共找到16條詞條名為郭宇的結果 展開
郭宇
南開大學藥學院講師
郭宇,男,漢族,1985年11月出生,中共黨員,南開大學藥學院講師。學科方向為結構生物學、化學生物學、針對傳染性疾病與癌症的機制與創新藥物研究。2012年6月獲理學博士學位;2012年7月加入南開大學藥學院工作。
,讀南科院技術專業,獲;,免試南科院化系,獲博;南葯院。研究針傳染疾病癌症靶蛋,X射線衍射晶體學的方法,探求其結構生物學基礎與分子機制,並進行相關創新藥物的開發。研究成果已發表在Proc Natl Acad Sci USA, Protein Cell, J Virol.等知名國際期刊上。
構、化、針傳染疾病癌症制創葯研究。
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2. A structural view of the antibiotic degradation enzyme NDM-1 from Guo, Wang J, Niu G, Shui W, Sun Y, Zhou H, Zhang Y, Yang C, Lou Z, Rao Z. Protein Cell. 2011 May;2(5):384-94.
3. Crystal structure and mutagenesis analysis of chitinase CrChi1 from the nematophagous fungus Clonostachys rosea in complex with the inhibitor caffeine.Yang J, Gan Z, Lou Z, Tao N, Mi Q, Liang L, Sun Y, Guo Y, Huang X, Zou C, Rao Z, Meng Z, Zhang KQ. Microbiology. 2010 Dec;156(Pt 12):3566-74. Epub 2010 Sep 9.
4. A novel non-radioactive assay for HIV-RT (RdDp) based on pyrosequencing for high-throughput drug screening.Zhang C, Wu Y, Sun Y, Hong C, Xiang K, Guo Y, Bartlam M, Lou Z. Protein Cell. 2010 Mar;1(3):284-90.
5. The crystal structures of two cuticle-degrading proteases from nematophagous fungi and their contribution to infection against nematodes.Liang L, Meng Z, Ye F, Yang J, Liu S, Sun Y, Guo Y, Mi Q, Huang X, Zou C, Rao Z, Lou Z, Zhang KQ. FASEB J. 2009 Dec 18.
6. Crystal structure of porcine reproductive and respiratory syndrome virus leader protease Nsp1alpha.Sun Y, Xue F, Guo Y, Ma M, Hao N, Zhang XC, Lou Z, Li X, Rao Z. J Virol. 2009 Nov;83(21):10931-40.
7. Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center.Zhao C, Lou Z, Guo Y, Ma M, Chen Y, Liang S, Zhang L, Chen S, Li X, Liu Y, Bartlam M, Rao Z. J Virol. 2009 Sep;83(18):9024-30.
8. Preliminary crystallographic study of two cuticle-degrading proteases from the nematophagous fungi Lecanicilliumpsalliotae and, Liang L, Mi Q, Yang J, Lou Z, Sun Y, Guo Y, Meng Z, Zhang K. ActaCrystallogr Sect F StructBiolCrystCommun. 2009 Mar 1;65(Pt 3):271-4.
9. Structural basis of beta-catenin recognition by Tax-interacting protein-1.Zhang J, Yan X, Shi C, Yang X, Guo Y, Tian C, Long J, Shen Y. J Mol Biol. 2008 Dec 5;384(1):255-63. Epub 2008 Sep 21.
2020年4月,獲評為2020年全國向上向善好青年(創新創業好青年)。