李坤

代表性成果（獲獎成果、專著、論文、專利）

1. Liao, Y.-X.Li, K.*, Wu, M.-Y.; Wu, T.; Yu, X.-Q.* A selenium-contained aggregation-induced “turnon” fluorescent probe for hydrogen peroxideOrg. Biomol. Chem.2014,DOI: 10.1039/c4ob00206g

2. He, T.;Li, K.*; Wang, N.; Liao, Y.-X.; Wang, X.; Yu X.-Q * A ferrocene-based multiple- stimuli responsive organometallogel.Soft Matter.2014, DOI: 10.1039/c3sm53141d

3. He, T.;Li, K.*; Wu, M.Y.; Liao, Y.-X. and Yu, X.-Q.* Visual detection of amino acids by supramolecular gel collapse.RSC Adv.,2014,4, 2119-2123.

4. Wu, M.-Y.;Li, K.*; Li, C.-Y.; Hou, J.-T.; Yu, X.-Q.* A Water-Soluble Near-Infrared Probe for Colorimetric and Ratiometric Sensing of SO2 Derivatives in Living Cells.Chem. Commun.2徠014,50, 183-185.

5. Hou, J.-T.;Li, K.* Yu, K.-K.; Ao, M.-Z.; Wang, X.; Yu, X.-Q.* Novel triazole-based fluorescent probes for Pd2+ in aqueous solutions: design, theoretical calculations and Imaging.Analyst,2013,138, 6632–6638

6. Wu, M.-Y.; He, T.;Li, K.*; Wu, M.-B.; Huang, Z.; Xie, Y.-M.*; Yu, X.-Q.* “A real-time colorimetric and ratiometric fluorescent probe for sulfite”Analyst2013,138(10), 3018-3025.

7. Xu, H.-R.;Li, K.*; Liu, Q.; Wu, T.-M.; Wang, M.-Q.; Hou, J.-T.; Huang, Z.; Xie, Y.-M.*; Yu, X.-Q.* “Dianthracene-cyclen conjugate: the first equal-equivalent responding fluorescent chemosensor for Pb in aqueous solution”Analyst2013,138(8), 2329-2334.

8. Hou, J.-T.;Li, K.*; Yu, K.-K.; Wu, M.-Y.; Yu, X.-Q.* “Coumarin-DPA-Cu(II) as a chemosensing ensemble towards histidine determination in urine and serum”Org. Biomol. Chem.2013, 11(5), 717-720.

9. Hou, J.-T.; Liu, B.-Y. ;Li K.* ; Yu K.-K.; Wu, M.-B.; Yu, X.-Q.* Two birds with one stone: Multifunctional and highly selective fluorescent probe for distinguishing Zn2+ from Cd2+ and selective recognition of sulfide anion.Talanta,2013,116, 434–440.

10.Jiao, S.-Y.; Peng, L.-L.;Li, K.*; Xie, Y.-M.; Ao, M.-Z.; Wang, X.*; Yu, X.-Q.*A BINOL-based ratiometric fluorescent sensor for Zn and in situ generated ensemble for selective recognition of histidine in aqueous solution.Analyst,2013, 138, 5762-5768.

11.He, T.;Li, K.*; Wu, M.-Y.; Wu, M.-B.; Wang, N.; Pu, L.; Yu, X.-Q.* “Water promoted enantioselective aldol Reaction by proline-cholesterol and -diosgenin based amphiphilic organocatalysts”Tetrahedron2013,69(25), 5136-5143.

12.Li, K.; Xu, H.-R.; Yu, K.-K.; Hou, J.-T.; Yu, X.-Q.* “A coumarin-based chromogenic and ratiometric probe for hydrazine”Anal. Methods2013,5, 2653-2656.

13.Hou, J.-T.;Li, K.*; Liu, B.-Y.; Liao, Y.-X.; Yu, X.-Q.* “The first ratiometric probe for lysine in water”Tetrahedron2013,69(9), 2118-2123.

14.Wang, M.-Q.;Li K.*; Xu, H.-R.; Yu X.-Q.* Imidazolium-based 1,1′-bi-2-naphthol fluorescent probe for ratiometric and selective detection of DNA in water.Anal. Methods2013,5, 5903-5907

15.Yu, K.-K.;Li, K.*; Hou, J.-T.;Yu, X.-Q.* Coumarin–TPA derivative: a reaction-based ratiometric fluorescent probe for Cu(I).Tetrahedron Lett.2013,54, 5771–5774

16.Wang, M.-Q.;Li K.*; Hou J.-T.; Wu, M.-Y., Huang, Z.; Yu X.-Q.* “BINOL-Based Fluorescent Sensor for Recognition of Cu(II) and Sulfide Anion in Water”J. Org. Chem.2012,77, 8350−8354.

17.Wu, M.-Y.,Li, K.*; Hou, J.-T.; Huang, Z.; Yu, X.-Q.* “A selective colorimetric and ratiometric fluorescent probe for hydrogen sulfide”Org. Biomol. Chem.2012,10, 8342-8347.

