高輝

1.生物醫用高分子合成及其性能研究

2.抗癌藥物、蛋白質、肽類藥物等的緩、控釋體系

3.環境響應性智能給葯系統

講授課程：藥用高分子材料 葯事管理學 藥學專業英語

⒈ Y N Ma,H Gao,* W X Gu,Y W Yang,Y N Wang,Y G Fan,G L Wu,and J B Ma,Carboxylated poly(glycerol methacrylate)s for doxorubicin delivery,Eur J Pharm Sci,2012,45: 65-72. （IDS Number: 892FL,IF=3.3）；

⒉ X Y Lu,H Gao,* C Li,Y W Yang,Y N Wang,Y G Fan,G L Wu,and J B Ma. Polyelectrolyte complex nanoparticles of amino poly(glycerol methacrylate)s and insulin,Int J Pharm,2012,423: 195-201. （IDS Number:,IF=3.6）；

⒊ H Gao,Lu X Y,Y N Ma,Y W Yang,J F Li,G L Wu,Y N Wang,Y G Fan,and Ma J B*. Amino poly(glycerol methacrylate)s for oligonucleic acid delivery with enhanced transfection efficiency and low cytotoxicity,Soft Matter,2011,7: 9239-9247. （IDS Number: 822YE,IF=4.6）；

⒋ H Gao,* Y N Ma,X Y Lu,Y R Liang,B Q Chen,and J B Ma. PH-responsive nano-assemblies of amino poly(glycerol methacrylate),Eur Pol J,2011,47:1232-1239（IDS Number: 776GX,IF=2.9）.

⒌ H G Fu,H Gao,* G L Wu,Y N Wang,Y G Fan,and J B Ma. Preparation and tunable temperature-sensitivity of biodegradable polyurethane nanoassemblies from diisocyanate and poly(ethylene Glycol),Soft Matter,2011,7: 3546-3552（IDS Number: 738XZ,IF=4.6）.

⒍ X K Sun,H Gao,* G L Wu,Y N Wang,Y G Fan,and J B Ma. Biodegradable and temperature-responsive polyurethanes for adriamycin delivery,Int J Pharm,2011,412:52-58（IDS Number: 793EH,IF=3.0）.

⒎ H. Gao,M. Elsabahy,E.V. Giger,D.K. Li,R.E. Prud’homme,J.C. Leroux,Aminated linear and star-shape poly(glycerol methacrylate)s: synthesis and self-assembling properties,Biomacromolecules,2010,11: 889-895.（IDS Number: 581WW,IF=4.5）.

⒏ J. Leblond,; H. Gao,A. Petitjean,Leroux,J.C. Leroux,pH-Responsive molecular tweezers,J Am Chem Soc,2010,132：8544-8545. （IDS Number:,IF=8.6）.

⒐ H. Gao,M.C. Jones,J. Chen,Y.R. Liang,R. E. Prud’homme,J.-C. Leroux,Hydrophilic nanoreservoirs embedded into polymeric nanoparticles - An approach to compatibilize polar molecules with hydrophobic matrices. Chem Mater,2008; 20: 4191–4193. （IDS Number: 321BM,IF=5.4）.

⒑ H. Gao,M.C. Jones,J. Chen,R. E. Prud’homme,J.-C. Leroux,Core cross-linked reverse polymeric micelles. Chem Mater,2008; 20: 3063–3067. （IDS Number: 297NM,IF=5.4）.

⒒ M.C. Jones,H. Gao,J.-C. Leroux,Reverse polymeric micelles for pharmaceutical applications. J. Controlled release,2008;132:208-215. （IDS Number: 386SL,IF=5.9）.

⒓ H. Gao,Y.N. Wang,Y.-G. Fan,J.-B. Ma. Ethylenediamino bridged bis（β-cyclodextrin)/ poly(DL-lactic-co-glycolic acid) nanoparticles prepared by modified double emulsion method: effect of polyvinyl alcohol on nanoparticle properties. J Appl Polym Sci,2008; 107: 571–576. （IDS Number: 229RP,IF=1.2）.

⒔ H. Gao,M.C. Jones,P. Tewari,M. Ranger,J.-C. Leroux,Star-Shaped alkylated poly (glycerol methacrylate) reverse micelles: synthesis and evaluation of their solubilizing properties in dichloromethane. J Polym Sci Part A: Polym Chem,2007; 45:2425-2435. （IDS Number: 173SZ,IF=4.0）.

⒕ H. Gao,Y.N. Wang,Y.-G. Fan,J.-B. Ma. Conjugates of poly(DL-lactide-co-glycolide) on amino cyclodextrins and their nanoparticles as protein delivery system. J Biomed Mater Res Pt A,2007; 80A:111-122. （IDS Number: 114PN,IF=2.8）.

⒖ H. Gao,Y.N. Wang,Y.-G. Fan,J.-B. Ma. Conjugates of poly(DL-lactic acid) with ethylenediamino or diethylenetriamino bridged bis(beta-cyclodextrin)s and their nanoparticles as protein delivery systems. J control release,2006; 112:301-311. （IDS Number: 057NA,IF=5.9）.

⒗ H. Gao,Y.N. Wang,Y.-G. Fan,J.-B. Ma. Interactions of some modified mono- and bis-beta-cyclodextrins with bovine serum albumin. Bioorgan & Med Chem,2006; 14:131-137. （IDS Number: 989YB,IF=2.8）.

⒘ H. Gao,Y.N. Wang,Y.-G. Fan,J.-B. Ma. Synthesis of a biodegradable tadpole-shaped polymer via the coupling reaction of polylactide onto mono（6-（2-aminoethyl) amino-6-deoxy)- β -cyclodextrin and its properties as the new carrier of protein delivery system. J control release,2005; 107:158-173. （IDS Number: 970YW,IF=5.9）.

項目:

1. 國家自然科學基金項目：含多氫鍵給體的高分子的合成及其作為基因載體的性能研究（21074092），2011.01-2013.12，35萬，主持；

2. 國家自然科學基金項目：含 beta-環糊精高分子的合成、反相膠束的構建及其在肽類藥物控制釋放中的應用，2013.01-2013.12, 10萬，主持；

3. 天津市自然科學基金：側鏈降解型聚陽離子基因載體的合成及其性能研究（10JCYBJC26800），2010.10 - 2013.09，10萬，主持；

4. 973計劃前期專項：新型生物降解高分子納米材料的合成及其環境響應性能（2009CB626612），2009.04-11.08，55萬元，與南開大學馬建標教授合作項目；是天津理工大學方負責人（結題）；

5. 天津市高等學校科技發展基金計劃項目：羧基聚甲基丙烯酸甘油酯的合成及對阿黴素的控制釋放，2009.12-2012.12，3萬元，主持（結題）。

6. 教育部新世紀優秀人才支持計劃，2012.01-2014.12，50萬，主持；

專著

1. 功能高分子材料，馬建標主編，之第九章醫用高分子材料，第二版：化學工業出版社,2010年.

專利

1．高輝，孫現科，馬建標，發明，具有pH響應性的生物降解聚氨酯材料的製備方法

獲獎:

1．馬建標、王亦農、王小紅、高輝、范雲鴿，天然生物高分子的修飾及其生物醫學性能（2010ZR-3-006）天津市自然科學三等獎（2010年）；

2. Japanese Society for Promotion of Science (JSPS)日本振興會社青年學者獎(L-11524). （2011）個人獎。