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吳斌

中山大學附屬第三醫院教授

吳斌,教授,博士研究生,2004年畢業,博士研究生導師

主研方向


研究的興趣主要集中在:
(1) 解析胃腸及肝臟發育,生長,分化,凋亡和癌變的生理與病理生理機制;
(2) 研究肝硬化及肝衰竭的分子基礎和臨床治療;
(3) 理解的炎症性腸病分子病理機制和基因調控。

社會兼職


Gastroenterology Report 副主編
Am J Physiol Gastrointest Liver Physiol
J Gastroenterol
Exp Mol Pathol
Internal Medicine 等雜誌審稿專家

醫療專長


(1) 消化系統疾病的診斷和治療;
(2) 消化道早期癌的診斷和內鏡下微創治療;
(3) 肝硬化及食管靜脈曲張的診斷與內鏡治療。

獲獎情況


1. Research Fellowship Award at Harvard Medical School , USA .
2. Postgraduate Awards at Saga Medical School , Saga University , Japan .
3. Scholarship Award of the Ministry of Education and Science of Japan

論著


1.Qiu W, Wu B*, et al. Puma-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. J Clin Invest 2011; 12(5):1722-1732.
2. Wu B* , et al. Downregulation of cyclooxygenase-1 involves gastric mucosal apoptosis via death signaling in portal hypertensive rats. Cell Res 2009; 19(11):1269-1278.
3. Wu B, et al. p53-independent induction of PUMA mediates intestinal apoptosis in response to ischemia reperfusion. Gut 2007; 56(5):645-654.
4. Wu B, et al. T cell deficiency leads to liver carcinogenesis in azoxymethane-treated rats. Exp Biol Med 2006; 231(1):91-98.
5. Wu B , et al. Dietary corn oil promotes colon cancer by inhibiting mitochondria-dependent apoptosis in azoxymethane-treated rats. Exp Biol Med 2004; 229(10):1017-1025.
6. Wu B , et al. Ischemic preconditioning attenuates ischemia-reperfusion-induced mucosal apoptosis by inhibiting mitochondria-dependent pathway in rat small intestine. Am J Physiol Gastrointest Liver Physiol 2004; 286(4):G580-G587.
7. Wu B , et al. Venous congestion induces mucosal apoptosis via tumor necrosis factor-alpha-mediated cell death in the rat small intestine. J Gastroenterol 2004; 39(11):1056-1062.
8. Wu B , et al. Platelet-activating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion. FASEB J 2003; 17(9):1156-1158. Epub 2003 Apr 22.
9.Wu B , et al. iNOS enhances rat intestinal apoptosis after ischemia-reperfusion. Free Radic Biol Med 2002; 33(5):649-658.

專著


1. 主編: 《消化道出血診斷和治療學》,北京:科技出版社, 2010
2. 參編: 《 Oxidative Stress and Digestive Diseases 》, KARGER 出版社, 2001