孫超

西北農林科技大學教授

孫超,男,漢族,1968年9月27日生於陝西省商南縣,教授,博士生導師。

人物經歷


孫超
孫超
1989年9月-1993年7月在原西北農業大學畜牧專業上大學,畢業后留校任教至今;1995年9月-1998年7月在西北農林科技大學攻讀動物遺傳育種碩士學位;1998年9月-2001年12月在西北農林科技大學攻讀動物遺傳育種博士學位;1999年2月-2001年7月在第四軍醫大學細胞生物學實驗室做合作研究;2001年12月晉陞副教授;2003年5月被聘為碩士生導師;2003年9月-2006年7從本校生物學博士后流動站出站,2004年8月-2007年8月任學校實驗室管理處副處長;2005年入選學校首批“青年學術骨幹支持計劃”,2006年5月由副教授直聘為博導,2007年入選教育部“新世紀優秀人才支持計劃”,2008年10月晉陞教授;2009年2月-2011年2月在美國賓夕法尼亞州立大學醫學院肥胖與糖尿病研究中心做訪問學者和博士后研究;2013年12月至今任動物科技學院副院長。

獲得榮譽


2006年動物脂肪細胞增殖分化及其調控機理研究陝西省科學技術二等獎

主要成就


主講課程

一直從事動物生物化學、分子生物學的教學與科研工作。先後承擔本科生動物生物化學、酶與蛋白質工程等課程教學,為博、碩士研究生講授高級動物生物化學、高級動物生物化學研究技術、分子營養學等課程。

研究方向

動物脂質代謝的可塑性調控及其遺傳機理、動物肉脂性狀形成的分子遺傳調控機理、肥胖症與糖尿病的發生機理及其防治、現代生物技術與動物分子育種。

科研項目

(1)豬肌內脂肪形成分子調控與新品種選育創新團隊,陝西省重點科技創新團隊建設項目(2017KCT-24),2017/01-2019/12,100萬
(2)Leptin及相關因子調控豬脂肪發育的分子機制,973計劃項目(2015CB943102),2016/01-2019/12,450萬
(3)膠原XV通過“Ca2+-內質網”軸調節豬白色脂肪棕色化的作用機制,國家自然科學基金(31572365),2016/01-2019/12,76.8萬
(4)豬脂肪沉積關鍵基因bambi的克隆及功能驗證,農業部轉基因重大專項,2014/01-2016/12,170萬元
(5)生豬綠色安全養殖、疾病防控技術研究與示範,陝西省農業攻關項目,2014/01-2016/12,8萬元
(6)節能環保發酵床使用技術推廣,陝西省農業專項,2014/1-2016/12,15萬元
(7)αMSH通過PKA和ERK信號通路調節豬脂肪沉積和Leptin及Foxc2分泌的分子機制,國家自然科學基金(31172185),2014/01-2016/12,58.0萬 

科研獎勵

(1)Leptin調控脂肪細胞發育與代謝的分子機制,吳常信動物遺傳育種科技成果獎,2015,排名1;
(2)西北五省區重要地方畜禽遺傳資源研究,陝西省人民政府,陝西省科學技術獎,二等,2012,排名3;
(3)豬脂肪沉積及其調控機制研究,陝西省人民政府,陝西省科學技術獎,三等,2016,排名4; 

