan Wang, Qiang Chen, Xiangqun Zeng. Potentiometric biosensor for studying hydroquinone cytotoxicity in vitro. Biosensors and Bioelectronics