王岩

2003.9 -2007.6 山東師範大學生命科學學院，本科

2007.9-2012.12 山東大學微生物技術國家重點實驗室，博士 導師：李越中教授

2010.10-2012.10 美國內布拉斯加-林肯大學化學系訪問學者，合作導師：杜良成教授

2013.2-2014.5 美國內布拉斯加-林肯大學化學系博士后，合作導師：杜良成教授

2014.5-2019.7 中國海洋大學海洋生命學院，“青年英才工程第三層次”，副教授

2019.7至今 中國海洋大學海洋生命學院，“青年英才第一層次”，教授，博士生導師

1.Yan Wang*(通訊作者), Tian Tian, Jingjing Zhang, Xin Jin, Huan Yue, Xiao-Hua Zhang, Liangcheng Du, Fan Bai, 2019,Indole reverses intrinsic antibiotic resistance by activating a novel dual-function importer. mBio,2019,Volume 10 Issue 3 e00676-19

2. Jiayi Wang, Jing Lin, Yunhui Zhang, Jingjing Zhang, Tao Feng, Hui Li, Xianghong Wang, Qingyang Sun, Xiaohua Zhang and Yan Wang* (通訊作者), 2019, Activity Improvement and Vital Amino Acid Identification on the Marine-Derived Quorum Quenching Enzyme MomL by Protein Engineering, Marine Drugs2019, 17, 300; doi:10.3390/md17050300

3. Jingjing Zhang, Jiayi Wang, Tao Feng , Rui Du , Xiaorong Tian , Yan Wang * (通訊作者) and Xiao-Hua Zhang, 2019 Heterologous Expression of the Marine-Derived Quorum Quenching Enzyme MomL Can Expand the Antibacterial Spectrum of Bacillus brevis. Marine Drugs2019, 17, 128; doi:10.3390/md17020128

4. Ying Su, Kaihao Tang, Jiwen Liu, Yan Wang, Yanfen Zheng, Xiao-Hua Zhang, 2019. Quorum sensing system of Ruegeria mobilisRm01 controls lipase and biofilm formation. Frontiers in Microbiology,

5. Yong Han, Wang Yan(並列一作), Yameng Yu, Haotong Chen, Yuemao Shen, Liangcheng Du,2017.Indole-induced Reversion of Intrinsic Multi-antibiotic Resistance in Lysobacter enzymogenes. Applied and Environmental Microbiology.17;83(17). pii: e00995-17（co-first author）

6. Wang Yan, Hui Li, Xinxin Cui& Xiao-Hua Zhang*,2017.A novel stress response mechanism, triggered by indole,involved in quorum quenching enzyme MomL and iron-sulfur cluster in Muricauda olearia Th120. Scientific Reports26;7(1):4252 ( doi:10.1038/s41598-017-04606-8)

7. Zhuo Li, Wang Yan(並列一作), Zhang Zheng, Li Jian, Zhang Xiao-Hua, Li Yue-zhong, 2017. Myxococcus xanthus DK1622 coordinates expressions of the duplicate groELand single groESgenes for synergistic functions of GroELs and GroES. Frontiers in Microbiology. (doi: 10.3389/fmicb.2017.00733)（co-first author）

8. Wang Yan, Qinghao Song, Xiao-Hua Zhang*. 2016. Marine Microbiological Enzymes: Studies with Multiple Strategies and Prospects. Marine Drugs, 14(10), 171; doi:10.3390/md14100171.

9. Qinghao Song, Wang Yan*(通訊作者), Chong Yin, Xiao-Hua Zhang*. 2016. LaaA, a novel cold-adaptive alkalophilic alpha-amylase from deep-sea bacterium Luteimonas abyssiXH031. Enzyme and Microbial Technology, DOI:10.1016/j.enzmictec.2016.05.003 (corresponding author)

10. Li Zhang, Wang Yan(並列一作), Jing Liang, Qinghao Song, Xiao-Hua Zhang*. 2016.Degradation properties of various macromolecules of cultivable psychrophilic bacteria from the deep sea water of the South Pacific Gyre. Extremophiles, DOI: 10.1007/s00792-016-0856-4 (co-first author)

11.Wang Yan, Xiaojing Chen, and Yue-zhong Li*. 2016. Duplicated groEL genes in Myxococcus xanthus DK1622. Stress and Enviromental Regulation of Gene Expression and Adaptation in Bacteria, chapter 14.5.