主要論文

(1)LuGan,ZhenjiangLiu,FeiFeng,TianjiaoWu,DanLuo,ChingyuanHu,ChaoSun.(2017)Foxc2coordinatesinflammationandbrowningofwhiteadiposebyleptin-STAT3-PRDM16signalinmice.Internationaljournalofobesity.Inpress
(2)FeiFeng,QianRen,SongWu,MuhammadSaeed,ChaoSun.(2017)Hoxa5IncreasesMitochondrialApoptosisbyInhibitingAkt/mTORC1/S6K1PathwayinMiceWhiteAdipocytes.Oncotarget.
(3)GuannvLiu,MeihangLi,YataoXu,SongWu,MuhammadSaeedChaoSun.(2017)ColXVPromotesAdipocyteDifferentiationviaInhibitingDNAMethylationandcAMP/PKAPathwayinMice.Oncotarget.;8:60135-60148
(4)WeinaCao,MeihangLi,TianjiaoWu,FeiFeng,TongyingFeng,YangXuandChaoSun.(2017)αMSHpreventsROS-inducedapoptosisbyinhibitingFoxo1/mTORC2inmiceadiposetissue.Oncotarget.;8:40872-40884.
(5)ZhenjiangLiu,LuGan,YataoXu,DanLuo,QianRen,SongWu,ChaoSun*(2017)Melatoninalleviatesinflammasome-inducedpyroptosisthroughinhibitingNF-κB/GSDMDsignalinmiceadiposetissue..DOI:10.1111/jpi.12414.JournalofPinealResearch.
(6)GuannvLiu,MeihangLi,MuhammadSaeed,YataoXu,QianRen,ChaoSun.(2017)αMSHInhibitsAdiposeInflammationviaReducingFoxOsTranscriptionandBlockingAkt/JNKPathwayinMice.Oncotarget.8:47642-47654
(7)LiM,BeaucheminH,PopovicN,PetersonA,d'HennezelE,PiccirilloCA,SunC,PolychronakosC.(2017)Thecommon,autoimmunity-predisposing620Arg>TrpvariantofPTPN22modulatesmacrophagefunctionandmorphology.JAutoimmun.22.pii:S0896-8411(16)30324-9.
(8)LiuZhenjiang,GuHuihui,GanLu,XuYatao,FengFei,SaeedMuhammad,SunChao.(2017)ReducingSmad3/ATF4wasessentialforSirt1inhibitingERstress-inducedapoptosisinmicebrownadiposetissue.Oncotarget.Feb7;8(6):9267-9279.
(9)LiuZhenjiang,GanLu,LuoDan,SunChao.(2017)Melatoninpromotescircadianrhythm-inducedproliferationthroughClock/histonedeacetylase3/c-Mycinteractioninmouseadiposetissue.JournalofPinealResearch.May;62(4)..
(10)ZhenjiangLiu,LuGan,TianjiaoWu,FeiFeng,DanLuo,GuannvLiu,HuihuiGu,ShiminLiuandChaoSun*.(2016)AdiponectinreducesERstressandapoptosisviaPPARαtranscriptionalregulatesATF2andAMPK/PKCsignalinmiceadipose.Celldeath&disease.Nov24;7(11):e2487.
(11)LuGan,ZhenjiangLiu,TianjiaoWu,FeiFeng,ChaoSun*.(2017)αMSHpromotespreadipocyteproliferationbyalleviatingERstress-inducedleptinresistanceandbyactivatingNotch1signalinmice.BBA-MolecularBasisofDisease.,(16)30245-9.
(12)LuGan,ZhenjiangLiu,YuzheChen,DanLuo,FeiFeng,GuannvLiu,ChaoSun*.(2016)α-MSHandFoxc2promotefattyacidoxidationthroughC/EBPβnegativetranscriptioninmiceadiposetissue.SciRep.Nov7;6:36661
(13)LiuZ,GanL,ChenY,LuoD,ZhangZ,CaoW,ZhouZ,LinX,SunC*.(2016)Mark4promotesoxidativestressandinflammationviabindingtoPPARγandactivatingNF-κBpathwayinmiceadipocytes.SciRep.6:21382.
(14)LiuZ,GanL,LiuG,ChenY,WuT,FengF,SunC*.(2016)Sirt1decreasedadiposeinflammationbyinteractingwithAkt2andinhibitingmTOR/S6K1pathwayinmice.JLipidRes.Jun17.pii:jlr.M063537.
(15)YangH,AnJJ,SunC*,XuB.(2016)RegulationofEnergyBalanceviaBDNFExpressedinNonparaventricularHypothalamicNeurons.MolEndocrinol.30(5):494-503.
