尹航

2004至2007年在美國賓夕法尼亞大學醫學院從事博士后研究；加入清華大學之前於美國科羅拉多大學化學和生物化學系任終身教授。

2018年起任清華大學藥學院教授、副院長，中藥研究院院長，藥學技術中心主任，清華大學校學術委員會委員，校學位評定委員會生物學分委會委員，生命科學聯合中心高級研究員。

在本領域一流期刊發表研究論文超130篇，引用超過一萬次，科研成果已申請專利11項（授予美國、歐盟、日本等專利4項），並有多項專利成果已經商業化。

代表性論文

● ● Huang, J.; Yuan, Y.; Zhao, N.; Pu, D.; Tang,Q.; Zhang, S.; Luo, S.; Yang, X.; Wang, N.; Xiao, Y.; Zhang, T.; Liu. Z.;Sakata-Kato, Y.; Hirata, K.; *Jiang, X.; *Kato, N.; *Yan, N.; *Yin, H. “Orthosteric-Allosteric Dual Inhibitors of PfHT1 as Selective Anti-MalarialAgents”, Proc.Natl. Acad. Sci. U. S. A. 2021, 118, e2017749118.

● ● Jiang, X.; Yuan, Y.; Huang, J.; Zhang, S.;Luo, S.; Wang, N.; Pu, D.; Zhao, N.; Tang, Q.; Hirata, K.; Yang, X.; Jiao, Y.;Sakata-Kato, Y.; Wu, J.; Yan, C.; Kato, N.; *Yin, H.; *Yan, N. “Structural Basis for Blocking Sugar Uptake into theMalaria Parasite Plasmodium falciparum”,Cell 2020, 183, 258-268.

● ● Xu, Q.; Dai, C.; Kong, J.; Chen, H.; Feng,J.; Zhang, Y.; *Yin, H.“Immune Profiling Before Treatment is Predictive of TLR9-Induced AntitumorEfficacy”, Biomaterials 2020, 263, 120379.

● ● Xiao, Y.; Driedonks, T.; Witwer, K.; Wang,Q.; *Yin, H. “How Does an RNASelfie Work? EV-Associated RNA in Innate Immunity as Self or Danger”, J.Extracell. Vesicles 2020,9, e1793515.

● ● Wang, Y.; Zhang,S.; Li, H.; Wang, H.; Zhang, T.; Hutchinson, M.; *Yin, H.;*Wang, X. “Small Molecule Modulators of Toll-Like Receptors”, Acc. Chem. Res. 2020, 53, 1046-1055.

● ● Jiang, S.; Tanji, H.;Yin, K.; Zhang, S.; Sakaniwa, K.; Huang, J.; Yang, Y.; Li, J.; Ohto, U.;Shimizu, T.; *Yin, H. “Rationally Designed Small-MoleculeInhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface”, J. Med. Chem. 2020, 63, 4117-4132

● ● Gao, M.; Huang, J.;Jiang, X.; Yuan, Y.; Luo, S.; Wang, N.; Pang, H.; Deng, D.; Yao, C.; Lin, Z.;Pu, D.; Liu, Z.; Hu, Z.; *Yin, H. “Regulation of Aerobic Glycolysis toDecelerate Tumor Proliferation by Small Molecule Inhibitors Targeting GlucoseTransporters”, Protein Cell 2020, 11, 446-451.

● ● Zhang, Y.; Jin, X.;Liang, J.; Guo, Y.; Sun, G.; Zeng, X.; *Yin, H. “Extracellular Vesicles Derived from ODN-Stimulated Macrophages Promote TheirCellular Uptake by the Transfer and Activation of Cdc42”, Sci. Adv. 2019, 5, eaav1564.

● ● Padilla-Salinas, R.; Anderson, R.; Sakaniwa,K.; Zhang, S.; Nordeen, P.; Lu, C.; Shimizu, S.; *Yin, H. “Discovery ofNovel Small Molecule Dual Inhibitors Targeting Toll-Like Receptor 7 and 8”, J. Med.Chem. 2019, 62,10221-10244.

● ● Tamura, R.; Balabanova, A.; Frakes, S. A.;Bargmann, A.; Koch, T. H.; *Yin, H.“Photoactivatable Prodrug ofDoxazolidine Targeting Exosomes”, J. Med. Chem. 2019, 62, 1959-1970.

● ● Hu, Z.;Tanji, H.; Jiang, S.; Zhang, S.; Koo, K.; Chan, J.; Sakaniwa, K.; Ohto, U.; Candia,A.; Shimizu, T.; *Yin, H. “Small Molecule TLR8 Antagonistsvia Structure-Based Rational Design”, CellChem. Biol. 2018, 25, 1286-1291.

● ● Bhattacharyya, S.; Wang, W.; Qin, W.; Cheng,K.; Coulup, S.; Chavez, S.; Raparia, K.; De Almeida, L. M.; Stehlik, C.;Tamaki, Z.; *Yin, H.; *Varga, J.“TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skinand Lung”, JCI Insight 2018, 3, e98850.

● ● Zhang, L.; Shi, L.; Soars, S. M.;Kamps, J.; *Yin, H. “Discovery ofNovel Small-Molecule Inhibitors of NF-κB Signaling with Anti-Inflammatory andAnti-Cancer Properties”, J. Med. Chem.2018, 61, 5881-5899.

● ● Zhang,S.; Hu, Z.; Tanji, H.; Jiang, S.; Das, N.; Li, J.; Sakaniwa, K.; Jin, J.; Bian,Y.; Ohto, U.; Shimizu, T.; *Yin, H. “Small Molecule Inhibition ofTLR8 through Stabilization of Its Resting State”, Nat. Chem. Biol. 2018, 14, 58-64.