12. Han Y, Wang Yan(並列一作), Simon Tombosa, Stephen Wright, Justin Huffman, Gary Yuen, Guoliang Qian, Fengquan Liu, Yuemao Shen, Liangcheng Du. 2015. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes. Appl Microbiol Biotechnol, 99(2):801-11. (co-first author)

13.Wang Yan., X. Li, W. Zhang, X. Zhou, and Y. Z. Li. 2014. The groEL2gene, but not groEL1, is required for biosynthesis of the secondary metabolite myxovirescin in Myxococcus xanthus DK1622. Microbiology160:488-495.

14.Wang Yan, W. Y. Zhang, Z. Zhang, J. Li, Z. F. Li, Z. G. Tan, T. T. Zhang, Z. H. Wu, H. Liu, and Y. Z. Li. 2013. Mechanisms Involved in the Functional Divergence of Duplicated GroEL Chaperonins in Myxococcus xanthus DK1622. PLoS Genetics9:e1003306.

15.Wang Yan,G. Qian, F. Liu, Y. Z. Li, Y. Shen, and L. Du. 2013. Facile method for site-specific gene integration in Lysobacter enzymogenesfor yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF. ACS Synth Biol 2:670-678. (ACS Synthetic Biology launched on 2012, IF: 6.1)

16.Wang Yan, Qian, GL., Li, YY., Wang, YS., Wang, YL., Wright Stephen, Li, YZ., Shen, YM., Liu, FQ., Du, LC. 2013. Biosynthetic mechanism for sunscreen of the biocontrol agent lysobacter enzymogenes. PLoS One8(6): e66633.doi:10.1371/journal.pone.0066633. (Cited by Cell)

17. Zhang, W., Y. Li, G. Qian,Wang Yan, H. Chen, Y. Z. Li, F. Liu, Y. Shen, and L. Du. 2011. Identification and characterization of the anti-methicillin-resistant Staphylococcus aureus WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenesOH11. Antimicrob Agents Chemother 55:5581-5589.

18. Li, J.,Wang Yan(並列一作), C. Y. Zhang, W. Y. Zhang, D. M. Jiang, Z. H. Wu, H. Liu, and Y. Z. Li. 2010. Myxococcus xanthus viability depends on groELsupplied by either of two genes, but the paralogs have different functions during heat shock, predation, and development. Journal of Bacteriology192:1875-1881. (co-first author)

19. Li Zhuo, Wang Yan, Zheng Zhang, and Yue-Zhong Li. Dynamic Interplay oftheMyxobacterial Chaperonins. Prokaryotic Chaperonins: multiple copies and multitude functions2017, Springer

1. 入選2016年度中國科協“青年人才托舉工程”人才支持計劃；

2. 2014年山東省優秀博士論文；

3. 2015年國際合成生物學大賽世界銀獎；

4. 美國內布拉斯加大學生化會議最佳海報獎。

1. 海洋微生物群體感應與感應淬滅機制；

2.抑制病害細菌耐藥性的新策略研究；

3. 海洋微生物蛋白資源發掘及在抑制病害菌方面的應用技術。

1.國家自然科學基金面上項目：“吲哚抑制細菌耐藥性的新型機制研究”（31870023，2019.01-2022.12），項目負責人

2. 國家自然科學基金面上項目：“新型密度感應淬滅酶MomL的作用機制及其在植物細菌性病害防治中的應用”（31571970，2016.01-2019.12），項目負責人

3. 國家自然科學基金青年項目：“深海新菌深淵藤黃單胞菌新型α-澱粉酶的溫度適應性機制研究”（41506160，2016.01-2018.12），項目負責人

4. 中國科協“青年人才托舉工程”支持計劃，2016-2018，項目負責人

5.中國海洋大學優青培育計劃，2018-2021，項目負責人

6.鰲山科技創新計劃，青島海洋科學與技術國家實驗室，海洋微型生物多樣性格局與演化機制，2018.01-2020.12，參加

7. 山東省自然科學基金：“海洋耐油具柄菌密度感應淬滅酶的作用機制研究及應用”（2014ZRE29014，2014.12-2017.12），項目負責人

8. 留學回國基金：項目負責人

9. 中國博士后基金面上項目一等資助：“耐油具柄菌信號分子降解酶MalM與鐵硫簇suf相關性分析”（2014.8-2016.1），項目負責人

10. 中國博士后基金特別資助：項目負責人

11. 中國海洋大學英才計劃科研啟動基金：（2014.6-2016.5），項目負責人