(16)Gan,L.,Liu,Z.J.,Cao,W.N.,Zhang,Z.Z.,Sun,C*.(2015).FABP4reversedtheregulationofleptinonmitochondrialfattyacidoxidationinmiceadipocytes.ScientificReports.Aug27;5:13588.
(17)Gan,L.,Liu,Z.J.,Jin,W.,Zhou,Z.J.,Sun,C*.(2015).Foxc2enhancesproliferationandinhibitsapoptosisthroughactivatingAkt/mTORC1signalingpathwayinmousepreadipocytes.JournalofLipidResearch,56(8),1471-1480.
(18)Gan,L,Yan,J,Liu,Z.J.,Feng,M,Sun,C*.(2015)Adiponectinpreventsreductionoflipid-inducedmitochondrialbiogenesisviaAMPK/ACC2pathwayinchickenadipocytes.JournalofCellularBiochemistry,116(6),1090-1100.
(19)Yan,Jun,Tan,Xiao,Yan,Guoyong,Feng,Min,Yang,Haili,Sun,C*.(2014).RecombinantGlobularAdiponectinInhibitsLipidDepositionbyp38MAPK/ATF-2andTOR/p70S6KinasePathwaysinChickenAdipocytes.BiochemistryandCellBiology.92(1):53-60.
(20)Gan,L.,Liu,Z.J,Zhang,Z.Z.,Yang,X.b.,Liu,J.,Sun,C*.(2014).SOCS2inhibitedmitochondriabiogenesisviainhibitingp38MAPK/ATF2pathwayinC2C12cells.Molecularbiologyreports,41(2),627-637.
(21)Liu,Z.J,Gan,L.,Yang,X.B.,Zhang,Z.Z.,Liu,J.,Sun,C*.(2014).HydrodynamictailveininjectionofSOCS3eukaryoticexpressionvectorinvivopromotedliverlipidmetabolismandhepatocyteapoptosisinmouse.BiochemistryandCellBiology.92(2).
(22)YanJ.,GanL.,ChenD.,SunC*.(2013)Adiponectinimpairschickenpreadipocytesdifferentiationthroughp38MAPK/ATF-2andTOR/p70S6Kinasepathways.PLOSONE.10.1371/journal.pone.0077716
(23)YanJ.,GanL.,QiR.L.SunC*.(2013)Adiponectindecreaseslipidsdepositionbyp38MAPK/ATF2signalingpathwayinmuscleofbroilers.MolecularBiologyReports,40(12):7017-25.doi:10.1007
(24)JiangD.F.,ZhangX.G.,YangH.L.,SunC*.(2013).Differentialexpressionoflipidmetabolismgenesintheliverandadiposetissueofmicetreatedwithevodiamine.GeneticsandMolecularResearch.doi:10.4238
(25)YanJ.,YangH.L.,GanL.,SunC*.(2013).Adiponectin-impairedadipocytedifferentiationnegativelyregulatesfatdepositioninchicken.JournalofAnimalPhysiologyandAnimalNutrition.doi:10.1111/jpn.12107
(26)YangH.L.,FengM,TanX,YanG.Y.,GanL,SunC*.(2013).Constructionofsuppressorofcytokinesignaling2(SOCS2)adenoviraloverexpressionvectoranditsimpactongrowth-hormone-inducedlipolysisinswineprimaryadipocytes.GeneticsandMolecularResearch,12(2),1283-1293.
(27)Li,Y.,Ohms,S.J.,Sun,C*.,&Fan,J.Y.(2013).NF-kappaBcontrolsIl2andCsf2expressionduringTcelldevelopmentandactivationprocess.MolecularBiologyReports,40(2),1685-1692.doi:10.1007/s11033-012-2219-2
(28)Qi,R.L.,Feng,M.,Tan,X.,Gan,L.,Yan,G.Y.,Sun,C*.(2013).FATP1silenceinhibitsthedifferentiationandinducestheapoptosisinchickenpreadipocytes.MolecularBiologyReports,40(4),2907-2914.
(29)Yan,J.,Gan,L.,Yang,H.L.,Sun,C*.(2013).Theproliferationanddifferentiationcharacteristicsofco-culturedporcinepreadipocytesandmusclesatellitecellsinvitro.MolecularBiologyReports,40(4),3197-3202.doi:10.1007/s11033-012-2395-0
