黃曉華

南京師範大學化學院教授

黃曉華,從事化學與生物學交叉研究領域,主要研究方向為生物無機化學,即將生物物理化學研究手段、細胞化學方法與細胞生物學技術優化組合,研究稀土元素、重金屬離子、醫用納米材料對細胞及其生物酶分子的結構、功能及其微觀化學過程的影響。

在研項目


(1)稀土對辣根的劑量效益評價及其研究(GFZ20612108,2007-2009)
(2)重金屬Tb作用於植物細胞膜的微觀化學行為研究(2009-2012)
(3)聚氨酯無機仿生表面構建的關鍵技術及生物醫用研究(2009-2012)
(4)稀土作用於辣根細胞膜的若干生物無機化學行為研究(2010-2012)

成果介紹


作為項目主持人近三年來,完成中美合作項目、國家自然科學基金國家發改委、江蘇省高技術及教育部重點項目等8項、在研項目3項。在J.Biol.Inorg.Chem.,J.Phys.Chem.,Dalton Transactions,Ecotoxicology and Environmental Safety,Annals of Botany,Electrochimica Acta.,J.Electro. Chem.,J.Mater.Chem.等學術期刊上合作發表SCI論文60餘篇(其中第一及通信作者42篇)。被國外SCI期刊Journal of Physical Chemistry(B、C),Dalton Transactions,International Journal of Biological Sciences,Biological Trace Element Research,Langmuir,Ecotoxicology and Environmental Safety,Annals of Botany,Environmental Chemistry Letters等他引223次,單篇最高引用17次。2007年應邀在“13th International Conference on Biological Inorganic Chemistry(ICBIC13,維也納)”會上報告;2009年又收到“ICBIC14,日本”會議報告的邀請。獲得1項美國專利及6項中國(授權)發明專利。其中,一項特色研究成果用於出口經濟作物,05-07連續三年該產品獲得歐盟生態證書及出口美國、加拿大、丹麥、德國等國家和地區,凈增經濟效益96萬美元。

研究項目


(1)稀土生態轉光膜分子設計及研製(BG2005040.2005-2007);
(2)稀土離子對辣根植物過氧化酶的結構和生物活性影(20471030,2005-2007);
(3)稀土離子對辣根植物過氧化酶的毒害機理(IFZ2051210,2006-2008);

研究成果


(1)Huang, X.H., Zhou, Q., Lu,T.H., Guo, S.F (2009). Design and preparation of plant growth regulator of rare earth element-amino acid-vitamine, United States Patent(EFSID;4978659;PCT/CN07/01912).
(2)Guo , X.Y., Yin,W.Q., Sun, X.H., Huang, X.H.*,. Lu, T.H.(2009). Study on intreaction between Eu(III) and thermosensitive microsphere. Polym.Bull. 62:337-344.
(3)Guo, S.F., Cao, R., Lu, A.H., Zhou, Q., Lu, T.H., Ding, X.L., Li, C.J., Huang, X.H.* (2008) One of the Possible Mechanisms for the Inhibition Effect of Tb (III) on Peroxidase Activity in Horseradish (Armoracia Rusticana) Treated with Tb (III). Journal of Biological Inorganic Chemistry. 13(4): 587-597.
(4)Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2008) Inhibition Mechanism of Tb-III on Horseradish Peroxidase Activity. Chemistry & Biodiversity. 5(10): 2050-2059.
(5)Ye, Y.X., Wang, L.H., Huang, X.H.*, Lu, T.H., Ding, X.L., Zhou, Q.*, Guo, S.F. (2008) Subcellular Location of Horseradish Peroxidase in Horseradish Leaves Treated with La(III), Ce(III) and Tb(III). Ecotoxicology and Environmental Safety. 71(3): 677-684.
(6)Wang, L.H., Huang, X.H.*, Zhou, Q.* (2008) Effects of Rare Earth Elements on the Distribution of Mineral Elements and Heavy Metals in Horseradish. Chemosphere. 73(3): 314-319.
(7)Liu, H.K. *, Huang, X.H.*, Lu, T.H., Wang, X.J., Sun, W.Y., Kang, B.S. (2008) Discrete and Infinite 1d, 2d/3d Cage Frameworks with Inclusion of Anionic Species and Anion-Exchange Reactions of Ag3l2 Type Receptor with Tetrahedral and Octahedral Anions. Dalton Transactions. (24): 3178-3188.
(8)Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2008) Spectroscopic Studies of Interactions Involving Horseradish Peroxidase and Tb3+. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy. 70(4): 818-823.
(9)Zhou, H., Lu, T.H., Shi, H.X., Dai, Z.H., Huang, X.H.* (2008) Direct Electrochemistry and Electrocatalysis of Catalase Immobilized on Multi-Wall Carbon Nanotubes Modified Glassy Carbon Electrode and Its Application. Journal of Electroanalytical Chemistry. 612(2): 173-178.
(10)Guo, X.Y., Lu, T.H., Huang, X.H.* (2008) Eu(III)-Modified Properties of Thermosensitive Core-Shell Microspheres. Colloid and Polymer Science. 286(4): 469-473.
(11)Guo, X.Y., Chen, M.Q., Lu, T.H., Huang, X.H.* (2008) Effect of Tb(III) on the Properties of P(Nipam-Co-St) Copolymer Microspheres. Journal of Polymer Research. 15(2): 141-145.
(12)Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2007)Inhibition Effect of Tb(III) on Horseradish Peroxidase Activity. Journal of Biological Inorganic Chemistry. 12, (S1): S203.
(13)Guo, X.S., Zhou, Q., Zhu, X.D., Lu, T.H., Huang, X.H.* (2007) Migration of a Rare Earth Element Cerium(III) in Horseradish. Acta Chimica Sinica. 65(17): 1922-1924.
(14)Guo, X.S., Zhou, Q., Lu, T.H., Fang, M., Huang, X.H.* (2007) Distribution and Translocation of Ce-141 (III) in Horseradish. Annals of Botany. 100(7): 1459-1465.
(15)Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2007) Interaction between La3+ and Mp-11 in the Physiological Solution. Electrochimica Acta. 52(5): 2032-2038.
(16)Zhao, B.*, Rong, Y.Z., Huang, X.H., Shen, J.S. (2007) Experimental and Theoretical Study on the Structure and Electronic Spectra of Imiquimod and its Synthetic Intermediates. Bioorganic & Medicinal Chemistry Letters. 17(17): 4942-4946.
(17)Huang, X.H.*, Guo, S.F., Zhou, Q., Lu, T.H.*, Ding, X.L. (2007) Effect of La3+ on Structure and Electrochemical Reaction of Microperoxidase-11 in Imitated Physiological Solution. Journal of Electroanalytical Chemistry. 600(2): 227-235.
(18)Yin, W.Q., Chen, M.Q., Lu, T.H., Akashi, M., Huang, X.H.* (2007) Properties of Complex of Tb(III) and Poly(N-Isopropylacrylamide)-G-Poly(N-Isopropylacrylamide-Co-Styrene) Core-Shell Nanoparticles. Journal of Alloys and Compounds. 432(1-2): L18-L21.