● ● Zhang, L.; Dewan, V.; *Yin, H. “Discovery of Small Moleculesas Multi-TLR Agonists with Proinflammatory and Anticancer Activities”, J. Med. Chem. 2017, 60, 5029-5044.

● ● Smith, C. E.; Soti, S.; Jones, T.A.; Nakagawa, A.; Xue, D.; *Yin, H. “NSAIDs are Caspase Inhibitors”, CellChem. Biol. 2017, 24,281-292.

● ● Das, N.; Dewan, V.; Grace, P. M.;Rosenfeld-Gunn, R. J.; Tamura, R.; Tzarum, N.; Watkins, L. R.; Wilson, I. A.; *Yin, H. “HMGB-1 ActivatesProinflammatory Signaling via TLR5 Leading to Allodynia”, CellRep. 2016, 17,1128-1140.

● ● *Yin, H.;Flynn, A. D. “DruggingMembrane Protein Interactions”, Annu. Rev. Biomed. Eng. 2016,18, 51-76.

● ● Daniele, S. G.; Beraud, D.;Davenport, C.; Cheng, K.; *Yin, H.;*Maguire-Zeiss, K. A. “Activation of MyD88-Dependent TLR1/2 Signaling byMisfolded α-Synuclein, a Protein Linked to Neurodegenerative Disorders”, Sci. Signal. 2015, 8, ra45.

● ● Cheng, K.; Gao, M.; Godfroy III, J. I.; Brown, P. N.; Kastelowitz, N.; *Yin, H.“Specific Activation of the TLR1-TLR2 Heterodimer by Small-molecule Agonists”, Sci. Adv. 2015, 1, e1400139.

● ● Smith, C. E.; Wang, X.H.; *Yin, H. “Caspases Come TogetherOver LPS”, Trends Immunol. 2015,36, 59-61.

● ● Csakai, A.; Smith, C.; Davis, E.;Martinko, A.; Coulup, S.; *Yin, H. “SaccharinDerivatives as Inhibitors of Interferon-Mediated Inflammation”, J. Med. Chem. 2014, 57, 5348-5355.

● ● Wang, X. H.; Smith, C.; *Yin, H. “Targeting Toll-LikeReceptors with Small Molecule Agents”, Chem.Soc. Rev. 2013, 42, 4859-4866.

● ● Morton, L. A.; Yang, H.; Saludes, J. P.; Fiorini, Z.; Beninson, L.;Chapman, E. R.; Fleshner, M.; Xue, D.; *Yin,H. “MARCKS-ED Peptide as a Membrane Curvature Sensor”, ACS Chem. Biol. 2013, 8, 218-225.

● ● Cheng, K.; Wang, X. H.; Zhang, S.; *Yin,H.“Discovery ofSmall-Molecules that Inhibit the Protein Complex of Toll-Like Receptor 1 and 2”, Angew. Chem. Int. Ed. 2012, 51, 12246-12249.

● ● Saludes, J. P.; Morton, L. A.; Ghosh, N.; Beninson, L.; Chapman, E.R.; Fleshner, M.; *Yin, H. “Detectionof Highly Curved Membrane Surfaces Using a Cyclic Peptide Derived fromSynaptotagmin-I”, ACS Chem. Biol. 2012,7, 1629-1635.

● ● Wang, X. H.; Loram, L. C.; Ramos, K.; de Jesus, A.; Thomas, J.; Cheng,K.; Reddy, A.; Somogyi, A. A.; Hutchinson, M. R.; Watkins, L. R.; *Yin, H. “Morphine Activates Neuroinflammation in a Parallel Manner toEndotoxin”, Proc. Natl. Acad. Sci. U. S.A. 2012, 109, 6325-6330.

● ● Chavez, S. A.; Martinko, A. J.; Lau, C.; Pham, M. N.; Cheng, K.;Mollnes, T. E.; *Yin, H. “Development of β–Amino Alcohol Derivatives that Inhibit TLR4-Mediated InflammatoryResponse as Potential Antiseptics”, J. Med.Chem. 2011, 54, 4659-4669.

● ● Cheng, K.; Wang, X. H.; *Yin,H. “Small Molecule Inhibitors of the TLR3/dsRNA Complex”, J. Am. Chem. Soc. 2011, 133, 3764-3767.

● ● *Yin, H. “ExogenousAgents that Target Transmembrane Domains of Proteins”, Angew. Chem. Int. Ed. 2008,47, 2744-2752.

● ● Yin, H.; Slusky, J. S; Berger, B. W.;Walters, R. S.; Vilaire, G.; Litvinov, R. I.; Lear, J. D.; Caputo,G.A.; Bennett, J. S.; DeGrado, W. F. “Computational Design of Peptides thatTarget Transmembrane Helices”, Science2007, 315, 1817-1822.

曾任國際細胞外囊泡協會執行理事、現任中國研究型醫院協會細胞外囊泡分委會副主任委員、中國藥學會藥物化學專委會委員、《Journal of Extracellular Vesicle》(2019影響因子=14.976 )責任主編、多家國際刊物編委。其實驗組的成果在新華社、美國廣播公司ABC、《自然》《科學》《美國國家科學院院刊》、美國化學會會刊《C&EN》等雜誌作為“科研亮點”重點報道。培養的研究生和博士后已有多名在國內外的著名大學和科研機構獨立領導研究組，前博士生Christina Boville入選MIT Technology Review Innovators Under 35全球榜單，前博士后Jonel P. Saludes現任菲律賓San Agustin大學副校長。