(30)Yang,H.L.,Feng,M.,Tan,X.,Yan,G.Y.,Sun,C*.(2013).TheroleofSOCS2inrecombinanthumangrowthhormone(rhGH)regulatinglipidmetabolisminhigh-fat-diet-inducedobesitymice.MolecularBiologyReports,40(3),2319-2326.
(31)Zhao,Xia,Qi,Renli,Sun,Chao*,Xie,Yunfei.(2013)SilencingSOCS3couldinhibitTNF-alphainducedapoptosisin3T3-L1andmousepreadipocytes.MolecularBiologyReports,39(9):8853-8860,2012/9.
(32)Sun,C*.,Tian,L.,Nie,J.,Zhang,H.,Han,X.,Shi,Y.G.(2012).InactivationofMARK4,anAMP-activatedProteinKinase(AMPK)-relatedKinase,LeadstoInsulinHypersensitivityandResistancetoDiet-inducedObesity.JournalOfBiologicalChemistry,287(45).doi:10.1074/jbc.M112.388934
(33)Nie,J.,Sun,C.,Faruque,O.,Ye,G.M.,Li,J.,Liang,Q.R.,Shi,Y.G.(2012).SynapsesofAmphidsDefective(SAD-A)KinasePromotesGlucose-stimulatedInsulinSecretionthroughActivationofp21-activatedKinase(PAK1)inPancreaticbeta-Cells.JournalOfBiologicalChemistry,287(31),26435-26444.doi:10.1074/jbc.M112.378372
(34)Sun,Chao*,Qi,Renli,Wang,Li,Yan,Jun,Wang,Yong.p38MAPKregulatescalciumsignal-mediatedlipidaccumulationthroughchangingVDRexpressioninprimarypreadipocytesofmice.MolecularBiologyReports,39(3):3179-3184,2012/3
(35)Sun,Chao*,Wang,Li,Yan,Jun,Liu,Shumin.(2012).Calciumamelioratesobesityinducedbyhigh-fatdietanditspotentialcorrelationwithp38MAPKpathwayMolecularBiologyReports,39(2):1755-1763,2012/2.
(36)Renli,Q.,Chao,S.*,Jun,Y.,Chan,S.,&Yunfei,X.(2012).Changesinfatmetabolismofblack-bonechickensduringearlystagesofinfectionwithNewcastlediseasevirus.Animal,6(8),1246-1252.doi:10.1017/s1751731112000365
(37)Li,Y.,Chen,G.B.,Ma,L.N.,Ohms,S.J.,Sun,C*.,Shannon,M.F.,Fan,J.Y.(2012).PlasticityofDNAmethylationinmouseTcellactivationanddifferentiation.BMCMolecularBiology,13.doi:10.1186/1471-2199-13-16
(38)Li,Y.,Ohms,S.J.,Shannon,F.M.,Sun,C*.,Fan,J.Y.(2012).IL-2andGM-CSFareregulatedbyDNAdemethylationduringactivationofTcells,Bcellsandmacrophages.BiochemicalAndBiophysicalResearchCommunications,419(4),748-753.doi:10.1016/j.bbrc.2012.02.094
(39)Liu,J.,Jing,X.B.,Gan,L.,Sun,C*.(2012).TheJAK2/STAT3SignalPathwayRegulatestheExpressionofGenesRelatedtoSkeletalMuscleDevelopmentandEnergyMetabolisminMiceandMouseSkeletalMuscleCells.BioscienceBiotechnologyAndBiochemistry,76(10),1866-1870.doi:10.1271/bbb.120324
(40)Yang,H.L.,Sun,C*.,Sun,C.,&Qi,R.L.(2012).Effectofsuppressorofcytokinesignaling2(SOCS2)onfatmetabolisminducedbygrowthhormone(GH)inporcineprimaryadipocyte.MolecularBiologyReports,39(9),9113-9122.doi:10.1007/s11033-012-1783-9
(41)LiJ,RomestaingC,HanX,LiY,HaoX,WuY,SunC,LiuX,JeffersonLS,XiongJ,LanoueKF,ChangZ,LynchCJ,WangH,ShiY.(2010).CardiolipinremodelingbyALCAT1linksoxidativestressandmitochondrialdysfunctiontoobesity.Cellmetabolism,12(2),154-165. 

主要貢獻

主持完成1項國家自然科學基金、3項陝西省農業攻關項目。目前主持國家自然科學基金、教育部新世紀優秀人才支持計劃、教育部重點科研項目、陝西省農業攻關、陝西省自然科學基金等9項研究課題。
近年來,先後在《CellMetabolism》《MolecularBiologyReport》《AnimalScience》《生物工程學報》《中國農業科學》《畜牧獸醫學報》等刊物上發表論文60餘篇,其中SCI收錄文章8篇;主編出版著作3部,參編著作9部。目前已培養碩士研究生18名;在讀碩士研究生8名,博士研究生7名。