18.Wu, M.-Y.;Li K.*; Wang, N.; He T.; Yu X.-Q.* A Novel Catalyst-Free Tandem Reaction for the Synthesis of 5-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones in Water Medium (feature article).Synthesis2011,12, 1831-1839.

19.Wu, M.-Y.; Wang, M.-Q.;Li K.*; Feng, X.-W.; He T.; Wang N.; Yu X.-Q.*, An Efficient, Transition-Metal-Free Process for the Synthesis of Substituted Dihydrofurans via a Michael/Cyclization Tandem Reaction.Tetrahedron Lett.2011,52, 679-683.

20.Wu, M.-Y.;Li, K.*; He, T.; Feng, X.-W.; Wang, N.; Wang, X.-Y.; Yu X.-Q.*, A Novel Enzymatic Tandem Process: Utilization of Biocatalytic Promiscuity for High Stereoselective Synthesis of Hydroxyimino-Substituted Dihydrofurans Derivatives.Tetrahedron2011,67, 2681-2688.

21.He, T.,Li, K.*; Wu, M.-Y.; Feng, X.-W.; Wang, N., Wang, H.-Y.; Li, C.; Yu X.-Q.* Utilization of biocatalytic promiscuity for lipase-catalyzed direct Mannich reaction.J. Mol. Catal. B: Enzym.2010,67, 189-194.

22.Chen, X.; Huang, Z.; Chen, S.-Y.;Li, K.; Yu X.-Q.*; Pu, L.*, Enantioselective Gel Collapsing: A New Means of Visual Chiral Sensing.J. Am. Chem. Soc.2010,132, 7297–7299.

23.Liu, P.-Y.;Li, K.*; Zhang, J.; Zhang, D.-W.; Lin, H.-H.; Yu X.-Q.*, Who is the king? ‘β-OH-acraldehyde or catechol B ring’: Research on the relationship between the structure of quercetin derivatives and their pro-oxidative abilities.Chem. Biodiv.2010,7, 236-244.

24.Li, K.; He T.; Li, C.; Feng, X.-W., Wang, N.; Yu X.-Q.*, Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity to C-C bond formation in a “one-pot” synthesis.Green Chem.2009,11, 777-779.

25.Li, K.; Zhang, J.; Zhang, Z.-W.; Xiang, Y.-Z.; Lin, H.-H.; Yu X.-Q.*, Immobilization Cyclen Copper (II) on Merrifield Resin:Efficient Oxidative Cleavage of Plasmid DNA.J. Appl. Polym. Sci.2009,111. 2485–2492.

26.Li, K.; Zhou, L.-H.; Zhang, J.; Chen, S.-Y.; Zhang, Z.-W.; Zhang, J.-J.; Lin, H.-H.; Yu X.-Q.*, ‘‘Self-activating’’ chemical nuclease: Ferrocenyl cyclen Cu(II) complexes act as efficient DNA cleavage reagents in the absence of reductant.Eur. J. Med. Chem.2009,44, 1768-1772.

27.Li, K.; Wang, N.; Yang, F.; Zhang, Z.-W.; Zhou, L.-H.; Chen, S.-Y; Lin, H.-H; Tian, Y.-F.; Yu, X.-Q.*, Cyclen-based side-chain homopolymer self-assembly with plasmid DNA: Protection of DNA from enzymatic degradation.Chem. Biodiv.2009,6, 754-763.

28.Feng, X.-W.; Li, C.; Wang, N.,Li, K.; Zhang, W.-W.; Wang, Z.; Yu X.-Q.*,Lipase-catalysed decarboxylative aldol reaction and decarboxylative Knoevenagel reaction,Green Chem.,2009,11, 1933-1936.

專利：

1. 余孝其，李坤，吳明雨，王娜，一種合成4-芳基-4，5-二氫呋喃類衍生物的新方法。專利號：ZL 201010160246.7

2. 余孝其，李坤，后際挺取代的水楊醛-TCF衍生物及其製備方法和用途。專利申請號: 201410023272.3

（1）化學生物學：熒光探針的設計、合成及在生命體內的應用研究

（2）有機化學：具有生理活性的有機小分子的合成及性質研究

科研項目：

1. 四川大學優秀青年學者基金（A）：DNA甲基化過程中胞嘧啶類衍生物的選擇性識別，項目負責人，2013.10-2016.12

2. 國家自然科學基金青年項目（21001077），“自活化”序列選擇性人工核酸酶的設計合成及應用研究，項目負責人，2011.1-2013.12。

3. 教育部新教師基金（20100181120040），生物催化多功能性合成二氫呋喃肟衍生物及其生物活性研究，項目負責人，2011.1-2013.12。

1999.9-2003.7 煙台大學 化學生物理工學院 學士

2003.9-2008.6 四川大學 化學學院 碩、博士

2008.7- 2011.6 四川大學 化學學院 講師

2010.11-2011.10 香港大學 化學學院 博士后

2011.7-至今 四川大學 化學學院 副教授